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Abbreviation : sCD40L
Long Form : soluble CD40L
No. Year Title Co-occurring Abbreviation
2020 Aspirin Reduces the Potentiating Effect of CD40L on Platelet Aggregation via Inhibition of Myosin Light Chain. ASA
2020 CD40L membrane retention enhances the immunostimulatory effects of CD40 ligation. iDC, mCD40L, TA
2020 Cytokine release syndrome in COVID-19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sex. ---
2020 Expression of CD40 Ligand on T Cells and Soluble CD40 Ligand in Children With Kawasaki Disease: A Single-Center Preliminary Study From North India. CD40L, CI, IVIG, KD
2020 Yin Yang-1 suppresses CD40 ligand-CD40 signaling-mediated anti-inflammatory cytokine interleukin-10 expression in pulmonary adventitial fibroblasts by promoting histone H3 tri-methylation at lysine 27 modification on interleukin-10 promoter. CD40L, EZH2, IL-10, mRNA, PAH, YY-1
2019 RNA-binding protein SFPQ cooperates with HDAC1 to suppress CD40 transcription in pulmonary adventitial fibroblasts. CD40L, DBHS, H3K27ac, HDAC1, PAH
2018 A critical role for both CD40 and VLA5 in angiotensin II-mediated thrombosis and inflammation. Ang II, CD40L, WT
2018 Dengue Virus Induces the Release of sCD40L and Changes in Levels of Membranal CD42b and CD40L Molecules in Human Platelets. DENV-2
2018 Induction of Apoptosis in Cancer Cells of pre-B ALL Patients after Exposure to Platelets, Platelet-Derived Microparticles and Soluble CD40 Ligand. 7-AAD, PBMCs, PLT, Plt-MPs, pre-B ALL
10  2018 Integration of magnetic resonance imaging and protein and metabolite CSF measurements to enable early diagnosis of secondary progressive multiple sclerosis. MBP, MCP-1, MDC, MRI, PDGF-AA, RRMS, TGF-alpha, TNF-alpha
11  2017 Elevated levels of soluble CD40 ligand are associated with antiphospholipid antibodies in patients with systemic lupus erythematosus. aPL, APS
12  2017 Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in FSGS. CD40L, FSGS, GECs, NS
13  2016 Enhanced Soluble Serum CD40L and Serum P-Selectin Levels in Primary Aldosteronism. BP, EH, PA
14  2016 Immunometabolic biomarkers of inflammation in Behcet's disease: relationship with epidemiological profile, disease activity and therapeutic regimens. BD, IL, MCP-1, MPO, OPG, SAA
15  2016 Modeling HIV-1 Induced Neuroinflammation in Mice: Role of Platelets in Mediating Blood-Brain Barrier Dysfunction. BBB, HAND, MuLV-1, WT
16  2016 NORE1A induction by membrane-bound CD40L (mCD40L) contributes to CD40L-induced cell death and G1 growth arrest in p21-mediated mechanism. mCD40L
17  2016 Short-term in vivo modifications of platelet NADPH oxidase 2 (NOX2) and prostaglandin F2alpha in HIV-1 patients on abacavir-based therapies. ABC, NOX2
18  2015 CD40 ligand induces expression of vascular cell adhesion molecule 1 and E-selectin in orbital fibroblasts from patients with Graves' orbitopathy. CD40L, GO, MAPKs, NF-kappaB, OFs, PCR, PI3K, VCAM-1
19  2015 Endothelial Dysfunction and Altered Coagulation As Mediators of Thromboembolism in Behcet Disease. BD
20  2015 Is signal peptide-CUB-EGF domain-containing protein1 a diagnostic biomarker in patients with hypertensive crises. HI, HT, HU, SCUBE1
21  2015 Mechanisms of Nifedipine-Downregulated CD40L/sCD40L Signaling in Collagen Stimulated Human Platelets. CCB, MMP-2, NO, ROS
22  2015 Self-complementary adeno-associated virus 5-mediated gene transduction of a novel CD40L mutant confers direct antitumor effects in lung carcinoma. CD40L, scAAV5, scAAV5-CD40L-M
23  2015 Soluble CD40 ligand: a novel biomarker in the pathogenesis of periodontal disease. GCF
