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Abbreviation : pMCAO
Long Form : permanent middle cerebral artery occlusion
No. Year Title Co-occurring Abbreviation
2020 1-Trifluoromethoxyphenyl-3-(1-Propionylpiperidin-4-yl) Urea Protects the Blood-Brain Barrier Against Ischemic Injury by Upregulating Tight Junction Protein Expression, Mitigating Apoptosis and Inflammation In Vivo and In Vitro Model. Bax, BBB, HBMVECs, IL-1beta, MMP-9, NF-kappaB, OGD/R, ROS, sEH, TJs, TNF-alpha, TPPU, ZO-1
2020 An enriched environment increases the expression of fibronectin type III domain-containing protein 5 and brain-derived neurotrophic factor in the cerebral cortex of the ischemic mouse brain. BDNF, FDNC5
2020 Change in CSF Dynamics Responsible for ICP Elevation After Ischemic Stroke in Rats: a New Mechanism for Unexplained END? CSF, DWI, END, ICP
2020 Chinese medicine Tongxinluo capsule protects against blood-brain barrier disruption after ischemic stroke by inhibiting the low-density lipoprotein receptor-related protein 1 pathway in mice. BBB, LRP-1, RAP, TJ, TXL, ZO-1
2020 Dichloromethane extraction from Piper nigrum L. and P. longum L. to mitigate ischemic stroke by activating the AKT/mTOR signaling pathway to suppress autophagy. DF, p-AKT, p-mTOR
2020 Early acid/base and electrolyte changes in permanent middle cerebral artery occlusion: Aged male and female rats. ---
2020 Early Reperfusion Following Ischemic Stroke Provides Beneficial Effects, Even After Lethal Ischemia with Mature Neural Cell Death. CNS, tMCAO
2020 Edaravone-Loaded Macrophage-Derived Exosomes Enhance Neuroprotection in the Rat Permanent Middle Cerebral Artery Occlusion Model of Stroke. Edv, Exo
2020 Electroacupuncture Attenuates Inflammation after Ischemic Stroke by Inhibiting NF-kappaB-Mediated Activation of Microglia. IP, TNF-alpha
10  2020 Impact of stroke co-morbidities on cortical collateral flow following ischaemic stroke. LSCI, SHRSP
11  2020 Knockdown of Arginyl-tRNA Synthetase Attenuates Ischemia-Induced Cerebral Cortex Injury in Rats After Middle Cerebral Artery Occlusion. ArgRS, AV, NTC, SD, shRNA
12  2020 Machine learning-based segmentation of ischemic penumbra by using diffusion tensor metrics in a rat model. AUC, DTI, IC, IP, MD, ML, NT
13  2020 miR-330 regulates Drp-1 mediated mitophagy by targeting PGAM5 in a rat model of permanent focal cerebral ischemia. Drp1, PGAM5
14  2020 Neuroprotective effect of poly(lactic-co-glycolic acid) nanoparticle-bound brain-derived neurotrophic factor in a permanent middle cerebral artery occlusion model of ischemia in rats. BBB, BDNF, mNSS, NPs, PLGA, S100beta
15  2020 Pericyte-Mediated Tissue Repair through PDGFRbeta Promotes Peri-Infarct Astrogliosis, Oligodendrogenesis, and Functional Recovery after Acute Ischemic Stroke. ACM, CBF, OL, PCM, PDGFB, PDGFRbeta
16  2020 Post-Treatment of Synthetic Polyphenolic 1,3,4 Oxadiazole Compound A3, Attenuated Ischemic Stroke-Induced Neuroinflammation and Neurodegeneration. COX-2, GST, Iba-1, LPO, NF-kappaB, NO, Nrf2, TNF-alpha
17  2020 Pseudoginsenoside-F11 Accelerates Microglial Phagocytosis of Myelin Debris and Attenuates Cerebral Ischemic Injury Through Complement Receptor 3. OGD, PF11
18  2020 Quercetin Reduces Ischemic Brain Injury by Preventing Ischemia-induced Decreases in the Neuronal Calcium Sensor Protein Hippocalcin. ---
19  2020 Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1alpha/VEGF Signaling and Blood-Brain Barrier Integrity. BBB, GFAP, HIF-1alpha, KO, OGD, Sirt3, VEGF, WT
20  2020 SUR1-TRPM4 channels, not KATP, mediate brain swelling following cerebral ischemia. AS-ODNs, ODNs, SUR
21  2020 The protective effect of polyethylene glycol-conjugated urokinase nanogels in rat models of ischemic stroke when administrated outside the usual time window. COX-2, EB, IL-1beta, LRP, NF-kappaB, NMDARs, PDGF-C, PEG-UK, TNF-alpha, UK
