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Abbreviation : p38 MAPK
Long Form : p38 mitogen-activated protein kinase
No. Year Title Co-occurring Abbreviation
2020 12-HETE is a regulator of PGE2 production via COX-2 expression induced by a snake venom group IIA phospholipase A2 in isolated peritoneal macrophages. 12-HETE, 12-LO, COX, MT, NF, PG, PKC, sPLA2
2020 Aflibercept and Ranibizumab Modulate Retinal Pigment Epithelial Cells Function by Acting on Their Cross Talk with Vascular Endothelial Cells. HUVEC, PI3K
2020 Beneficial effects of genistein in suppression of proliferation, inhibition of metastasis, and induction of apoptosis in PC3 prostate cancer cells. MMP2
2020 Cardioprotective Efficacy of Silymarin Liquisolid in Isoproterenol Prompted Myocardial Infarction in Rats. BNP, CVDs, IL-10, iNOS, MDA, MI, miR-34a, SEM, SM, SOD, TGF, VEGF
2020 Changes in mediators of pro-cell growth, senescence, and inflammation during murine gestation. GSK3beta, HO-1, IHC, PPARgamma
2020 Electroacupuncture Attenuates Limb Ischemia-Reperfusion-Induced Lung Injury Via p38 Mitogen-Activated Protein Kinase-Nuclear Factor Erythroid-2-Related Factor-2/Heme Oxygenase Pathway. HO, LIR, Nrf2
2020 Exposure to both formaldehyde and high relative humidity exacerbates allergic asthma by activating the TRPV4-p38 MAPK pathway in Balb/c mice. AHR, OVA, TRPV4
2020 Glucose Fluctuations Promote Aortic Fibrosis through the ROS/p38 MAPK/Runx2 Signaling Pathway. BP, C-STZ, ROS, STZ, STZ-GF, U-STZ
2020 Inconsistently impairment of immune function and structural integrity of head kidney and spleen by vitamin A deficiency in grass carp (Ctenopharyngodon idella). MLCK, NF-kappaB p65, Nrf2, TJs, TOR, VA
10  2020 Lipoxin A4 attenuates hyperoxia‑induced lung epithelial cell injury via the upregulation of heme oxygenase‑1 and inhibition of proinflammatory cytokines. LXA4, SOD
11  2020 Lovastatin-mediated MCF-7 cancer cell death involves LKB1-AMPK-p38MAPK-p53-survivin signalling cascade. AMPK, LKB1
12  2020 Low-intensity pulsed ultrasound inhibits VEGFA expression in chondrocytes and protects against cartilage degeneration in experimental osteoarthritis. LIPUS, OA, VEGF-A
13  2020 Ly-6Chigh inflammatory-monocyte recruitment is regulated by p38 MAPK/MCP-1 activation and promotes ventilator-induced lung injury. CCR2, HTV, Ly-6Chigh, MCP-1, VILI
14  2020 MicroRNA-9 overexpression suppresses vulnerable atherosclerotic plaque and enhances vascular remodeling through negative regulation of the p38MAPK pathway via OLR1 in acute coronary syndrome. ACS, miR-9, siRNA
15  2020 P38 MAPK signaling pathway mediates COM crystal-induced crystal adhesion change in rat renal tubular epithelial cells. COM, IL-1beta
16  2020 Ras isoforms: signaling specificities in CD40 pathway. GEF, IL
17  2020 Sodium acetate alleviated high-carbohydrate induced intestinal inflammation by suppressing MAPK and NF-kappaB signaling pathways in Nile tilapia (Oreochromis niloticus). p-NF-kappaB, SCFAs
18  2019 1,2,4-Trisubstituted imidazolinones with dual carbonic anhydrase and p38 mitogen-activated protein kinase inhibitory activity. CA
19  2019 A new exvivo human oral mucosa model reveals that p38MAPK inhibition is not effective in preventing autoantibody-induced mucosal blistering in pemphigus. Dsg, mdPV, PV, PV-IgG
20  2019 A novel role of glutathione S-transferase A3 in inhibiting hepatic stellate cell activation and rat hepatic fibrosis. alpha-SMA, DMN, FN, GSK-3beta, GSTA3, HSCs, JNK, MDA, ROS, WB
