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Abbreviation : AR
Long Form : amphiregulin
No. Year Title Co-occurring Abbreviation
1988 Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7. ---
1990 The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. EGF, TGF-alpha
1991 A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin. ELISA, KAF
1991 Differential expression of epidermal growth factor-related proteins in human colorectal tumors. EGF, EGFR, HER3, kb, TGF-alpha
1991 Response to and expression of amphiregulin by ovarian carcinoma and normal ovarian surface epithelial cells: nuclear localization of endogenous amphiregulin. OSEs
1992 Amphiregulin messenger RNA is elevated in psoriatic epidermis and gastrointestinal carcinomas. ---
1992 Autocrine action of amphiregulin in a colon carcinoma cell line and immunocytochemical localization of amphiregulin in human colon. ---
1992 Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family. CRDGF, EGF, EGFR, HPLC, TGF-alpha
1992 Differential immunohistochemical detection of amphiregulin and cripto in human normal colon and colorectal tumors. ---
10  1992 Heparin inhibition of autonomous growth implicates amphiregulin as an autocrine growth factor for normal human mammary epithelial cells. HMECs, TGF-alpha
11  1992 Inhibition of autonomous human keratinocyte proliferation and amphiregulin mitogenic activity by sulfated polysaccharides. k-d AR, KAF
12  1992 Regulation of amphiregulin mRNA by TGF-beta in the human lung adenocarcinoma cell line A549. ---
13  1992 The interaction of amphiregulin with nuclei and putative nuclear localization sequence binding proteins. EGF, NLS
14  1993 Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor and p185erbB2. Evidence that amphiregulin acts exclusively through the epidermal growth factor receptor at the surface of human epithelial cells. EGF, EGFR, mAb
15  1993 Characterization of high and low molecular weight forms of amphiregulin that differ in glycosylation and peptide core length. Evidence that the NH2-terminal region is not critical for bioactivity. EGF, LMW-AR
16  1993 Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung. EGF, EGFR, NSCLC, TGF-alpha
17  1993 Expression of amphiregulin, a novel gene of the epidermal growth factor family, in human gastric carcinomas. ---
18  1993 Expression of amphiregulin, cripto-1, and heregulin-alpha in human breast-cancer cells. CR-1, EGF, HRGalpha, ICC, RT-PCR
19  1993 Expression of the genes for the epidermal growth factor receptor and its ligands in porcine corpora lutea. HB-EGF, RT-PCR, TGF alpha
20  1994 Amphiregulin as an autocrine growth factor for c-Ha-ras- and c-erbB-2-transformed human mammary epithelial cells. ADG, EGF
21  1994 Auto- and cross-induction within the mammalian epidermal growth factor-related peptide family. BTC, EGF, EGFR, HB-EGF, TGF-alpha
22  1994 Epidermal growth factor-related peptides in the pathogenesis of human breast cancer. CR-1, EGF, HRG, TGF alpha
23  1994 Expression of the genes for the epidermal growth factor receptor and its ligands in porcine oviduct and endometrium. EGF, HB-EGF, RT-PCR, TGF alpha
24  1994 Expression of transforming growth factor alpha, amphiregulin and cripto-1 in human breast carcinomas. CR-1, EGF, ICC, ILCs, TGF-alpha
25  1994 Frequent immunohistochemical detection of EGF supergene family members in ovarian carcinogenesis. EGF, EGFR, TGF-alpha
26  1994 Heparan sulfate is essential to amphiregulin-induced mitogenic signaling by the epidermal growth factor receptor. EGF
27  1994 Immunohistochemical detection of cripto-1, amphiregulin and transforming growth-factor-alpha in human gastric carcinomas and intestinal metaplasias. CR-1, TGF alpha
28  1994 Immunolocalization of criptoregulin and amphiregulin in rectal-cancer - correlation with prognosis. ---
29  1994 Induction and expression of amphiregulin in human pancreatic cancer. ---
