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Abbreviation : shRNAs
Long Form : small hairpin RNAs
No. Year Title Co-occurring Abbreviation
2020 Hepatitis C Virus NS2 Protein Suppresses RNA Interference in Cells. dsRNAs, HCV, RNAi, siRNAs, VSRs
2020 Rab5a Promotes Cytolethal Distending Toxin B-Induced Cytotoxicity and Inflammation. CdtB, ELISAs, IL-1beta, JNK, NF-kappaB, PI-IBS, qPCR, Rab5a
2020 The 3A protein of coxsackievirus B3 acts as a viral suppressor of RNA interference. CVB3, CVB5, dsRNAs, RNAi, siRNAs, VSRs
2019 CRISPR/Cas9-Mediated Hitchhike Expression of Functional shRNAs at the Porcine miR-17-92 Cluster. CSFV, miRNA, PFFs, pmiR-17-92, RNAi, Tg
2019 Long noncoding RNA NEAT1 drives aggressive endometrial cancer progression via miR-361-regulated networks involving STAT3 and tumor microenvironment-related genes. ECs, lncRNAs, miR-361
2018 Genetically modified pigs are protected from classical swine fever virus. CSF, CSFV, pRosa26, RNAi, SCNT, Tg
2018 Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice Without Affecting Regeneration. HCC, siRNAs
2018 Overexpression of UQCRC2 is correlated with tumor progression and poor prognosis in colorectal cancer. CRC, UQCRC2
2018 Reduced QSOX1 enhances radioresistance in nasopharyngeal carcinoma. CCK-8, ELISA, IHC, IR, NPC
10  2018 RNAi-mediated SYT14 knockdown inhibits the growth of human glioma cell line U87MG. NSC, SYT14
11  2018 Selective downregulation of vesicular glutamate transporter2 in ventral posterolateral nucleus of thalamus attenuates neuropathic mechanical allodynia in mice. SNI, VGLUTs, VPL
12  2017 A lentiviral system for efficient knockdown of proteins in neuronal cultures [version 1; referees: 2 approved]. miRNA
13  2017 Enhancing Angiogenesis in Mice by VEGF-Targeting Small Activating RNAs. ncRNAs
14  2017 Flow Cytometric Analysis of HIV-1 Transcriptional Activity in Response to shRNA Knockdown in A2 and A72 J-Lat Cell Lines. BET, P-TEFb
15  2017 Honokiol induces proteasomal degradation of AML1-ETO oncoprotein via increasing ubiquitin conjugase UbcH8 expression in leukemia. AML, HNK
16  2017 Stable knockdown of CREB, HIF-1 and HIF-2 by replication-competent retroviruses abrogates the responses to hypoxia in hepatocellular carcinoma. CREB
17  2016 Deletion of sirtuin 6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice. SIRT6
18  2016 FRAT1 expression regulates proliferation in colon cancer cells. FRAT1
19  2016 Global gene expression profiling of JMJD6- and JMJD4-depleted mouse NIH3T3 fibroblasts. JMJD4, Jmjd6
20  2016 nArgBP2 regulates excitatory synapse formation by controlling dendritic spine morphology. KD, nArgBP2, PAK, SAPAP3, WAVE1
21  2016 RNA interference-induced hepatotoxicity results from loss of the first synthesized isoform of microRNA-122 in mice. miR, rAAV, RNAi
22  2016 shRNA inhibits the expression of chicken telomerase reverse transcriptase in MDCC-MSB1 cells. chTERT
23  2016 shRNA targeting long non-coding RNA CCAT2 controlled by tetracycline-inducible system inhibits progression of bladder cancer cells. lncRNAs
24  2016 shRNA‑mediated silencing of TARBP2 inhibits NCI‑H1299 non‑small cell lung cancer cell invasion and migration via the JNK/STAT3/AKT pathway. COX, IL, MMP2, STAT3, ZNF395
25  2016 Silencing Estrogen Receptor-alpha with siRNA in the Intact Rodent Brain. AAV, ERalpha
26  2016 Silencing of SOX12 by shRNA suppresses migration, invasion and proliferation of breast cancer cells. SOX12
27  2016 Suppression of bromodomain-containing protein 4 by shRNA: A new approach for cancer treatment. RNAi
28  2016 Systemic inflammatory response syndrome following burns is mediated by brain natriuretic peptide/natriuretic peptide A receptor-induced shock factor 1 signaling pathway. BNP, CRP, ELISA, HSF-1, IL, MNCs, NPR-A, SIRS, TNF, WB
29  2015 Aberrant Purkinje cell activity is the cause of dystonia in a shRNA-based mouse model of Rapid Onset Dystonia-Parkinsonism. AAV, RDP
30  2015 beta-Catenin is required for the tumorigenic behavior of triple-negative breast cancer cells. ---
31  2015 Differential Regulation of Vascular Endothelial Growth Factors by Promoter-targeted shRNAs. VEGFs