21  2019 A phase 1 dose-escalation study of checkpoint kinase 1 (CHK1) inhibitor prexasertib in combination with p38 mitogen-activated protein kinase (p38 MAPK) inhibitor ralimetinib in patients with advanced or metastatic cancer. Chk1, CTCAE, RECIST, RP2D
22  2019 Adenosine receptors as a new target for resveratrol-mediated glioprotection. HO-1, LPS, NF-kappaB, Nrf2, PI3K, SIRT1
23  2019 Ameloblastin attenuates RANKL-mediated osteoclastogenesis by suppressing activation of nuclear factor of activated T-cell cytoplasmic 1 (NFATc1). AMBN, BCL6, Blimp-1, CREB, IRF8, JNK, MafB, NFATc1, OC-STAMP, RANKL, TRAP
24  2019 Anti-inflammatory and renal protective effect of gingerol in high-fat diet/streptozotocin-induced diabetic rats via inflammatory mechanism. N-kappaB
25  2019 Apoptosis-promoting and migration-suppressing effect of alantolactone on gastric cancer cell lines BGC-823 and SGC-7901 via regulating p38MAPK and NF-kappaB pathways. MMP, NF-kappaB
26  2019 Baicalein retards proliferation and collagen deposition by activating p38MAPK-JNK via microRNA-29. alpha-SMA, BAI, CCK-8, JNK, miR-29, qRT-PCR, TGF-beta1
27  2019 Blockade of AMPA Receptor Regulates Mitochondrial Dynamics by Modulating ERK1/2 and PP1/PP2A-Mediated DRP1-S616 Phosphorylations in the Normal Rat Hippocampus. AMPAR, Drp1, JNK, NMDAR, PP
28  2019 Caenorhabditis Elegans and Probiotics Interactions from a Prolongevity Perspective. IIS
29  2019 Candesartan and epigallocatechin-3-gallate ameliorate gentamicin-induced renal damage in rats through p38-MAPK and NF-kappaB pathways. EGCG, NF-kappaB
30  2019 Connexin43 dephosphorylation at serine 282 is associated with connexin43-mediated cardiomyocyte apoptosis. Cx43, NRVMs, S282A
31  2019 Critical roles of NLRP3 inflammasome in IL-1beta secretion induced by Corynebacterium pseudotuberculosis in vitro. AIM2, ASC, Casp-1, IL-1beta, NF-kappaB, NLRP3, TLR4
32  2019 Detrimental effects of lipopolysaccharides on maturation of bovine oocytes. COCs, IL, LPS, NF-kappaB, TLR4, TNF, Trx
33  2019 Downregulation of LPXN expression by siRNA decreases the malignant proliferation and transmembrane invasion of SHI-1 cells. ERK, FAM, JNK, LPXN, MMP
34  2019 Dysfunction of 67-kDa Laminin Receptor Disrupts BBB Integrity via Impaired Dystrophin/AQP4 Complex and p38 MAPK/VEGF Activation Following Status Epilepticus. AQP4, BBB, eNOS, PC, VEGF
35  2019 Effects of a Tripeptide on Mitogen-Activated Protein Kinase and Glycogen Synthase Kinase Activation in a Cell Line Derived from the Foetal Hippocampus of a Trisomy 16 Mouse: an Animal Model of Down Syndrome. DS, ERK, GSK-3beta
36  2019 Effects of Dietary Zearalenone on Oxidative Stress, Cell Apoptosis, and Tight Junction in the Intestine of Juvenile Grass Carp (Ctenopharyngodon idella). DI, GST, Keap1, MI, MLCK, Nrf2, PI, ZEA
37  2019 EGFR and Prion protein promote signaling via FOXO3a-KLF5 resulting in clinical resistance to platinum agents in colorectal cancer. EGFR, KLF5
38  2019 Eicosapentaenoic Acid (EPA) Modulates Glucose Metabolism by Targeting AMP-Activated Protein Kinase (AMPK) Pathway. AMPK, BCAAs, CaMKK, EPA, GLUT4
39  2019 Electroacupuncture for pain relief in labour inhibits spinal p38 MAPK-mediated prostaglandin E2 release and uterine prostaglandin E2 receptor expression in rats. EA, PGE2, PGER2, PLA2
40  2019 Epiregulin enhances odontoblastic differentiation of dental pulp stem cells via activating MAPK signalling pathway. DPSCs, EREG, JNK, rhEREG