30  1994 The heparin-binding domain of amphiregulin necessitates the precursor pro-region for growth factor secretion. EGF, HB-EGF, TGF-alpha
31  1995 Amphiregulin and cripto overexpression in breast-cancer - relationship with prognosis and clinical and molecular-variables. ---
32  1995 Amphiregulin anti-sense oligodeoxynucleotides inhibit growth and transformation of a human colon carcinoma cell line. ADG, AIG, EGF, TGF alpha
33  1995 Amphiregulin is a potent mitogen in human pancreatic-cancer cells - correlation with patient survival. EGF
34  1995 Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus. ---
35  1995 Association of epidermal growth factor-related peptides and type I receptor tyrosine kinase receptors with prognosis of human colorectal carcinomas. CR-1, EGFR, TGF alpha
36  1995 Carboxyl-terminal truncation of leucine76 converts heparin-binding EGF-like growth factor from a heparin-enhancible to a heparin-suppressible growth factor. HB-EGF
37  1995 Detection and location of amphiregulin and Cripto-1 expression in the developing postnatal mouse mammary gland. CR-1, EGF, ICC, RT-PCR, TEB, TGF alpha
38  1995 Differential effects of a heparin antagonist (hexadimethrine) or chlorate on amphiregulin, basic fibroblast growth factor, and heparin-binding EGF-like growth factor activity. bFGF, HB-EGF
39  1995 Estrogen and phorbol esters regulate amphiregulin expression by two separate mechanisms in human breast cancer cell lines. mRNA, PKC, TPA
40  1995 Expression of amphiregulin in human gastric cancer cell lines. EGF, TGF-alpha
41  1995 Expression of messenger RNA for amphiregulin, heregulin, and cripto-1, three new members of the epidermal growth factor family, in human breast carcinomas. CR-1, HRG
42  1995 Frequent expression of genes for receptor tyrosine kinases and their ligands in human pancreatic cancer cells. mAb, RTKs, TGF-alpha
43  1995 Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1. EGF, IGF, TGF-alpha
44  1995 Localization of amphiregulin in the human placenta and decidua throughout gestation: role in trophoblast growth. EGF
45  1995 Modulation of the receptor binding affinity of amphiregulin by modification of its carboxyl terminal tail. EGF
46  1995 The role of amphiregulin in breast cancer. EGF
47  1996 Amphiregulin in lung branching morphogenesis: interaction with heparan sulfate proteoglycan modulates cell proliferation. ECM, HSPG
48  1996 Autocrine growth loop of the epidermal growth factor receptor in normal and immortalized human bronchial epithelial cells. EGF, EGFR, HBE, mAb, TGF-alpha
49  1996 Characterization of a novel amphiregulin-related molecule in 12-O-tetradecanoylphorbol-13-acetate-treated breast cancer cells. PKC, TPA
50  1996 Co-expression of heparin-binding EGF-like growth factor and related peptides in human gastric carcinoma. BTC, EGF, EGF-R, TGF-alpha
51  1996 COOH-terminal extended recombinant amphiregulin with bioactivity comparable with naturally derived growth factor. EGF
52  1996 Detection of amphiregulin and Cripto-1 in mammary tumors from transgenic mice. CR-1
53  1996 Differential immunohistochemical detection of transforming growth factor alpha, amphiregulin and CRIPTO in human normal and malignant breast tissues. DCIS, ER, IBC, PgR, TGF alpha
54  1996 Expression of epidermal growth factor family proteins and epidermal growth factor receptor in human endometrium. CR, EGF, EGFR, TGF-alpha
55  1996 Growth inhibition of human colon carcinoma cells by combinations of anti-epidermal growth factor-related growth factor antisense oligonucleotides. AIG, CR, TGF-alpha
56  1996 Induction of anchorage-independent growth by amphiregulin. AIG, EGFR
57  1996 Induction of ductal morphogenesis and lobular hyperplasia by amphiregulin in the mouse mammary gland. ---
58  1996 Oxidative stress increases gene expression of heparin-binding EGF-like growth factor and amphiregulin in cultured rat gastric epithelial cells. HB-EGF
