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Abbreviation : sIL-6R
Long Form : soluble IL-6 receptor
No. Year Title Co-occurring Abbreviation
2020 Effect of NMO-IgG on the interleukin-6 cascade in astrocytes via activation of the JAK/STAT3 signaling pathway. AQP4, IL-6, NMOSD
2020 Estrogen downregulates gp130 expression in HUVECs by regulating ADAM10 and ADAM17 via the estrogen receptor. ADAM10, gp130, HUVECs, IL-6, sgp130
2020 The ADAM17 protease promotes tobacco smoke carcinogen-induced lung tumorigenesis. NNK
2020 Tumour necrosis factor alpha promotes secretion of 14-3-3eta by inducing necroptosis in macrophages. IL, MLKL, RA, TNF
2019 A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity. CVDs, MR
2019 Blocking interleukin-6 trans-signaling protects against renal fibrosis by suppressing STAT3 activation. IL-6, IR, STAT, TGF, UUO
2019 Correlation of magnetic resonance imaging grades with cytokine levels of synovial fluid of patients with temporomandibular joint disorders: a cross-sectional study. IL, MRI, NRS, TMJ
2019 Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation. IL-6TS, U-BIOPRED
2019 IL-6 Trans-signaling Controls Liver Regeneration After Partial Hepatectomy. gp130, IL-6
10  2019 Inhibition of interleukin-6 trans-signaling prevents inflammation and endothelial barrier disruption in retinal endothelial cells. HRECs, IL-6
11  2019 Interleukin 6 trans-signalling and risk of future cardiovascular events. CI, CV, CVE, HR, IL-6
12  2019 Plasma interleukin 6 levels are associated with cardiac function after ST-elevation myocardial infarction. IL-6, LVEF, sGP, STEMI
13  2019 The synergistic action of phosphate and interleukin-6 enhances senescence-associated calcification in vascular smooth muscle cells depending on p53. ESRD, IL-6, STAT3, VSMCs
14  2018 Association between allergic and nonallergic rhinitis and obstructive sleep apnea. NAR, OSA, SDB
15  2018 Combination of 4-hydroperoxy cyclophosphamide and methotrexate inhibits IL-6/sIL-6R-induced RANKL expression in fibroblast-like synoviocytes via suppression of the JAK2/STAT3 and p38MAPK signaling pathway. 4-H-CTX, FLS, IL, MTX, RA, RANKL
16  2018 Fungal metabolite (+)-terrein suppresses IL-6/sIL-6R-induced CSF1 secretion by inhibiting JAK1 phosphorylation in human gingival fibroblasts. CSF1, HGFs, IL-6, JAK1, VEGF
17  2018 High Glucose-Mediated Cytokine Regulation in Gingival Fibroblasts and THP-1 Macrophage: a Possible Mechanism of Severe Periodontitis with Diabetes. CM, CPT, DM, GCF, HG, HGFs, IL, IL-1ra, MMPs, NG, TIMP-1
18  2018 Interleukin-6 contributes to the increase in fibroblast growth factor 23 expression in acute andchronic kidney disease. AKI, CKD, FGF23, HIL-6, IL-6
19  2018 Interleukin-6-mediated trans-signaling inhibits transforming growth factor-beta signaling in trabecular meshwork cells. HTM, MLC2, POAG, TGF-beta2
20  2018 Lipid Peroxidation and Immune Biomarkers Are Associated with Major Depression and Its Phenotypes, Including Treatment-Resistant Depression and Melancholia. CIRS, HDRS, IL, MADRS, sIL-1RA, sIL-2R, TBARS, TRD
21  2018 Lymphatic growth factors are expressed in human gingiva and upregulated in gingival fibroblasts after stimulation. ELISA, HGFs, LPS, qRT-PCR, VEGF
22  2018 Neonatal Inflammatory Markers Are Associated with Childhood B-cell Precursor Acute Lymphoblastic Leukemia. ALL, CRP, MCP
23  2018 Soluble glycoprotein 130 is inversely related to severity of coronary atherosclerosis. CAD, IL-6, sgp130
24  2018 Whole cell melanoma vaccine genetically modified to stem cells like phenotype generates specific immune responses to ALDH1A1 and long-term survival in advanced melanoma patients. MSC
