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Abbreviation: 6-OHDA
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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
oxidative stress induced by 6-hydroxydopamine
(14 times)
Neurology
(4 times)
PD (6 times)
GPx (2 times)
MDA (2 times)
2002 Effects of (-)-nicotine and (-)-cotinine on 6-hydroxydopamine-induced oxidative stress and neurotoxicity: relevance for Parkinson's disease.
observed in 6-hydroxydopamine
(13 times)
Neurology
(6 times)
PD (5 times)
DA (4 times)
LC (2 times)
1981 Evidence for an interaction of opioid and noradrenergic locus coeruleus systems in the regulation of environmental stimulus-directed behavior.
6-OH-dopamine
(12 times)
Neurology
(4 times)
ACh (2 times)
NA (2 times)
PD (2 times)
1976 On spinal noradrenaline receptor supersensitivity: correlation between nerve terminal densities and flexor reflexes various times after intracisternal 6-hydroxydopamine.
neurotoxin, 6-hydroxy dopamine
(9 times)
Neurology
(5 times)
DA (2 times)
PD (2 times)
PKD1 (2 times)
1988 Dopamine and serotonin in cat retina: electroretinography and histology.
H2O2- or 6-hydroxydopamine
(4 times)
Neurology
(1 time)
HO (1 time)
Hon (1 time)
NQO1 (1 time)
2006 Ondamtanggamibang protects neurons from oxidative stress with induction of heme oxygenase-1.
oxidative neurotoxin 6-hydroxydopamine
(4 times)
Pharmacology
(2 times)
DA (2 times)
PD (2 times)
FGF (1 time)
2006 Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease.
Oertel 6-hydroxydopamine
(3 times)
Science
(1 time)
CMV (1 time)
DAT (1 time)
GI (1 time)
1997 Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats.
operation with 6-hydroxydopamine
(3 times)
Pharmacology
(1 time)
ACh (1 time)
Ang II (1 time)
BW (1 time)
1978 Prevention of compensatory ovarian hypertrophy by local treatment of the ovary with 6-OHDA.
oral activity in neonatal 6-hydroxydopamine
(2 times)
Neurology
(1 time)
DA (2 times)
DOPAC (1 time)
HVA (1 time)
1992 Supersensitization of the oral response to SKF 38393 in neonatal 6-OHDA-lesioned rats is mediated through a serotonin system.
10  other cats 6-hydroxydopamine
(2 times)
Pharmacology
(1 time)
AR (1 time)
BP (1 time)
GFAP (1 time)
1987 Protection of CGS 10078B against ouabain-induced arrhythmia in the cat.
11  out with either 6-hydroxydopamine
(2 times)
Brain
(2 times)
5,6-DHT (1 time)
alpha-MPT (1 time)
DMI (1 time)
1981 Effect of manipulating central catecholamines on puberty and the surge of luteinizing hormone and gonadotropin releasing hormone induced by pregnant mare serum gonadotropin in female rats.
12  toxin 6-hydroxy dopamine
(2 times)
Neurology
(2 times)
DA (1 time)
GFP (1 time)
KA (1 time)
2006 A method for a more complete in vitro Parkinson's model: slice culture bioassay for modeling maintenance and repair of the nigrostriatal circuit.
13  (5-HT) or with 6-hydroxydopamine
(1 time)
Pharmacology
(1 time)
5-HT (1 time)
NA (1 time)
1979 Alcohol intake, ethanol-induced narcosis and intoxication in rats following neonatal 6-hydroxydopamine or 5, 7-dihydroxytryptamine treatment.
14  14-month-old rats pretreated with either 6-hydroxydopamine
(1 time)
Geriatrics
(1 time)
NTS (1 time)
1993 Age-related reduction of reflex bradycardia in conscious rats by catecholaminergic nucleus tractus solitarius lesions.
15  17beta-oestradiol in defending dopaminergic neurones against 6-hydroxydopamine
(1 time)
Endocrinology
(1 time)
GDNF (1 time)
PD (1 time)
SN (1 time)
2012 GDNF contributes to oestrogen-mediated protection of midbrain dopaminergic neurones.
16  8-OH-DPAT were attenuated by i.v. and intra-adrenal treatment with 6-hydroxydopamine
(1 time)
Drug Therapy
(1 time)
8-OH-DPAT (1 time)
1994 Central stimulation of adrenocortical secretion by 5-hydroxytryptamine1A agonists is mediated by sympathomedullary activation.