59  1996 STAT activation by epidermal growth factor (EGF) and amphiregulin. Requirement for the EGF receptor kinase but not for tyrosine phosphorylation sites or JAK1. EGF, WT
60  1996 The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4. EGF, HB-EGF, TGF-alpha
61  1996 Transforming growth factor-alpha and other growth factors stimulate cell division in olfactory epithelium in vitro. EGF, OE, TGF-alpha
62  1997 A raf-independent epidermal growth factor receptor autocrine loop is necessary for Ras transformation of rat intestinal epithelial cells. EGF, HB-EGF, TGF alpha
63  1997 Anti-sense oligonucleotides directed against EGF-related growth factors enhance anti-proliferative effect of conventional anti-tumor drugs in human colon-cancer cells. 5-FU, ADR, CR, MIT, TGF alpha
64  1997 Clinicopathologic analysis of amphiregulin and heregulin immunostaining in breast neoplasia. HRG
65  1997 Differential effects of EGF and amphiregulin on adhesion molecule expression and migration of colon carcinoma cells. EGF, PI
66  1997 Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells. EGF, MMP-9, TGF alpha
67  1997 Expression and function of amphiregulin during murine preimplantation development. S-oligo
68  1997 Expression of epidermal growth factor-related proteins and epidermal growth factor receptor in common epithelial ovarian tumors. EGF, EGFR, LMP, TGF-alpha
69  1997 Expression of epidermal growth factor-related proteins in the aged adult mouse mammary gland and their relationship to tumorigenesis. CR-1, EGF, RT-PCR, TGF alpha
70  1997 Human monocytes express amphiregulin and heregulin growth factors upon activation. EGFR, HB-EGF, HRG, PDBu
71  1997 Immunohistochemical studies on EGF family growth factors in normal and ulcerated human gastric mucosa. EGF, EGFR, PCNA, TGF-alpha
72  1997 Influence of the host microenvironment on the clonal selection of human colon carcinoma cells during primary tumor growth and metastasis. CEA, EGR-R, HCC, TGF-alpha
73  1997 Monoclonal antibodies directed against the EGF receptor show differential bindings of amphiregulin and EGF to the EGF receptor. EGFR, HB-EGF
74  1997 Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype. EGF
75  1998 Altered expression of epidermal growth factor receptor ligands in tumor promoter-treated mouse epidermis and in primary mouse skin tumors induced by an initiation-promotion protocol. BTC, EGFR, HB-EGF, KGF, TGF alpha, TPA
76  1998 Calphostin C induces expression of amphiregulin mRNA via reactive oxygen species in IEC-6 cells. TPA
77  1998 Cell surface ectodomain cleavage of human amphiregulin precursor is sensitive to a metalloprotease inhibitor. Release of a predominant N-glycosylated 43-kDa soluble form. ---
78  1998 Differential dose-dependent effects of epidermal growth factor on gene expression in A431 cells: evidence for a signal transduction pathway that can bypass Raf-1 activation. EGF, MAP, mRNA
79  1998 Epidermal growth factor-related peptides as targets for experimental therapy of human colon carcinoma. AS, CR, EGF, TGF-alpha
80  1998 Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival. EGFR, NSCLC, RH, TGF alpha
81  1998 Helicobacter pylori upregulates expression of epidermal growth factor-related peptides, but inhibits their proliferative effect in MKN 28 gastric mucosal cells. HB-EGF
82  1998 Heparin-binding epidermal growth factor-like growth factor stimulates mitogenic signaling and is highly expressed in human malignant gliomas. EGF, HB-EGF, SDGF
83  1998 Heregulin-dependent autocrine loop regulates growth of K-ras but not erbB-2 transformed rat thyroid epithelial cells. BTC, CR-1, EGF, HRG, TGF alpha
84  1999 A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling. EGF, EGFR, WT
85  1999 Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis. EGF, EGFR, HCA-7, TGF-alpha
