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Abbreviation : A2AR
Long Form : A2A receptor
No. Year Title Co-occurring Abbreviation
1999 Stimulation of expression for the adenosine A2A receptor gene by hypoxia in PC12 cells. A potential role in cell protection. ---
1999 [Adenosine reduces ischemia/reperfusion-induced liver injury by inhibiting leukocyte activation]. A2R, fMLP, I/R
2001 Adenosine A2A agonist CGS 21680 decreases the affinity of dopamine D2 receptors for dopamine in human striatum. D2R
2001 Ultrastructural localization of adenosine A2A receptors suggests multiple cellular sites for modulation of GABAergic neurons in rat striatum. GABA
2002 Adenosine A2A agonist reduces paralysis after spinal cord ischemia: correlation with A2A receptor expression on motor neurons. I/R, Sham
2002 The A2A receptor mediates an endogenous regulatory pathway of cytokine expression in THP-1 cells. cAMP, CREB, LPS, TNF
2003 Aggravated brain damage after hypoxic ischemia in immature adenosine A2A knockout mice. HI
2003 The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin. ---
2004 Adenosine A2A receptor occupancy stimulates expression of proteins involved in reverse cholesterol transport and inhibits foam cell formation in macrophages. ABCA1, IC, RCT
10  2004 Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors. D2R, GST-A2ACT
11  2004 Genetic and pharmacological inactivation of the adenosine A2A receptor attenuates 3-nitropropionic acid-induced striatal damage. 3-NP, CSC, KO, WT
12  2004 Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer. BRET, FRET
13  2005 Genetic and pharmacological inactivation of adenosine A2A receptor reveals an Egr-2-mediated transcriptional regulatory network in the mouse striatum. KO, SCH, VEH, WT
14  2005 Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury. ARDS
15  2006 Adenosine A2A receptors are up-regulated in Pick's disease frontal cortex. PiD
16  2006 Adenosine A2A receptors in bone marrow-derived cells but not in forebrain neurons are important contributors to 3-nitropropionic acid-induced striatal damage as revealed by cell-type-selective inactivation. 3-NP, BMDCs, KO
17  2006 Adenosine2A receptor vasodilation of rat preglomerular microvessels is mediated by EETs that activate the cAMP/PKA pathway. EET, L-NAME, PGMV
18  2006 Contractile effects of adenosine A1 and A2A receptors in isolated murine hearts. A1R, antiadrenergic action, CCPA, ISO, LVP
19  2006 Functional coupling of the Galpha(olf) variant XLGalpha(olf) with the human adenosine A2A receptor. ---
20  2006 Involvement of adenosine A2A and dopamine receptors in the locomotor and sensitizing effects of cocaine. DA
21  2006 Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes. KO
22  2007 Adenosine A2A-receptor stimulation inhibits lipopolysaccharide-induced interleukin-18 production in monocytes. cAMP, IL, LPS, PKA
23  2007 Synergistic up-regulation of vascular endothelial growth factor (VEGF) expression in macrophages by adenosine A2A receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter. LPS, TLR, VEGF
24  2007 Wound healing is impaired in MyD88-deficient mice: a role for MyD88 in the regulation of wound healing by adenosine A2A receptors. TLR, VEGF
25  2007 [Adenosine receptor--relation to dopaminergic system]. BP, D2R, PD
26  2008 Adenosine A2A and beta-adrenergic calcium transient and contractile responses in rat ventricular myocytes. A1R, beta1R, CGS, CTR, ISO, MSS, TTL, TTR, Vmax
27  2008 Adenosine A2A receptor signaling regulation of cardiac NADPH oxidase activity. ROS
28  2008 Involvement of A2A receptors in anxiolytic, locomotor and motivational properties of ethanol in mice. CPP, CTA
29  2008 Myocardial blood flow and adenosine A2A receptor density in endurance athletes and untrained men. ET, LV, MBF, UT
30  2009 Preactivation of NKT cells with alpha-GalCer protects against hepatic ischemia-reperfusion injury in mouse by a mechanism involving IL-13 and adenosine A2A receptor. alpha-GalCer, IR, NKT
