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Abbreviation : p-JNK
Long Form : phosphorylated c-Jun N-terminal kinase
No. Year Title Co-occurring Abbreviation
2020 (-)-Epigallocatechin-3-gallate induces interferon-lamda2 expression to anti-influenza A virus in human bronchial epithelial cells (BEAS-2B) through p38 MAPK signaling pathway. EGCG, IAV, IFN, NP, p-ERK, pp38 MAPK, qRT-PCR
2020 7-methoxyflavanone alleviates neuroinflammation in lipopolysaccharide-stimulated microglial cells by inhibiting TLR4/MyD88/MAPK signalling and activating the Nrf2/NQO-1 pathway. 7MF, COX-2, Iba-1, ICAM-1, IL-6, iNOS, LPS, MCP-1, MyD88, NQO1, Nrf2, TLR4, TNF-alpha
2020 Anti-Amnesic Effect of Walnut via the Regulation of BBB Function and Neuro-Inflammation in Abeta1-42-Induced Mice. ACh, AChE, BBB, ChAT, COX-2, HO-1, ICR, IL-1beta, MDA, MMP, p-Akt, ROS, SOD, TNF-alpha, TNFR1, ZO-1
2020 Chebulanin exerts its anti-inflammatory and anti-arthritic effects via inhibiting NF-kappaB and MAPK activation in collagen-induced arthritis mice. CIA, ERK, IL-6, LPS, MAPK, NF-kappaB, p-IkappaBalpha, RA, TNF-alpha
2020 Dendrobium officinale Attenuates Myocardial Fibrosis via Inhibiting EMT Signaling Pathway in HFD/STZ-Induced Diabetic Mice. DCM, DOE, EMT, HDL-C, HFD, LDL-C, p-IRS-1, PPAR-alpha, STZ, TC, TG, TGF-beta1
2020 Effect of Hataedock Treatment on Epidermal Structure Maintenance through Intervention in the Endocannabinoid System. AD, CB, CD1a, DFE, ECS, GPR55, GPX4, HTD, LASS2, p-ERK, p-mTOR, PEA
2020 Effect of Wenshen-Yanggan Decoction on Movement Disorder and Substantia Nigra Dopaminergic Neurons in Mice with Chronic Parkinson's Disease. Bcl-2, DA, ELISA, PD, TH
2020 Efficacy of decoction from Jieduan Niwan formula on rat model of acute-on-chronic liver failure induced by porcine serum. ACLF, AI, AST, BUN, Cr, Cyt C, HMGB-1, IL-10, IL-1beta, IL-6, JDNW, PTA, TBIL, TGF-beta1, TNF-alpha
2020 Glycine, the smallest amino acid, confers neuroprotection against D-galactose-induced neurodegeneration and memory impairment by regulating c-Jun N-terminal kinase in the mouse brain. Gly, LPO, ROS, Syn, SYP
10  2020 Hydroxytyrosol enhances cisplatin-induced ototoxicity: Possible relation to the alteration in the activity of JNK and AIF pathways. AIF, CCK-8, DCFH-DA, HEI-OC1, HT, TdT
11  2020 Laodelphax striatellus Atg8 facilitates Rice stripe virus infection in an autophagy-independent manner. Atg8, RSV, VgR
12  2020 Leptin improves intestinal flora dysfunction in mice with high-fat diet-induced obesity. HFD, TLR4
13  2020 Li-Dan-He-Ji Improves Infantile Cholestasis Hepatopathy Through Inhibiting Calcium-Sensing Receptor-Mediated Hepatocyte Apoptosis. CaSR, ICH, LDHJ, p-ERK
14  2020 Long-term effects of the glucocorticoid receptor modulator CORT113176 in murine motoneuron degeneration. ALS, GR, HMGB1, IL18, MyD88, NF-kappaB, TNF
15  2020 Methylation-Induced Silencing of ALDH2 Facilitates Lung Adenocarcinoma Bone Metastasis by Activating the MAPK Pathway. ALDH2, BM, EMT, LUAD, MAPK, MBD4
16  2020 MiR-144 affects proliferation and apoptosis of high glucose-induced AC16 cardiomyocytes by regulating CTRP3/JNK signaling. CCK-8, CTRP3, DCM, miRNAs, qRT-PCR
17  2020 NOD2/c-Jun NH2-Terminal Kinase Triggers Mycoplasma ovipneumoniae-Induced Macrophage Autophagy. CCU, MDP, RT-PCR, siRNA
18  2020 Oral Administration of Alpha Linoleic Acid Rescues Abeta-Induced Glia-Mediated Neuroinflammation and Cognitive Dysfunction in C57BL/6N Mice. ALA, APP, BACE-1, GFAP, i.c.v, TLR4, TNF
