A Search Service for Abbreviation / Long Form

■ Related PubMed/MEDLINE Info.

[Related PubMed/MEDLINE]
Total Number of Papers: 465
[Display Entries]
100 entries :
      (Publication year, Descending)
100 entries :
      (Publication year, Ascending)
all entries
[Entries Per Page]
 per page
Page Control
Page: of
Abbreviation : IGF1R
Long Form : insulin-like growth factor 1 receptor
No. Year Title Co-occurring Abbreviation
1989 Characterization of insulin-like growth factor 1 receptors (IGF1-R) in human breast cancer cell lines. ---
1989 Prognostic value of receptors for insulin-like growth factor 1, somatostatin, and epidermal growth factor in human breast cancer. EGFR, SSR
1990 Insulin-like growth factor 1 receptors (IGF1-R) and IGF1 in human breast tumors. HAA
1990 Prognostic significance of insulin-like growth factor 1 receptors in human breast cancer. GHP, OS, RFS
1991 An infant with deletion of the distal long arm of chromosome 15 (q26.1----qter) and loss of insulin-like growth factor 1 receptor gene. IUGR
1991 Detecting high-resolution polymorphisms in human coding loci by combining PCR and single-strand conformation polymorphism (SSCP) analysis. SSCP
1992 Sporadic amplification of the insulin-like growth factor 1 receptor gene in human breast tumors. ---
1993 Impairment of myocyte contractility following coronary artery narrowing is associated with activation of the myocyte IGF1 autocrine system, enhanced expression of late growth related genes, DNA synthesis, and myocyte nuclear mitotic division in rats. CAN, IGF1, PCNA
1993 Ring chromosome 15 involving deletion of the insulin-like growth factor 1 receptor gene in a patient with features of Silver-Russell syndrome. SRS
10  1993 The insulin-like growth factor 1 receptor gene is normally biallelically expressed in human juvenile tissue and tumours. BWS
11  1995 Localization of IGF1R and EDN genes to pig chromosomes 1 and 7 by in situ hybridization. EDN
12  1997 A common polymorphism in exon 16 of the human insulin-like growth factor-1 receptor gene (IGF1R). ---
13  1997 Gene homologs on human chromosome 15q21-q26 and a chicken microchromosome identify a new conserved segment. B2M
14  1997 Linkage assignment of eleven genes to the porcine genome. ACP5, CCKBR, Chro, ITGAM, ITGbeta2, OPRM1, RBP3, ZP1
15  1998 A third fibronectin type III domain in the extracellular region of the insulin receptor family. FNIII, IR
16  1998 Insulin-like growth factors in human breast cancer. ---
17  1999 Alcohol intake and late-stage promotion of breast cancer. ---
18  2000 Genome-wide search for genes related to the fat-free body mass in the Quebec family study. cM, FFM, GHRH, MC4R, NPY, QFS
19  2000 Opposite effects of androgens and estrogens on adipogenesis in rat preadipocytes: evidence for sex and site-related specificities and possible involvement of insulin-like growth factor 1 receptor and peroxisome proliferator-activated receptor gamma2. DHT
20  2000 Protein tyrosine kinases in malignant melanoma. FGFR-4, PTKs
21  2000 [Effect of IGF1 receptor gene antisense oligodeoxynucleotide on T24 urinary bladder cancer cells]. ODN
22  2001 Congenital glaucoma and Silver-Russell phenotype associated with partial trisomy 7q and monosomy 15q. ---
23  2001 Insulin-like growth factor (IGF) I down-regulates type 1 IGF receptor (IGF 1R) and reduces the IGF I response in A549 non-small-cell lung cancer and Saos-2/B-10 osteoblastic osteosarcoma cells. FCS, IGF, IGFBPs
24  2002 IGF1 receptor expression protects against microenvironmental stress found in the solid tumor. ---
25  2002 Overgrowth and trisomy 15q26.1-qter including the IGF1 receptor gene: report of two families and review of the literature. ---
26  2002 Postnatal overgrowth by 15q-trisomy and intrauterine growth retardation by 15q-monosomy due to familial translocation t(13;15): dosage effect of IGF1R? FISH, IUGR
27  2003 Antiproliferative and proapoptotic effect of ascorbyl stearate in human pancreatic cancer cells: association with decreased expression of insulin-like growth factor 1 receptor. Asc-S
28  2003 Expression and distribution of insulin-like growth factor-1 receptor in human carcinomas. ---
29  2003 Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathway. IGF1
30  2003 Modification of insulin-like growth factor 1 receptor, c-Src, and Bcl-XL protein expression during the progression of Barrett's neoplasia. HGDs, LGDs
31  2004 Effect of paternal tamoxifen on the expression of insulin-like growth factor 2 and insulin-like growth factor type 1 receptor in the post-implantation rat embryos. IGF, IGF2, PIL, POL
32  2004 Inhibition of insulin-like growth factor I receptor autophosphorylation by novel 6-5 ring-fused compounds. CHO
33  2004 Insulin-like growth factor 1 receptor mRNA expression and autophosphorylation in human myometrium and leiomyoma. ---
34  2004 Prenatal overgrowth and mosaic trisomy 15q25-qter including the IGF1 receptor gene. ---
35  2004 The association between paired basic amino acid cleaving enzyme 4 gene haplotype and diastolic blood pressure. DBP, MEF2A, PACE4, SNPs
36  2005 External imaging of CCND1, MYC, and KRAS oncogene mRNAs with tumor-targeted radionuclide-PNA-peptide chimeras. PET, PNA
37  2005 Meg1/Grb10 overexpression causes postnatal growth retardation and insulin resistance via negative modulation of the IGF1R and IR cascades. IR
38  2005 Noninvasive molecular imaging of MYC mRNA expression in human breast cancer xenografts with a [99mTc]peptide-peptide nucleic acid-peptide chimera. PNA
39  2006 Alternative tyrosine phosphorylation of signaling kinases according to hormone receptor status in breast cancer overexpressing the insulin-like growth factor receptor type 1. ER, p-AKT
40  2006 An aging pathway controls the TrkA to p75NTR receptor switch and amyloid beta-peptide generation. BACE1
41  2006 Immunohistochemical prognostic factors in resected colorectal lung metastases using tissue microarray analysis. ---
42  2006 Membrane initiated estrogen signaling in breast cancer. EGFR
43  2006 Monitoring the activation state of insulin/insulin-like growth factor-1 hybrid receptors using bioluminescence resonance energy transfer. BRET, IR-A, Rluc, YFP
44  2006 Potential crosstalk between insulin-like growth factor receptor type 1 and epidermal growth factor receptor in progression and metastasis of pancreatic cancer. EGFR
45  2007 Analysis of polymorphisms in the insulin-like growth factor 1 receptor (IGF1R) gene from Japanese quail selected for body weight. SNP
46  2007 Association of the GAA1013-->GAG polymorphism of the insulin-like growth factor-1 receptor (IGF1R) gene with premature pubarche. IGF-1, PP, SNP
47  2007 Estradiol-17beta regulates mouse uterine epithelial cell proliferation through insulin-like growth factor 1 signaling. GSK3beta
48  2007 Insulin-like growth factor signaling regulates zebrafish embryonic growth and development by promoting cell survival and cell cycle progression. ---
49  2007 JAK2, the JAK2 V617F mutant and cytokine receptors. ---
50  2007 PET imaging of CCND1 mRNA in human MCF7 estrogen receptor positive breast cancer xenografts with oncogene-specific [64Cu]chelator-peptide nucleic acid-IGF1 analog radiohybridization probes. mRNA, PNA
51  2007 Proportional growth failure and oculocutaneous albinism in a girl with a 6.87 Mb deletion of region 15q26.2-->qter. FISH
52  2007 Radiohybridization PET imaging of KRAS G12D mRNA expression in human pancreas cancer xenografts with [(64)Cu]DO3A-peptide nucleic acid-peptide nanoparticles. Ala, PET, PNA
53  2007 Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling. CM, EGFR, FGF-2, hESC, IR, KSR, MEF, RTKs
54  2007 [Inhibitory effect of IGF1R siRNA on the growth of human liver cancer SMMC7721 cell xenograft in nude mice]. MVD, siRNA, TUNEL
55  2008 A comparative structural bioinformatics analysis of the insulin receptor family ectodomain based on phylogenetic information. IR, IRR
56  2008 A pivotal role for heat shock protein 90 in Ewing sarcoma resistance to anti-insulin-like growth factor 1 receptor treatment: in vitro and in vivo study. 17-AAG, ES, HSP