25  2017 A Role for Soluble IL-6 Receptor in Osteoarthritis. ADAM, gp130, IL-6, JAK/STAT, MMP-9, NGAL, OA, RA
26  2017 Beneficial potential of intravenously administered IL-6 in improving outcome after murine experimental stroke. IL-6, pMCAO
27  2017 Blockade of the IL-6 trans-signalling/STAT3 axis suppresses cachexia in Kras-induced lung adenocarcinoma. IL
28  2017 Cellular and Oxidative Mechanisms Associated with Interleukin-6 Signaling in the Vasculature. IL-6, IL-6R, NO
29  2017 Circulating Soluble IL-6 Receptor Concentration and Visceral Adipocyte Size Are Related to Insulin Resistance in Taiwanese Adults with Morbid Obesity. BMI, HOMA-IR, IL, mIL-6R
30  2017 COPD monocytes demonstrate impaired migratory ability. IL-6, NS
31  2017 IL-6 Trans-Signaling Links Inflammation with Angiogenesis in the Peritoneal Membrane. HPMCs, PD, VEGF
32  2017 Inflammatory Markers and Frailty in Long-Term Care Residents. hs-CRP, IL-6, LTC, TNF-alpha
33  2017 Inhibitory Mechanism of the Outer Membrane Growth of Chronic Subdural Hematomas. CSDHs, CSF, IL-6, JAK, PIAS3, SAH, sgp130, SOCS3, STAT
34  2017 Interleukin-6 and soluble interleukin-6 receptor are elevated in large-vessel vasculitis: a cross-sectional and longitudinal study. GCA, NCs, TAK
35  2017 Interleukin-6 signaling in patients with chronic heart failure treated with cardiac resynchronization therapy. CHF, CRT, IL-6, sgp130
36  2017 Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies. HCs, IL-6, MDD, TNF
37  2017 Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation. ADAM17, IL-6
38  2017 Soluble IL6R Expressed by Myeloid Cells Reduces Tumor-Specific Th1 Differentiation and Drives Tumor Progression. ---
39  2016 Associations Between Delirium and Preoperative Cerebrospinal Fluid C-Reactive Protein, Interleukin-6, and Interleukin-6 Receptor in Individuals with Acute Hip Fracture. CRP, CSF, IL-6, IQCODE, IQR
40  2016 IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3. HuMC, MC, SOCS3
41  2016 IL-6 stimulates a concentration-dependent increase in MCP-1 in immortalised human brain endothelial cells. BBB, IL-6
42  2016 IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis. ---
43  2015 Age-related increased prevalence of asthma and nasal polyps in chronic rhinosinusitis and its association with altered IL-6 trans-signaling. CRS, CRSwNP, sgp130, TNF
44  2015 Allergen-induced IL-6 trans-signaling activates gammadelta T cells to promote type 2 and type 17 airway inflammation. HDM, IL-6R
45  2015 Effects of diet and/or n-3 fatty acid supplementation on components of the interleukin-6 trans-signalling system in elderly men. CV, IL-6, Md, n-3 PUFA, sgp130, ts
46  2015 IL-6 trans-signaling plays important protective roles in acute liver injury induced by acetaminophen in mice. AAP, CYP2E1, IL-6, pSTAT3
47  2015 Inhibition of interleukin-6 abolishes the promoting effects of pair housing on post-stroke neurogenesis. IL-6, NPCs, PH, PH, rIL-6, SVZ, tMCAO
48  2015 Interleukin-6-mediated functional upregulation of TRPV1 receptors in dorsal root ganglion neurons through the activation of JAK/PI3K signaling pathway: roles in the development of bone cancer pain in a rat model. DRG, IL-6, JAK, PI3K, TRPV1
49  2015 Role played by interleukin-6 in evoking the exercise pressor reflex in decerebrate rats: effect of femoral artery ligation. sGP
50  2015 Soluble interleukin-6 receptor is elevated during influenza A virus infection and mediates the IL-6 and IL-32 inflammatory cytokine burst. IAV