17  anti-oxidative properties in 6-hydroxydopamine
(1 time)
Neurosciences
(1 time)
DCFH-DA (1 time)
GCLM (1 time)
HO-1 (1 time)
2018 Simvastatin Inhibits Activation of NADPH Oxidase/p38 MAPK Pathway and Enhances Expression of Antioxidant Protein in Parkinson Disease Models.
18  control, 6-hydroxy-dopamine
(1 time)
Pharmacology
(1 time)
CAR (1 time)
1979 Effects of pretreatment with 6-hydroxydopamine or noradrenergic receptor blockers on the clonidine-induced distruption of conditioned avoidance responding.
19  hemisphere or bilateral intrastriatal 6-hydroxydopamine
(1 time)
Neurology
(1 time)
ICMS (1 time)
SNc (1 time)
2009 Neocortical movement representations are reduced and reorganized following bilateral intrastriatal 6-hydroxydopamine infusion and dopamine type-2 receptor antagonism.
20  hemispheres of unilaterally 6-hydroxydopamine
(1 time)
Chemistry Techniques, Analytical
(1 time)
Dyn A (1 time)
2005 Altered extracellular striatal in vivo biotransformation of the opioid neuropeptide dynorphin A(1-17) in the unilateral 6-OHDA rat model of Parkinson's disease.
21  HIPP of sham-lesioned and 6-hydroxydopamine
(1 time)
Neurology
(1 time)
HIPP (1 time)
l-DOPA (1 time)
PD (1 time)
2010 High-frequency stimulation of the subthalamic nucleus and L-3,4-dihydroxyphenylalanine inhibit in vivo serotonin release in the prefrontal cortex and hippocampus in a rat model of Parkinson's disease.
22  hippocampus of 6-hydroxydopamine
(1 time)
Neurology
(1 time)
PD (1 time)
VGSCs (1 time)
2019 Voltage-Gated Sodium Channels Are Involved in Cognitive Impairments in Parkinson's Disease- like Rats.
23  homogenates of control and 6-hydroxydopamine
(1 time)
Biochemistry
(1 time)
DHA (1 time)
NE (1 time)
QNB (1 time)
1982 Characterization of postsynaptic beta-adrenergic receptors and presynaptic muscarinic cholinergic receptors in the rat spleen.
24  hyperlocomotion of neonatal 6-hydroxydopamine
(1 time)
Brain
(1 time)
ADHD (1 time)
DA (1 time)
1994 Proposed animal model of attention deficit hyperactivity disorder.
25  hyperoside on 6-hydroxydopamine
(1 time)
Chemistry
(1 time)
HO-1 (1 time)
Nrf2 (1 time)
ROS (1 time)
2019 Suppression of 6-Hydroxydopamine-Induced Oxidative Stress by Hyperoside Via Activation of Nrf2/HO-1 Signaling in Dopaminergic Neurons.
26  metabolic homeostasis due to 6-hydroxydopamine
(1 time)
Neurosciences
(1 time)
GC (1 time)
PD (1 time)
2018 Glucose Homeostasis Is Not Affected in a Murine Model of Parkinson's Disease Induced by 6-OHDA.
27  neonatal 6-hydroxy-dopamine
(1 time)
Neurology
(1 time)
ADHD (1 time)
2011 Caffeine improves attention deficit in neonatal 6-OHDA lesioned rats, an animal model of attention deficit hyperactivity disorder (ADHD).
28  neurons had degenerated following an intranigral injection of 6-hydroxydopamine
(1 time)
Pharmacology
(1 time)
CDP (1 time)
DA (1 time)
1981 Effects of CDP-choline on striatal dopamine level and behavior in rats.
29  observed after PC12 cell-containing capsules were implanted into unilaterally 6-hydroxydopamine
(1 time)
Cell Biology
(1 time)
CNS (1 time)
DA (1 time)
1992 Polymer-encapsulated PC12 cells: long-term survival and associated reduction in lesion-induced rotational behavior.
30  observed autophagic vacuoles and lysosomes were accumulated in the 6-hydroxydopamine
(1 time)
Neurology
(1 time)
3-MA (1 time)
PD (1 time)
2011 Parkinson's disease involves autophagy and abnormal distribution of cathepsin L.
31  observed in animals unilaterally infused with 6-hydroxydopamine
(1 time)
Behavioral Sciences
(1 time)
--- 2007 Unilateral implantation of dopamine-loaded biodegradable hydrogel in the striatum attenuates motor abnormalities in the 6-hydroxydopamine model of hemi-parkinsonism.