32  2015 Functional characterization of TRAP1-like protein involved in modulating fibrotic processes mediated by TGF-beta/Smad signaling in hypertrophic scar fibroblasts. FN, HSFB, TLP
33  2015 Nhej1 Deficiency Causes Abnormal Development of the Cerebral Cortex. DSBs, NHEJ, Nhej1
34  2015 Presynaptic protein Synaptotagmin1 regulates the neuronal polarity and axon differentiation in cultured hippocampal neurons. anti-NaCh
35  2014 A New Gene Therapy Approach for Cardiovascular Disease by Non-coding RNAs Acting in the Nucleus. lncRNAs, ncRNAs
36  2014 Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells. HD, HTT, SNP
37  2014 Mouse fetal liver culture system to dissect target gene functions at the early and late stages of terminal erythropoiesis. EPO
38  2014 Neogenin as a receptor for early cell fate determination in preimplantation mouse embryos. ICM, RGMc, TE
39  2014 Silencing of HIV-1 gag gene from epidemic strains among men who have sex with men (MSM) in Tianjin, China by a broad-spectrum short hairpin RNA. HIV, MSM, RNAi
40  2014 Trim58 degrades Dynein and regulates terminal erythropoiesis. ---
41  2013 A Direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration. ---
42  2013 Effects of SOCS 1/3 gene silencing on the expression of C/EBPalpha and PPARgamma during differentiation and maturation of rat preadipocytes. CG-IUGR
43  2013 Long non-coding RNA HOTAIR, a driver of malignancy, predicts negative prognosis and exhibits oncogenic activity in oesophageal squamous cell carcinoma. ESCC, HOTAIR, HOXC
44  2013 miRNA and shRNA expression vectors based on mRNA and miRNA processing. miRNAs, RNAi
45  2013 Organic small hairpin RNAs (OshR): a do-it-yourself platform for transgene-based gene silencing. 3'UTR, OshR, RNAi, siRNAs
46  2013 Transfer and Expression of Small Interfering RNAs in Mammalian Cells Using Lentiviral Vectors. ---
47  2012 A transgenic Marc-145 cell line of piggyBac transposon-derived targeting shRNA interference against porcine reproductive and respiratory syndrome virus. PRRS, PRRSV
48  2012 Effects of palmitoylethanolamide on aqueous humor outflow. MAPK, PEA
49  2012 EGFR and c-Met Cross Talk in Glioblastoma and Its Regulation by Human Cord Blood Stem Cells. EGFR, hGBM, hUCBSCs, RTK
50  2012 Hepatocytes that express variants of cyclophilin A are resistant to HCV infection and replication. CypA, HCV, PPIA, SNPs
51  2012 High mobility group-box 3 overexpression is associated with poor prognosis of resected gastric adenocarcinoma. HMGB3, NC, TNM
52  2012 Inhibition of Ca(2+)-activated Cl(-) channel ANO1/TMEM16A expression suppresses tumor growth and invasiveness in human prostate carcinoma. ---
53  2012 Inhibition of rabies virus multiplication by siRNA delivered through adenoviral vector in vitro in BHK-21 cells and in vivo in mice. rAdV, rAdV-L, rAdV-Neg, RV, siRNA
54  2012 Knockdown of HMGA1 expression by short/small hairpin RNA inhibits growth of ovarian carcinoma cells. HMGA1, RT-PCR
55  2012 Optimized models for design of efficient miR30-based shRNAs. ---
56  2012 Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing. AGO1, RISC, siRNAs, sshRNAs
57  2012 siRNA-mediated suppression of Japanese encephalitis virus replication in cultured cells and mice. JEV, p.i
58  2012 Specific inhibition of SRC kinase impairs malignant glioma growth in vitro and in vivo. ---
59  2012 WT1 silencing by RNAi synergizes with chemotherapeutic agents and induces chemosensitization to doxorubicin and cisplatin in B16F10 murine melanoma cells. shRNAi
60  2011 Endogenous APOBEC3B restricts LINE-1 retrotransposition in transformed cells and human embryonic stem cells. hESCs, LINE-1 or L1
61  2011 Evidence of a role for the novel zinc-finger transcription factor ZKSCAN3 in modulating Cyclin D2 expression in multiple myeloma. MMGP, mRNA, ZKSCAN3
62  2011 Lentiviral vector delivery of shRNA into cultured primary myogenic cells: a tool for therapeutic target validation. GSDII
63  2011 Neuroprotection by gene therapy targeting mutant SOD1 in individual pools of motor neurons does not translate into therapeutic benefit in fALS mice. AAV6, ALS, MN, mSOD1
64  2011 RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. AML, BRD4, RNAi
65  2011 Targeting of human interleukin-12B by small hairpin RNAs in xenografted psoriatic skin. IL-12, TNF-alpha
