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■ Search Result - Abbreviation : CYP7A1

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Abbreviation: CYP7A1
Appearance Frequency: 395 time(s)
Long forms: 51

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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
cholesterol 7alpha-hydroxylase
(307 times)
Biochemistry
(101 times)
FXR (65 times)
SHP (41 times)
TC (28 times)
1999 Hepatocyte nuclear factor 1 binds to and transactivates the human but not the rat CYP7A1 promoter.
cytochrome P450 7A1
(29 times)
Biochemistry
(7 times)
FXR (4 times)
BA (3 times)
CDCA (3 times)
2000 A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.
cytochrome P450, family 7, subfamily A, polypeptide 1
(6 times)
Nutritional Sciences
(3 times)
HMGCR (2 times)
ABC (1 time)
ACC (1 time)
2008 Clock mutation facilitates accumulation of cholesterol in the liver of mice fed a cholesterol and/or cholic acid diet.
classic pathway initiated by cholesterol 7alpha-hydroxylase
(3 times)
Biochemistry
(2 times)
BA (1 time)
FGF19 (1 time)
StAR (1 time)
2001 Alternate pathways of bile acid synthesis in the cholesterol 7alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding.
cholesterol 7 alpha-hydroxylase activities
(2 times)
Science
(1 time)
ALB (1 time)
BMSCs (1 time)
CK-18 (1 time)
1998 Reduced hepatic expression of CYP7A1 and CYP2C13 in rats with spontaneous hyperlipidaemia.
cholesterol levels through the activation of cholesterol 7alpha-hydroxylase
(2 times)
Complementary Therapies
(1 time)
CC (1 time)
GGPP (1 time)
HFD (1 time)
2012 Dietary resveratrol increases the expression of hepatic 7alpha-hydroxylase and ameliorates hypercholesterolemia in high-fat fed C57BL/6J mice.
conversion of cholesterol into bile acids is cholesterol 7alpha-hydroxylase
(2 times)
Genetics, Medical
(1 time)
CH (1 time)
FD (1 time)
FH (1 time)
2004 Modulating effect of the A-278C promoter polymorphism in the cholesterol 7alpha-hydroxylase gene on serum lipid levels in normolipidaemic and hypertriglyceridaemic individuals.
c-Jun protein and cholesterol 7a-hydroxylase
(1 time)
Pharmacology
(1 time)
HDL (1 time)
JNK (1 time)
LDL (1 time)
2014 Puerarin attenuates carbon tetrachloride-induced liver oxidative stress and hyperlipidaemia in mouse by JNK/c-Jun/CYP7A1 pathway.
cAMP inhibit cholesterol 7alpha-hydroxylase
(1 time)
Gastroenterology
(1 time)
cAMP (1 time)
PEPCK (1 time)
PGC-1alpha (1 time)
2006 Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in human hepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis.
10  can activate cholesterol 7alpha-hydroxylase
(1 time)
Biochemistry
(1 time)
ERK (1 time)
MAPK (1 time)
2007 A novel regulatory pathway for cholesterol degradation via lactostatin.
11  can activate the JNK pathway and down-regulate cholesterol 7alpha-hydroxylase
(1 time)
Biochemistry
(1 time)
ASM (1 time)
DCA (1 time)
FASR (1 time)
2004 Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation.
12  cassette sub-family G member 5/8 (ABCG5/G8) and 7alpha-hydroxylase1
(1 time)
Complementary Therapies
(1 time)
ACC (1 time)
ERS (1 time)
GIN (1 time)
2018 Zingiber officinale extract administration diminishes steroyl-CoA desaturase gene expression and activity in hyperlipidemic hamster liver by reducing the oxidative and endoplasmic reticulum stress.
13  cassette transporter G5/G8 (ABCG5/8), cholesterol 7 alpha-hydroxylase
(1 time)
Food
(1 time)
ACC (1 time)
FAS (1 time)
GPx (1 time)
2016 Xylobiose, an Alternative Sweetener, Ameliorates Diabetes-Related Metabolic Changes by Regulating Hepatic Lipogenesis and miR-122a/33a in db/db Mice.
14  catalyzed by cholesterol 7alpha-hydroxylase
(1 time)
Gastroenterology
(1 time)
ACAT (1 time)
CEH (1 time)
HMGR (1 time)
2001 Effects of CYP7A1 overexpression on cholesterol and bile acid homeostasis.
15  catalyzed by the liver-specific enzyme cholesterol 7alpha-hydroxylase
(1 time)
Biochemistry
(1 time)
RT-PCR (1 time)
1998 Analysis of human CYP7A1 mRNA decay in HepG2 cells by reverse transcription-polymerase chain reaction.
16  catalyzing the 7alpha-hydroxylation, cholesterol 7alpha-hydroxylase
(1 time)
Drug Therapy
(1 time)
--- 2007 The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins to chromatin remodelling to reduce plasma cholesterol.
17  caused by the increased expression of cholesterol 7alpha-hydroxylase
(1 time)
Chemistry
(1 time)
--- 2009 Effects of dietary fish protein on serum and liver lipid concentrations in rats and the expression of hepatic genes involved in lipid metabolism.