32  observed in maternal rats following dopamine-depleting 6-hydroxydopamine
(1 time)
Behavioral Sciences
(1 time)
--- 1994 Maternal behavior of female rats with 6-OHDA lesions in the ventral striatum: characterization of the pup retrieval deficit.
33  observed in neonatal rats given 6-hydroxydopamine
(1 time)
Brain
(1 time)
5-HIAA (1 time)
DBH (1 time)
NE (1 time)
1994 Heterotypic sprouting of serotonergic forebrain fibers in the brindled mottled mutant mouse.
34  observed in previous studies that 6-hydroxydopamine
(1 time)
Neurology
(1 time)
IR (2 times)
DA (1 time)
TH (1 time)
2009 Involvement of astroglial fibroblast growth factor-2 and microglia in the nigral 6-OHDA parkinsonism and a possible role of glucocorticoid hormone on the glial mediated local trophism and wound repair.
35  observed in the rats with additional 6-hydroxydopamine
(1 time)
Psychopharmacology
(1 time)
5-MeODMT (1 time)
alpha-MT (1 time)
DRN (1 time)
1982 Possible mechanism of 5-methoxy-N,N-dimethyltryptamine-induced turning behaviour in DRN lesioned rats.
36  observed in the SNC following treatment with the neurotoxin 6-hydroxydopamine
(1 time)
Neurology
(1 time)
CB (1 time)
CR (1 time)
DAergic (1 time)
2001 GFRalpha-1 mRNA in dopaminergic and nondopaminergic neurons in the substantia nigra and ventral tegmental area.
37  observed with and without pretreatment by 6-hydroxydopamine
(1 time)
Occupational Medicine
(1 time)
DA (1 time)
DBH (1 time)
NE (1 time)
1985 [The response of monoamines in the rat brain to local vibration exposure].
38  obtained from animals given 6-hydroxydopamine
(1 time)
Brain
(1 time)
LTP (1 time)
TRH (1 time)
1991 Effects of thyrotropin-releasing hormone and a related analog, CNK-602A, on long-term potentiation in the mossy fiber-CA3 pathway of guinea pig hippocampal slices.
39  obtained ipsilateral and contralateral to 6-hydroxydopamine
(1 time)
Neurology
(1 time)
--- 1993 Electrophysiological characterization of rat striatal neurons in vitro following a unilateral lesion of dopamine cells.
40  obtained with benextramine in femoral arteries acutely denervated with 6-hydroxydopamine
(1 time)
Cardiology
(1 time)
CRC (1 time)
1996 Serotonin-induced vasoconstriction in rabbit femoral artery: mediation by both 5-HT2 serotonergic and alpha 1-adrenoceptors.
41  obtained with intraventricular 6-hydroxydopamine
(1 time)
Psychopharmacology
(1 time)
DA (1 time)
1976 Decreased intracranial self-stimulation after neuroleptics or 6-hydroxydopamine: evidence for mediation by motor deficits rather than by reduced reward.
42  occlusal disharmony in rats injected with 6-hydroxydopamine
(1 time)
Neurology
(1 time)
CRH (1 time)
HPA (1 time)
NA (1 time)
2011 Lesions of the ventral ascending noradrenergic bundles decrease the stress response to occlusal disharmony in rats.
43  occurred in a concentration-dependent manner after exposure to 6-hydroxydopamine
(1 time)
Neurology
(1 time)
--- 2008 Rapid activation of ERK by 6-hydroxydopamine promotes survival of dopaminergic cells.