57  2008 Association of a single nucleotide polymorphism in the insulin-like growth factor-1 receptor gene with spinal disc degeneration in postmenopausal Japanese women. IGF-1, SNP
58  2008 Colorectal Cancer Treatment: What's Next? (or: Is There Life After EGFR and VEGF?). anti-CTLA4, mTOR
59  2008 Evolution of the insulin receptor family and receptor isoform expression in vertebrates. IR, IRR, ML
60  2008 Knockdown of insulin-like growth factor 1 receptor enhances chemosensitivity to cisplatin in human lung adenocarcinoma A549 cells. shRNA
61  2008 Polymorphisms in the IGF1 and IGF1R genes and children born small for gestational age: results of large population studies. IGF1, SGA
62  2008 Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor. IR, PQIP, RTK
63  2008 TRAIL stimulates proliferation of vascular smooth muscle cells via activation of NF-kappaB and induction of insulin-like growth factor-1 receptor. VSMC
64  2008 [Suppression of insulin-like growth factor-1 receptor by RNA interference inhibits cell growth in vitro and induces chemosensitization of HO8910PM cell to cisplatin]. Bcl-2, CCK-8, FCM, siRNA
65  2009 Expression of insulin receptor isoform A and insulin-like growth factor-1 receptor in human acute myelogenous leukemia: effect of the dual-receptor inhibitor BMS-536924 in vitro. AML, IR
66  2009 Igf1r+/CD34+ immature ICC are putative adult progenitor cells, identified ultrastructurally as fibroblast-like ICC in Ws/Ws rat colon. FL-ICC, ICC-AP
67  2009 Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach. ---
68  2009 Low activation of Insulin-like Growth Factor 1-Receptor (IGF1R) is associated with local recurrence in early breast carcinoma. BC
69  2009 MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib. HCCs, miR-122, SRF
70  2009 Sequence variation in IGF1R is associated with differences in insulin levels in nondiabetic Old Order Amish. ---
71  2009 The insulin-like growth factor (IGF) receptor type 1 (IGF1R) as an essential component of the signalling network regulating neurogenesis. IGF
72  2009 Two short children born small for gestational age with insulin-like growth factor 1 receptor haploinsufficiency illustrate the heterogeneity of its phenotype. GH, SGA
73  2009 [A case of partial trisomy 15q25.3-qter]. aCGH, BAC
74  2010 A comprehensive in silico analysis of the functional and structural impact of SNPs in the IGF1R gene. SNPs
75  2010 Activation of Erk1/2 phosphorylation but not of Akt/Pkb through an inducible CSF1R/IRR-receptor construct in INS-1E beta-cells. CSF1R, IR, IRR
76  2010 Astrocytes regulate the expression of insulin-like growth factor 1 receptor (IGF1-R) in primary cortical neurons during in vitro senescence. IGF1
77  2010 Expression of growth factor receptors and targeting of EGFR in cholangiocarcinoma cell lines. CC, HGFR, IGF2R
78  2010 Gene expression in the adrenal glands of three spontaneously hypertensive rat substrains. APLN, BP, EPHX2, GJA1, KYNU, M-SHRSP, RGS2, SHR, UTS2, WKY
79  2010 Increased insulin-like growth factor 1 receptor protein expression and gene copy number in small cell lung cancer. SCLC
80  2010 Insulin-like growth factor receptor 1 (IGF1R) expression and survival in surgically resected non-small-cell lung cancer (NSCLC) patients. EGFR, NSCLC
81  2010 Insulin-like growth factor receptor 1 (IGF1R) gene copy number is associated with survival in operable non-small-cell lung cancer: a comparison between IGF1R fluorescent in situ hybridization, protein expression, and mRNA expression. EGFR, IHC, NSCLC, qRT-PCR
82  2010 Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice. ADPKD, CC3, HIF-1alpha, IGF1, LCE, LCECs, mTOR, p-mTOR, PCNA, PKA, VEGF
83  2010 Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma. BAD, CDKN2A, MTAP
84  2010 MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells. ---
85  2010 Molecular markers for novel therapies in neuroendocrine (carcinoid) tumors. BP, EGFR, Hsp90, mTOR, PDGFRA, SSTR5, TGFBR1
86  2010 Phenotype-genotype correlation in a familial IGF1R microdeletion case. FISH, MLPA, SNP
87  2010 Regeneration associated growth factor receptor and epithelial marker expression in lymphoid aggregates of ulcerative colitis. CK, EGFR, HGFR, LA, NSC, TMAs, UC
88  2010 Strong expression of IGF1R in pediatric gastrointestinal stromal tumors without IGF1R genomic amplification. GISTs, WT
89  2010 Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases. ---
90  2010 Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation. SDC1, siRNAs
91  2010 Synthetic lethality screens reveal RPS6 and MST1R as modifiers of insulin-like growth factor-1 receptor inhibitor activity in childhood sarcomas. MST1R, PTK, rpS6, siRNA
92  2010 The emerging role of insulin-like growth factor 1 receptor (IGF1r) in gastrointestinal stromal tumors (GISTs). GISTs
93  2010 The insulin-like growth factor signaling pathway as a target for treatment of colorectal carcinoma. CRC, IGFs
94  2010 Thrombopoietin receptor levels in tumor cell lines and primary tumors. EpoR, TPO
95  2010 Vitamin E and rutin synergistically inhibit expression of vascular endothelial growth factor through down-regulation of binding activity of activator protein-1 in human promyelocytic leukemia (HL-60) cells. AP-1, IRS-1, ROS, VE, VEGF
96  2011 A chimeric receptor of the insulin-like growth factor receptor type 1 (IGFR1) and a single chain antibody specific to myelin oligodendrocyte glycoprotein activates the IGF1R signalling cascade in CG4 oligodendrocyte progenitors. ChR, IGFR1, MOG
97  2011 A mutant Ahr allele protects the embryonic kidney from hydrocarbon-induced deficits in fetal programming. BaP, EGFR, Lhx1, PAX2, SDC1, SFRP1, Wnt4
98  2011 Changes in breast cancer biomarkers in the IGF1R/PI3K pathway in recurrent breast cancer after tamoxifen treatment. HER2, PgR
99  2011 Differential activation of MAPK and PI3K/AKT/mTOR pathways and IGF1R expression in gastrointestinal stromal tumors. GISTs, MAPK, PDGFRA, WT
100  2011 Divergent effects of insulin-like growth factor-1 receptor expression on prognosis of estrogen receptor positive versus triple negative invasive ductal breast carcinoma. BCSS, DFS, DFS, IDC, TN-IDC
101  2011 Establishment of platform for screening insulin-like growth factor-1 receptor inhibitors and evaluation of novel inhibitors. SPR
102  2011 Evasion mechanisms to Igf1r inhibition in rhabdomyosarcoma. ARMS
103  2011 Genomic and molecular characterization of malignant peripheral nerve sheath tumor identifies the IGF1R pathway as a primary target for treatment. IHC, MPNST
104  2011 High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling. LIC, T-ALL
105  2011 IGF1R mutations as cause of SGA. SGA
106  2011 IGF2 actions on trophoblast in human placenta are regulated by the insulin-like growth factor 2 receptor, which can function as both a signaling and clearance receptor. CTB, IGF2, IGF2R, siRNA
107  2011 IGF2 derived from SH-SY5Y neuroblastoma cells induces the osteoclastogenesis of human monocytic precursors. IGF2, NB
108  2011 Increased insulin-like growth factor-1 receptor mRNA expression predicts poor survival in immunophenotypes of early breast carcinoma. ---
109  2011 Inhibition of IGF1R activity enhances response to trastuzumab in HER-2-positive breast cancer cells. siRNA
110  2011 Insulin-like growth factor-1 receptor gene expression is associated with survival in breast cancer: a comprehensive analysis of gene copy number, mRNA and protein expression. BCSS
111  2011 Involvement of GDF-9, leptin, and IGF1 receptors associated with adipose tissue transplantation on fertility restoration in obese anovulatory mice. GDF9, LEPR
112  2011 Orbital fibrosis in a mouse model of Graves' disease induced by genetic immunization of thyrotropin receptor cDNA. GD, TSHR
113  2011 Phase 1 clinical trials for sarcomas: the cutting edge. ALK
114  2011 Targeted morphoproteomic profiling of Ewing's sarcoma treated with insulin-like growth factor 1 receptor (IGF1R) inhibitors: response/resistance signatures. mTOR
115  2011 Targeted Therapy of Ewing's Sarcoma. EWS
116  2011 [Mutations in insulin-like growth factor receptor 1 gene (IGF1R) resulting in intrauterine and postnatal growth retardation]. SGA