31  2010 Activation of adenosine A2A receptor attenuates inflammatory response in a rat model of small-for-size liver transplantation. ICAM-1, MIP-2, NF-kappaB, TNF-alpha
32  2010 Adenosine A2A receptor expression in peripheral blood mononuclear cells of patients with mild cognitive impairment. AD, aMCI, mcd-MCI, MCI
33  2010 Ecto-5'-nucleotidase (CD73) attenuates allograft airway rejection through adenosine 2A receptor stimulation. BO, LB, WT
34  2010 Genetic deletion of the adenosine A2A receptor confers postnatal development of relative myopia in mice. EIR, KO, OCT, WT
35  2010 Immunomodulatory properties of pentoxifylline are mediated via adenosine-dependent pathways. PMN, PTX
36  2012 Activation of the adenosine A2A receptor attenuates experimental autoimmune myasthenia gravis severity. AChR, EAMG
37  2012 Adenosine A2A receptor upregulation in human PMNs is controlled by miRNA-214, miRNA-15, and miRNA-16. miRNAs, PMNs
38  2012 Pharmacological blockade of adenosine A2A receptors diminishes scarring. ---
39  2012 The immunosuppressive role of adenosine A2A receptors in ischemia reperfusion injury and islet transplantation. IRI, T1DM
40  2013 A feedback loop in PPARgamma-adenosine A2A receptor signaling inhibits inflammation and attenuates lung damages in a mouse model of LPS-induced acute lung injury. ALI, CRE, PKA, PPARgamma
41  2013 A2A adenosine receptor function in patients with vasovagal syncope. VVS
42  2013 Adenosine A(2A) receptors regulate the activity of sleep regulatory GABAergic neurons in the preoptic hypothalamus. Fos-IR, MnPN, SS-rBF, VLPO
43  2013 Adenosine A2A receptor (A2AR) is a fine-tune regulator of the collagen1:collagen3 balance. Col1, Col3, NHDF
44  2013 Adenosine A2A receptor deficiency alleviates blast-induced cognitive dysfunction. bTBI, KO, TBI
45  2013 Adenosine A2A receptor: a target for regulating renal interstitial fibrosis in obstructive nephropathy. EMT, RIF, UUO
46  2013 Adenosine A2A receptors in secondary progressive multiple sclerosis: a [(11)C]TMSX brain PET study. EDSS, FA, GM, MRI, MS, NAWM, PET, SPMS
47  2013 Adenosine A₂A receptors in striatal glutamatergic terminals and GABAergic neurons oppositely modulate psychostimulant action and DARPP-32 phosphorylation. KO
48  2013 Adenosine signaling in striatal circuits and alcohol use disorders. A1R, DMS
49  2013 Adenosine transporter ENT1 regulates the acquisition of goal-directed behavior and ethanol drinking through A2A receptor in the dorsomedial striatum. DMS
50  2013 Caffeine and adenosine A(2A) receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease. MJD
51  2013 Caffeine consumption prevents memory impairment, neuronal damage, and adenosine A2A receptors upregulation in the hippocampus of a rat model of sporadic dementia. AD, i.c.v, STZ
52  2013 Caffeine regulates frontocorticostriatal dopamine transporter density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorder. ADHD, DAT
53  2013 Design and synthesis of (4E)-4-(4-substitutedbenzylideneamino)-3-substituted-2,3-dihydro-2-thioxothiazole-5-carbonitrile as novel A2A receptor antagonists. ---
54  2013 Extracellular adenosine regulates naive T cell development and peripheral maintenance. PI3K
55  2013 Guanosine controls inflammatory pathways to afford neuroprotection of hippocampal slices under oxygen and glucose deprivation conditions. GUO, OGD
56  2013 Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington's disease. HD
57  2013 MALDI/post ionization-ion mobility mass spectrometry of noncovalent complexes of dopamine receptors' epitopes. IM, NCX
58  2013 Microinjection of adenosine into the hypothalamic ventrolateral preoptic area enhances wakefulness via the A1 receptor in rats. A1R, AD, NREM, REM, VLPO
59  2013 Plasma glutamate-modulated interaction of A2AR and mGluR5 on BMDCs aggravates traumatic brain injury-induced acute lung injury. ALI, BMDC, mGluR5, TBI
60  2013 Search for adenosine A2A spare receptors on peripheral human lymphocytes. ---