51  2015 STAT1 is Constitutively Activated in the T/C28a2 Immortalized Juvenile Human Chondrocyte Line and Stimulated by IL-6 Plus Soluble IL-6R. rhIL-6, STAT1
52  2014 Human umbilical cord blood-derived stromal cells: a new resource for the proliferation and apoptosis of myeloma cells. Bcl-2, BMSCs, HME, hUCBDSCs, ICAM-1, IL, mIL-6R, MM, NF-kappaB
53  2014 IL-6 amplifies TLR mediated cytokine and chemokine production: implications for the pathogenesis of rheumatic inflammatory diseases. IL, PBMCs, RA, SFMCs, sJIA, TCZ, TLR
54  2014 IL-6-accelerated calcification by induction of ROR2 in human adipose tissue-derived mesenchymal stem cells is STAT3 dependent. hADSCs, ROR2, siRNA, STAT3, WNT
55  2014 Induction of an inflammatory and prodegradative phenotype in autologous fibroblast-like synoviocytes by the infrapatellar fat pad from patients with knee osteoarthritis. COX-2, FLS, IFP, IL-6, MMPs, mRNA, OA, PGE2, SCAT, sPLA2, TNF-alpha
56  2014 Interleukin-6 and soluble interleukin-6 receptor levels in posttraumatic stress disorder: associations with lifetime diagnostic status and psychological context. IL-6
57  2014 Synthetic (+)-terrein suppresses interleukin-6/soluble interleukin-6 receptor induced-secretion of vascular endothelial growth factor in human gingival fibroblasts. IL, VEGF
58  2014 Targeting classical IL-6 signalling or IL-6 trans-signalling in depression? sgp130
59  2014 The inhibition of N-glycosylation of glycoprotein 130 molecule abolishes STAT3 activation by IL-6 family cytokines in cultured cardiac myocytes. ERK, gp130, IL-6, JAKs, LIF, PTP1B, SOCSs, TM
60  2013 Alternative splicing and proteolytic rupture contribute to the generation of soluble IL-6 receptors (sIL-6R) in rheumatoid arthritis. RA
61  2013 Are pentraxin 3 and transsignaling early markers for immunologic injury severity in polytrauma? A pilot study. ISS, OF, PTS, PTX3, TSR
62  2013 Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR). ADAM10, EGFR, IL-6, mTOR, SASP
63  2013 Components of the interleukin-6 transsignalling system are associated with the metabolic syndrome, endothelial dysfunction and arterial stiffness. FPG, IL-6, MetS, PWP, sgp130
64  2013 Critical role of STAT3 in IL-6-mediated drug resistance in human neuroblastoma. EMDR, IL, Treg
65  2013 IL-6 is produced by adipose-derived stromal cells and promotes osteogenesis. ASCs, ChIP, IL-6, siRNA, TLRs
66  2013 miR145 targets the SOX9/ADAM17 axis to inhibit tumor-initiating cells and IL-6-mediated paracrine effects in head and neck cancer. HNC, IL, Spg-miR145, TIC
67  2013 Psychologic and biologic factors associated with fatigue in patients with persistent radiculopathy. IL, NP
68  2013 Regulatory effect of calcineurin inhibitor, tacrolimus, on IL-6/sIL-6R-mediated RANKL expression through JAK2-STAT3-SOCS3 signaling pathway in fibroblast-like synoviocytes. FLS, RA, RANKL, STAT3
69  2013 Role of interleukin-6, its receptor and soluble gp130 in chronic lung disease of prematurity. BALF, CLD, IL-6, sgp130
70  2013 Significance of the IL-6 pathway in nasal polyposis in Chinese patients. IL-6, NP, p-STAT3, RORC, SOCS3
71  2013 Soluble interleukin-6 receptor-mediated innate immune response to DNA and RNA viruses. IL-6, IRF3, Mx, OAS, PKR
72  2013 The soluble interleukin-6 receptor is a mediator of hematopoietic and skeletal actions of parathyroid hormone. ---
73  2013 Tocilizumab in glucocorticoid-naive large-vessel vasculitis. GC, IL-6, LVV, TCZ
74  2013 Tumor necrosis factor-costimulated T lymphocytes from patients with systemic sclerosis trigger collagen production in fibroblasts. IL-6, SSc, TNF, TNFR