117  2012 A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation. EN, INSR, IRS-1, PI3K
118  2012 Aldosterone induces vascular insulin resistance by increasing insulin-like growth factor-1 receptor and hybrid receptor. VSMCs
119  2012 Clinical significance of IGF1R expression in non-small-cell lung cancer. DFS, IHC
120  2012 Contrasted outcomes to gefitinib on tumoral IGF1R expression in head and neck cancer patients receiving postoperative chemoradiation (GORTEC trial 2004-02). DFS, EGFR
121  2012 Cross-talk between integrin alpha6beta4 and insulin-like growth factor-1 receptor (IGF1R) through direct alpha6beta4 binding to IGF1 and subsequent alpha6beta4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions. IGF1
122  2012 Does tumour biology determine surgical success in the treatment of epithelial ovarian cancer? A systematic literature review. FDR
123  2012 Down-regulation of the microRNA-99 family members in head and neck squamous cell carcinoma. HNSCC, mTOR
124  2012 Establishment of phosphatidylinositol 3-kinase inhibitor-resistant cancer cell lines and therapeutic strategies for overcoming the resistance. PI3Kis, TKIs
125  2012 Evaluation of IGF1R and phosphorylated IGF1R as targets in HER2-positive breast cancer cell lines and tumours. TKIs
126  2012 Ewing's sarcoma: overcoming the therapeutic plateau. EWS, mTOR, PARP
127  2012 Expression of genes involved in energy homeostasis in the duodenum and liver of Holstein-Friesian and Jersey cows and their F(1) hybrid. GLP1R, HF, IGF1, JE, LEPR, POMC
128  2012 Expression of IGF1R is associated with tumor differentiation and survival in patients with lung adenocarcinoma. RT-PCR
129  2012 Heterodimerization of glycosylated insulin-like growth factor-1 receptors and insulin receptors in cancer cells sensitive to anti-IGF1R antibody. IP, IR
130  2012 IGF1R gene expression as a predictive marker of response to ionizing radiation for patients with locally advanced HPV16-positive cervical cancer. GAPDH, HPV
131  2012 IGFBP7 binds to the IGF-1 receptor and blocks its activation by insulin-like growth factors. IGFBP7, PI3K
132  2012 Immunohistochemical analysis of thymic carcinoma focusing on the possibility of molecular targeted and hormonal therapies. AR, EGFR, ER, HER2, LAT1, PgR, PPARgamma
133  2012 Immunophenotyping invasive breast cancer: paving the road for molecular imaging. EGFR, GLUT1, HER2
134  2012 Increased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas. EGFR, OS, PFS, PTEN
135  2012 Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells. ERalpha, I3C, IRS-1
136  2012 Involvement of signaling molecules in the prediction of response to imatinib treatment in metastatic GIST patients. GIST, PKCtheta, RKIP
137  2012 MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptor. ESCC, miRNA
138  2012 MiR-122 inhibits cell proliferation and tumorigenesis of breast cancer by targeting IGF1R. BC, miR-122
139  2012 Molecular imaging of insulin-like growth factor 1 receptor in cancer. ---
140  2012 Notch-mediated repression of miR-223 contributes to IGF1R regulation in T-ALL. GSI, T-ALL
141  2012 Polymorphism of IGF1R is associated with papillary thyroid carcinoma in a Korean population. CIs, ORs, PTC, SNPs
142  2012 Quantitative determination of insulin-like growth factor 1 receptor mRNA in formalin-fixed paraffin-embedded tissues of invasive breast cancer. FF, FFPE
143  2012 Repression of malignant tumor progression upon pharmacologic IGF1R blockade in a mouse model of insulinoma. ---
144  2012 Severe short stature caused by novel compound heterozygous mutations of the insulin-like growth factor 1 receptor (IGF1R). ---
145  2012 Short-time glucose exposure of embryonic carcinoma cells impairs their function as terminally differentiated cardiomyocytes. alpha-MHC, EB, ECC, GLUT4, IR
146  2012 Succinate dehydrogenase-deficient GISTs are characterized by IGF1R overexpression. GISTs, SDHB
147  2012 Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy. INSR
148  2012 The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r. lincRNA, miRNA
149  2012 The insulin-like growth factor 1 receptor (IGF1R) contributes to reduced size in dogs. SNP
150  2012 The nuclear receptor NR4A1 induces a form of cell death dependent on autophagy in mammalian cells. ---
151  2012 Treatment of breast cancer cells by IGF1R tyrosine kinase inhibitor combined with conventional systemic drugs. AKT, ERK
152  2012 Utility of insulin-like growth factor receptor-1 expression in gefitinib-treated patients with non-small cell lung cancer. EGFR
153  2012 Variant in the 5' untranslated region of insulin-like growth factor 1 receptor is associated with susceptibility to mastitis in cattle. FEZL
154  2012 Virtual screening of specific insulin-like growth factor 1 receptor (IGF1R) inhibitors from the National Cancer Institute (NCI) molecular database. IR, NCI, PMF
155  2013 Activation of the insulin-like growth factor-1 receptor alters p27 regulation by the epidermal growth factor receptor in oral squamous carcinoma cells. EGFR, OSCCs, TKIs
156  2013 Advanced glycation end products promote human aortic smooth muscle cell calcification in vitro via activating NF-kappaB and down-regulating IGF1R expression. AGEs, ChIP, HASMCs
157  2013 Association of two SNPs in the coding region of the insulin-like growth factor 1 receptor (IGF1R) gene with growth-related traits in Angus cattle. IGF-1, IGF-1R
158  2013 Autocrine insulin-like growth factor 1 and stem cell factor but not interleukin 6 support self-renewal of human myeloma cells. IGF1, IL, mAb, SCF
159  2013 Concomitant high gene copy number and protein overexpression of IGF1R and EGFR negatively affect disease-free survival of surgically resected non-small-cell-lung cancer patients. CNG, DFS, EGFR, FISH, HR, IHC, NSCLC
160  2013 Differential Pharmacokinetics of Ganitumab in Patients With Metastatic Pancreatic Cancer Versus Other Advanced Solid Cancers. PK
161  2013 Downregulation of miR-383 promotes glioma cell invasion by targeting insulin-like growth factor 1 receptor. ---
162  2013 Drug synergy screen and network modeling in dedifferentiated liposarcoma identifies CDK4 and IGF1R as synergistic drug targets. CDK4, DDLS, EGFR
163  2013 Effects in cattle of genetic variation within the IGF1R gene on the superovulation performance and pregnancy rates after embryo transfer. ET
164  2013 Evaluation of the expression and role of IGF pathway biomarkers in human sarcomas. IGF, IHC, ISH, MMP-2, NTT, OS
165  2013 Gene expression of the IGF pathway family distinguishes subsets of gastrointestinal stromal tumors wild type for KIT and PDGFRA. GISTs, ICCs, INSR, KIT, PDGFRA, SDH
166  2013 Growth factor receptor-bound protein 10-mediated negative regulation of the insulin-like growth factor-1 receptor-activated signalling pathway results in cognitive disorder in diabetic rats. Grb10, IR
167  2013 IGF-1 receptor and IGF binding protein-3 might predict prognosis of patients with resectable pancreatic cancer. IGFBP-3
168  2013 IGF1R mutation analysis in short children with Silver-Russell syndrome features. SRS
169  2013 Insulin-like growth factor 1 receptor (IGF1R) expression and survival in operable squamous-cell laryngeal cancer. DFS, IGFBP-3, IGFR, IHC, IRS, OS, SOCS2
170  2013 Insulin-like growth factor 1 receptor promotes the growth and chemoresistance of pancreatic cancer. ---
171  2013 Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia. CLL, IGF-1, RTK
172  2013 Intragenic deletions of the IGF1 receptor gene in five individuals with psychiatric phenotypes and developmental delay. ---
173  2013 MicroRNA-100 regulates IGF1-receptor expression in metastatic pancreatic cancer cells. ---
174  2013 MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor. EMT, GC, siRNA
175  2013 Minireview: nuclear insulin and insulin-like growth factor-1 receptors: a novel paradigm in signal transduction. INSR, IRS-1
176  2013 Modulation of microRNAs in hypertension-induced arterial remodeling through the beta1 and beta3-adrenoreceptor pathways. DSS, HS, miRNAs, PTEN, Syc
177  2013 Molecular predictors of sensitivity to the insulin-like growth factor 1 receptor inhibitor Figitumumab (CP-751,871). IGFBP5, IRS2