22  2019 Catalpol Enhances Neurogenesis And Inhibits Apoptosis Of New Neurons Via BDNF, But Not The BDNF/Trkb Pathway. BDNF
23  2019 Early initiation of a factor Xa inhibitor can attenuate tissue repair and neurorestoration after middle cerebral artery occlusion. ---
24  2019 Fractalkine Modulates Microglia Metabolism in Brain Ischemia. ---
25  2019 Glatiramer acetate reduces infarct volume in diabetic mice with cerebral ischemia and prevents long-term memory loss. GA
26  2019 Houshiheisan promotes angiogenesis via HIF-1alpha/VEGF and SDF-1/CXCR4 pathways: in vivo and in vitro. Ang-1, Ang-2, CD31, CXCR4, HE, HIF-1alpha, HSHS, Im-HUVECs, MS, SDF-1, TCM, VEGF, VEGF-A, VEGFR2
27  2019 Inhibition of the NF-kappaB signaling pathway on endothelial cell function and angiogenesis in mice with acute cerebral infarction. bFGF, GLI1, IFN, NF-kappaB, VEGF
28  2019 Intravenous Administration of Human Adipose Derived-Mesenchymal Stem Cells Is Not Efficient in Diabetic or Hypertensive Mice Subjected to Focal Cerebral Ischemia. hADMSC
29  2019 Intravenous delivery of adipose tissue-derived mesenchymal stem cells improves brain repair in hyperglycemic stroke rats. alpha-SMA, GFAP, hAD-MSCs
30  2019 JLX001 Modulated the Inflammatory Reaction and Oxidative Stress in pMCAO Rats via Inhibiting the TLR2/4-NF-kappaB Signaling Pathway. OGD, ROS
31  2019 Mild hypothermia alleviates diabetes aggravated cerebral ischemic injury via activating autophagy and inhibiting pyroptosis. LC3B, NLRP3, OGD/R
32  2019 miRNA-223-3p and let-7b-3p as potential blood biomarkers associated with the ischemic penumbra in rats. miRNA, PCR
33  2019 Mitochondrial protective effect of neferine through the modulation of nuclear factor erythroid 2-related factor 2 signalling in ischaemic stroke. Nef, TBHP
34  2019 Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia. ALP, TFEB
35  2019 Peripheral Administration of IL-13 Induces Anti-inflammatory Microglial/Macrophage Responses and Provides Neuroprotection in Ischemic Stroke. Arg1, IL-13, PI
36  2019 Piperine as a neuroprotective functional component in rats with cerebral ischemic injury. cyt c, TTC
37  2019 Protective effects of leonurine against ischemic stroke in mice by activating nuclear factor erythroid 2-related factor 2 pathway. CAT, GSH-Px, MDA, Nrf2, ROS, RT-PCR, SOD, VEGF
38  2019 Protective effects of Vitex agnus-castus in ovariectomy mice following permanent middle cerebral artery occlusion. IL-10, MMP-9, VAC
39  2019 Protective Role of SOCS3 Modified Bone Marrow Mesenchymal Stem Cells in Hypoxia-Induced Injury of PC12 Cells. BMSCs, EGFP, SOCS3
40  2019 Role of rno-miR-124-3p in regulating MCT1 expression in rat brain after permanent focal cerebral ischemia. MCT1, miRNAs, TTC
41  2019 S1PR2 antagonist alleviates oxidative stress-enhanced brain endothelial permeability by attenuating p38 and Erk1/2-dependent cPLA2 phosphorylation. cPLA2, EBD, ERK, S1PR2
42  2019 Shengui Sansheng San Ameliorates Cerebral Energy Deficiency via Citrate Cycle After Ischemic Stroke. alpha-SMA, ATP, CBF, CS, CSF, GLUT, MCT1, p-PDHA1, SSS
43  2019 Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke. CK1, Cx43, MAPK, PKC, WT
44  2019 The Beneficial Effects of Raffinee in Permanent Occulted Stroke Mice. IL, MMP
45  2019 The sonic hedgehog pathway mediates Tongxinluo capsule-induced protection against blood-brain barrier disruption after ischaemic stroke in mice. BBB, Shh, Smo, TJ, TXL, ZO-1
46  2019 Topical Administration of a Soluble TNF Inhibitor Reduces Infarct Volume After Focal Cerebral Ischemia in Mice. ---
47  2019 [Improvements of motor and cognitive functions in the rats with permanent middle cerebral artery occlusion treated with acupuncture and rota-rod training]. rpm
48  2018 Acute connexin43 temporal and spatial expression in response to ischemic stroke. Cx43, MAP2
49  2018 Ceruloplasmin Plays a Neuroprotective Role in Cerebral Ischemia. Cp, TfR1