19  2020 Schisandra Chinensis Acidic Polysaccharide Improves the Insulin Resistance in Type 2 Diabetic Rats by Inhibiting Inflammation. CRP, IL-1beta, IL-6, IR, NF-kappaB, p-Akt, p-IRS-1, p-PI3K, SCAP, T2D, TNF-alpha
20  2020 Tangeretin mitigates l-NAME-induced ventricular dysfunction and remodeling through the AT1R/pERK1/2/pJNK signaling pathway in rats. eNOS, l-NAME
21  2020 [Effect of psoralen on rat osteoblasts injuries induced by TCP wear particles in vitro and its mechanism]. TCP
22  2019 A30P mutant alpha-synuclein impairs autophagic flux by inactivating JNK signaling to enhance ZKSCAN3 activity in midbrain dopaminergic neurons. PD
23  2019 Adipokine Chemerin Stimulates Progression of Atherosclerosis in ApoE-/- Mice. IL-1beta, NF-kappaBp65, p-p38 MAPK, PCNA, TGF-beta1, TNF-alpha
24  2019 Ambroxol attenuates cisplatin-induced hepatotoxicity and nephrotoxicity via inhibition of p-JNK/p-ERK. p-ERK
25  2019 Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains. Bax, Bcl-2, HO-1, LPO, LPS, Nrf2, p-NF-kB, ROS, TLR4
26  2019 Chlorogenic acid protects against aluminum toxicity via MAPK/Akt signaling pathway in murine RAW264.7 macrophages. Al, MAPK
27  2019 Chronic Alcohol Exposure Induced Neuroapoptosis: Diminishing Effect of Ethyl Acetate Fraction from Aralia elata. 3,5-diCQA, ACh, AChE, Bax, CQA, DCF-DA, MDA, MTT, p-Akt, pTau, SOD
28  2019 Down-regulation of long non-coding RNA MALAT1 inhibits granulosa cell proliferation in endometriosis by up-regulating P21 via activation of the ERK/MAPK pathway. AUC, CDK2, ERK, GCs, lncRNA, MALAT1, MAPK, qRT-PCR, ROC
29  2019 Effect of transcutaneous electrical acupuncture point stimulation on expression of p-JNK in the dorsal root ganglion in a rat model of myofascial pain syndrome. DRG, MPS, PWTL, TEAS
30  2019 Esculentoside B inhibits inflammatory response through JNK and downstream NF-kappaB signaling pathway in LPS-triggered murine macrophage RAW 264.7 cells. EsB, NF-kappaB, NO, TCM
31  2019 Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammation, Apoptosis and Memory Impairments by Modulating TLR4/NF-kappaB Signaling. Bcl-2, IL-1beta, LPS, Nrf2, p-NF-kappaB, pCREB, PSD-95, ROS/LPO, TLR4, TNF-alpha
32  2019 Mangiferin ameliorates acetaminophen-induced hepatotoxicity through APAP-Cys and JNK modulation. MAN, NAPQI, ROS
33  2019 Phytomedicine-Based Potent Antioxidant, Fisetin Protects CNS-Insult LPS-Induced Oxidative Stress-Mediated Neurodegeneration and Memory Impairment. CD14, CNS, i.p, IL1-beta, LPS, ROS, TNF-alpha
34  2019 Protective effect of Cordyceps militaris against hydrogen peroxide-induced oxidative stress in vitro. CM, NO, p-ERK, p-p38 MAPK, ROS
35  2019 Retinoic Receptor Signaling Regulates Hypertrophic Chondrocyte-specific Gene Expression. MAPK, MMP13, RT-PCR, TG-2
36  2019 The Effect of Schisandra chinensis Baillon on Cross-Talk between Oxidative Stress, Endoplasmic Reticulum Stress, and Mitochondrial Signaling Pathway in Testes of Varicocele-Induced SD Rat. CTR, ER, FSH, GPx, Grp 78, LH, MDA, p-IRE1alpha, RNS, ROS, SC, SOD, StAR, VC, VC
37  2019 The Role of Phospho-c-Jun N-Terminal Kinase Expression on hepatocyte Necrosis and Autophagy in the Cholestatic Liver. BDL, TAA
38  2019 The Superior Antitumor Effect of Self-Assembled Paclitaxel Nanofilaments for Lung Cancer Cells. CHOP, ER, IRE1alpha, NSCLC, PERK, PTX, SA