178  2013 Novel polymorphisms of the IGF1R gene and their association with average daily gain in Egyptian buffalo (Bubalus bubalis). aa
179  2013 Overexpression of insulin-like growth factor 1 receptor and frequent mutational inactivation of SDHA in wild-type SDHB-negative gastrointestinal stromal tumors. GISTs, SDH
180  2013 Pituitary tumor transforming gene and insulin-like growth factor 1 receptor expression and immunohistochemical measurement of Ki-67 as potential prognostic markers of pituitary tumors aggressiveness. NCN, PA, PTTG
181  2013 Synstatin: a selective inhibitor of the syndecan-1-coupled IGF1R-alphavbeta3 integrin complex in tumorigenesis and angiogenesis. SDC1
182  2013 Synthesis of the IGF-II-like hormone vesiculin using regioselective formation of disulfide bonds. IR
183  2013 Targeted therapy in advanced urothelial carcinoma. EGFR, UC, VEGFR
184  2013 Targeting non-small cell lung cancer cells by dual inhibition of the insulin receptor and the insulin-like growth factor-1 receptor. IR, IR, NSCLC
185  2013 The miRNA let-7a1 inhibits the expression of insulin-like growth factor 1 receptor (IGF1R) in prostate cancer PC-3 cells. 3' UTR, miRNA
186  2013 The potential of hypoxia markers as target for breast molecular imaging--a systematic review and meta-analysis of human marker expression. CAIX, CI, CXCR4, GLUT1, HIF-1alpha
187  2013 The prognostic role of ephrin A2 and endothelial growth factor receptor pathway mediators in patients with advanced colorectal cancer treated with cetuximab. AREG, CRC, EGFR, EphA2, EREG, FFPE, HER2, HR, IGFBP-2, RT-PCR
188  2013 The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells. EGF, EGFR, EMT, INSR, PDGFR, RTK
189  2013 Two is better than one: combining IGF1R and MEK blockade as a promising novel treatment strategy against KRAS-mutant lung cancer. NSCLC
190  2013 Vascular endothelial-cadherin stimulates syndecan-1-coupled insulin-like growth factor-1 receptor and cross-talk between alphaVbeta3 integrin and vascular endothelial growth factor receptor 2 at the onset of endothelial cell dissemination during angiogenesis. SDC1, SSTN, VE, VE-cadherin, VEGF, VEGFR2
191  2013 [miR-378 suppresses HBV-related hepatocellular carcinoma tumor growth by directly targeting the insulin-like growth factor 1 receptor]. HBV, HCC, miR, UTR
192  2014 A human blood-brain barrier transcytosis assay reveals antibody transcytosis influenced by pH-dependent receptor binding. TfR
193  2014 Activated cMET and IGF1R-driven PI3K signaling predicts poor survival in colorectal cancers independent of KRAS mutational status. CEER, CRC, DFS, ERK, HER1, KRAS, PI3K, RTKs
194  2014 Alterations of insulin-like growth factor-1 receptor gene copy number and protein expression are common in non-small cell lung cancer. NSCLC, SCC
195  2014 Association between insulin-like growth factor-1 receptor (IGF1R) negativity and poor prognosis in a cohort of women with primary breast cancer. DDFS, ER, p-mTOR, p-S6rp
196  2014 Association of polymorphisms and haplotypes in the insulin-like growth factor 1 receptor (IGF1R) gene with the risk of breast cancer in Korean women. IGF, LD, SNPs
197  2014 Associations of polymorphisms in GHRL, GHSR, and IGF1R genes with feed efficiency in chickens. BW, BW49, BWG, FCR, FI, GHRL, MALDI-TOF MS
198  2014 Biomarker changes associated with the development of resistance to aromatase inhibitors (AIs) in estrogen receptor-positive breast cancer. AI, AIs, ER, HER2, IRS-1, PgR
199  2014 BRCA1 regulates insulin-like growth factor 1 receptor levels in ovarian cancer. BRCA1
200  2014 Cardiac-targeting magnetic lipoplex delivery of SH-IGF1R plasmid attenuate norepinephrine-induced cardiac hypertrophy in murine heart. ---
201  2014 Classifying the adverse mitogenic mode of action of insulin analogues using a novel mechanism-based genetically engineered human breast cancer cell panel. INSR
202  2014 Clinical and biological significance of miR-378a-3p and miR-378a-5p in colorectal cancer. CRC
203  2014 Deep Sequencing the microRNA profile in rhabdomyosarcoma reveals down-regulation of miR-378 family members. 5-aza-dC, ARMSs, ERMSs, miRNAs, NSM, RMS
204  2014 Delineating the mTOR kinase pathway using a dual TORC1/2 inhibitor, AZD8055, in multiple myeloma. ---
205  2014 Downregulation of IGFBP2 is associated with resistance to IGF1R therapy in rhabdomyosarcoma. IGF, mTOR, PI3K, RMS
206  2014 Epigenetic silencing of miR-375 induces trastuzumab resistance in HER2-positive breast cancer by targeting IGF1R. miRNAs
207  2014 Familial short stature is associated with a novel dominant-negative heterozygous insulin-like growth factor 1 receptor (IGF1R) mutation. ---
208  2014 Fibulin-3-mediated inhibition of epithelial-to-mesenchymal transition and self-renewal of ALDH+ lung cancer stem cells through IGF1R signaling. CSCs, EMT, FBLNs, IGF, PI3K
209  2014 Generation and screening of monoclonal antibodies for immunoPET imaging of IGF1R in prostate cancer. ---
210  2014 Genes of human longevity: an endless quest? APOE, GEHA, mTOR
211  2014 Genome-wide association study for poor sperm motility in Holstein-Friesian bulls. ALPL, CAPN1, CATSPER1, CFTR, ETNK1, HIBADH, KLHL1, MC4R, PDZRN4, PRKCB, SNP, SRD5A2, TRIM36
212  2014 High coexpression of both EGFR and IGF1R correlates with poor patient prognosis in resected non-small-cell lung cancer. ADCs, EGFR, IHC, NSCLC, OS, SCCs
213  2014 Identification of a gonad-expression differential gene insulin-like growth factor-1 receptor (Igf1r) in the swamp eel (Monopterus albus). IGF-1R
214  2014 IGF1R tyrosine kinase inhibitor enhances the cytotoxic effect of methyl jasmonate in endometrial cancer. MJ
215  2014 Inhibition of Let7c microRNA is neuroprotective in a rat intracerebral hemorrhage model. ICH, miRNA
216  2014 Insulin-like growth factor 1 pathway mutations and protein expression in resected non-small cell lung cancer. SNP
217  2014 Insulin-like growth factor 1 receptor and response to anti-IGF1R antibody therapy in osteosarcoma. OS
218  2014 Insulin-like growth factor receptor 1 (IGF1R) expression and survival in non-small cell lung cancer patients: a meta-analysis. DFS, HRs, NSCLC, ORs, OS
219  2014 Insulin-like growth factor receptor 1 mRNA expression as a prognostic marker in advanced non-small cell lung cancer. IHC, NSCLC, qRT-PCR
220  2014 Insulin-like growth factor-1 receptor overexpression is associated with outcome in invasive urothelial carcinoma of urinary bladder: a retrospective study of patients treated using radical cystectomy. HRs, UC
221  2014 Integrative effects of feeding Aspergillus awamori and fructooligosaccharide on growth performance and digestibility in broilers: promotion muscle protein metabolism. AA, CPU, DMD, FOS, GHS-R, HDL-C, IGF-1, LDL-C
222  2014 Let-7b-5p regulates proliferation and apoptosis in multiple myeloma by targeting IGF1R. MM
223  2014 MicroRNA let-7i induced autophagy to protect T cell from apoptosis by targeting IGF1R. AS
224  2014 miR-1271 regulates cisplatin resistance of human gastric cancer cell lines by targeting IGF1R, IRS1, mTOR, and BCL2. IRS-1, miRNAs
225  2014 miR-133a suppresses ovarian cancer cell proliferation by directly targeting insulin-like growth factor 1 receptor. UTR
226  2014 MiR-143 and MiR-145 regulate IGF1R to suppress cell proliferation in colorectal cancer. 3'-UTR, IGF-1
227  2014 MiR-195 inhibits the growth and metastasis of NSCLC cells by targeting IGF1R. miRNAs, NSCLC
228  2014 MiR-503 regulates cisplatin resistance of human gastric cancer cell lines by targeting IGF1R and BCL2. Bcl-2, miRNAs
229  2014 Negative regulation of Grb10 Interacting GYF Protein 2 on insulin-like growth factor-1 receptor signaling pathway caused diabetic mice cognitive impairment. GIGYF2, Grb10, STZ
230  2014 Novel secondary somatic mutations in Ewing's sarcoma and desmoplastic small round cell tumors. CR, DSRCT, ES, PCR, PR
231  2014 O-GlcNAcylation of FoxO1 in pancreatic beta cells promotes Akt inhibition through an IGFBP1-mediated autocrine mechanism. IGFBP-1, PI3K
232  2014 Reciprocal regulation of microRNA-99a and insulin-like growth factor I receptor signaling in oral squamous cell carcinoma cells. MAPK, miR-99a, miRNAs, OSCC, PI3K, qRT-PCR