50  2018 Diffusion Tensor-Derived Properties of Benign Oligemia, True "at Risk" Penumbra, and Infarct Core during the First Three Hours of Stroke Onset: A Rat Model. ADC, DT, IC, NT, rFA, TP
51  2018 Effect of Ginkgo biloba extract-761 on motor functions in permanent middle cerebral artery occlusion rats. ---
52  2018 Evaluation of neuregulin-1's neuroprotection against ischemic injury in rats using diffusion tensor imaging. CC, DTI, FA, NRG-1
53  2018 Focal, but not global, cerebral ischaemia causes loss of myenteric neurons and upregulation of vasoactive intestinal peptide in mouse ileum. CCH, ENS, GI, IR, nNOS, VIP
54  2018 HMG-CoA Reductase Inhibitors Relieve Endoplasmic Reticulum Stress by Autophagy Inhibition in Rats With Permanent Brain Ischemia. 3-MA, AMCAO
55  2018 Hypertension prevents a sensory stimulation-based collateral therapeutic from protecting the cortex from impending ischemic stroke damage in a spontaneously hypersensitive rat model. SHRs
56  2018 Intra-arterial human urinary kallidinogenase alleviates brain injury in rats with permanent middle cerebral artery occlusion through PI3K/AKT/FoxO1 signaling pathway. HUK, IL, TNF
57  2018 Ischemia-induced Neuronal Cell Death Is Mediated by Chemokine Receptor CX3CR1. ---
58  2018 Loss of neuronal CD200 contributed to microglial activation after acute cerebral ischemia in mice. ELISA, i.c.v, NSE, rCD200
59  2018 Microglia and macrophages differ in their inflammatory profile after permanent brain ischemia. Arg-1
60  2018 Myricetin against ischemic cerebral injury in rat middle cerebral artery occlusion model. IL, MAPK, MDA, NF, SOD, TNF
61  2018 Neurochemical changes in unilateral cerebral hemisphere during the subacute stage of focal cerebral ischemia-reperfusion in rats: An ex vivo 1H magnetic resonance spectroscopy study. Cre, GABA, Gln, Glu, Lac, mIns, NAA, SUC, tMCAO
62  2018 Neuroprotective Effect and Mechanism of Action of Tetramethylpyrazine Nitrone for Ischemic Stroke Therapy. ---
63  2018 Neuroprotective Effects of DTIO, A Novel Analog of Nec-1, in Acute and Chronic Stages After Ischemic Stroke. DTIO, I/R, LDH, Nec-1, OGD, OGD/R, RIP1K
64  2018 Plasma Unesterified Fatty-Acid Profile Is Dramatically and Acutely Changed under Ischemic Stroke in the Mouse Model. ---
65  2018 RIP1K Contributes to Neuronal and Astrocytic Cell Death in Ischemic Stroke via Activating Autophagic-lysosomal Pathway. GFAP, LC3II, LMP, MAP2, OGD, RIP1K
66  2018 Sex differences in the effects of PARP inhibition on microglial phenotypes following neonatal stroke. ---
67  2018 Sphingosine-1-Phosphate Receptor 1 Activation Enhances Leptomeningeal Collateral Development and Improves Outcome after Stroke in Mice. eNOS, S1P1
68  2018 Temporal remodeling of pial collaterals and functional deficits in a murine model of ischemic stroke. MCA-ACA
69  2018 The effect of exercise preconditioning on stroke outcome in ovariectomized mice with permanent middle cerebral artery occlusion. IL-10, MMP-9
70  2018 The protective roles of L-borneolum, D-borneolum and synthetic borneol in cerebral ischaemia via modulation of the neurovascular unit. BBB, DCI, ELISA, NVU
71  2018 Therapeutic effects of JLX001 on cerebral ischemia through inhibiting platelet activation and thrombus formation in rats. ADP, CVB-D, ELISA, MCAO, PKC, PLCbeta3, SD
72  2018 Time-course investigation of blood-brain barrier permeability and tight junction protein changes in a rat model of permanent focal ischemia. BBB, PSD-95, SYP, TJ
73  2017 A Linear Temporal Increase in Thrombin Activity and Loss of Its Receptor in Mouse Brain following Ischemic Stroke. PAR1
74  2017 Activation of Alpha-7 Nicotinic Acetylcholine Receptor Reduces Brain Edema in Mice with Ischemic Stroke and Bone Fracture. alpha7 nAchR, BBB, MAO-B, PHA 568487
75  2017 Administration of sonic hedgehog protein induces angiogenesis and has therapeutic effects after stroke in rats. FITC, OGD, PBS, RBMECs, Shh, VEGF