44  occurred in chronic ANH rats following chemical sympathectomy with 6-hydroxydopamine
(1 time)
Neurology
(1 time)
ANH (1 time)
MDH (1 time)
NA (1 time)
1991 Adjacent neuropathic hyperalgesia in rats: a model for sympathetic independent pain.
45  OECs to the neurotoxin 6-hydroxydopamine
(1 time)
Cell Biology
(1 time)
CNS (1 time)
GFs (1 time)
OECs (1 time)
2016 Phenotypic Modulation and Neuroprotective Effects of Olfactory Ensheathing Cells: a Promising Tool for Cell Therapy.
46  officinalis, for alleviating the motor deficits induced by 6-hydroxydopamine
(1 time)
Neurology
(1 time)
PD (1 time)
TH (1 time)
2011 Protective and restorative effects of magnolol on neurotoxicity in mice with 6-hydroxydopamine-induced hemiparkinsonism.
47  oil for 50 days and subjected to unilateral intrastriatal 6-hydroxydopamine
(1 time)
Neurology
(1 time)
iNOS (1 time)
NO (1 time)
PD (1 time)
2018 Neuroprotective effect of omega-3 polyunsaturated fatty acids in the 6-OHDA model of Parkinson's disease is mediated by a reduction of inducible nitric oxide synthase.
48  olfactory bulb, both in healthy and in a 6-hydroxydopamine
(1 time)
Pharmacology
(1 time)
miR-124 (1 time)
NPs (1 time)
PD (1 time)
2016 MicroRNA-124 loaded nanoparticles enhance brain repair in Parkinson's disease.
49  olfactory tubercle had been produced by 6-hydroxydopamine
(1 time)
Neurology
(1 time)
3MT-HVA (1 time)
DA (1 time)
1990 Acetorphan, an Enkephalinase Inhibitor, Modulates Dopaminergic Transmission in Rat Olfactory Tubercle, but not in the Nucleus Accumbens and Striatum.
50  oligos ameliorated the motor symptoms in the 6-hydroxydopamine
(1 time)
Cell Biology
(1 time)
NR1 (1 time)
NR2B (1 time)
PD (1 time)
2013 Small interfering RNA specific for N-methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase.
51  Once stable responding was achieved with this schedule, bilateral 6-hydroxydopamine
(1 time)
Psychopharmacology
(1 time)
BP (1 time)
DA (1 time)
DOPAC (1 time)
1996 Effect of 6-hydroxydopamine lesions of the medial prefrontal cortex on intravenous cocaine self-administration under a progressive ratio schedule of reinforcement.
52  one day following treatment with 6-hydroxydopamine
(1 time)
Behavioral Sciences
(1 time)
--- 1984 Sympathetic control of sexual reflexes: peripheral 6-hydroxydopamine administration facilitates the onset of penile reflexes in male rats.
53  one given lesioning with 6-hydroxydopamine
(1 time)
General Surgery
(1 time)
ABC (1 time)
ANS (1 time)
CNS (1 time)
1998 Asymmetry of sympathetic activity in a rat model of Parkinson's disease induced by 6-hydroxydopamine: haemodynamic, electrocardiographic and biochemical changes.
54  one procedure, rats were stereotaxically injected with 6-hydroxydopamine
(1 time)
Brain
(1 time)
NADPH-d (1 time)
NO (1 time)
NOS (1 time)
2003 Effects of electrolytic and 6-hydroxydopamine lesions of rat nigrostriatal pathway on nitric oxide synthase and nicotinamide adenine dinucleotide phosphate diaphorase.
55  One such factor is 6-hydroxydopamine
(1 time)
Metabolism
(1 time)
PD (1 time)
2007 Cell stress induced by the parkinsonian mimetic, 6-hydroxydopamine, is concurrent with oxidation of the chaperone, ERp57, and aggresome formation.
56  one such input - the superior colliculus - in 6-hydroxydopamine
(1 time)
Neurology
(1 time)
--- 2013 Enhanced visual responses in the superior colliculus and subthalamic nucleus in an animal model of Parkinson's disease.
57  one suprasylvian cortex to 6-hydroxydopamine
(1 time)
Brain
(1 time)
HPLC (1 time)
1985 Visual discrimination learning and interhemispheric transfer in the cat, as affected by 6-hydroxydopamine.
58  One week following gene delivery, the neurotoxin 6-hydroxydopamine
(1 time)
Pharmacology
(1 time)
DA (1 time)
GDNF (1 time)
SN (1 time)
2001 Adenoviral vector-mediated delivery of glial cell line-derived neurotrophic factor provides neuroprotection in the aged parkinsonian rat.