39  2019 YQWY decoction reverses cardiac hypertrophy induced by TAC through inhibiting GATA4 phosphorylation and MAPKs. ANP, EF, ELISA, FS, HE, IF, IHC, MAPKs, MYH7, NT-proBNP, p-ERK, P-GATA4, P-P38, TAC, TTE, WB, YQWY
40  2019 [Effect of rivaroxaban on the injury during endotoxin-induced damage to human umbilical vein endothelial cells]. ELISA, FXa, HUVEC, LPS, MAPK, NF-KappaB, p-NF-KappaBp65, p-TAK1, TNF-alpha
41  2019 [Salidroside induces anti-tumor effect in dendritic cells via ERK pathway]. CTLs, DCs, JNK, MAPK/ERK, NS, pERK, Sal
42  2018 17beta-Estradiol via SIRT1/Acetyl-p53/NF-kB Signaling Pathway Rescued Postnatal Rat Brain Against Acute Ethanol Intoxication. p-mTOR, p-NF-kB, ROS
43  2018 Anti-fibrotic effects of pirfenidone by interference with the hedgehog signalling pathway in patients with systemic sclerosis-associated interstitial lung disease. GLI1, Hh, pGSK-3beta, pSMAD2, SSc-ILD, Sufu
44  2018 Beneficial Role of Rosuvastatin in Blood-Brain Barrier Damage Following Experimental Ischemic Stroke. BBB, LRP1, MAPK, MCAO, MMPs, p-ERK, PDGFRalpha, rt-PA, TIMPs
45  2018 CDK5RAP1 targeting NF-kappaB signaling pathway in human malignant melanoma A375 cell apoptosis. BAD, Bcl-2, Bcl-xl, CDK5RAP1, NF-kappaB, PDTC, ROS, siRNA
46  2018 Downregulated apoptosis and autophagy after anti-Abeta immunotherapy in Alzheimer's disease. aCasp-3, AD, GSK3betatyr216
47  2018 Effect of silibinin on CFLAR-JNK pathway in oleic acid-treated HepG2 cells. CYP2E1, NASH, NO, NRF2, OA, p-Akt, PI3K, PNPLA3, PPARalpha, SREBP-1C, TG
48  2018 Ethyl acetate fraction from Hibiscus sabdariffa L. attenuates diabetes-associated cognitive impairment in mice. CQA, DM, MWM, p-tau, STZ
49  2018 Functional components in Scutellaria barbata D. Don with anti-inflammatory activity on RAW 264.7 cells. ---
50  2018 Ginkgo biloba Leaf Extract Protects against Myocardial Injury via Attenuation of Endoplasmic Reticulum Stress in Streptozotocin-Induced Diabetic ApoE-/- Mice. CHOP, STZ
51  2018 Hepatoprotective effect of methyl ferulic acid against carbon tetrachloride-induced acute liver injury in rats. AST, Bax, Bcl, IL, MAPK, MFA, NOX, ROS, TAC, TBARS, TNF
52  2018 Hyperbaric Oxygen Alleviates the Inflammatory Response Induced by LPS Through Inhibition of NF-kappaB/MAPKs-CCL2/CXCL1 Signaling Pathway in Cultured Astrocytes. CCL2, HBOT, LPS, p-ERK, p-NF-kappaB, p-p38
53  2018 Lutein and Zeaxanthin Isomers Protect against Light-Induced Retinopathy via Decreasing Oxidative and Endoplasmic Reticulum Stress in BALB/cJ Mice. ATF4, ERG, ERS, Nrf2, OS, p-PERK
54  2018 Mechanism of Astragalus polysaccharides in attenuating insulin resistance in Rats with type 2 diabetes mellitus via the regulation of liver microRNA‑203a‑3p. APS, CHOP, ERS, GK, GRP, IR, mi, miR, T2DM
55  2018 Neonatal hyperglycemia induces cell death in the rat brain. Bax, Bcl-2, CNS, FJC, GSK3beta, JNK, p-Akt, STZ
56  2018 Oxymatrine Causes Hepatotoxicity by Promoting the Phosphorylation of JNK and Induction of Endoplasmic Reticulum Stress Mediated by ROS in LO2 Cells. ER, NAC, OMT
57  2018 Peroxiredoxin1 promotes cell proliferation, migration and invasion of colorectal cancer via p38MAPK signaling. CCK-8, ERK, JNK, p-ERK, p-p38, PRDX1
58  2018 Programmed cell death 4 overexpression enhances sensitivity to cisplatin via the JNK/c-Jun signaling pathway in bladder cancer. BCa, EMT, JNK, PDCD4, PDCD4-pcDNA3