86  1999 Antisense expression for amphiregulin suppresses tumorigenicity of a transformed human breast epithelial cell line. EFG, EGFR
87  1999 Biological actions of the epidermal growth factors-like domain peptides of mouse schwannoma-derived growth factor and human amphiregulin. AChE, EGF, SDGF
88  1999 Differential regulation of EGF-like growth factor genes in human keratinocytes. HB-EGF
89  1999 EGF-related peptides are involved in the proliferation and survival of MDA-MB-468 human breast carcinoma cells. ADG, CR, EGF, TGF-alpha
90  1999 Expression of c-erbB receptors and ligands in human bronchial mucosa. BTC, EGF, HB-EGF, mRNA, RT-PCR, TGF-alpha
91  1999 Expression of cripto and amphiregulin in colon mucosa from high risk colon cancer families. CR-I, EGF
92  1999 Growth factors and their receptors in the olfactory system. EGF, FGFs, IGFs, NGF, TGF alpha, TGFs-beta
93  1999 Preneoplastic mammary tumor markers: Cripto and Amphiregulin are overexpressed in hyperplastic stages of tumor progression in transgenic mice. Cr, MMTV-PyMT, Tgm
94  1999 Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. EGFR
95  2000 Activation of epidermal growth factor receptor during corneal epithelial migration. anti-PT, EGF, EGFR, FITC, TGF
96  2000 Dysregulation of EGF family of growth factors and COX-2 in the uterus during the preattachment and attachment reactions of the blastocyst with the luminal epithelium correlates with implantation failure in LIF-deficient mice. COX-2, HB-EGF, LIF, PGs
97  2000 EGF-related antisense oligonucleotides inhibit the proliferation of human ovarian carcinoma cells. CR, EGF, RT-PCR, TGF alpha
98  2000 Expression and regulation of c-ERBB ligands in human head and neck squamous carcinoma cells. BTC, EGF, HB-EGF, HNSCC, HRG, TGF-alpha
99  2000 Involvement of growth factors in the regulation of pubertal mammary growth in cattle. EGF, GH, INS, MDGF-1, PDGF
100  2000 Mechanism of gastric mucosal proliferation induced by gastrin. ECL, HB-EGF
101  2000 Simultaneous blockage of different EGF-like growth factors results in efficient growth inhibition of human colon carcinoma xenografts. CR, EGF, TGF alpha
102  2001 A subclass of HER1 ligands are prognostic markers for survival in bladder cancer patients. betaCL, EGF, EPI, HB-EGF, TGF-alpha
103  2001 Differential regulation of cell proliferation and protease secretion by epidermal growth factor and amphiregulin in tumoral versus normal breast epithelial cells. EGF, PA, uPA
104  2001 Expression of amphiregulin and epidermal growth factor receptor in human breast cancer: analysis of autocriny and stromal-epithelial interactions. EGFR, SBR
105  2001 Regulation of mouse mammary gland development and tumorigenesis by the ERBB signaling network. EGFR, NRG
106  2001 The proamphiregulin cytoplasmic domain is required for basolateral sorting, but is not essential for constitutive or stimulus-induced processing in polarized Madin-Darby canine kidney cells. ---
107  2002 Autocrine ligands for the epidermal growth factor receptor mediate interleukin-8 release from bronchial epithelial cells in response to cigarette smoke. CS, CSE, EGF, EGFR, IL-8, TGF-alpha
108  2002 Transforming growth factor alpha, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas. CR-1, TGF alpha
109  2002 Transgenic overexpression of amphiregulin induces a mitogenic response selectively in pancreatic duct cells. EGF, TGF
110  2003 Amphiregulin overexpression results in rapidly growing keratinocytic tumors: an in vivo xenograft model of keratoacanthoma. BCC, KA, SCC
111  2003 Betacellulin and amphiregulin induce upregulation of cyclin D1 and DNA synthesis activity through differential signaling pathways in vascular smooth muscle cells. BTC, HTASMCs, PI 3'-kinase
112  2003 Effect of exogenous epidermal-like growth factors on mammary gland development and differentiation in the estrogen receptor-alpha knockout (ERKO) mouse. EGF, ERalpha, ERKO, HRG, TGF alpha, WT