76  2017 Beneficial potential of intravenously administered IL-6 in improving outcome after murine experimental stroke. IL-6, sIL-6R
77  2017 Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep. Coll IV, CRTL, CSPG, ECM, NeuN, NVU, PNs, WFA
78  2017 Effects of Dl-3-n-butylphthalide on Cerebral Ischemia Infarction in Rat Model by Mass Spectrometry Imaging. MALDI-TOF MS, mNSS, MRM, NBP
79  2017 Fumarate decreases edema volume and improves functional outcome after experimental stroke. DMF, HCAR2, HSP, iNOS, Keap1, MMF, Nrf
80  2017 Inhibition of autophagy blocks cathepsins-tBid-mitochondrial apoptotic signaling pathway via stabilization of lysosomal membrane in ischemic astrocytes. 3-MA, cyt c, Hsp70.1B, MEF, OGD, Wort
81  2017 Isosteviol Sodium Protects Against Permanent Cerebral Ischemia Injury in Mice via Inhibition of NF-kappaB-Mediated Inflammatory and Apoptotic Responses. I/R, mRNA, NF-kappaB, qPCR
82  2017 KCa3.1 Inhibition Switches the Astrocyte Phenotype during Astrogliosis Associated with Ischemic Stroke Via Endoplasmic Reticulum Stress and MAPK Signaling Pathways. AD, ER, GFAP, OGD
83  2017 lncRNAs HIF1A-AS2 facilitates the up-regulation of HIF-1alpha by sponging to miR-153-3p, whereby promoting angiogenesis in HUVECs in hypoxia. HUVECs, lncRNAs
84  2017 Neuroinflammatory response to experimental stroke is inhibited by boldine. ---
85  2017 Neuroprotective effects of Kukoamine A against cerebral ischemia via antioxidant and inactivation of apoptosis pathway. KuA
86  2017 Nicotinic Acetylcholine Receptor Alpha7 Subunit Mediates Vagus Nerve Stimulation-Induced Neuroprotection in Acute Permanent Cerebral Ischemia by a7nAchR/JAK2 Pathway. AC
87  2017 Pseudoginsenoside-F11 attenuates cerebral ischemic injury byalleviating autophagic/lysosomal defects. PF11
88  2017 Role of fractalkine/CX3CR1 signaling pathway in the recovery of neurological function after early ischemic stroke in a rat model. CX3CL1, CX3CR1, IL-1beta, sFkn
89  2017 Salvia miltiorrhiza Bunge (Danshen) extract attenuates permanent cerebral ischemia through inhibiting platelet activation in rats. ADP, PKC, PLC, PRP, TXA2
90  2017 Systemic antimiR-337-3p delivery inhibits cerebral ischemia-mediated injury. BBB, LNA, OGD
91  2017 Testing the effects of sensory stimulation as a collateral-based therapeutic for ischemic stroke in C57BL/6J and CD1 mouse strains. ISOI, LSI
92  2017 The ameliorative effect of bloodletting puncture at hand twelve Jing-well points on cerebral edema induced by permanent middle cerebral ischemia via protecting the tight junctions of the blood-brain barrier. BBB, HTWP
93  2017 The potassium channel KCa3.1 constitutes a pharmacological target for astrogliosis associated with ischemia stroke. ---
94  2016 2-(3',5'-Dimethoxybenzylidene) cyclopentanone, a novel synthetic small-molecule compound, provides neuroprotective effects against ischemic stroke. DMBC, GFAP, i.p, LDH, MAP2, OGD
95  2016 An optimized dosing regimen of cimaglermin (neuregulin 1beta3, glial growth factor 2) enhances molecular markers of neuroplasticity and functional recovery after permanent ischemic stroke in rats. ---
96  2016 BDNF/PI3K/Akt and Nogo-A/RhoA/ROCK signaling pathways contribute to neurorestorative effect of Houshiheisan against cerebral ischemia injury in rats. ELISA, HE, HSHS, NeuN, qRT-PCR, SD
97  2016 beta-Dystroglycan cleavage by matrix metalloproteinase-2/-9 disturbs aquaporin-4 polarization and influences brain edema in acute cerebral ischemia. AQP4, DG, MMP, PCR, rmMMP
98  2016 Bone Fracture Pre-Ischemic Stroke Exacerbates Ischemic Cerebral Injury in Mice. ---
99  2016 Carbonic anhydrase inhibition for the management of cerebral ischemia: in vivo evaluation of sulfonamide and coumarin inhibitors. CA
100  2016 Effect of ischaemic brain injury on sexual function in adult mice. ---