233  2014 Temporal changes in histomorphology and gene expression in goat testes during postnatal development. FSHR, GSTA3, HSPA8, LHCGR, ODF2, PRM1, SOX9, Stra8
234  2014 The combination of insulin-like growth factor receptor 1 (IGF1R) antibody cixutumumab and mitotane as a first-line therapy for patients with recurrent/metastatic adrenocortical carcinoma: a multi-institutional NCI-sponsored trial. ACC, PFS
235  2014 The insulin-like growth factor 1 receptor causes acquired resistance to erlotinib in lung cancer cells with the wild-type epidermal growth factor receptor. EGFR, ER
236  2014 The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland. ---
237  2014 The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice. AF, HF
238  2014 Treatment with insulin-like growth factor 1 receptor inhibitor reverses hypoxia-induced epithelial-mesenchymal transition in non-small cell lung cancer. EMT, HIF-1alpha, IGFBP-3, NSCLC, TGF-beta1
239  2015 5-Nitro-5'-hydroxy-indirubin-3'-oxime (AGM130), an indirubin-3'-oxime derivative, inhibits tumor growth by inducing apoptosis against non-small cell lung cancer in vitro and in vivo. CQ, MAPK, PCNA
240  2015 5‑Azacytidine inhibits human rhabdomyosarcoma cell growth by downregulating insulin‑like growth factor 2 expression and reactivating the H19 gene product miR‑675, which negatively affects insulin‑like growth factors and insulin signaling. DMR, IGF2, INS, INSR, LOI, RMS
241  2015 A phase I study of continuous oral dosing of OSI-906, a dual inhibitor of insulin-like growth factor-1 and insulin receptors, in patients with advanced solid tumors. IR
242  2015 Adenovirus E4-ORF1 Dysregulates Epidermal Growth Factor and Insulin/Insulin-Like Growth Factor Receptors To Mediate Constitutive Myc Expression. Dlg1, EGFR, INSR, PI3K
243  2015 An immunohistochemical study of potential diagnostic and therapeutic biomarkers of wild-type gastrointestinal stromal tumours. EGFR, GISTs, SDHB
244  2015 Anticancer activity of the type I insulin-like growth factor receptor antagonist, ganitumab, in combination with the death receptor 5 agonist, conatumumab. MTD
245  2015 Association between exonic polymorphism (rs629849, Gly1619Arg) of IGF2R gene and obesity in Korean population. IGF2R, IGFs, SNPs
246  2015 Atypical protein kinase C zeta: potential player in cell survival and cell migration of ovarian cancer. ITGB3, PRKCZ, siRNA
247  2015 Available evidence and new biological perspectives on medical treatment of advanced thymic epithelial tumors. EGFR, TETs
248  2015 Basal expression of insulin-like growth factor 1 receptor determines intrinsic resistance of cancer cells to a phosphatidylinositol 3-kinase inhibitor ZSTK474. PI3K, PI3Kis
249  2015 Bidirectional signaling between TM4SF5 and IGF1R promotes resistance to EGFR kinase inhibitors. ECM, EMT, ERKs, PDGFR, S6K, TKIs
250  2015 Both epidermal growth factor and insulin-like growth factor receptors are dispensable for structural intestinal adaptation. EGFR, POD, SBR, WT
251  2015 Crizotinib-induced antitumour activity in human alveolar rhabdomyosarcoma cells is not solely dependent on ALK and MET inhibition. ALK, ARMS, RMS, ROS
252  2015 Deguelin induces apoptosis by targeting both EGFR-Akt and IGF1R-Akt pathways in head and neck squamous cell cancer cell lines. EGFR, HNSCC, PARP
253  2015 Differential organ phenotypes after postnatal Igf1r gene conditional deletion induced by tamoxifen in UBC-CreERT2; Igf1r fl/fl double transgenic mice. ---
254  2015 Downregulation of microRNA-100 protects H2O2-induced apoptosis in neonatal cardiomyocytes. miR-100
255  2015 Endogenous LPS alters liver GH/IGF system gene expression and plasma lipoprotein lipase in goats. GH, GHR, HCD, LCD, LPL, LPS
256  2015 Extracellular vimentin interacts with insulin-like growth factor 1 receptor to promote axonal growth. ---
257  2015 FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells. FAK, shRNA, TNBC
258  2015 GSK1838705A, an insulin-like growth factor-1 receptor/insulin receptor inhibitor, induces apoptosis and reduces viability of docetaxel-resistant prostate cancer cells both in vitro and in vivo. IR
259  2015 Increased insulin-like growth factor 1 receptor (IGF1R) expression in small cell lung cancer and the effect of inhibition of IGF1R expression by RNAi on growth of human small cell lung cancer NCI-H446 cell. SCLC
260  2015 Insulin-like factor regulates neural induction through an IGF1 receptor-independent mechanism. IR
261  2015 Insulin/Insulin-like growth factors in cancer: new roles for the aryl hydrocarbon receptor, tumor resistance mechanisms, and new blocking strategies. AhR, IR
262  2015 let-7a and its target, insulin-like growth factor 1 receptor, are differentially expressed in recurrent prostate cancer. miRNAs, PCa
263  2015 LMP1 promotes expression of insulin-like growth factor 1 (IGF1) to selectively activate IGF1 receptor and drive cell proliferation. EBV, IGF1, LMP1, PPP, shRNA
264  2015 Membranous Insulin-like Growth Factor-1 Receptor (IGF1R) Expression Is Predictive of Poor Prognosis in Patients with Epidermal Growth Factor Receptor (EGFR)-Mutant Lung Adenocarcinoma. ADCs, EGFR, HR, NSCLC, PFS, SqCCs
265  2015 MicroRNA-139-5p inhibits cell proliferation and invasion by targeting insulin-like growth factor 1 receptor in human non-small cell lung cancer. miRNAs, NSCLC, qRT-PCR
266  2015 miR-15b/16-2 deletion promotes B-cell malignancies. CCND1, CCND2, miR
267  2015 MiR-30a suppresses non-small cell lung cancer progression through AKT signaling pathway by targeting IGF1R. NSCLC
268  2015 Mutational analysis of the insulin-like growth factor 1 receptor tyrosine kinase domain in non-small cell lung cancer patients. EGFR, NSCLC, SNPs, TK
269  2015 Phase I study of intermittent oral dosing of the insulin-like growth factor-1 and insulin receptors inhibitor OSI-906 in patients with advanced solid tumors. IR, MTD
270  2015 Prenatal physical activity and diet composition affect the expression of nutrient transporters and mTOR signaling molecules in the human placenta. AMPK, FATP4, GLUT1, IGF1, mTOR, PCR
271  2015 Proliferative and signaling activities of insulin analogues in endometrial cancer cells. INSR
272  2015 Quantitative phosphoproteomics analysis reveals a key role of insulin growth factor 1 receptor (IGF1R) tyrosine kinase in human sperm capacitation. ---
273  2015 Specific insulin/IGF1 hybrid receptor activation assay reveals IGF1 as a more potent ligand than insulin. IR
274  2015 Succinate dehydrogenase-deficient gastrointestinal stromal tumors. GISTs, PDGFRA, SDH, VEGFR, WT GISTs
275  2015 The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study. CMC, DFI, IHC, TN
276  2015 The insulin and IGF1 receptor kinase domains are functional dimers in the activated state. IR
277  2015 Trabectedin efficacy in Ewing sarcoma is greatly increased by combination with anti-IGF signaling agents. EWS
278  2015 Tumor suppressor role of miR-133a in gastric cancer by repressing IGF1R. GC, miR, qRT-PCR
279  2016 Activation of the IGF1R pathway potentially mediates acquired resistance to mutant-selective 3rd-generation EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer. IGFBP-3
280  2016 Anti-proliferative role and prognostic implication of miR-141 in gastric cancer. miR-141
281  2016 Deciphering Brain Insulin Receptor and Insulin-Like Growth Factor 1 Receptor Signalling. IR
282  2016 Divergence and polymorphism analysis of IGF1Ra and IGF1Rb from orange-spotted grouper, Epinephelus coioides (Hamilton). ---
283  2016 Endometrial Cancer Insulin-Like Growth Factor 1 Receptor (IGF1R) Expression Increases with Body Mass Index and Is Associated with Pathologic Extent and Prognosis. BMI, CI, DFS, EC, OS, pT
284  2016 Gene expression profiling of human bone marrow-derived mesenchymal stem cells during adipogenesis. HDAC1, hMSCs, MAPK, PI3KR1
285  2016 IGF1R Derived PI3K/AKT Signaling Maintains Growth in a Subset of Human T-Cell Acute Lymphoblastic Leukemias. IL-7, T-ALL
286  2016 Implications of Insulin-like Growth Factor 1 Receptor Activation in Lung Cancer. CSC, EMT, IGF1