59  2018 Protective effect of MOTILIPERM in varicocele-induced oxidative injury in rat testis by activating phosphorylated inositol requiring kinase 1alpha (p-IRE1alpha) and phosphorylated c-Jun N-terminal kinase (p-JNK) pathways. ER, MDA, p-IRE1alpha, RNS, ROS
60  2018 RBBP6 promotes human cervical carcinoma malignancy via JNK signaling pathway. RBBP6
61  2018 Sex Differences in the Effects of a Kappa Opioid Receptor Antagonist in the Forced Swim Test. KOR, nor-BNI
62  2018 Subclinical hypothyroidism in pregnant rats impaired learning and memory of their offspring by promoting the p75NTR signal pathway. CON, LTP, MWM, p75NTR, SCH
63  2018 Transforming growth factor-beta decreases side population cells in hepatocellular carcinoma in vitro. CD, HCC, SP, TGF-beta
64  2018 TSC1 deletion in fibroblasts alleviates lipopolysaccharide-induced acute kidney injury. AKI, ECE1, EDN1, JNK, LPS, MEFs, mTORC1, pS6, TSC1
65  2018 [Effect and mechanism of dexmedetomidine on lungs in patients of sepsis complicated with acute respiratory distress syndrome]. APACHE II, ARDS, BALF, ELISA, ICU, IL-6, MV, MyD88, RASS, TLR4
66  2018 [Salidroside inhibits inflammatory factor release in BV-2 cells through p38 and JNK pathways]. p-p38
67  2017 Carvedilol alleviates the biliary cirrhosis through inhibiting the endoplasmic reticulum stress. alpha-SMA, AST, ATF4, COX-2, iNOS, IRE1, MDA, RT-PCR, SOD, TBIL, TGF-beta1
68  2017 Daphnoretin modulates differentiation and maturation of human dendritic cells through down-regulation of c-Jun N-terminal kinase. DCs
69  2017 DBA-induced caspase-3-dependent apoptosis occurs through mitochondrial translocation of cyt-c in the rat hippocampus. cyt c, DBA, p-ASK1, PARP-1, PKCdelta, ROS, SOD
70  2017 GADD45a Regulates Olaquindox-Induced DNA Damage and S-Phase Arrest in Human Hepatoma G2 Cells via JNK/p38 Pathways. GADD45a, p-ERK, p-p38, ROS
71  2017 Ginkgetin inhibits growth of breast carcinoma via regulating MAPKs pathway. GK, MAPKs, p-ERK
72  2017 Ginsenoside Rg1 Protects Cardiomyocytes Against Hypoxia/Reoxygenation Injury via Activation of Nrf2/HO-1 Signaling and Inhibition of JNK. GSH-Px, HO-1, Nrf2, ROS, SOD
73  2017 IGFBP2 enhances adipogenic differentiation potentials of mesenchymal stem cells from Wharton's jelly of the umbilical cord via JNK and Akt signaling pathways. IGFBP-2, MSC, PDLSCs
74  2017 Interactions between Sirt1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo. IL-1beta, MAPK, mNSS, p-ERK, p-p38
75  2017 Inulin-Type Fructans Modulates Pancreatic-Gut Innate Immune Responses and Gut Barrier Integrity during Experimental Acute Pancreatitis in a Chain Length-Dependent Manner. AP, IRAK4, ITFs, NF-kappaB
76  2017 Involvement of the MEK-ERK/p38-CREB/c-fos signaling pathway in Kir channel inhibition-induced rat retinal Muller cell gliosis. COH, GFAP, MAPK, pCREB
77  2017 miR-214 suppresses the osteogenic differentiation of bone marrow-derived mesenchymal stem cells and these effects are mediated through the inhibition of the JNK and p38 pathways. ALP, BMSCs, Col I, FGF, miR, OCN, OPN, p-p38
78  2017 Molecular mechanisms of anticancer activity of deoxyelephantopin in cancer cells. DOE, p-mTOR, p-STAT3, PARP, uPA, uPAR
79  2017 Neuroprotective effects of astragaloside IV on Parkinson disease models of mice and primary astrocytes. AS-IV, Bax, MPTP, PD
80  2017 Periostin promotes migration and osteogenic differentiation of human periodontal ligament mesenchymal stem cells via the Jun amino-terminal kinases (JNK) pathway under inflammatory conditions. ALP, JNK, MAPK, MSC, PDLSCs, POSTN, rhPOSTN