59  One week following two bilateral 6-hydroxydopamine
(1 time)
Brain
(1 time)
DA (1 time)
mPFC (1 time)
NAc (1 time)
1999 Dopamine depletion in the medial prefrontal cortex induces sensitized-like behavioral and neurochemical responses to cocaine.
60  one week later, 6-hydroxydopamine
(1 time)
Molecular Biology
(1 time)
CDNF (1 time)
CDNF-BMSCs (1 time)
DA (1 time)
2015 Effects of engineered conserved dopamine neurotrophic factor-expressing bone marrow stromal cells on dopaminergic neurons following 6-OHDA administrations.
61  only dopaminergic deficiency with 6-hydroxydopamine
(1 time)
Behavioral Sciences
(1 time)
--- 2004 Behavioral and neurochemical effects of noradrenergic depletions with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine in 6-hydroxydopamine-induced rat model of Parkinson's disease.
62  operant behavior in mice, mice with 6-hydroxydopamine
(1 time)
Behavioral Sciences
(1 time)
--- 2011 Lever pressing responses under a fixed-ratio schedule of mice with 6-hydroxydopamine-induced dopamine depletion in the nucleus accumbens.
63  opiate receptor antagonist naloxone and the neurotoxic drug 6-hydroxydopamine
(1 time)
Reproductive Medicine
(1 time)
--- 1989 Effect of simultaneous local injection of 6-hydroxydopamine and naloxone on the testis of neonatal rats.
64  optic nerve and complete 6-hydroxydopamine
(1 time)
Genetics, Medical
(1 time)
GDNF (1 time)
2006 Potentiation of in vivo neuroprotection by BclX(L) and GDNF co-expression depends on post-lesion time in deafferentiated CNS neurons.
65  optimized cell culture protocol prior to intrastriatal transplantation into 6-hydroxydopamine
(1 time)
Cell Biology
(1 time)
BDNF (1 time)
DA (1 time)
EGFP (1 time)
2012 The colayer method as an efficient way to genetically modify mesencephalic progenitor cells transplanted into 6-OHDA rat model of Parkinson's disease.
66  or, as a control, with the toxin 6-hydroxydopamine
(1 time)
Physiological Phenomena
(1 time)
AMPA (1 time)
AP (1 time)
HR (1 time)
2017 Reduced responses to glutamate receptor agonists follow loss of astrocytes and astroglial glutamate markers in the nucleus tractus solitarii.
67  orally as a pre-treatment prior to 6-hydroxydopamine
(1 time)
Brain
(1 time)
EGCG (1 time)
2009 Oral pre-treatment with epigallocatechin gallate in 6-OHDA lesioned rats produces subtle symptomatic relief but not neuroprotection.
68  order to determine whether unilateral 6-hydroxydopamine
(1 time)
Brain
(1 time)
Acb (1 time)
TH (1 time)
1996 Altered Fos-like immunoreactivity in terminal regions of the mesotelencephalic dopamine system is associated with reappearance of tyrosine hydroxylase immunoreactivity at the sites of focal 6-hydroxydopamine lesions in the nucleus accumbens.
69  orexin-A neuroprotection in 6-hydroxydopamine
(1 time)
Geriatrics
(1 time)
COX-2 (1 time)
MTT (1 time)
Nrf2 (1 time)
2017 Orexin-A Protects Human Neuroblastoma SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Neurotoxicity: Involvement of PKC and PI3K Signaling Pathways.
70  ORG 31433 accelerated functional recovery from 6-hydroxydopamine
(1 time)
Biochemistry
(1 time)
--- 1991 Structural modifications of the ACTH-(4-9) analog ORG 2766 yields peptides with high biological activity.
71  organotypic ex vivo slices: axotomy, rotenone, and 6-hydroxydopamine
(1 time)
Brain
(1 time)
GDNF (1 time)
PD (1 time)
SN (1 time)
2019 Therapeutic efficacy of glial cell-derived neurotrophic factor loaded collagen scaffolds in ex vivo organotypic brain slice Parkinson's disease models.