287  2016 In vitro study comparing the efficacy of the water-soluble HSP90 inhibitors, 17-AEPGA and 17-DMAG, with that of the non‑water-soluble HSP90 inhibitor, 17-AAG, in breast cancer cell lines. 17-AAG, 17-DMAG, EGFR1, HER2, HSP
288  2016 Inhibition of IGF1R signaling abrogates resistance to afatinib (BIBW2992) in EGFR T790M mutant lung cancer cells. EGFR, NSCLC, TKIs
289  2016 InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma. INSR, PDX, RTKs
290  2016 Insulin-like growth factor 1 antagonizes lumbar disc degeneration through enhanced autophagy. LDD, PI3K
291  2016 Insulin-like growth factor 1 receptor (IGF1R) signaling regulates osterix expression and cartilage matrix mineralization during endochondral ossification. ---
292  2016 Insulin-Like Growth Factors Are Expressed in the Taste System, but Do Not Maintain Adult Taste Buds. ---
293  2016 Insulin-mediated signaling promotes proliferation and survival of glioblastoma through Akt activation. INSR
294  2016 Integrating network reconstruction with mechanistic modeling to predict cancer therapies. EGFR, IRS-1
295  2016 Lidocaine Impairs Proliferative and Biosynthetic Functions of Aged Human Dermal Fibroblasts. CI, HFB, IGF-1, TGF-beta1
296  2016 Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling. AIRAPL, IGF-1
297  2016 Low bone mineral density in patients with type 1 diabetes: association with reduced expression of IGF1, IGF1R and TGF B 1 in peripheral blood mononuclear cells. IGF1, T1D, TGFB1
298  2016 Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition. LOF
299  2016 MicroRNA-182 suppresses clear cell renal cell carcinoma migration and invasion by targeting IGF1R. ccRCC, miR, qRT-PCR, siRNA
300  2016 MicroRNA-223 affects IL-6 secretion in mast cells via the IGF1R/PI3K signaling pathway. IGF1, IL-6, miR-223, p-AKT, PI3K, RT-qPCR
301  2016 miR-139 is up-regulated in osteoarthritis and inhibits chondrocyte proliferation and migration possibly via suppressing EIF4G2 and IGF1R. EIF4G2, miRNAs, OA
302  2016 MiR-18b suppresses high-glucose-induced proliferation in HRECs by targeting IGF-1/IGF1R signaling pathways. DR, HRECs, IGF-1, miR-18b, miRNAs, VEGF
303  2016 miR-223 reverses the resistance of EGFR-TKIs through IGF1R/PI3K/Akt signaling pathway. EGFR, NSCLC, PI3K, TKIs
304  2016 miR-448 suppresses proliferation and invasion by regulating IGF1R in colorectal cancer cells. ANT, CRC, qRT-PCR, TNM
305  2016 miR-494 inhibits invasion and proliferation of gastric cancer by targeting IGF-1R. GC, qRT-PCR, UTR
306  2016 miR-494 suppresses tumor growth of epithelial ovarian carcinoma by targeting IGF1R. EOC, FIGO, miR-494, miRNAs
307  2016 Non-Small Cell Lung Cancer Cells Acquire Resistance to the ALK Inhibitor Alectinib by Activating Alternative Receptor Tyrosine Kinases. ALK, HER3, NSCLC, TKI
308  2016 Overexpression of Insulin-like Growth Factor-1 Receptor Is Associated With Penile Cancer Progression. PFS
309  2016 Regulation of Ligand and Shear Stress-induced Insulin-like Growth Factor 1 (IGF1) Signaling by the Integrin Pathway. FAK, IGF1, SRC
310  2016 Role of IGF1R(+) MSCs in modulating neuroplasticity via CXCR4 cross-interaction. FCS, hDSCs, hUCS, MSCs
311  2016 San Huang Shel Shin Tang beta-cyclodextrin complex augmented the hepatoprotective effects against carbon tetrachloride-induced acute hepatotoxicity in rats. beta-CD, SHSST, SHSSTc, TGF-beta
312  2016 Selection of reference genes in canine uterine tissues. RT-qPCR
313  2016 Sensitizing Triple-Negative Breast Cancer to PI3K Inhibition by Cotargeting IGF1R. TNBC
314  2016 The influence of insulin-like Growth Factor-1-Receptor expression and endocrine treatment on clinical outcome of postmenopausal hormone receptor positive breast cancer patients: A Dutch TEAM substudy analysis. BC, BCSS, CI, HR, OS, RFS
315  2016 TMPRSS2-ERG fusion protein regulates insulin-like growth factor-1 receptor (IGF1R) gene expression in prostate cancer: involvement of transcription factor Sp1. AP2M1, Cav-1
316  2016 Transcriptomic responses of marine medaka's ovary to hypoxia. FSH, LIF
317  2016 Tumor suppressor role of miR-217 in human epithelial ovarian cancer by targeting IGF1R. EOC, miR-217
318  2016 Two familial microduplications of 15q26.3 causing overgrowth and variable intellectual disability with normal copy number of IGF1R. ---
319  2016 uPAR enhances malignant potential of triple-negative breast cancer by directly interacting with uPA and IGF1R. ER, HER2, PR, TNBC, uPAS
320  2017 A Comparative Study on the WCRF International/University of Bristol Methodology for Systematic Reviews of Mechanisms Underpinning Exposure-Cancer Associations. WCRF
321  2017 A novel heterozygous IGF-1 receptor mutation associated with hypoglycemia. ---
322  2017 Adverse Events and Efficacy of Cixutumumab in Phase II Clinical Trials: A systematic Review and Meta-Analysis. CR, HR, PFS
323  2017 Association of IGF1 and IGF1R gene polymorphisms with high myopia in a Han Chinese population. IGF1, OR, SNPs
324  2017 Attenuated airway hyperresponsiveness and mucus secretion in HDM-exposed Igf1r-deficient mice. AHR, BALF, HDM
325  2017 Bioinformatics analysis to identify the critical genes, microRNAs and long noncoding RNAs in melanoma. DEGs, lncRNAs, miRNA, PPI, RT-PCR
326  2017 Carbonate apatite nanoparticles carry siRNA(s) targeting growth factor receptor genes egfr1 and erbb2 to regress mouse breast tumor. EGF, EGFR1, EGFR2, GFRs, NPs, siRNAs
327  2017 Characterization of the acute inflammatory profile and resolution of airway inflammation after Igf1r-gene targeting in a murine model of HDM-induced asthma. HDM
328  2017 Chromosome 15 structural abnormalities: effect on IGF1R gene expression and function. ---
329  2017 Co-targeting PI3K, mTOR, and IGF1R with small molecule inhibitors for treating undifferentiated pleomorphic sarcoma. Akt, UPSs
330  2017 Differential expression of microRNA let-7b-5p regulates burn-induced hyperglycemia. miRNAs, TBSA
331  2017 Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling. IGF1
332  2017 Distinct Afatinib Resistance Mechanisms Identified in Lung Adenocarcinoma Harboring an EGFR Mutation. IGFBP-3, NSCLC, TKI
333  2017 Downregulation of microRNA-100/microRNA-125b is associated with lymph node metastasis in early colorectal cancer with submucosal invasion. CRCs, miRNAs, mTOR, XIAP
334  2017 Epithelial IGF1R is dispensable for IGF2 mediated enhanced intestinal adaptation in retinoblastoma-deficient mice. IGF2, Rb, SBR
335  2017 Evidence that fibroblast growth factor 10 plays a role in follicle selection in cattle. CYP19A1, FGF, FSHR
336  2017 Exercise-induced modification of the skeletal muscle transcriptome in Arabian horses. DEGs, EGF, HGF, INSR, VEGF-B
337  2017 Expanding the clinical spectrum of chromosome 15q26 terminal deletions associated with IGF-1 resistance. IGF-1
338  2017 Expression and purification of functional insulin and insulin-like growth factor 1 holoreceptors from mammalian cells. IR, RTKs
339  2017 Expression of GRK2 and IGF1R in hepatocellular carcinoma: clinicopathological and prognostic significance. GRK2, HCC
340  2017 Expressions of insulin-like growth factor receptor-1 and cezanne-1 in lung adenocarcinoma. IHC
341  2017 Formation of the IGF1R/CAV1/SRC tri-complex antagonizes TRAIL-induced apoptosis in gastric cancer cells. Cav-1, TRAIL
342  2017 Global transcriptomic analysis of induced cardiomyocytes predicts novel regulators for direct cardiac reprogramming. ACMs, CaMK, CFs, CMs, iCMs, MEF2A, PKD1, PPARGC1A, PRKA, PRKC, TFs
343  2017 HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor. HASF
344  2017 Hsa_circ_0045714 regulates chondrocyte proliferation, apoptosis and extracellular matrix synthesis by promoting the expression of miR-193b target gene IGF1R. circRNA, OA
345  2017 Identification of BRCA1 As a Potential Biomarker for Insulin-Like Growth Factor-1 Receptor Targeted Therapy in Breast Cancer. ---
346  2017 IGF1R deficiency attenuates acute inflammatory response in a bleomycin-induced lung injury mouse model. ---
347  2017 IGF1R depletion facilitates MET-amplification as mechanism of acquired resistance to erlotinib in HCC827 NSCLC cells. EMT