61  2013 Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A2A receptor agonist regadenoson. IFN-gamma, iNKT, pVOC, SCD
62  2013 SKCa Channels Blockage Increases the Expression of Adenosine A2A Receptor in Jurkat Human T Cells. ---
63  2013 The adenosine A2A receptor agonist CGS 21680 decreases ethanol self-administration in both non-dependent and dependent animals. ---
64  2013 The effects of adenosine A2A receptor knockout on renal interstitial fibrosis in a mouse model of unilateral ureteral obstruction. KO, RIF, UUO, WT
65  2014 Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3. Col1, Col3
66  2014 Adenosinergic regulation of striatal clock gene expression and ethanol intake during constant light. AUD, ENT1, ENT1, WT
67  2014 Binding kinetics of ZM241385 derivatives at the human adenosine A2A receptor. SAR, SKR
68  2014 Caffeine inhibits the activation of hepatic stellate cells induced by acetaldehyde via adenosine A2A receptor mediated by the cAMP/PKA/SRC/ERK1/2/P38 MAPK signal pathway. HSC
69  2014 Continuous adenosine A2A receptor antagonism after focal cerebral ischemia in spontaneously hypertensive rats. CSC
70  2014 Different adenosine A2A receptor expression in peripheral cells from elderly patients with vascular dementia and Alzheimer's disease. AD, VaD
71  2014 Dynamic behavior of the active and inactive states of the adenosine A(2A) receptor. GPCRs
72  2014 Histamine H3 receptor activation counteracts adenosine A2A receptor-mediated enhancement of depolarization-evoked [3H]-GABA release from rat globus pallidus synaptosomes. GP, H3Rs
73  2014 Impact of invivo chronic blockade of adenosine A2A receptors on the BDNF-mediated facilitation of LTP. AD, BDNF, LTP
74  2014 Increased striatal adenosine A2A receptor levels is an early event in Parkinson's disease-related pathology and it is potentially regulated by miR-34b. PD
75  2014 Intracellular calcium levels determine differential modulation of allosteric interactions within G protein-coupled receptor heteromers. D2R
76  2014 Maternal separation is associated with DNA methylation and behavioural changes in adult rats. DNMTs, MS, NAc, PP1C
77  2014 Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment. DC, MDSC, NK
78  2014 N-acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertension through the modulation of adenosine AA2R activity. EC, eNOS, MCT, PAH, PLB, RV
79  2014 NF-kappaB enhances hypoxia-driven T-cell immunosuppression via upregulation of adenosine A(2A) receptors. ADA, HIF-1alpha, NF-kappaB, PKA
80  2014 Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety. FST, OFT, SPT, WT
81  2014 Photomodulation of G protein-coupled adenosine receptors by a novel light-switchable ligand. A3R
82  2014 Rapid Computational Prediction of Thermostabilizing Mutations for G Protein-Coupled Receptors. beta1AR, GPCRs, NTSR1
83  2014 Role of microglia adenosine A(2A) receptors in retinal and brain neurodegenerative diseases. ---
84  2014 Roles of the adenosine receptor and CD73 in the regulatory effect of gammadelta T cells. ---
85  2014 Striatal adenosine A2A receptor expression is controlled by S-adenosyl-L-methionine-mediated methylation. mRNA, SAM
86  2014 Test-retest variability of adenosine A2A binding in the human brain with (11)C-TMSX and PET. BPND
87  2014 The role of adenosine signaling in sickle cell therapeutics. A2BR, SCD
88  2014 Uncovering caffeine's adenosine A2A receptor inverse agonism in experimental parkinsonism. PD
89  2015 Absence of the Adenosine A2A Receptor Confers Pulmonary Arterial Hypertension Through RhoA/ROCK Signaling Pathway in Mice. KO, PAH
90  2015 Adenosine A2A Receptors Mediate Anti-Inflammatory Effects of Electroacupuncture on Synovitis in Mice with Collagen-Induced Arthritis. CIA, EA, TNF-alpha
91  2015 Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure. EHP, ELISA, IL-1beta, IOP, LPS, qPCR, RGCs, TNF
92  2015 Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer. D2R