113  2003 Inhibition of apoptosis by amphiregulin via an insulin-like growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines. IGF-1R, IGF1, NSCLC
114  2003 Prostaglandin E2 stimulates the growth of colon cancer cells via induction of amphiregulin. ---
115  2003 Regulation of extracellular matrix metalloproteinase inducer and matrix metalloproteinase expression by amphiregulin in transformed human breast epithelial cells. AS, EGFR, EMMPRIN, MMP
116  2003 TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. EGFR, GPCR, TACE
117  2003 TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase. HB-EGF, TGF alpha
118  2003 Transforming growth factor beta-1 and amphiregulin act in synergy to increase the production of urokinase-type plasminogen activator in transformed breast epithelial cells. EGF, TGF-beta1, uPA
119  2004 Autocrine extracellular signal-regulated kinase (ERK) activation in normal human keratinocytes: metalloproteinase-mediated release of amphiregulin triggers signaling from ErbB1 to ERK. EGF, ERK, GF, NHKs
120  2004 Clinical relevance of amphiregulin and VEGF in primary breast cancers. IDC, PgR
121  2004 Fine particulate matter induces amphiregulin secretion by bronchial epithelial cells. EGFR, ERK, GM-CSF, MAP, PM, PM2.5
122  2004 Growth, differentiation and senescence of normal human urothelium in an organ-like culture. CK, HB-EGF, TGF alpha, UP
123  2004 Prostaglandin E2 synergistically enhances receptor tyrosine kinase-dependent signaling system in colon cancer cells. COX, EGFR
124  2004 Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency. BTC, EGF, HB, TGF-alpha
125  2004 Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early-onset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermis is also associated with synovitis. INV-AR, K14-ARGE
126  2004 The epidermal growth factor-like growth factor amphiregulin is strongly induced by the adenosine 3',5'-monophosphate pathway in various cell types. ---
127  2005 Amphiregulin causes functional downregulation of adherens junctions in psoriasis. ---
128  2005 Amphiregulin is a novel growth factor involved in normal bone development and in the cellular response to parathyroid hormone stimulation. EGF, PTH
129  2005 Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells. IGF1, NSCLC
130  2005 Epidermal growth factor family members: endogenous mediators of the ovulatory response. BTC, EGF, ER
131  2005 Expression of the epidermal growth factor system in human endometrium during the menstrual cycle. BCL, EGF, Ep, HB, HER1, TGF alpha
132  2005 Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells. ERK, HAT, PAR-2 AP, PAR2, TACE
133  2005 Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. CA, CRC, DCA, EGFR, PGs
134  2005 Stimulation of amphiregulin expression in osteoblastic cells by parathyroid hormone requires the protein kinase A and cAMP response element-binding protein signaling pathway. CRE, PGE2, PKA, PTH
135  2005 Tobacco smoke stimulates the transcription of amphiregulin in human oral epithelial cells: evidence of a cyclic AMP-responsive element binding protein-dependent mechanism. AhR, cAMP, EGFR
136  2005 Transforming growth factor alpha (TGF-alpha) and other targets of tumor necrosis factor-alpha converting enzyme (TACE) in murine polycystic kidney disease. ARPKD, BUN, BW, EGF, HB-EGF, KW, TACE, TGF-alpha
137  2005 [Amphiregulin antisense RNA expression inhibits angiogenesis of human breast cancer in nude mice]. HMEC
138  2006 Amphiregulin as a tumor promoter for oral squamous cell carcinoma: involvement of cyclooxygenase 2. COX-2, EGF, EGFR-1, SCC
139  2006 Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells. EGFR
140  2006 Autocrine and juxtacrine effects of amphiregulin on the proliferative, invasive, and migratory properties of normal and neoplastic human mammary epithelial cells. EGF, EGFR