348  2017 IGF1R Expression in Ovarian Granulosa Cells Is Essential for Steroidogenesis, Follicle Survival, and Fertility in Female Mice. FSH, GCs
349  2017 IGF1R Protein Expression Is Not Associated with Differential Benefit to Concurrent Trastuzumab in Early-Stage HER2+ Breast Cancer from the North Central Cancer Treatment Group (Alliance) Adjuvant Trastuzumab Trial N9831. DFS, WS
350  2017 Improved decision making for prioritizing tumor targeting antibodies in human xenografts: Utility of fluorescence imaging to verify tumor target expression, antibody binding and optimization of dosage and application schedule. HER
351  2017 Inhibition of PI3K/Akt/mTOR overcomes cisplatin resistance in the triple negative breast cancer cell line HCC38. EGFR, mTOR, PI3K, TNBC
352  2017 Insulin-like Growth Factor 1 Receptor Expression in Advanced Non-small-cell Lung Cancer and its Impact on Overall Survival. IHC, NSCLC, OS, SCC, T2DM
353  2017 Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury. ---
354  2017 Insulin-like growth factor 2 axis supports the serum-independent growth of malignant rhabdoid tumor and is activated by microenvironment stress. IGF2, INSR, MRTs
355  2017 Mechanisms of Resistance to NTRK Inhibitors and Therapeutic Strategies in NTRK1-Rearranged Cancers. NTRK1, TKI
356  2017 MicroRNA-30a Inhibits Colorectal Cancer Metastasis Through Down-Regulation of Type I Insulin-Like Growth Factor Receptor. ---
357  2017 MiR-122 modification enhances the therapeutic efficacy of adipose tissue-derived mesenchymal stem cells against liver fibrosis. CCNG1, HSCs, MSC, P4HA1
358  2017 miR-15b Inhibits the Progression of Glioblastoma Cells Through Targeting Insulin-like Growth Factor Receptor 1. miRNAs
359  2017 miR-182 selectively targets HOXA10 in goat endometrial epithelium cells in vitro. COX-2, ERa, gEECs, OPN, PRB, PRLR, PTN, VEGF
360  2017 miR-29a-3p suppresses cell proliferation and migration by downregulating IGF1R in hepatocellular carcinoma. HCC, miRNAs
361  2017 miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy. ---
362  2017 MiR-99a suppresses proliferation, migration and invasion of esophageal squamous cell carcinoma cells through inhibiting the IGF1R signaling pathway. CCK-8, EMT, ESCC, GEO
363  2017 Muscle RAS oncogene homolog (MRAS) recurrent mutation in Borrmann type IV gastric cancer. MRAS, Type IV
364  2017 Novel Hsp90 inhibitor platycodin D disrupts Hsp90/Cdc37 complex and enhances the anticancer effect of mTOR inhibitor. Cdc37, EGFR, Hsp90, PD
365  2017 Nuclear insulin-like growth factor-1 receptor (IGF1R) displays proliferative and regulatory activities in non-malignant cells. ---
366  2017 Oncomirs Expression Profiling in Uterine Leiomyosarcoma Cells. EGFR, miRNAs, MM, ULM, ULMS, VEGF-A
367  2017 PAPP-A2 a new key regulator of growth. ALS, GH/IGF, IGF1, PAPP-A, PAPP-A2
368  2017 Regulation of insulin-like growth factor receptors by Ubiquilin1. INSR, UBQLN1
369  2017 Relation of the IGF/IGF1R system to autophagy in colitis and colorectal cancer. MetS
370  2017 Role of Insulin-like Growth Factor, Insulin-like Growth Factor Receptors, and Insulin-like Growth Factor-binding Proteins in Ovarian Cancer. EOC, IGFBPs, IGFs, OC
371  2017 Sensitivity of non-small cell lung cancer to erlotinib is regulated by the Notch/miR-223/FBXW7 pathway. EGFR-TKIs, FBXW7, miR-223, NSCLC
372  2017 Simultaneous inhibition of IGF1R and EGFR enhances the efficacy of standard treatment for colorectal cancer by the impairment of DNA repair and the induction of cell death. 5-FU, CRC, DSBs, EGFR, RCT, RTKs
373  2017 Snail-Modulated MicroRNA 493 Forms a Negative Feedback Loop with the Insulin-Like Growth Factor 1 Receptor Pathway and Blocks Tumorigenesis. IRS-1, MAPK1, miR-493, UTR
374  2017 Strong association of insulin-like growth factor 1 receptor expression with histologic grade, subtype, and HPV status in penile squamous cell carcinomas: a tissue microarray study of 112 cases. HPV, SCC
375  2017 Targeted Therapies Against Growth Factor Signaling in Breast Cancer. EGFR, FGFR, TGF-beta
376  2017 The Alzheimer's disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons. ---
377  2017 The crucial role of SRPK1 in IGF-1-induced EMT of human gastric cancer. GC, SRPK1
378  2017 The role of H19, a long non-coding RNA, in mouse liver postnatal maturation. IGF2, miR-675
379  2017 Up-regulation of miR-497 confers resistance to temozolomide in human glioma cells by targeting mTOR/Bcl-2. IRS-1, mTOR, TMZ
380  2017 Zanthoxylum alkylamides ameliorate protein metabolism disorder in STZ-induced diabetic rats. ALB, InR, STZ, TP
381  2018 Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis. IR, KRAS, NSCLC
382  2018 Activated receptor tyrosine kinases in granulosa cells of ovulating follicles in mice. eCG, EPHB1, FGF-2, FGFR2, hCG, LH, RTKs
383  2018 Analysis of genetic polymorphisms associated with intervertebral disc degeneration. IVDD, MMP2, VDR
384  2018 Anthricin‑induced caspase‑dependent apoptosis through IGF1R/PI3K/AKT pathway inhibition in A549 human non‑small lung cancer cells. ---
385  2018 Antitumor effects of beta-elemene via targeting the phosphorylation of insulin receptor. ESFTs, IR
386  2018 Characterization of an activating R1353H insulin-like growth factor 1 receptor variant in a male with extreme tall height. AR
387  2018 Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis. MS, TGFBR1, Treg
388  2018 Circulating microRNA-99 family as liquid biopsy marker in pancreatic adenocarcinoma. PDAC, ROC
389  2018 CKS1BP7, a Pseudogene of CKS1B, is Co-Amplified with IGF1R in Breast Cancers. CKS1B, CKS1BP7, CNAs, DCIS, QM-FISH
390  2018 Coffee Is Associated With Lower Breast Tumor Insulin-Like Growth Factor Receptor 1 Levels in Normal-Weight Patients and Improved Prognosis Following Tamoxifen or Radiotherapy Treatment. BMI, HR
391  2018 Controlled dimerization of insulin-like growth factor-1 and insulin receptors reveals shared and distinct activities of holo and hybrid receptors. HybRs, INSR
392  2018 Effect of acute stressors, adrenocorticotropic hormone administration, and cortisol release on milk yield, the expression of key genes, proliferation, and apoptosis in goat mammary epithelial cells. ACTH, GHR, IGF1
393  2018 Evidence for Compromised Insulin Signaling and Neuronal Vulnerability in Experimental Model of Sporadic Alzheimer's Disease. APP, i.c.v, IGF2, IR, IRS2, p-GSK3betaser9, SAD, STZ, t-GSK3beta
394  2018 Function of insulin-like growth factor 1 receptor in cancer resistance to chemotherapy. ---
395  2018 Genome-Wide Analyses Identify Filamin-A As a Novel Downstream Target for Insulin and IGF1 Action. FLNA
396  2018 Genomewide DNA Methylation Responses in Patients with beta-Thalassemia Treated with Yisui Shengxue Granules (). Hb, JAK3, MAPK10, RBCs, RET
397  2018 Identification and functional analysis of a novel G310D variant in the insulin-like growth factor 1 receptor (IGF1R) gene associated with type 2 diabetes in American Indians. OR, T2D
398  2018 Identifying Involvement of H19-miR-675-3p-IGF1R and H19-miR-200a-PDCD4 in Treating Pulmonary Hypertension with Melatonin. LV, MCT, PAH, PDCD4, RV, sPAP
399  2018 IDH1R132H Promotes Malignant Transformation of Benign Prostatic Epithelium by Dysregulating MicroRNAs: Involvement of IGF1R-AKT/STAT3 Signaling Pathway. IDH, PCa
400  2018 IGF1R signaling drives antiestrogen resistance through PAK2/PIX activation in luminal breast cancer. ---
401  2018 IGF1R signalling in testicular germ cell tumour cells impacts on cell survival and acquired cisplatin resistance. TGCTs
402  2018 IGF1R upregulation confers resistance to isoform-specific inhibitors of PI3K in PIK3CA-driven ovarian cancer. GA, OC, PI3K
403  2018 Inflammation in the hippocampus affects IGF1 receptor signaling and contributes to neurological sequelae in rheumatoid arthritis. IRS-1, RA
404  2018 Inhibition of insulin-like growth factor 1 receptor enhances the efficacy of sorafenib in inhibiting hepatocellular carcinoma cell growth and survival. HCC, VEGFR
405  2018 Insulin induces an EMT-like process in mammary epithelial cells MCF10A. EMT
406  2018 Insulin-like growth factor 1 receptor signaling regulates embryonic epicardial cell proliferation through focal adhesion kinase pathway. EPCs