75  2012 An intermediate-risk multiple myeloma subgroup is defined by sIL-6r: levels synergistically increase with incidence of SNP rs2228145 and 1q21 amplification. MM
76  2012 Elevated urinary sVCAM-1, IL6, sIL6R and TNFR1 concentrations indicate acute kidney transplant rejection in the first 2 weeks after transplantation. IL-6, IL1Ra, sVCAM-1, TNFR1
77  2012 Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model. GPI, IL-6, MTX
78  2012 Interleukin-6 upregulates expression of ADAMTS-4 in fibroblast-like synoviocytes from patients with rheumatoid arthritis. ERK, FLS, IL, MAPK, mRNA, RA, STAT3
79  2012 Intraperitoneal IL-6 signaling in incident patients treated with icodextrin and glucose bicarbonate/lactate-based peritoneal dialysis solutions. IL-6, PD, sGp130
80  2012 Osteocyte apoptosis regulates osteoclast precursor adhesion via osteocytic IL-6 secretion and endothelial ICAM-1 expression. ---
81  2012 Pregnancy-associated inflammatory markers are elevated in pregnant women with systemic lupus erythematosus. CBA, ELISA, gp130, IL, SLE
82  2012 Proinflammatory cytokine activation is linked to apoptotic mediator, soluble Fas level in patients with chronic heart failure. CHF, GP, IL, sFas, TNF
83  2012 Rescue treatment with tocilizumab for Takayasu arteritis resistant to TNF-alpha blockers. IL-6, TA
84  2012 Secretion of IL-6 and IL-8 from lysophosphatidic acid-stimulated oral squamous cell carcinoma promotes osteoclastogenesis and bone resorption. BMMs, CM, EGFR, LPA, NF, OSCC, rIL-6
85  2012 Spinal interleukin-6 is an amplifier of arthritic pain in the rat. IL-6
86  2012 The balance between soluble receptors regulating IL-6 trans-signaling is predictive for the RANKL/osteoprotegerin ratio in postmenopausal women with rheumatoid arthritis. BMD, GC, IL-6, OPG, RA, sgp130
87  2011 Correlations among inflammatory markers in plasma, saliva and oral mucosal transudate in post-menopausal women with past intimate partner violence. CRP, IPV, OMT
88  2011 Dynamic expression of IL-6 trans-signalling molecules in the lungs of preterm baboons undergoing mechanical ventilation. IL, MCP-1, sgp130
89  2011 Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines. GAG, GR, IL-6, mRNA, TNF-alpha
90  2011 Increased expression of C-reactive protein gene in inflamed gingival tissues could be derived from endothelial cells stimulated with interleukin-6. HCAECs, HGECs, HGFBs, hs-CRP, IL
91  2011 Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor. sgp130, sgp130
92  2011 Interleukin-6 and soluble interleukin-6 receptor suppress osteoclastic differentiation by inducing PGE(2) production in chondrocytes. COX, IL-6, M-CSF, OPG, RANKL, TRAP
93  2011 Post-transcriptional regulation of IL-6 production by Zc3h12a in fibroblast-like synovial cells. FLS, RA, STAT3
94  2011 Radiographic bone damage in chronic gout is negatively associated with the inflammatory cytokines soluble interleukin 6 receptor and osteoprotegerin. IL-1ss, OPG, RANKL
95  2011 SHBG, sex hormones, and inflammatory markers in older women. CRP
96  2011 Soluble gp130 regulatess interleukin-6 in cerebrospinal fluid after subarachnoid haemorrhage. CSF, IL-6, SAH, sgp130
97  2010 Differential effects of locally and systemically administered soluble glycoprotein 130 on pain and inflammation in experimental arthritis. AIA, IL-6, sgp130
98  2010 High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor, MKP-1. ERK, HA, IL-6, MAPK, MEK, MKP-1, MMPs, STAT
99  2010 IL-6 and IL-1 synergistically enhanced the production of MMPs from synovial cells by up-regulating IL-6 production and IL-1 receptor I expression. MMPs
100  2010 Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis. BALF, CF, IL-8