18  cells express cholesterol-7 alpha-hydroxylase
(1 time)
Biochemistry
(1 time)
--- 2002 Expression of cholesterol-7alpha-hydroxylase in murine macrophages prevents cholesterol loading by acetyl-LDL.
19  central to feedback repression of cholesterol 7alpha hydroxylase gene
(1 time)
Cell Biology
(1 time)
--- 2004 Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP.
20  chicken cholesterol 7alpha hydroxylase
(1 time)
Molecular Biology
(1 time)
HMGR (1 time)
LDLR (1 time)
LXRs (1 time)
2011 Regulation of bile acid, cholesterol, and fatty acid synthesis in chicken primary hepatocytes by different concentrations of T0901317, an agonist of liver X receptors.
21  cholesterol 7-alpha-monooxygenase
(1 time)
Food Technology
(1 time)
HC (1 time)
LDLR (1 time)
ND (1 time)
2016 Hypocholesterolemic effect of quercetin-rich onion peel extract in C57BL/6J mice fed with high cholesterol diet.
22  cholesterol 7a-hydroxylase expression
(1 time)
Nutritional Sciences
(1 time)
APOE (1 time)
LXRalpha (1 time)
2012 Cyanidin-3-O-beta-glucoside upregulates hepatic cholesterol 7alpha-hydroxylase expression and reduces hypercholesterolemia in mice.
23  cholesterol and cholesterol 7alpha-hydroxylase
(1 time)
mTOR (1 time)
2017 Targeting the Enterohepatic Bile Acid Signaling Induces Hepatic Autophagy via a CYP7A1-AKT-mTOR Axis in Mice.
24  cholesterol biosynthesis, and up-regulated the mRNA of cholesterol 7alpha-hydroxylase
(1 time)
Chemistry
(1 time)
AAPH (1 time)
AMVN (1 time)
ESR (1 time)
2008 Effects of wheat antioxidants on oxygen diffusion-concentration products in liposomes and mRNA levels of HMG-CoA reductase and cholesterol 7alpha-hydroxylase in primary rat hepatocytes.
25  cholesterol concentrations were increased and cholesterol 7alpha-hydroxylase
(1 time)
Nutritional Sciences
(1 time)
IFP (1 time)
2009 The mechanism of the cholesterol-lowering effect of water-insoluble fish protein in ovariectomised rats.
26  cholesterol efflux, such as cholesterol 7 alpha-hydroxylase
(1 time)
Food
(1 time)
ABCA1 (1 time)
ABCG1 (1 time)
LXRalpha (1 time)
2019 Formulation and Characterization of Quercetin-loaded Oil in Water Nanoemulsion and Evaluation of Hypocholesterolemic Activity in Rats.
27  cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene
(1 time)
Biochemistry
(1 time)
LXRalpha (1 time)
RXR (1 time)
2002 Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic mice.
28  cholesterol feeding regulates cholesterol 7alpha-hydroxylase
(1 time)
Biochemistry
(1 time)
ABCA1 (1 time)
CETP (1 time)
FXR (1 time)
2003 FXR-mediated down-regulation of CYP7A1 dominates LXRalpha in long-term cholesterol-fed NZW rabbits.
29  cholesterol levels and hepatic cholesterol 7alpha-hydroxylase activity
(1 time)
Nutritional Sciences
(1 time)
CH (1 time)
2003 The effect of taurine on the cholesterol metabolism in rats fed diets supplemented with cholestyramine or high amounts of bile acid.
30  cholesterol metabolism by affecting activity of hepatic cholesterol 7alpha-hydroxylase
(1 time)
Biochemistry
(1 time)
HCMV (1 time)
HDL (1 time)
2012 Dual-color bioluminescent assay using infected HepG2 cells sheds new light on Chlamydia pneumoniae and human cytomegalovirus effects on human cholesterol 7alpha-hydroxylase (CYP7A1) transcription.
31  cholesterol metabolism-related enzymes including HMG-CoA reductase and cholesterol 7alpha-hydroxylase
(1 time)
Pharmacology
(1 time)
AI (1 time)
FTZ (1 time)
HDL-C (1 time)
2011 A new TCM formula FTZ lowers serum cholesterol by regulating HMG-CoA reductase and CYP7A1 in hyperlipidemic rats.
32  cholesterol metabolism-related genes including cholesterol 7alpha-hydroxylase
(1 time)
Complementary Therapies
(1 time)
CAE (1 time)
FXR (1 time)
LDL-C (1 time)
2012 Hypocholesterolemia of Rhizoma Coptidis alkaloids is related to the bile acid by up-regulated CYP7A1 in hyperlipidemic rats.
33  cholesterol to bile acids by cholesterol 7alpha-hydroxylase
(1 time)
Biochemistry
(1 time)
FXR (1 time)
SHP (1 time)
TG (1 time)
2009 Loss of small heterodimer partner expression in the liver protects against dyslipidemia.
34  cholesterol-7alpha-hydroxylase encoding gene
(1 time)
Medicine
(1 time)
CDCA (1 time)
2016 Diurnal variation in cholesterol 7alpha-hydroxylase activity is determined by the -203A>C polymorphism of the CYP7A1 gene.