41  2019 Ethanol Extract of Centipeda minima Exerts Antioxidant and Neuroprotective Effects via Activation of the Nrf2 Signaling Pathway. D-gal, ECM, ERK, HO-1, JNK, NQO1, Nrf2, PSD-95, ROS, SOD2, SYN, TBHP
42  2019 Evaluation of PECAM-1 and p38 MAPK expressions in cerebellum tissue of rats treated with caffeic acid phenethyl ester: a biochemical and immunohistochemical study. CAPE, PECAM-1, TBI
43  2019 Fluorofenidone affects hepatic stellate cell activation in hepatic fibrosis by targeting the TGF-beta1/Smad and MAPK signaling pathways. alpha-SMA, ERK, HSCs, JNK, PS, RT-qPCR, Smad, TGF
44  2019 Genistein improves viability, proliferation and mitochondrial function of cardiomyoblasts cultured in physiologic and peroxidative conditions. ERs, GPER, NO
45  2019 Gentiopicrin exerts anti-rheumatic effect in human fibroblast-like synoviocytes via inhibition of p38MAPK/NF-kappaB pathway. DMEM, ELISA, FBS, HFLS, IL-1beta, IL-6, NF-kappaB, qRT-PCR, RA
46  2019 Ghrelin exhibited antidepressant and anxiolytic effect via the p38-MAPK signaling pathway in hippocampus. CSDS, GHS-R
47  2019 Ginger Extract Reduces Chronic Morphine-Induced Neuroinflammation and Glial Activation in Nucleus Accumbens of Rats. GFAP, NAcc
48  2019 Ginkgetin inhibits proliferation of HeLa cells via activation of p38/NF-kappaB pathway. ELISA, FBS, HeLa, IL-1beta, IL-8, NF-kappaB, qRT-PCR, TNF-alpha
49  2019 Ginsenoside Rg3 promotes Fc gamma receptor-mediated phagocytosis of bacteria by macrophages via an extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent mechanism. ERK, IgGbeads
50  2019 Gossypetin Inhibits Solar-UV Induced Cutaneous Basal Cell Carcinoma Through Direct Inhibiting PBK/TOPK Protein Kinase. BCC, MST, PBK/TOPK
51  2019 High Glucose with Insulin Induces Cell Cycle Progression and Activation of Oncogenic Signaling of Bladder Epithelial Cells Cotreated with Metformin and Pioglitazone. Bax, CDK4, ERK, HBlEpCs
52  2019 High level of dietary olive oil decreased growth, increased liver lipid deposition and induced inflammation by activating the p38 MAPK and JNK pathways in large yellow croaker (Larimichthys crocea). ALT, FO, JNK, LDL-C, MDA, OO, SOD, T-AOC, TG
53  2019 High TNF-alpha and/or p38MAPK expression predicts a favourable prognosis in patients with T1N0M0 hepatocellular carcinoma: An immunohistochemical study. DFS, HCC, OS, TNF-alpha, TNM
54  2019 HIV gp120-induced neuroinflammation potentiates NMDA receptors to overcome basal suppression of inhibitory synapses by p38 MAPK. GFP, IL-1beta
55  2019 Hydrogen sulfide alleviates uranium-induced rat hepatocyte cytotoxicity via inhibiting Nox4/ROS/p38 MAPK pathway. MDA, NOX4, ROS
56  2019 Inhibiting c-Jun N-terminal kinase (JNK)-mediated apoptotic signaling pathway in PC12 cells by a polysaccharide (CCP) from Coptis chinensis against Amyloid-beta (Abeta)-induced neurotoxicity. CCP, ERK, JNK, LDH
57  2019 Inhibition of cytochrome P450 3A protein degradation and subsequent increase in enzymatic activity through p38 MAPK activation by acetaminophen and salicylate derivatives. GP78
58  2019 Inhibition of JNK and p38 MAPK-mediated inflammation and apoptosis by ivabradine improves cardiac function in streptozotocin-induced diabetic cardiomyopathy. DCM, HR, JNK, mRNA, STZ
59  2019 Inhibition of TREM-1 attenuates early brain injury after subarachnoid hemorrhage via downregulation of p38MAPK/MMP-9 and preservation of ZO-1. BBB, EBI, eSAH, MMP-9, SAH, TREM-1, ZO-1
60  2019 Irbesartan suppresses cardiac toxicity induced by doxorubicin via regulating the p38-MAPK/NF-kappaB and TGF-beta1 pathways. DOX, IRB, NF-kappaB, NO, TGF-beta1, TNF-alpha