66  2011 The effect of murine cytomegalovirus IE-3 specific shRNA is dependent on intragenic target site due to multiple transcription initiation sites. HCMV, IE-3, MCMV
67  2011 Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes. RISC
68  2011 Use of transporter knockdown Caco-2 cells to investigate the in vitro efflux of statin drugs. A-to-B, BCRP, MRP2, P-gp
69  2010 Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs. 2'-OMe, siRNAs, sshRNAs
70  2010 Generation of mammalian cell lines with gene knock-down for human MCHR2. MCH
71  2010 Minimal-length short hairpin RNAs: the relationship of structure and RNAi activity. bp, nt
72  2010 Roles of PKC isoforms in the induction of apoptosis elicited by aberrant Ras. PKC
73  2010 Viral envelope protein 53R gene highly specific silencing and iridovirus resistance in fish Cells by AmiRNA. amiRNAs, MCP, RGV, RNAi
74  2009 A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling. BAR, BIO, DHFR, GSK3beta, LPS, PI3K
75  2009 Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism: a novel example of epigenetherapy. VEGF-A
76  2009 Evaluation of stem cell differentiation in diabetic rats transplanted with bone marrow mesenchymal stem cells. BM-MSC, Ngn3
77  2009 pSM155 and pSM30 vectors for miRNA and shRNA expression. miRNAs, RNAi, siRNAs
78  2009 RNA interference protects horse cells in vitro from infection with Equine Arteritis Virus. EAV, RNAi, siRNAs
79  2009 Uptake of plasmid-loaded nanoparticles in breast cancer cells and effect on Plk1 expression. HER2, HSA, Plk1
80  2008 AAV-mediated knockdown of phospholamban leads to improved contractility and calcium handling in cardiomyocytes. AAV, PLN, RT-PCR
81  2008 Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen. ABC, DLBCL, IKKbeta, NF-kappaB
82  2008 Conditional gene expression and knockdown using lentivirus vectors encoding shRNA. ---
83  2008 Evaluation of small hairpin RNA silencing efficiency in live cells by cotransfection of two fluorescent probes. siRNA
84  2008 Interaction between simian virus 40 large T antigen and insulin receptor substrate 1 is disrupted by the K1 mutation, resulting in the loss of large T antigen-mediated phosphorylation of Akt. IRS-1, Rb, SV40, Tag, WT
85  2008 Intermediate filament protein synemin contributes to the migratory properties of astrocytoma cells by influencing the dynamics of the actin cytoskeleton. IF
86  2008 Microglia-derived TGF-beta as an important regulator of glioblastoma invasion--an inhibition of TGF-beta-dependent effects by shRNA against human TGF-beta type II receptor. TbetaIIR, TGF-beta
87  2008 siRNA pool targeting different sites of human hepatitis B surface antigen efficiently inhibits HBV infection. HBsAg, HBV, siRNAs
88  2007 Anticancer activity of an adenoviral vector expressing short hairpin RNA against BK virus T-ag. siRNA, Tag
89  2007 Gene silencing by small regulatory RNAs in mammalian cells. miRNAs, RNAi, siRNAs
90  2007 Gephyrin clustering is required for the stability of GABAergic synapses. sIPSCs
91  2007 In vitro c-met inhibition by antisense RNA and plasmid-based RNAi down-modulates migration and invasion of hepatocellular carcinoma cells. HCC
92  2007 RNA interference and its application in bone-related diseases. RNAi, siRNAs
93  2007 Use of herpes simplex virus type 1-based amplicon vector for delivery of small interfering RNA. HSV-1, siRNAs
94  2007 Variability in RNA interference in neuroendocrine PC12 cell lines stably transfected with an shRNA plasmid. RNAi, siRNAs
95  2007 [Effect of hypoxia on the chemotherapeutic sensitivity of human ovarian cancer cells to paclitaxel and its mechanism]. HIF-1alpha, MDR-1, MIT, P-gp, RT-PCR
96  2006 A loss-of-function RNA interference screen for molecular targets in cancer. DLBCL
97  2006 Design and cloning of lentiviral vectors expressing small interfering RNAs. RNAi
98  2006 Expression of small hairpin RNAs for S100A9 used in the protein function research. ATRA, NBT
99  2006 Inhibition of hepatitis C IRES-mediated gene expression by small hairpin RNAs in human hepatocytes and mice. HCV IRES
100  2006 MADD/DENN splice variant of the IG20 gene is necessary and sufficient for cancer cell survival. SVs