81  2017 Role of Paeonol in an Astrocyte Model of Parkinson's Disease. Bcl-2, COX-2, DA, FCM, iNOS, p-ERK, PD, SNc
82  2017 Shenfuqiangxin Capsule inhibits apoptosis through mitogen-activated protein kinase signal pathway in rats with cardio-renal syndrome induced by infrarenal aortic-clamping. CRS, HRP, MAPK, p-p38, RT-PCR
83  2017 The expression and significance of IL-6, IFN-gamma, SM22alpha, and MMP-2 in rat model of aortic dissection. AD, BAPN, IFN-gamma, IHC, IL-6, MMP-2, SM22alpha
84  2017 Urotensin II inhibitor eases neuropathic pain by suppressing the JNK/NF-kappaB pathway. CCI, IL-1beta, NF-kappaB, TNF-alpha, UII
85  2017 Wheat germ agglutinin-conjugated liposomes incorporated with cardiolipin to improve neuronal survival in Alzheimer's disease treatment. AD, CL, CRM, LIP, NGF, p-p38
86  2017 [Biliverdin protects the isolated lungs from ischemia/reperfusion injury via anti-apoptosis]. BV, Cst, HO-1, LIRI, SD, TUNEL, VT
87  2017 [Effect of heat shock factor 1 on airway hyperresponsiveness and airway inflammation in mice with allergic asthma]. BALF, HMGB1, HSF1, IFN-gamma, IL-13, IL-4, IL-5, OVA
88  2017 [Effect of RNA Interference-silenced TAK1 on Kasumi-1 cell Proliferation Inhibition Induced by As2O3 and Its Mechanism]. TAK1
89  2017 [Effects of TAK gene silencing on the expressions of IL-6 and IL-8 induced by TNF-alpha in fibroblast-like synoviocytes]. NF-kappaB, p-ERK, P-P38, p-p65, RA, ScRNA, TAK1
90  2016 Agglutinin isolated from Arisema heterophyllum Blume induces apoptosis and autophagy in A549 cells through inhibiting PI3K/Akt pathway and inducing ER stress. AHA, AVOs, CHOP, IRE1alpha, p-eIF2alpha, RA
91  2016 Anti-inflammatory activity of ethanolic extract from skipjack tuna (Katsuwonus pelamis) heart in LPS-induced RAW 264.7 cells and mouse ear edema model. COX-2, IL-6, iNOS, LPS, MAPKs, NF-kappaB p65, NO, p-ERK, TNF-alpha
92  2016 Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. BCTC, CDK, p-p38, PCa, TRPM8
93  2016 Cerebral dopamine neurotrophic factor alleviates Abeta25-35-induced endoplasmic reticulum stress and early synaptotoxicity in rat hippocampal cells. AD, CDNF, ER, p-eIF2alpha, PSD-95
94  2016 Diterpenoid Tanshinones, the extract from Danshen (Radix Salviae Miltiorrhizae) induced apoptosis in nine human cancer cell lines. ATF4, p-eIF2alpha, PARP
95  2016 Endoplasmic reticulum stress-induced neuronal inflammatory response and apoptosis likely plays a key role in the development of diabetic encephalopathy. 4-PBA, ATF6, DEP, ER, GRP78, HG, IL-6, TNF-alpha, XBP1
96  2016 Fasudil inhibits LPS-induced migration of retinal microglial cells via regulating p38-MAPK signaling pathway. LPS, MMP-2, pp38 MAPK, RMG
97  2016 Glycine inhibits ethanol-induced oxidative stress, neuroinflammation and apoptotic neurodegeneration in postnatal rat brain. COX2, FJB, Gly, p-NF-kB, ROS, TNF-alpha
98  2016 High-Dose Fluoride Impairs the Properties of Human Embryonic Stem Cells via JNK Signaling. EB, hESCs, MAPKs, MMP, ROS
99  2016 IGFBP5 enhances osteogenic differentiation potential of periodontal ligament stem cells and Wharton's jelly umbilical cord stem cells, via the JNK and MEK/Erk signalling pathways. ALP, IGFBP-5, MSC, PDLSCs, rhIGFBP5, WJCMSCs
100  2016 miR-613 suppresses ischemia-reperfusion-induced cardiomyocyte apoptosis by targeting the programmed cell death 10 gene. Bcl-2, CHOP, I/R, LDH, MDA, miRNAs, p-Akt, PDCD10