141  2006 Bidirectional cross talk between ERalpha and EGFR signalling pathways regulates tamoxifen-resistant growth. ChIP, EGFR, ERalpha, MAPK, Tam-R, WT-MCF-7
142  2006 Concomitant cell growth and differentiation are dependent on erbB1 and integrin activation in an autonomously surviving colon adenocarcinoma: involvement of autocrine amphiregulin secretion. ---
143  2006 Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively. EGF
144  2006 Metalloprotease-dependent amphiregulin release mediates tumor necrosis factor-alpha-induced IL-8 secretion in the human airway epithelial cell line NCI-H292. EGF, EGFR, IL-8, TACE, TNF-alpha
145  2006 Novel function of ovarian growth factors: combined studies by DNA microarray, biochemical and physiological approaches. ADAMs, EGF, Ep
146  2006 PGE2 up-regulates EGF-like growth factor biosynthesis in human granulosa cells: new insights into the coordination between PGE2 and LH in ovulation. COX-2, Ep, MAPK, PKA
147  2006 Protection by GDNF and other trophic factors against the dopamine-depleting effects of neurotoxic doses of methamphetamine. DA, GDNF, HPLC, HRG-beta1, METH, TGF-alpha
148  2006 Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo. HB, tRA
149  2006 Roles of myofibroblasts in prostaglandin E2-stimulated intestinal epithelial proliferation and angiogenesis. COX, HGF, PG, VEGF-A
150  2007 A hypothetical mechanism of intraepidermal neurite formation in NC/Nga mice with atopic dermatitis. AD, CONV, Dsg3, SPF, ZO-1
151  2007 Alteration of the serum levels of the epidermal growth factor receptor and its ligands in patients with non-small cell lung cancer and head and neck carcinoma. EGF, HNC, NSCLC, sEGFR, TGF-alpha
152  2007 Amphiregulin: a new growth factor in hepatocarcinogenesis. EGFR
153  2007 Effects of PM2.5 components in the release of amphiregulin by human airway epithelial cells. EGFR, NHNE, PM
154  2007 Human corneal epithelial cell proliferation by epiregulin and its cross-induction by other EGF family members. EGF, EGFRs, HB-EGF, HCECs, TGF-alpha
155  2007 Insulin induces a transcriptional activation of epiregulin, HB-EGF and amphiregulin, by a PI3K-dependent mechanism: identification of a specific insulin-responsive promoter element. EPI, HB-EGF
156  2007 Intraepidermal nerve fibers increase in dry skin of acetone-treated mice. NGF, SC, TEWL
157  2007 Potentiation of oxyntic atrophy-induced gastric metaplasia in amphiregulin-deficient mice. EGFR, SPEM
158  2007 Regulation of amphiregulin, EGFR-like factor expression by hCG in cultured human granulosa cells. EGF, LHR
159  2008 3',5'-cyclic adenosine monophosphate response element binding protein up-regulated cytochrome P450 lanosterol 14alpha-demethylase expression involved in follicle-stimulating hormone-induced mouse oocyte maturation. COCs, CREB, EGF, PKA
160  2008 AMP-activated protein kinase is involved in hormone-induced mouse oocyte meiotic maturation in vitro. ACC, AICAR, AMPK, ara-A, CEO, FSH, GV
161  2008 Amphiregulin is a promising prognostic marker for liver metastases of colorectal cancer. HER2
162  2008 EGF-like peptides mediate FSH-induced maturation of cumulus cell-enclosed mouse oocytes. BIM I, CEO, DO, EGF, EGFR, GVB
163  2008 Epidermal growth factor receptor activation by protein kinase C is necessary for FSH-induced meiotic resumption in porcine cumulus-oocyte complexes. EGF, EGFR, PKC
164  2008 Plasma-membrane-anchored growth factor pro-amphiregulin binds A-type lamin and regulates global transcription. ---
165  2008 The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis. EGFR
166  2008 The kinetics of the hydrogen/deuterium exchange of epidermal growth factor receptor ligands. ER, HB-EGF, TGF-alpha
167  2009 Altered EGFR localization and degradation in human breast cancer cells with an amphiregulin/EGFR autocrine loop. EGFR
168  2009 Amphiregulin induces the alternative splicing of p73 into its oncogenic isoform DeltaEx2p73 in human hepatocellular tumors. EGFR, HCC, pre-mRNA