93  2015 Analysis of various types of single-polypeptide-chain (sc) heterodimeric A₂AR/D₂R complexes and their allosteric receptor-receptor interactions. D2R, GPCR, sc, TM
94  2015 Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. PDE4
95  2015 ATP as a multi-target danger signal in the brain. P2R
96  2015 Automated reference region extraction and population-based input function for brain [(11)C]TMSX PET image analyses. CNS, PBIF, PET
97  2015 Brain-derived neurotrophic factor mediates neuroprotection against Abeta-induced toxicity through a mechanism independent on adenosine 2A receptor activation. BDNF
98  2015 Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress. CUS
99  2015 Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain. DA
100  2015 Deletion of adenosine A2A receptors from astrocytes disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to schizophrenia. AMPAR, GLT-I, KO, NMDAR
101  2015 Direct or indirect stimulation of adenosine A2A receptors enhances bone regeneration as well as bone morphogenetic protein-2. BMP-2
102  2015 Dual target strategy: combining distinct non-dopaminergic treatments reduces neuronal cell loss and synergistically modulates L-DOPA-induced rotational behavior in a rodent model of Parkinson's disease. mGluR5, MPEP, PD
103  2015 Effect of hyperoxic and hyperbaric conditions on the adenosinergic pathway and CD26 expression in rat. ADA
104  2015 Effect of SCH442416 on glutamate uptake in retinal Muller cells at increased hydrostatic pressure. GLAST, GS
105  2015 Effects of a Proprietary Standardized Orthosiphon stamineus Ethanolic Leaf Extract on Enhancing Memory in Sprague Dawley Rats Possibly via Blockade of Adenosine A 2A Receptors. A1R, RI
106  2015 Ex Vivo Perfusion With Adenosine A2A Receptor Agonist Enhances Rehabilitation of Murine Donor Lungs After Circulatory Death. DCD, EVLP
107  2015 G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent. GPCRs, SMA, SMALP
108  2015 Graft versus host disease: New insights into A2A receptor agonist therapy. CGD, GVHD, SCID
109  2015 Human adenosine A2A receptor binds calmodulin with high affinity in a calcium-dependent manner. ---
110  2015 Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease. D1R, PKA
111  2015 Is there a role for ADORA2A polymorphisms in levodopa-induced dyskinesia in Parkinson's disease patients? PD
112  2015 Novel approaches for targeting the adenosine A2A receptor. FBDD, VS
113  2015 Synaptic mechanisms of adenosine A2A receptor-mediated hyperexcitability in the hippocampus. ---
114  2015 The mutual regulation between miR-214 and A2AR signaling plays an important role in inflammatory response. ---
115  2015 The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system. GPR37
116  2015 Untangling dopamine-adenosine receptor-receptor assembly in experimental parkinsonism in rats. D2R, PD
117  2016 A critical role of striatal A2A R-mGlu5 R interactions in modulating the psychomotor and drug-seeking effects of methamphetamine. KO
118  2016 A2A adenosine receptor deletion is protective in a mouse model of Tauopathy. AD
119  2016 Aberrant adenosine A2A receptor signaling contributes to neurodegeneration and cognitive impairments in a mouse model of synucleinopathy. alpha-Syn
120  2016 Activation of the A2A adenosine G-protein-coupled receptor by conformational selection. ---
121  2016 Activation of the adenosine A2A receptor attenuates experimental autoimmune encephalomyelitis and is associated with increased intracellular calcium levels. EAE, MS
122  2016 Activation of the adenosine A2A receptor exacerbates experimental autoimmune neuritis in Lewis rats in association with enhanced humoral immunity. ---
123  2016 Adenosine A2A receptor plays an important role in radiation-induced dermal injury. A2ARKO, WT
124  2016 Adenosine A2A receptor signaling attenuates LPS-induced pro-inflammatory cytokine formation of mouse macrophages by inducing the expression of DUSP1. DUSP, LPS
125  2016 Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity. A1R, ADK