24  2014 Clinical significance of elevated serum soluble CD40 ligand levels as a diagnostic and prognostic tumor marker for pancreatic ductal adenocarcinoma. CD40L, PDAC, ROC
25  2014 PPARgamma ligands decrease hydrostatic pressure-induced platelet aggregation and proinflammatory activity. PPARgamma, TZDs
26  2014 Total adiponectin is inversely associated with platelet activation and CHA₂DS₂-VASc score in anticoagulated patients with atrial fibrillation. AF, APN
27  2013 An explorative study comparing levels of soluble mediators in control and osteoarthritic synovial fluid. ELISAs, G-CSF, IL, IP, MDC, MIP, OA, PCA, PDGF, RANTES, SF
28  2013 CD40 ligand as a potential biomarker for atherosclerotic instability. ACI, CAS, PBMCs
29  2013 CD40-CD40L: linking pancreatic, adipose tissue and vascular inflammation in type 2 diabetes and its complications. T2DM
30  2013 Quantification of cardiovascular disease biomarkers via functionalized magnetic beads and on-demand detachable quantum dots. CVD
31  2013 Soluble CD40 ligand stimulates CD40-dependent activation of the beta2 integrin Mac-1 and protein kinase C zeda (PKCzeta) in neutrophils: implications for neutrophil-platelet interactions and neutrophil oxidative burst. PKCzeta
32  2013 The expression and concentration of CD40 ligand in normal pregnancy, preeclampsia, and hemolytic anemia, elevated liver enzymes and low platelet count (HELLP) syndrome. CD40L, HELLP
33  2013 The role of soluble CD40L in immunosuppression. ---
34  2012 Apolipoprotein A-I inhibits CD40 proinflammatory signaling via ATP-binding cassette transporter A1-mediated modulation of lipid raft in macrophages. ABCA1, apoA-I, CD40L, ELISA, FC, HDL, NF-kB, TRAF-6
35  2012 Autoreactive preplasma cells break tolerance in the absence of regulation by dendritic cells and macrophages. DCs
36  2012 Chronic hyper-reactivity of platelets resulting in enhanced monocyte recruitment in patients after ischaemic stroke. sCD62P, TRAP
37  2012 Does anti-TNF therapy cause any change in platelet activation in ankylosing spondylitis patients? A comparative study. AS, PMC, sE-selectin
38  2012 Excess soluble CD40L contributes to blood brain barrier permeability in vivo: implications for HIV-associated neurocognitive disorders. BBB, Gr1, HAND, Tat
39  2012 Involvement of nuclear factor kappaB in platelet CD40 signaling. CD40L, MAPK, NF-kappaB
40  2012 Plasma levels of soluble CD36, platelet activation, inflammation, and oxidative stress are increased in type 2 diabetic patients. 2alpha, sCD36
41  2012 Platelet lysate from whole blood-derived pooled platelet concentrates and apheresis-derived platelet concentrates for the isolation and expansion of human bone marrow mesenchymal stromal cells: production process, content and identification of active components. bFGF, CFU-F, ICAM-1, MSC, PDGF-AA, PL, TGF-beta1, VCAM-1
42  2012 Prevention of non-immune mediated transfusion-related acute lung injury; from blood bank to patient. lysoPCs, TRALI
43  2012 Serum concentrations and clinical significance of soluble CD40 ligand in patients with multiple myeloma. CD40L, HGF, IL-6, Ki-67 PI, MM, VEGF
44  2012 The CD40-CD40L axis and IFN-gamma play critical roles in Langhans giant cell formation. CD40L, Con A, DC-STAMP, LGCs
45  2011 Comparison of soluble CD40L concentrations and release capacities in apheresis and prestorage pooled platelet concentrates. ---
46  2011 Inhibitory effects of lipoteichoic acid from Staphylococcus aureus on platelet function and platelet-monocyte aggregation. LTA
47  2011 Platelet activation in chronic cocaine users: effect of short term abstinence. MPA, NAP-2, RANTES
48  2010 CD40 ligand shedding is regulated by interaction between matrix metalloproteinase-2 and platelet integrin alpha(IIb)beta(3). IIb, MMP-2