169  2009 Amphiregulin is much more abundantly expressed than transforming growth factor-alpha and epidermal growth factor in human follicular fluid obtained from patients undergoing in vitro fertilization-embryo transfer. EGF, TGF alpha
170  2009 Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia. IM
171  2009 Critical role of ESCRT machinery in EGFR recycling. ESCRTs, siRNA
172  2009 Differential regulation of betacellulin and heparin-binding EGF-like growth factor in cultured zebrafish ovarian follicle cells by EGF family ligands. BTC, EGF, HB-EGF, TGF alpha
173  2009 EGF-like growth factors as LH mediators in the human corpus luteum. Ep
174  2009 Essential role of c-Cbl in amphiregulin-induced recycling and signaling of the endogenous epidermal growth factor receptor. EGF, EGFR, siRNA, TGF-alpha
175  2009 Mechanical stretch promotes fetal type II epithelial cell differentiation via shedding of HB-EGF and TGF-alpha. AP, BTC, EGFR, EPR, HB-EGF, TGF
176  2009 Mitochondrial dysfunction-induced amphiregulin upregulation mediates chemo-resistance and cell migration in HepG2 cells. mtDNA, ROS
177  2009 Proneoplastic effects of PGE2 mediated by EP4 receptor in colorectal cancer. COX-2, CRC, PGE2
178  2009 The epidermal growth factor receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression. APP, APR, EGFR, HCC, IL-6, OSM
179  2010 A novel signaling pathway of tissue kallikrein in promoting keratinocyte migration: activation of proteinase-activated receptor 1 and epidermal growth factor receptor. EGFR, ERK, HB-EGF, PKC
180  2010 Amphiregulin is not essential for induction of contact hypersensitivity. CHS, DC, DNFB, EPO, FITC, Ig, MPO
181  2010 Amphiregulin is not essential for ovalbumin-induced acute airway inflammation in mice. BAL, OVA
182  2010 Antisense inhibition of amphiregulin expression reduces EGFR phosphorylation in transformed human breast epithelial cells. EGFR
183  2010 The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia. AOM, DSS, PGE 2, TLR4
184  2010 Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury. DSS, EGFR, EPI, IEC, LPS, siRNA, TLR4
185  2010 [Novel role of growth factors in ovary function]. ADAMs, EGF, Ep
186  2011 Clinical impact of amphiregulin expression in patients with epidermal growth factor receptor (EGFR) wild-type nonsmall cell lung cancer treated with EGFR-tyrosine kinase inhibitors. EGFR, NSCLC, TKIs, WT
187  2011 Effect of heparin-binding EGF-like growth factor and amphiregulin on the MAP kinase-induced production of vascular endothelial growth factor by human granulosa cells. HB-EGF, VEGF
188  2011 Levels of the epidermal growth factor-like peptide amphiregulin in follicular fluid reflect the mode of triggering ovulation: a comparison between gonadotrophin-releasing hormone agonist and urinary human chorionic gonadotrophin. FF
189  2011 Role of size and composition of traffic and agricultural aerosols in the molecular responses triggered in airway epithelial cells. PAH, PM, Rur S, uf, Urb S
190  2012 Amphiregulin stimulates liver regeneration after small-for-size mouse liver transplantation. BrdU, EGFR, PCNA
191  2012 Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-beta-induced pulmonary fibrosis. ---
192  2012 Clinical significance of amphiregulin and epidermal growth factor in colostrum. EGF, TGF-alpha
193  2012 Comparison of follicular fluid amphiregulin and EGF concentrations in patients undergoing IVF with different stimulation protocols. COS, EGF, FF, GnRH-a, IVF-ET, LH
194  2012 EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling. EGF, EGFR, TGF alpha
195  2012 Epidermal growth factor receptor signaling in hepatocellular carcinoma: inflammatory activation and a new intracellular regulatory mechanism. EGFR, HCC, TNF
196  2012 Evolution of the predictive markers amphiregulin and epiregulin mRNAs during long-term cetuximab treatment of KRAS wild-type tumor cells. CTX, EPI, LPT, TZB, WT