35  cholesterol-catabolizing enzyme cholesterol 7alpha-hydroxylase
(1 time)
Biochemistry
(1 time)
--- 2007 Effects of dipeptides having a C-terminal lysine on the cholesterol 7alpha-hydroxylase mRNA level in HepG2 cells.
36  cMRP group in the level of cholesterol 7 alpha-hydroxylase
(1 time)
Veterinary Medicine
(1 time)
HMGR (1 time)
MRP (1 time)
wMRP (1 time)
2015 Dietary Maillard reaction products and their fermented products reduce cardiovascular risk in an animal model.
37  Compared with the Sow group, hepatic cholesterol 7alpha hydroxylase
(1 time)
Nutritional Sciences
(1 time)
SHP (1 time)
2018 Infant Formula Feeding Increases Hepatic Cholesterol 7alpha Hydroxylase (CYP7A1) Expression and Fecal Bile Acid Loss in Neonatal Piglets.
38  compared with Xbp1fl/fl mice, indicating reduced cholesterol 7alpha-hydroxylase
(1 time)
Biochemistry
(1 time)
UPR (1 time)
2017 Hepatic deletion of X-box binding protein 1 impairs bile acid metabolism in mice.
39  compensatory, same-day, 4-fold induction of hepatic cholesterol 7alpha-hydroxylase
(1 time)
Biochemistry
(1 time)
IBAT (1 time)
2002 Ileal bile acid transporter inhibition, CYP7A1 induction, and antilipemic action of 264W94.
40  composition and the expression of cholesterol 7alpha hydroxylase
(1 time)
General Surgery
(1 time)
BAAT (1 time)
BACS (1 time)
BAs (1 time)
2016 Effects of Bariatric Surgery on Serum Bile Acid Composition and Conjugation in a Diabetic Rat Model.
41  concentrations of insulin rapidly stimulated cholesterol 7alpha-hydroxylase
(1 time)
Biochemistry
(1 time)
FOXO1 (1 time)
SREBP-1c (1 time)
2006 Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c.
42  contrary to the up-regulation of cholesterol 7alpha-hydroxylase
(1 time)
Biochemistry
(1 time)
SRE (1 time)
SREBPs (1 time)
2004 Mechanisms of cholesterol and sterol regulatory element binding protein regulation of the sterol 12alpha-hydroxylase gene (CYP8B1).
43  contributes to repression of the gene encoding cholesterol 7alpha-hydroxylase
(1 time)
Gastroenterology
(1 time)
ChIP (1 time)
GAPDH (1 time)
HDAC2 (1 time)
2014 A GAPDH-mediated trans-nitrosylation pathway is required for feedback inhibition of bile salt synthesis in rat liver.
44  controlled by the enzyme cholesterol 7alpha-hydroxylase
(1 time)
Internal Medicine
(1 time)
BAs (1 time)
FGF19 (1 time)
2006 Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man.
45  correlated with increased hepatic expression of the cholesterol 7alpha-hydroxylase 1
(1 time)
Endocrinology
(1 time)
BA (1 time)
FGF (1 time)
RYGB (1 time)
2013 A role for fibroblast growth factor 19 and bile acids in diabetes remission after Roux-en-Y gastric bypass.
46  COS on hepatic cholesterol 7 alpha-hydroxylase
(1 time)
Biology
(1 time)
COS (1 time)
LDL (1 time)
LDLR (1 time)
2012 Chitosan oligosaccharides promote reverse cholesterol transport and expression of scavenger receptor BI and CYP7A1 in mice.
47  COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene
(1 time)
Biochemistry
(1 time)
BTEB (1 time)
COUP-TFII (1 time)
EMSA (1 time)
2000 HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1).
48  critical regulatory gene in bile acid synthesis, cholesterol 7alpha-hydroxylase
(1 time)
Biochemistry
(1 time)
FGF15 (1 time)
FGFR4 (1 time)
FXR (1 time)
2009 Bile acids: regulation of synthesis.
49  CYP7 which codes for cholesterol 7alpha-hydroxylase
(1 time)
Environmental Health
(1 time)
BAs (1 time)
CVDs (1 time)
HNF-4alpha (1 time)
2015 Hepatocyte nuclear factor-4alpha, a multifunctional nuclear receptor associated with cardiovascular disease and cholesterol catabolism.
50  cytochrome P450 cholesterol 7alpha-hydroxylase
(1 time)
Biochemistry
(1 time)
ABCA1 (1 time)
HNF-4 (1 time)
LXR (1 time)
2004 LXR (liver X receptor) and HNF-4 (hepatocyte nuclear factor-4): key regulators in reverse cholesterol transport.
51  cytomegalovirus effects on human cholesterol 7alpha-hydroxylase
(1 time)
Biochemistry
(1 time)
HCMV (1 time)
HDL (1 time)
2012 Dual-color bioluminescent assay using infected HepG2 cells sheds new light on Chlamydia pneumoniae and human cytomegalovirus effects on human cholesterol 7alpha-hydroxylase (CYP7A1) transcription.