126  2016 Adenosine receptors as markers of brain iron deficiency: Implications for Restless Legs Syndrome. A1R, ID, PLMS, RLS
127  2016 Allosteric mechanisms within the adenosine A2A-dopamine D2 receptor heterotetramer. D2R, GPCR
128  2016 An Fc-Small Molecule Conjugate for Targeted Inhibition of the Adenosine 2A Receptor. ZM
129  2016 Axonal elongation and dendritic branching is enhanced by adenosine A2A receptors activation in cerebral cortical neurons. BDNF
130  2016 Caffeine alters glutamate-aspartate transporter function and expression in rat retina. A1R, CNS, EAAs, EAATs, PN3
131  2016 Dissecting striatal adenosine-cannabinoid receptor interactions. New clues from rats over-expressing adenosine A2A receptors. CB1R
132  2016 Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors. AD, LTP
133  2016 Equilibrative nucleoside transporter ENT1 as a biomarker of Huntington disease. HD
134  2016 Evidence for the heterotetrameric structure of the adenosine A2A-dopamine D2 receptor complex. D1R, D2R, D3R, GPCRs
135  2016 Functional role of striatal A2A, D2, and mGlu5 receptor interactions in regulating striatopallidal GABA neuronal transmission. CHPG, D2R, mGluR5
136  2016 Getting personal: Endogenous adenosine receptor signaling in lymphoblastoid cell lines. GPCRs, LCLs, NTR
137  2016 Guanosine may increase absence epileptic activity by means of A2A adenosine receptors in Wistar Albino Glaxo Rijswijk rats. ADO, Guo, i.p, LPS, QA, SWDs
138  2016 High homocysteine levels prevent via H2 S the CoCl2 -induced alteration of lymphocyte viability. Hcy
139  2016 Hippocampal GABAergic transmission: a new target for adenosine control of excitability. GABA
140  2016 How does adenosine control neuronal dysfunction and neurodegeneration? ---
141  2016 Impact of purification conditions and history on A2A adenosine receptor activity: The role of CHAPS and lipids. CHAPS, CHS, DDM, GPCR
142  2016 Molecular Basis of Ligand Dissociation from the Adenosine A2A Receptor. GPCR
143  2016 NOX2 Activation of Natural Killer T Cells Is Blocked by the Adenosine A2A Receptor to Inhibit Lung Ischemia-Reperfusion Injury. iNKT, IR, NOX2, WT
144  2016 Predicting Binding Affinities for GPCR Ligands Using Free-Energy Perturbation. FEP, GPCRs
145  2016 Prevention of adenosine A2A receptor activation diminishes beat-to-beat alternation in human atrial myocytes. AF
146  2016 Protein phosphatase role in adenosine A1 receptor-induced AMPA receptor trafficking and rat hippocampal neuronal damage in hypoxia/reperfusion injury. A1R, AMPAR, APSD, PP1
147  2016 Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure-induced transient ischemic injury. EHP, IOP, RGCs
148  2016 Spare Adenosine A2a Receptors Are Associated With Positive Exercise Stress Test In Coronary Artery Disease. CAD, EST
149  2016 The adenosine metabolite inosine is a functional agonist of the adenosine A2A receptor with a unique signaling bias. ARs
150  2016 The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function. AD, HPA
151  2016 The Effect of A2A Receptor Antagonist on Microglial Activation in Experimental Glaucoma. COH, RGC, SD
152  2016 Therapeutic Opportunities for Caffeine and A2A Receptor Antagonists in Retinal Diseases. ---
153  2017 A2AR Binding Kinetics in the Ligand Depletion Regime. ---
154  2017 Active state structures of G protein-coupled receptors highlight the similarities and differences in the G protein and arrestin coupling interfaces. GPCRs, muOR
155  2017 Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration. A1R
156  2017 Adenosine A2A receptor and ERK-driven impulsivity potentiates hippocampal neuroblast proliferation. 5-CSRTT, dHip, DRL
157  2017 Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2 in mice. KO, PGD2, WT
158  2017 Adenosine A2A Receptor Gene Knockout Prevents l-3,4-Dihydroxyphenylalanine-Induced Dyskinesia by Downregulation of Striatal GAD67 in 6-OHDA-Lesioned Parkinson's Mice. AIMs, GAD, KO, l-DOPA, LID, PD