61  2019 MAPKAPK2: the master regulator of RNA-binding proteins modulates transcript stability and tumor progression. 3'-UTR, AREs, RBPs
62  2019 MicroRNA-105 promotes epithelial-mesenchymal transition of nonsmall lung cancer cells through upregulating Mcl-1. EMT, Mcl-1, miR, mTOR, NSCLC, PI
63  2019 MicroRNA-495 downregulates AQP1 and facilitates proliferation and differentiation of osteoblasts in mice with tibial fracture through activation of p38 MAPK signaling pathway. ALP, AQP1, IHC, miR-495
64  2019 MicroRNA‑802 increases hepatic oxidative stress and induces insulin resistance in high‑fat fed mice. ERK, HFD, IR, LPO, ROS
65  2019 miR-126 suppresses neuronal apoptosis in rats after cardiopulmonary resuscitation via regulating p38MAPK. JNK, miR-126, RT-qPCR
66  2019 Modulation of osteogenic and myogenic differentiation by a phytoestrogen formononetin via p38MAPK-dependent JAK-STAT and Smad-1/5/8 signaling pathways in mouse myogenic progenitor cells. ALP, BMPs, ERKs, FN, JAKs, OCN, STATs
67  2019 Neuroinflammatory Reactions in the Brain of 1,2-DCE-Intoxicated Mice during Brain Edema. 1,2-DCE, BBB, GFAP, Iba-1, ICAM-1, IL-1beta, iNOS, MMP-9, NF-kappaB, TJs, VCAM-1
68  2019 Notoginsenoside R1 protects human keratinocytes HaCaT from LPS-induced inflammatory injury by downregulation of Myd88. ELISA, IL-6, LPS, MyD88, NF-kappaB, NGR1, TNF-alpha
69  2019 Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation. COX, ELISA, FGF, IL-1, IL-1beta, NFAT5, PI3K, PLCgamma, RPE, RT, TGF-beta, VEGF
70  2019 Oxidative stress-induced downregulation of glycogen synthase kinase 3 beta in fetal membranes promotes cellular senescence†. beta-Cat, GSK3beta, Nrf2, OS
71  2019 p38 mitogen activated protein kinase mediates cardiac Na+/H+ exchanger inhibition induced by Sildenafil. PKG
72  2019 p38MAPK controls fibroblast growth factor 23 (FGF23) synthesis in UMR106-osteoblast-like cells and in IDG-SW3 osteocytes. FGF23
73  2019 p38MAPK plays a pivotal role in the development of acute respiratory distress syndrome. ARDS
74  2019 Parkia speciosa empty pod extract exerts anti-inflammatory properties by modulating NFkappaB and MAPK pathways in cardiomyocytes exposed to tumor necrosis factor-alpha. NF-kappaB, PSE, TNF-alpha
75  2019 Pharmacological advances in pemphigus. APRIL
76  2019 pNaKtide ameliorates renal interstitial fibrosis through inhibition of sodium-potassium adenosine triphosphatase-mediated signaling pathways in unilateral ureteral obstruction mice. MCP-1, TGF-beta1, UUO
77  2019 Protease-activated receptor 2 induces migration and promotes Slug-mediated epithelial-mesenchymal transition in lung adenocarcinoma cells. EMT, ERK2, PAR2
78  2019 Protein-ligand interaction fingerprints for accurate prediction of dissociation rates of p38 MAPK Type II inhibitors. PLI
79  2019 Pterostilbene Inhibits Adipocyte Conditioned-Medium-Induced Colorectal Cancer Cell Migration through Targeting FABP5-Related Signaling Pathway. aCM, CRC, ERK, FABP5, MMP2, NF-kappaB, PI3K, PPARgamma, PTS
80  2019 Quercetin relieved diabetic neuropathic pain by inhibiting upregulated P2X4 receptor in dorsal root ganglia. DRG, SGCs
81  2019 Rhein lysinate improves motor function in rats with spinal cord injury via inhibiting p38 MAPK pathway. BBB, GSH-Px, IHC, MDA, RHL, SCI, SCI-RHL group, SOD
82  2019 Role of epicardial adipose tissue NPR-C in acute coronary syndrome. ACS, CAD, EAT, NCAD, NPRs, SAT, UCP1