72  organs are selectively destroyed by 6-hydroxydopamine
(1 time)
General Surgery
(1 time)
--- 1979 Gastric acid secretion after chemical sympathectomy.
73  OS injury in 6-hydroxydopamine
(1 time)
Biochemistry
(1 time)
GSH-Px (1 time)
GSK-3beta-Ser9 (1 time)
MDA (1 time)
2018 Salidroside Protection Against Oxidative Stress Injury Through the Wnt/beta-Catenin Signaling Pathway in Rats with Parkinson's Disease.
74  osmotic minipumps to continuously deliver the neurotoxin 6-hydroxydopamine
(1 time)
Brain
(1 time)
--- 1984 The stability of 6-hydroxydopamine under minipump conditions.
75  ostreatus was treated against a dopaminergic neurotoxin, 6-hydroxydopamine
(1 time)
Biochemistry
(1 time)
PD (1 time)
PINK1 (1 time)
2019 Anthraquinone from Edible Fungi Pleurotus ostreatus Protects Human SH-SY5Y Neuroblastoma Cells Against 6-Hydroxydopamine-Induced Cell Death-Preclinical Validation of Gene Knockout Possibilities of PARK7, PINK1, and SNCA1 Using CRISPR SpCas9.
76  other DA metabolites, both in intact and in 6-hydroxydopamine
(1 time)
Brain
(1 time)
DA (1 time)
DOPALD (1 time)
MAO (1 time)
2000 Modulation of dihydroxyphenylacetaldehyde extracellular levels in vivo in the rat striatum after different kinds of pharmacological treatment.
77  other hand, tissues treated with 6-hydroxydopamine
(1 time)
Drug Therapy
(1 time)
--- 1981 Further studies on the mechanism of action of methyldopa on the vas deferens of the guinea-pig.
78  other rats injected with 6-hydroxydopamine hydrochloride
(1 time)
Veterinary Medicine
(1 time)
AVP (1 time)
1998 Model of emotional stress in rats.
79  out in unilateral 6-hydroxydopamine
(1 time)
Neurology
(1 time)
Ipt (1 time)
PD (1 time)
2006 Effects of systemic administration of iptakalim on extracellular neurotransmitter levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats.
80  Outgrowth and Attenuates 6-Hydroxydopamine
(1 time)
Nervous System
(1 time)
HO-1 (1 time)
Keap1 (1 time)
NGF (1 time)
2015 N-Propargyl Caffeate Amide (PACA) Potentiates Nerve Growth Factor (NGF)-Induced Neurite Outgrowth and Attenuates 6-Hydroxydopamine (6-OHDA)-Induced Toxicity by Activating the Nrf2/HO-1 Pathway.
81  outgrowth but also attenuated 6-hydroxydopamine
(1 time)
Nervous System
(1 time)
HO-1 (1 time)
Keap1 (1 time)
NGF (1 time)
2015 N-Propargyl Caffeate Amide (PACA) Potentiates Nerve Growth Factor (NGF)-Induced Neurite Outgrowth and Attenuates 6-Hydroxydopamine (6-OHDA)-Induced Toxicity by Activating the Nrf2/HO-1 Pathway.
82  ovariectomized, estrogen-primed rats, 6-hydroxydopamine
(1 time)
Endocrinology
(1 time)
VNAT (1 time)
1977 Effect of lesions in the ventral noradrenergic tract produced by microinjection of 6-hydroxydopamine on gonadotropin release in the rat.
83  over 11 days in rats with unilateral 6-hydroxydopamine
(1 time)
Behavioral Sciences
(1 time)
3-OMD (1 time)
COMT (1 time)
1994 3-O-methyl-DOPA is not involved in the development of behavioral supersensitivity after repeated L-dopa administration in 6-OHDA lesioned rats.
84  over the newborn rat cerebellum by 6-hydroxydopamine
(1 time)
Biology
(1 time)
--- 1985 Meningeal cells are involved in foliation, lamination, and neurogenesis of the cerebellum: evidence from 6-hydroxydopamine-induced destruction of meningeal cells.