159  2017 Adenosine A2A receptor mediates hypnotic effects of ethanol in mice. NREM
160  2017 Adenosine A2A receptor signaling affects IL-21/IL-22 cytokines and GATA3/T-bet transcription factor expression in CD4+ T cells from a BTBR T+ Itpr3tf/J mouse model of autism. GATA3, T-bet
161  2017 Adenosine A2A receptors are up-regulated and control the activation of human alveolar macrophages. ---
162  2017 Adenosine A2A receptors in the olfactory bulb suppress rapid eye movement sleep in rodents. OB, REM
163  2017 Adenosine A2A Receptors Modulate alpha-Synuclein Aggregation and Toxicity. A2AR KO, aSyn, PD
164  2017 Age-related decline of the acute local inflammation response: a mitigating role for the adenosine A2A receptor. WT
165  2017 Angiotensin II type 1/adenosine A 2A receptor oligomers: a novel target for tardive dyskinesia. AT1R, D2Rs, TD, VCM
166  2017 Baicalin attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A2A receptor-induced SDF-1/CXCR4/PI3K/AKT signaling. CXCR4, HPH, mCAP, PAH, PI3K, PKB, RVSP, SDF-1, WT
167  2017 Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma. HNSCC
168  2017 Caffeine preferentially protects against oxygen-induced retinopathy. OIR, ROP
169  2017 Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses. ---
170  2017 Calcium modulates calmodulin/alpha-actinin 1 interaction with and agonist-dependent internalization of the adenosine A2A receptor. ---
171  2017 Chronic oral administration of MPEP, an antagonist of mGlu5 receptor, during gestation and lactation alters mGlu5 and A2A receptors in maternal and neonatal brain. mGlu receptors, mGlu5, MPEP, PLC
172  2017 Crystal structure of the adenosine A2A receptor bound to an antagonist reveals a potential allosteric pocket. BRIL, Cmpd-1, ICL3, LCP, NR2B
173  2017 Dopamine-Induced Changes in Galphaolf Protein Levels in Striatonigral and Striatopallidal Medium Spiny Neurons Underlie the Genesis of l-DOPA-Induced Dyskinesia in Parkinsonian Mice. IHC, l-DOPA, LID, MSNs, PD, PLA
174  2017 Expression and Purification of Mini G Proteins from Escherichia coli. GPCRs
175  2017 Expression, Purification and Crystallisation of the Adenosine A2A Receptor Bound to an Engineered Mini G Protein. GPCRs
176  2017 Expressions of adenosine A2A receptors in coronary arteries and peripheral blood mononuclear cells are correlated in coronary artery disease patients. CAD, PBMC
177  2017 Human Adenosine A2A Receptor: Molecular Mechanism of Ligand Binding and Activation. ARs, GPCRs
178  2017 In Situ Reconstitution of the Adenosine A2A Receptor in Spontaneously Formed Synthetic Liposomes. ---
179  2017 Membrane cholesterol access into a G-protein-coupled receptor. GPCRs
180  2017 Perivascular AQP4 dysregulation in the hippocampal CA1 area after traumatic brain injury is alleviated by adenosine A2A receptor inactivation. p-tau, TBI
181  2017 Randomized phase 2 trial of regadenoson for treatment of acute vaso-occlusive crises in sickle cell disease. iNKT, SCD, VO
182  2017 Strategy for the Thermostabilization of an Agonist-Bound GPCR Coupled to a G Protein. GPCRs
183  2017 Striatal Galphaolf/cAMP Signal-Dependent Mechanism to Generate Levodopa-Induced Dyskinesia in Parkinson's Disease. cAMP, DA, LID, MSNs, PD
184  2017 Synthesis and Characterization of a New Bivalent Ligand Combining Caffeine and Docosahexaenoic Acid. DHA, PD
185  2017 Synthesis and Evaluation of Phenylxanthine Derivatives as Potential Dual A2AR Antagonists/MAO-B Inhibitors for Parkinson's Disease. PX
186  2017 The Parkinson's disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo. GPR37, PD
187  2017 Toll-like receptors, NF-kappaB, and IL-27 mediate adenosine A2A receptor signaling in BTBR T+ Itpr3tf/J mice. TLRs
188  2017 Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage. IR
189  2017 [Minocycline Prevent Microglial Activation via Suppression of Adenosine A 2A Receptor in a Rat Stroke Ischemia/Reperfusion Model]. I/R