49  2010 Modified serum profiles of inflammatory and vasoconstrictive factors in patients with emotional stress-induced acute coronary syndrome during World Cup Soccer 2006. ACS, ET, hs-CRP, MCP, RANTES, sVCAM, TNF
50  2010 Regulation of CD40L (CD154) and CD62P (p-selectin) surface expression upon GPIIb-IIIa blockade of platelets from stable coronary artery disease patients. ADP, TRAP
51  2010 Soluble CD40L (CD154) is increased in patients with shock. SIRS
52  2009 C-reactive protein but not soluble CD40 ligand and homocysteine is associated to common atherosclerotic risk factors in a cohort of coronary artery disease patients. Hcy, hs-CRP
53  2009 Elevated platelet-monocyte complexes in patients with psoriatic arthritis. CRP, PMC, PNC, PsA, sE-selectin
54  2009 Increased concentrations of soluble vascular cell adhesion molecule-1 and soluble CD40L in subjects with metabolic syndrome. MS, sE-selectin, sVCAM-1
55  2009 Validity of multiplex-based assays for cytokine measurements in serum and plasma from "non-diseased" subjects: comparison with ELISA. CRP, ELISA, IL-1beta, IL-1ra, IL-6, MIA, TNF-alpha
56  2008 CD40-induced signaling in human endothelial cells results in mTORC2- and Akt-dependent expression of vascular endothelial growth factor in vitro and in vivo. EC, siRNA, VEGF
57  2008 Clinical correlates, heritability, and genetic linkage of circulating CD40 ligand in the Framingham Offspring Study. CD40L, CVD
58  2008 Intravenous immunoglobulins induce CD32-mediated platelet aggregation in vitro. CMVIg, IVIG
59  2008 Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice. AD, HUCBCs, IgM
60  2008 Platelet products prepared by different methods of sedimentation undergo platelet activation differently during storage. APs, BC, CD40L, PCs, PLTs, PRP, sCD62
61  2008 Relationship between CD40 ligand expression and B type natriuretic peptide levels in patients with chronic heart failure. BNP, CD40L, CHF, ELISA, NYHA
62  2008 Soluble CD40 ligand and atrial fibrillation: relationship to platelet activation, and endothelial damage/dysfunction. AF, vWF
63  2008 Soluble CD40L, platelet surface CD40L and total platelet CD40L in congestive heart failure: relationship to platelet volume, mass and granularity. CHF, MPC, MPM, MPV, pCD40L
64  2008 The proinflammatory mediator CD40 ligand is increased in the metabolic syndrome and modulated by adiponectin. AN, CD40L, MS
65  2008 The regulation of autoreactive B cells during innate immune responses. DCs, SLE
66  2008 Tumour necrosis factor alpha upregulates platelet CD40L in patients with heart failure. HF, TNF-alpha
67  2007 CD40 ligand binds to alpha5beta1 integrin and triggers cell signaling. CD40L
68  2007 CD40-CD40 ligand signal induces the intercellular adhesion molecule-1 expression through nuclear factor-kappa B p50 in cultured salivary gland epithelial cells from patients with Sjogren's syndrome. ICAM-1, NF-kappaB, PDTC, SG cells, SS
69  2007 Critical role of the CD40 CD40-ligand pathway in regulating mucosal inflammation-driven angiogenesis in inflammatory bowel disease. CD40L, DSS, HGF, HIFs, HIMECs, IBD, IL-8, LPT, VEGF
70  2007 Early increase of oxidative stress and soluble CD40L in children with hypercholesterolemia. MAP
71  2007 Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia. HIV-1
72  2007 Human platelets can activate peripheral blood B cells and increase production of immunoglobulins. CD40L, Ig
73  2007 Increased serum levels of circulating CD40 ligand in patients with bullous pemphigoid: preliminary results. BP, CD40L, PV
74  2007 Phase I study of eptifibatide in patients with sickle cell anaemia. ACS, CD40L, SCA