85  overexpression and 6-hydroxydopamine
(1 time)
Neurology
(1 time)
DA (1 time)
hVPS41 (1 time)
PD (1 time)
2010 VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease.
86  oxidants such as hydrogen peroxide and 6-hydroxydopamine
(1 time)
Cell Biology
(1 time)
BFA (1 time)
DBM (1 time)
ER (1 time)
2007 A dibenzoylmethane derivative protects dopaminergic neurons against both oxidative stress and endoplasmic reticulum stress.
87  oxidation product, 6-hydroxydopamine
(1 time)
Chemistry
(1 time)
MPTP (1 time)
PD (1 time)
2010 L-DOPA-induced 6-hydroxydopamine production in the striata of rodents is sensitive to the degree of denervation.
88  oxidative damage and memory deficits in a 6-hydroxydopamine
(1 time)
Neurology
(1 time)
TBARS (1 time)
2016 Effects of crocin on brain oxidative damage and aversive memory in a 6-OHDA model of Parkinson's disease.
89  oxidative stress and alleviated mitochondrial injuries in the 6-hydroxydopamine
(1 time)
Genetics, Medical
(1 time)
PD (1 time)
2013 Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson's disease.
90  oxidative stress and dopaminergic neuron apoptosis induced by 6-hydroxydopamine
(1 time)
Medicine
(1 time)
SNcp (1 time)
T-SOD (1 time)
TH (1 time)
2003 [Protective effect of exogenous superoxide dismutase against rat midbrain dopaminergic neuron apoptosis induced by 6-hydroxydopamine].
91  oxidative stress and mitochondrial dysfunction induced by 6-hydroxydopamine
(1 time)
Neurology
(1 time)
--- 2019 KM-34, a Novel Antioxidant Compound, Protects against 6-Hydroxydopamine-Induced Mitochondrial Damage and Neurotoxicity.
92  oxidative stress in the nigrostriatal system in the 6-hydroxydopamine
(1 time)
Brain
(1 time)
CAT (1 time)
GSH-Px (1 time)
MDA (1 time)
2010 Acupuncture inhibits oxidative stress and rotational behavior in 6-hydroxydopamine lesioned rat.
93  oxidative stress induced in rat brain mitochondria by 6-hydroxydopamine
(1 time)
Biochemistry
(1 time)
LPO (1 time)
PBN (1 time)
PCO (1 time)
2008 Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides.
94  oxidative stress inducers Angiotensin II and 6-hydroxydopamine
(1 time)
HMOX1 (1 time)
KLF9 (1 time)
NQO1 (1 time)
2018 Data on the effect of Angiotensin II and 6-hydroxydopamine on reactive oxygen species production, antioxidant gene expression and viability of different neuronal cell lines.
95  oxidative stress markers were investigated in the intrastriatal 6-hydroxydopamine
(1 time)
Plants, Medicinal
(1 time)
PD (1 time)
2019 Effects of Boswellia serrata resin extract on motor dysfunction and brain oxidative stress in an experimental model of Parkinson's disease.
96  oxidative stress, and neurotoxicity produced by 1-methyl-4-phenylpyridinium (MPP(+)) and 6-hydroxydopamine
(1 time)
Brain
(1 time)
DA (1 time)
DAergic (1 time)
PD (1 time)
2000 Prevention of 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced nitration of tyrosine hydroxylase and neurotoxicity by EUK-134, a superoxide dismutase and catalase mimetic, in cultured dopaminergic neurons.
97  oxidative stresses, including incubation with the neurotoxin 6-hydroxydopamine
(1 time)
Biochemistry
(1 time)
--- 1986 Effect of 6-hydroxydopamine on polymerization of tubulin. Protection by superoxide dismutase, catalase, or anaerobic conditions.
98  oxidative stressor 6-hydroxydopamine
(1 time)
Science
(1 time)
DA (1 time)
PD (1 time)
2009 Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression.
99  oxidative toxicants, hydrogen peroxide (H(2)O(2)) and 6-hydroxydopamine
(1 time)
Neurology
(1 time)
GDNF (1 time)
MTT (1 time)
PD (1 time)
2003 Baculovirus p35 gene greatly enhances PC12 cell's resistance against oxidative stress.
100  oxidative treatment with 6-hydroxydopamine
(1 time)
Chemistry
(1 time)
ERN (1 time)
PD (1 time)
SFN (1 time)
2018 Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in in Vitro and in Vivo Models of Parkinson's Disease.