190  2018 A defect in KCa3.1 channel activity limits the ability of CD8+ T cells from cancer patients to infiltrate an adenosine-rich microenvironment. HD, HNSCC
191  2018 A2A Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21. BAT, FGF21, IBAT, WT
192  2018 A2AR Antagonism with CPI-444 Induces Antitumor Responses and Augments Efficacy to Anti-PD-(L)1 and Anti-CTLA-4 in Preclinical Models. ---
193  2018 Adenosine A2A receptor (A2AR) stimulation modulates expression of semaphorins 4D and 3A, regulators of bone homeostasis. RANKL/OPG, Sema
194  2018 Adenosine A2A receptor antagonists act at the hyperoxic phase to confer protection against retinopathy. OIR, ROP
195  2018 Adenosine A2A receptor inhibition restores the normal transport of endothelial glutamate transporters in the brain. EAATs, NKAs, OGD, TBI
196  2018 Adenosine A2A receptors are required for glutamate mGluR5- and dopamine D1 receptor-evoked ERK1/2 phosphorylation in rat hippocampus: involvement of NMDA receptor. NMDAR, TBS
197  2018 Adenosine A2A Receptors Control Glutamatergic Synaptic Plasticity in Fast Spiking Interneurons of the Prefrontal Cortex. FS, LTP, mPFC, PFC
198  2018 Adenosine A2A receptors modulate the dopamine D2 receptor-mediated inhibition of synaptic transmission in the mouse prefrontal cortex. PFC
199  2018 Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors. AD
200  2018 Amyotrophic Lateral Sclerosis (ALS) and Adenosine Receptors. ALS
201  2018 Antipsychotic-Like Efficacy of Dopamine D2 Receptor-Biased Ligands is Dependent on Adenosine A2A Receptor Expression. AMPH, BiLC, BRET, D2R
202  2018 Behavioral control by striatal adenosine A2A -dopamine D2 receptor heteromers. GPCR, PPI
203  2018 Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease. AD
204  2018 Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease. AD
205  2018 Blockade of microglial adenosine A2A receptor impacts inflammatory mechanisms, reduces ARPE-19 cell dysfunction and prevents photoreceptor loss in vitro. AMD, RPE
206  2018 Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy. AMPK, NHEKs, RNAi, ROS, SIRT3, UV
207  2018 Critical roles of adenosine A2A receptor in regulating the balance of Treg/Th17 cells in allergic asthma. ELISA, OVA, PBMCs, qPCR
208  2018 Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein. GPCR
209  2018 Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go. 5-HT1BR, beta2-AR, GPCRs
210  2018 Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats. AUD, D2R, NAc, sigma1R
211  2018 Enhancement of inosine-mediated A2AR signaling through positive allosteric modulation. PAM
212  2018 Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine A2A-Dopamine D2 Receptor Heterotetramers and Adenylyl Cyclase. AC5, D2R
213  2018 Gastrodia elata alleviates mutant huntingtin aggregation through mitochondrial function and biogenesis mediation. CREB, GE, HD, mHtt, PGC-1alpha
214  2018 Hypoxia-induced miR-214 expression promotes tumour cell proliferation and migration by enhancing the Warburg effect in gastric carcinoma cells. PRDM16
215  2018 Impaired autophagic flux is associated with the severity of trauma and the role of A2AR in brain cells after traumatic brain injury. AAV, ATG12, ATG5, CQ, KO, SQSTM1, TBI
216  2018 Induction of antiinflammatory purinergic signaling in activated human iNKT cells. iNKT, SCD
217  2018 Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions. LTP
218  2018 Occupancy of adenosine A2A receptors by istradefylline in patients with Parkinson's disease using 11C-preladenant PET. BPND, PD
219  2018 PBF509, an Adenosine A2A Receptor Antagonist With Efficacy in Rodent Models of Movement Disorders. L-DOPA, LID, PD
220  2018 Pediatric tolerogenic DCs expressing CD4 and immunoglobulin-like transcript receptor (ILT)-4 secrete IL-10 in response to Fc and adenosine. IL, ILT, NECA, tmDCs
221  2018 PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling. beta1AR, GPCRs
222  2018 Remote control of movement disorders using a photoactive adenosine A2A receptor antagonist. l-DOPA, PD