83  2019 Roscovitine Attenuates Microglia Activation and Monocyte Infiltration via p38 MAPK Inhibition in the Rat Frontoparietal Cortex Following Status Epilepticus. Cdk5, FPC, LAMP1, MCP-1
84  2019 SB203580, a p38MAPK inhibitor, attenuates olfactory dysfunction by inhibiting OSN apoptosis in AR mice (activation and involvement of the p38 mitogen-activated protein kinase in olfactory sensory neuronal apoptosis of OVA-induced allergic rhinitis). AR, NS, OMP, OSNs
85  2019 SCFAs-Induced GLP-1 Secretion Links the Regulation of Gut Microbiome on Hepatic Lipogenesis in Chickens. ERK, GLP-1, IECs, MAPK, SCFAs
86  2019 Schizandrin A Protects Human Retinal Pigment Epithelial Cell Line ARPE-19 against HG-Induced Cell Injury by Regulation of miR-145. DR, HG, IL-6, MCP-1, MyD88, NF-kappaB, ROS, Sch A, TCMs, TNF-alpha
87  2019 siRNA-mediated NCAM1 gene silencing suppresses oxidative stress in pre-eclampsia by inhibiting the p38MAPK signaling pathway. HUVECs, NCAM1, OS, PE, siRNA
88  2019 Sodium azide induces mitochondria‑mediated apoptosis in PC12 cells through Pgc‑1alpha‑associated signaling pathway. CaMK, COXIV, NRF, ROS
89  2019 Sulforaphane Exhibits Cytotoxic Effects against Primary Effusion Lymphoma Cells by Suppressing p38MAPK and AKT Phosphorylation. KSHV, PEL, SFN
90  2019 Synthesis of polyfluoroalkyl sp2-iminosugar glycolipids and evaluation of their immunomodulatory properties towards anti-tumor, anti-leishmanial and anti-inflammatory therapies. sp2-IGLs
91  2019 The Association of Ascorbic Acid, Deferoxamine and N-Acetylcysteine Improves Cardiac Fibroblast Viability and Cellular Function Associated with Tissue Repair Damaged by Simulated Ischemia/Reperfusion. Bax, Bcl-xL, JNK, PKB, ROS
92  2019 The protective effect and mechanism of catalpol on high glucose-induced podocyte injury. Bax, Bcl-2, DN, ELISA, HG, IL-1beta, IL-6, LDH, MDA, MyD88, NF-kappaB, NOX4, p-IkappaBalpha, p-p38MAPK, ROS, SOD, TLR4, TNF-alpha
93  2019 The renal protection of flavonoid-rich ethanolic extract from silkworm green cocoon involves in inhibiting TNF-alpha-p38 MAP kinase signalling pathway in type 2 diabetic mice. DN, EE, FN, GSH-Px, MCP-1, SOD, STZ, T2D
94  2019 WMJ-S-001, a Novel Aliphatic Hydroxamate-Based Compound, Suppresses Lymphangiogenesis Through p38mapk-p53-survivin Signaling Cascade. SV-LECs
95  2019 [Effect and mechanism of liraglutide on the apoptosis of human hepatocellular carcinoma HepG2 cells induced with palmitic acid]. Bax, Bcl-2, CHOP, CYP2E1, GRP78, JNK, MAPKs, MDA
96  2019 [Effect of deep and shallow electroacupuncture stimulation at "Huantiao"(GB30) on expression of phosphorylated-p38 and phosphorylated-p53 proteins and apoptosis in dorsal root ganglia in sciatic nerve injury rats]. CCI, DEA, DRG, EA, p-p38, p-p53, SEA, SFI
97  2019 [Eletroacupuncture improves lipid metabolic disorder by regulating hepatic AMPK/p38 MAPK/RRARgamma signaling in rats with high-fat diet-induced insulin resistance]. ADP, AMPK, CP, EA, ELISA, IR, LEP, PPARgamma, RES, TEM
98  2019 [Mechanism of Danzhi Jiangtang Capsules on improving liver injury in hyperlipidemia rats based on MAPK pathway]. AST, DJC, HDL-C, p-p38, RT-PCR, TC
99  2019 [Mechanism of delayed apoptosis of peripheral blood neutrophils in severely burned patients]. p-p38MAPK, ROS, TBSA
100  2019 [Mild hypothermia regulates aquaporin 4 expression in brain tissue of rats with cardiopulmonary resuscitation and reduces brain edema through p38 mitogen-activated protein kinase signaling pathway]. AQP4, CPR, HE, SD