197  2012 Nuclear translocation of pro-amphiregulin induces chemoresistance in gastric cancer. EGFR
198  2012 Polycystin-1 regulates amphiregulin expression through CREB and AP1 signalling: implications in ADPKD cell proliferation. ADPKD, AP-1
199  2012 Regulation of amphiregulin gene expression by beta-catenin signaling in human hepatocellular carcinoma cells: a novel crosstalk between FGF19 and the EGFR system. EGFR, FGF19, HCC
200  2013 A disintegrin and metalloproteinase 17 regulates TNF and TNFR1 levels in inflammation and liver regeneration in mice. ADAM17, ADAM17 m-KO, KO, LPS, PH, TNF
201  2013 A novel predictive strategy by immunohistochemical analysis of four EGFR ligands in metastatic colorectal cancer treated with anti-EGFR antibodies. EREG, HB-EGF, mCRC, TGF-alpha
202  2013 Intermittent hypoxia induces the proliferation of rat vascular smooth muscle cell with the increases in epidermal growth factor family and erbB2 receptor. EGF, ER, IH, NRG1, RASMC, SH, VSMCs
203  2014 Autocrine ligands of the epithelial growth factor receptor mediate inflammatory responses to diesel exhaust particles. DEP, EGFR, HB, MAPK, PBEC, TGF alpha
204  2014 EGFR ligands as pharmacodynamic biomarkers in metastatic colorectal cancer patients treated with cetuximab and irinotecan. EGF, EGFR, mCRC
205  2014 Expression of the epidermal growth factor system in human middle ear cholesteatoma. EGF, EPI, HB-EGF, TGF
206  2014 The human Cathelicidin LL-37 induces MUC5AC mucin production by airway epithelial cells via TACE-TGF-alpha-EGFR pathway. FRET, HB-EGF, sLL-37, TACE, TGF-alpha
207  2015 Amphiregulin activates human hepatic stellate cells and is upregulated in non alcoholic steatohepatitis. HCC, HSC, NAFLD, NASH, TACE
208  2015 Amphiregulin activates regulatory T lymphocytes and suppresses CD8+ T cell-mediated anti-tumor response in hepatocellular carcinoma cells. HCC
209  2015 Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf/MEK/ERK/AP-1 pathway. ---
210  2016 Epidermal growth factor is a potential biomarker for poor cetuximab response in tongue cancer cells. EGF, EGFR, EPR, rh
211  2017 Amphiregulin enhances VEGF-A production in human chondrosarcoma cells and promotes angiogenesis by inhibiting miR-206 via FAK/c-Src/PKCdelta pathway. VEGF-A
212  2017 Positive feedback of the amphiregulin-EGFR-ERK pathway mediates PM2.5 from wood smoke-induced MUC5AC expression in epithelial cells. EGFR, PM
213  2017 Prognostic value of rare and complex mutations in EGFR and serum levels of soluble EGFR and its ligands in non-small cell lung carcinoma patients. EGFR, NSCLC
214  2018 Amphiregulin enhances cardiac fibrosis and aggravates cardiac dysfunction in mice with experimental myocardial infarction partly through activating EGFR-dependent pathway. CF, EGFR, HF, MI
215  2018 Amphiregulin enhances cell migration and resistance to doxorubicin in chondrosarcoma cells through the MAPK pathway. DOX, r-AR
216  2018 Cold atmospheric plasma (CAP) activates angiogenesis-related molecules in skin keratinocytes, fibroblasts and endothelial cells and improves wound angiogenesis in an autocrine and paracrine mode. Ang, Ang-2, CAP, ET-1, FGF-2
217  2018 Development of a three-plex single molecule immunoassay enabling measurement of the EGFR ligands amphiregulin, betacellulin and transforming growth factor alpha simultaneously in human serum samples. BTC, TGF-alpha
218  2019 Amphiregulin Promotes Vascular Endothelial Growth Factor-C Expression and Lymphangiogenesis through STAT3 Activation in Human Chondrosarcoma Cells. LECs, VEGF-C
219  2019 Valproic acid-induced amphiregulin secretion confers resistance to temozolomide treatment in human glioma cells. GBM, TMZ, VPA
220  2020 Amphiregulin promotes cardiac fibrosis post myocardial infarction by inducing the endothelial-mesenchymal transition via the EGFR pathway in endothelial cells. AMI, CF, EndMT