407  2018 Insulin-like growth factor 1 receptor stabilizes the ETV6-NTRK3 chimeric oncoprotein by blocking its KPC1/Rnf123-mediated proteasomal degradation. ETV6, INSR, SILAC
408  2018 IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma. IR, IRS2, PILC
409  2018 Let-7c inhibits migration and epithelial-mesenchymal transition in head and neck squamous cell carcinoma by targeting IGF1R and HMGA2. EMT, HMGA2, HNSCC
410  2018 Lnc-SNHG1 may promote the progression of non-small cell lung cancer by acting as a sponge of miR-497. NSCLC
411  2018 Long noncoding RNA PVT1 enhances the viability and invasion of papillary thyroid carcinoma cells by functioning as ceRNA of microRNA-30a through mediating expression of insulin like growth factor 1 receptor. EMT, miR-30a, PTC
412  2018 Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons. IGF1, LUHMES
413  2018 MicroRNA-495 suppresses cell proliferation and invasion of hepatocellular carcinoma by directly targeting insulin-like growth factor receptor-1. HCC, TNM
414  2018 MicroRNA-Dependent Regulation of IGF1R Gene Expression in Hormone-Sensitive and Hormone-Resistant Prostate Cancer Cells. ---
415  2018 miR-100 inhibits the migration and invasion of nasopharyngeal carcinoma by targeting IGF1R. NPC, RT-qPCR
416  2018 MiR-30a-5p confers cisplatin resistance by regulating IGF1R expression in melanoma cells. miRNAs
417  2018 miRNA-376c-3p Mediates TWIST-1 Inhibition of Bone Marrow-Derived Stromal Cell Osteogenesis and Can Reduce Aberrant Bone Formation of TWIST-1 Haploinsufficient Calvarial Cells. ALP, BMSC, miRNAs, TWIST1
418  2018 Modulation of IGF1R Signaling Pathway by GIGYF1 in High Glucose-Induced SHSY-5Y Cells. AKT, ERK
419  2018 Nuclear translocation of IGF1R by intracellular amphiregulin contributes to the resistance of lung tumour cells to EGFR-TKI. EGFR-TKI
420  2018 Oncogenic fusion proteins adopt the insulin-like growth factor signaling pathway. ---
421  2018 POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer. SCLC, TF
422  2018 Protegrin 1 Enhances Innate Cellular Defense via the Insulin-Like Growth Factor 1 Receptor Pathway. AMPs
423  2018 Role of Insulin-like Growth Factor 1 Receptor Signaling in Stem Cell Stemness and Therapeutic Efficacy. ---
424  2018 Role of RBP2-Induced ER and IGF1R-ErbB Signaling in Tamoxifen Resistance in Breast Cancer. ER, RBP2, SRB
425  2018 RUNX1 promotes cell growth in human T-cell acute lymphoblastic leukemia by transcriptional regulation of key target genes. T-ALL
426  2018 SM22alpha (Smooth Muscle Protein 22-alpha) Promoter-Driven IGF1R (Insulin-Like Growth Factor 1 Receptor) Deficiency Promotes Atherosclerosis. IGF-1, SMC
427  2018 Suppression of cleavage factor Im 25 promotes the proliferation of lung cancer cells through alternative polyadenylation. APA, CCND1, CFIm25, dPAS, NSCLC
428  2018 Tanshinone IIA can inhibit MiaPaCa‑2 human pancreatic cancer cells by dual blockade of the Ras/Raf/MEK/ERK and PI3K/AKT/mTOR pathways. EGFR, ERK, MEK, mTOR, PI3K, PTEN, VEGFR
429  2018 Targeted Therapy-based Combination Treatment in Rhabdomyosarcoma. ERMS
430  2018 Tescalcin/c-Src/IGF1Rbeta-mediated STAT3 activation enhances cancer stemness and radioresistant properties through ALDH1. CSC, EMT, NSCLC, STAT3, TESC
431  2018 TGFbeta and IGF1R signaling activates protein kinase A through differential regulation of ezrin phosphorylation in colon cancer cells. CRC, PKA, TGF
432  2018 The association of diabetes mellitus and insulin treatment with expression of insulin-related proteins in breast tumors. INSR
433  2018 The Long Noncoding RNA 150Rik Promotes Mesangial Cell Proliferation via miR-451/IGF1R/p38 MAPK Signaling in Diabetic Nephropathy. Ago2, DN, EdU, lncRNAs, MCs, miR-451, RIP
434  2018 The proximity-labeling technique BioID identifies sorting nexin 6 as a member of the insulin-like growth factor 1 (IGF1)-IGF1 receptor pathway. IGF1, IRS-1, SHC1, SNX6
435  2018 The Role for Exosomal microRNAs in Disruption of Regulatory T Cell Homeostasis in Multiple Sclerosis. MS, TGFBR1
436  2018 Understanding the mechanism of bias signaling of the insulin-like growth factor 1 receptor: Effects of LL37 and HASF. ---
437  2018 Up-regulation of INSR/IGF1R by C-myc promotes TSCC tumorigenesis and metastasis through the NF-kappaB pathway. INSR, TSCC
438  2018 Upregulation of IGF1 by tumor-associated macrophages promotes the proliferation and migration of epithelial ovarian cancer cells. CM, EOC, IGF1, OC, TAMs
439  2019 A multi-targeted probe-based strategy to identify signaling vulnerabilities in cancers. INSR, NSCLC
440  2019 Benzyl isothiocyanate suppresses IGF1R, FGFR3 and mTOR expression by upregulation of miR-99a-5p in human bladder cancer cells. BC, BITC, FGFR3, mTOR, qPCR, RT
441  2019 beta-Pentagalloyl-Glucose Sabotages Pancreatic Cancer Cells and Ameliorates Cachexia in Tumor-Bearing Mice. HIF-1, IR
442  2019 Calycosin stimulates the osteogenic differentiation of rat calvarial osteoblasts by activating the IGF1R/PI3K/Akt signaling pathway. ALP, ALPL, BMP2, ROBs
443  2019 Cancer Vaccines Co-Targeting HER2/Neu and IGF1R. HER2, RTKs
444  2019 CuS Nanoparticles as a Photodynamic Nanoswitch for Abrogating Bypass Signaling To Overcome Gefitinib Resistance. NPs, ROS
445  2019 Decreased Amino Acid Concentrations are Involved in Congenital Heart Disease. AAs, AF, CHD
446  2019 Expression of PAPP-A2 and IGF Pathway-Related Proteins in the Hip Joint of Normal Rat and Those with Developmental Dysplasia of the Hip. DDH, IGF, IGFBP-5, PAPP-A2
447  2019 Ginsenoside F1 promotes angiogenesis by activating the IGF-1/IGF1R pathway. CAM, GF1, IGF-1, MCAO, MVD
448  2019 High Glucose Concentrations Negatively Regulate the IGF1R/Src/ERK Axis through the MicroRNA-9 in Colorectal Cancer. CRC, EMT, HG, miR-9
449  2019 Identification of Differentially Expressed Genes and Long Noncoding RNAs Associated with Parkinson's Disease. ceRNA, DEGs, DElncRNAs, GO, lncRNAs, PD
450  2019 Identification of nucleolar protein NOM1 as a novel nuclear IGF1R-interacting protein. MIF4G
451  2019 IGF1R as druggable target mediating PI3K-delta inhibitor resistance in a murine model of chronic lymphocytic leukemia. FOXO1, GSK3B
452  2019 Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis. ---
453  2019 Improvement of growth performance and parameters of intestinal function in liquid fed early weanling pigs. ATTD, CLDN2, ZO-1, ZO-2
454  2019 Insulin-like growth factor-1 receptor expression in upper tract urothelial carcinoma. CI, HR, TMAs, UTUC
455  2019 Knockdown of PSMC3IP suppresses the proliferation and xenografted tumorigenesis of hepatocellular carcinoma cell. eIF4E, HCC, PSMC3IP
456  2019 Let-7b acts as a tumor suppressor in osteosarcoma via targeting IGF1R. OS
457  2019 MicroRNA‑98 suppresses cell growth and invasion of retinoblastoma via targeting the IGF1R/k‑Ras/Raf/MEK/ERK signaling pathway. miRNAs, Rb
458  2019 Persistent endocrine-disrupting chemicals found in human follicular fluid stimulate the proliferation of granulosa tumor spheroids via GPR30 and IGF1R but not via the classic estrogen receptors. ESR1, ESR2, GCT, HCB, PCB153, PFOA, PFOS
459  2019 Phase II Study of Everolimus and Octreotide LAR in Patients with Nonfunctioning Gastrointestinal Neuroendocrine Tumors: The GETNE1003_EVERLAR Study. AEs, CI, GI-NETs, mTOR, NETs, ORR, OS, PFS, pS6, SSAs
460  2019 Possible mechanisms of prenatal cold stress induced-anxiety-like behavior depression in offspring rats. BDNF, CRHR1, DA, GABAB2, GFAP, GR, HPA, MR, NE, NeuN
461  2019 Role of miR-16-5p in the proliferation and metastasis of hepatocellular carcinoma. EMT, HCC, qRT-PCR, WB
462  2019 Sterol structure dependence of insulin receptor and insulin-like growth factor 1 receptor activation. IR
463  2019 Survivin in Insulin-Like Growth Factor-Induced Resistance to Lapatinib in Head and Neck Squamous Carcinoma Cells. EGFR, HNSCC, TKIs
464  2019 Targeting the insulin-like growth factor-1 receptor in MTAP-deficient renal cell carcinoma. MTA, MTAP, RCC
465  2019 Two prostate cancer‑associated polymorphisms in the 3'UTR of IGF1R influences prostate cancer susceptibility by affecting miRNA binding. mi, PCa, SNPs