75  2007 Relationship between upregulation of CD40 system and restenosis in patients after percutaneous coronary intervention. CD40L, CRP, MFI, PCI
76  2006 Association between enhanced soluble CD40 ligand and proinflammatory and prothrombotic states in major depressive disorder: pilot observations on the effects of selective serotonin reuptake inhibitor therapy. CAD, CD40L, FVIIa, IL-1beta, IL-6, MDD, sP-selectin, SSRI, TNF-alpha
77  2006 Differential regulation of soluble and membrane CD40L proteins in T cells. ---
78  2006 Soluble CD40 ligand and interleukin-6 in the coronary circulation after acute myocardial infarction. AMI, CD40L, CS, CS-A, IL, max, MMP, PCI
79  2006 Soluble CD40 ligand in prediction of acute severe pancreatitis. ---
80  2006 Soluble CD40 ligand levels in otherwise healthy subjects with impaired fasting glucose. hs-CRP, IFG
81  2006 Soluble P-selectin and CD40L levels in subjects with prediabetes, diabetes mellitus, and metabolic syndrome--the Chennai Urban Rural Epidemiology Study. CURES, IGT, MS, NGT, sP-selectin
82  2006 TNF-alpha blockade down-regulates the CD40/CD40L pathway in the mucosal microcirculation: a novel anti-inflammatory mechanism of infliximab in Crohn's disease. CD, CD40L, HIMEC, PBT
83  2005 Analysis of serum soluble CD40 ligand in patients with influenza virus-associated encephalopathy. CD40L, EBV, IE, IFS
84  2005 Anti-inflammatory effects of clopidogrel intake in renal transplant patients: effects on platelet-leukocyte interactions, platelet CD40 ligand expression, and proinflammatory biomarkers. CD40L, MMP-9
85  2005 Chorioamnionitis is associated with increased CD40L expression on cord blood platelets. CA, IL-6
86  2005 Inverse correlation between soluble CD40 ligand and soluble CD40 is absent in patients with unstable angina. CD40L, MMP, sCD40, UA
87  2005 Short-term treatment with atorvastatin reduces platelet CD40 ligand and thrombin generation in hypercholesterolemic patients. ---
88  2005 Soluble CD40 ligand levels in patients with hypertension. CD40, hs-CRP
89  2005 Soluble CD40L and cardiovascular risk in asymptomatic low-grade carotid stenosis. ALCS, CRF, CRP, CV
90  2004 Activated platelets rapidly up-regulate CD40L expression and can effectively mature and activate autologous ex vivo differentiated DC. CD40L, TNF-alpha
91  2004 CD40-induced transcriptional activation of vascular endothelial growth factor involves a 68-bp region of the promoter containing a CpG island. CD40L, EC, MeCP2, VEGF
92  2004 Characterization and application of two novel monoclonal antibodies against CD40L: epitope and functional studies on cell membrane CD40L and studies on the origin of soluble serum CD40L. AA, ELISA, ITP
93  2004 Differences of soluble CD40L in sera and plasma: implications on CD40L assay as a marker of thrombotic risk. mp-CD40L, PPP, serum-I
94  2004 Elevated circulating CD40L concentrations in patients with systemic sclerosis. dSSc, lSSc, SLE, SSc
95  2004 Relation between upregulation of CD40 system and complex stenosis morphology in patients with acute coronary syndrome. ACS, AMI, SA, UA
96  2004 Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization. GP, MMPs
97  2003 CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappa B signaling. ERK, JNK, mAb, MEK, MM, NF, PI3K, uPA
98  2003 Elevated plasma levels of the atherogenic mediator soluble CD40 ligand in diabetic patients: a novel target of thiazolidinediones. CD40L
99  2003 Expression of CD40 ligand on CD4+ T-cells and platelets correlated to the coronary artery lesion and disease progress in Kawasaki disease. CD40L, FC, IVIG, KD
100  2003 Preprocedural level of soluble CD40L is predictive of enhanced inflammatory response and restenosis after coronary angioplasty. MCP, PTCA