223  2018 Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum. CB1R
224  2018 Specific Pharmacological Profile of A2A Adenosine Receptor Predicts Reduced Fractional Flow Reserve in Patients With Suspected Coronary Artery Disease. CAD, cAMP, FFR, group 1, PBMC
225  2018 Synergistic interaction between a PDE5 inhibitor (sildenafil) and a new adenosine A2A receptor agonist (LASSBio-1359) improves pulmonary hypertension in rats. MCT, PAs, PDE5i, PH, RV
226  2018 Targeting adenosine A2A receptor antagonism for treatment of cancer. ---
227  2018 The adenosine A2A receptor agonist T1-11 ameliorates neurovisceral symptoms and extends the lifespan of a mouse model of Niemann-Pick type C disease. NOR
228  2018 The Corticostriatal Adenosine A2A Receptor Controls Maintenance and Retrieval of SpatialWorking Memory. DNMTP, WM
229  2018 The Role of Adenosine Tone and Adenosine Receptors in Huntington's Disease. HD
230  2019 Adenosine A2A receptor (A2AR) activation triggers Akt signaling and enhances nuclear localization of beta-catenin in osteoblasts. A2AKO, A2ARs
231  2019 Adenosine A2A Receptor Mediates Inhibition of Synovitis and Osteoclastogenesis after Electroacupuncture in Rats with Collagen-Induced Arthritis. CIA, EA, NF-kappaB, PKA, RANKL, TNF-alpha, TRAP
232  2019 Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells. N1ICD, TCR
233  2019 Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Hippocampus: Cannabidiol Blunts Delta9-Tetrahydrocannabinol-Induced Cognitive Impairment. CB1R, CBD, Delta9-THC
234  2019 Adenosine from a biologic source regulates neutrophil extracellular traps (NETs). ADO, HNE, MSCs, NETs
235  2019 Balance between dopamine and adenosine signals regulates the PKA/Rap1 pathway in striatal medium spiny neurons. D1R, D2R, MSNs, PKA
236  2019 Blockade of microglial adenosine A2A receptor suppresses elevated pressure-induced inflammation, oxidative stress, and cell death in retinal cells. ---
237  2019 Caffeine programs hepatic SIRT1-related cholesterol synthesis and hypercholesterolemia via A2AR/cAMP/PKA pathway in adult male offspring rats. cAMP, GD, PCE, PKA, PW, TCH
238  2019 CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110beta and predicts poor prognosis. EMT, HCC, NOG
239  2019 CD73-derived adenosine controls inflammation and neurodegeneration by modulating dopamine signalling. MPTP
240  2019 Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37-deficient mice. ---
241  2019 Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function. PAM, SWS
242  2019 Ethanol enhances endothelial ionic currents and nitric oxide release via intermediate-conductance calcium-activated potassium channel. HCAECs, KCa, PKA
243  2019 Extracellular adenosine and slow-wave sleep are increased after ablation of nucleus accumbens core astrocytes and neurons in mice. DT, GFAP, NAc, SWS
244  2019 Membrane cholesterol depletion reduces downstream signaling activity of the adenosine A2A receptor. beta2AR, CCM, GPCRs, MbetaCD
245  2019 Pharmacological profile of adenosine A2A receptors in patients with lower extremity peripheral artery disease and associated coronary artery disease: A pilot study. CAD, LE-PAD, PBMCs
246  2019 Reduction in Blood Glutamate Levels Combined With the Genetic Inactivation of A2AR Significantly Alleviate Traumatic Brain Injury-Induced Acute Lung Injury. TBI, TBI-ALI
247  2019 Region-specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats. mPFC
248  2019 Regulation of human brown adipose tissue by adenosine and A2A receptors - studies with [15O]H2O and [11C]TMSX PET/CT. BAT, WAT
249  2019 Spironolactone inhibits endothelial-mesenchymal transition via the adenosine A2A receptor to reduce cardiorenal fibrosis in rats. EndMT, HUVECs, ISO
250  2019 The lipid phase preference of the adenosine A2A receptor depends on its ligand binding state. GUPs
251  2019 The role of microRNA-16 in the pathogenesis of autoimmune diseases: A comprehensive review. ACVR, GDF5, miRNAs