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Abbreviation: Ca,L
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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
current-voltage relationship of I
(14 times)
Pharmacology
(6 times)
cyclic AMP (1 time)
cyclic GMP (1 time)
LTCC (1 time)
1997 Ionic mechanisms of tetrandrine in cultured rat aortic smooth muscle cells.
calcium transients and I
(2 times)
Physiology
(1 time)
ET-1 (1 time)
SCI (1 time)
2010 Spinal cord injury blunted effects of endothelin-1 on Ca(2+) transients and calcium current in isolated rat cardiomyocytes.
cardioprotective effects, we directly measured the I
(2 times)
Pharmacology
(1 time)
Ucn (1 time)
2004 Effect of urocortin on L-type calcium currents in adult rat ventricular myocytes.
clamp technique was employed to record I
(2 times)
Pharmacology
(1 time)
AP (1 time)
BNP (1 time)
GA (1 time)
2008 B-type natriuretic peptide (BNP) attenuates the L-type calcium current and regulates ventricular myocyte function.
completely inhibited the increase in I
(2 times)
Physiology
(1 time)
Ang II (1 time)
LIF (1 time)
NHE (1 time)
1999 Leukemia inhibitory factor, a potent cardiac hypertrophic cytokine, enhances L-type Ca2+ current and [Ca2+]i transient in cardiomyocytes.
concomitant blocking of I
(2 times)
Pharmacology
(1 time)
APD (1 time)
Ca.L (1 time)
2005 Risperidone-induced action potential prolongation is attenuated by increased repolarization reserve due to concomitant block of I(Ca,L).
could also increase I
(2 times)
Pharmacology
(1 time)
--- 2008 Stimulation of Na+-Ca2+ exchange by purified antibody against alpha-2 repeat of Na+-Ca2+ exchanger in rat cardiomyocytes.
voltage-clamp techniques, I
(2 times)
Pharmacology
(1 time)
STZ (1 time)
2002 Enhanced inhibition of L-type calcium currents by troglitazone in streptozotocin-induced diabetic rat cardiac ventricular myocytes.
AP-clamps, the peak I
(1 time)
Biophysics
(1 time)
AP (1 time)
RV (1 time)
SEP (1 time)
2010 Changes in the calcium current among different transmural regions contributes to action potential heterogeneity in rat heart.
10  C-terminal tail for the analogous domain from H-Ras, inhibited I
(1 time)
Cardiology
(1 time)
KS (1 time)
2010 Molecular mechanisms, and selective pharmacological rescue, of Rem-inhibited CaV1.2 channels in heart.
11  Ca influx via I
(1 time)
Cardiology
(1 time)
CaMK (1 time)
EADs (1 time)
2009 Oxidative-stress-induced afterdepolarizations and calmodulin kinase II signaling.
12  Ca release when block of I
(1 time)
Cardiology
(1 time)
PKA (1 time)
SMC (1 time)
SR (1 time)
2002 L-type Ca(2+) currents overlapping threshold Na(+) currents: could they be responsible for the "slip-mode" phenomenon in cardiac myocytes?
13  Ca(2+) transient amplitude (to 60+/-7%) with accompanying reductions in I
(1 time)
Cardiology
(1 time)
E-C (1 time)
SR (1 time)
2007 K201 modulates excitation-contraction coupling and spontaneous Ca2+ release in normal adult rabbit ventricular cardiomyocytes.
14  Ca(2+) transient amplitude (to 83+/-7%) without affecting I
(1 time)
Cardiology
(1 time)
E-C (1 time)
SR (1 time)
2007 K201 modulates excitation-contraction coupling and spontaneous Ca2+ release in normal adult rabbit ventricular cardiomyocytes.
15  Ca(V)betas on PKA modulation of I
(1 time)
Cardiology
(1 time)
PKA (1 time)
2008 Role of CaVbeta subunits, and lack of functional reserve, in protein kinase A modulation of cardiac CaV1.2 channels.
16  Ca+ transient, was maximal during I
(1 time)
Cardiology
(1 time)
NCX (1 time)
2010 Adverse bioenergetic consequences of Na+-Ca2+ exchanger-mediated Ca2+ influx in cardiac myocytes.
17  calcineurin induces robust increases in I
(1 time)
Cardiology
(1 time)
PK (1 time)
2009 Physical and functional interaction between calcineurin and the cardiac L-type Ca2+ channel.
18  calcineurin pharmacologically or with specific peptides decreased I
(1 time)
Cardiology
(1 time)
PK (1 time)
2009 Physical and functional interaction between calcineurin and the cardiac L-type Ca2+ channel.
19  calcineurin through an increase in I
(1 time)
Cardiology
(1 time)
LIF (1 time)
2000 Calmodulin kinases II and IV and calcineurin are involved in leukemia inhibitory factor-induced cardiac hypertrophy in rats.
20  calcium current and shifted the steady-state inactivation curve of I
(1 time)
Biochemistry
(1 time)
--- 2005 The saponin monomer of dwarf lilyturf tuber, DT-13, reduces L-type calcium currents during hypoxia in adult rat ventricular myocytes.
21  calcium inactivation of I
(1 time)
Neurology
(1 time)
SOP (1 time)
1999 Calcium dynamics underlying pacemaker-like and burst firing oscillations in midbrain dopaminergic neurons: a computational study.
22  calcium-dependent I
(1 time)
Physiology
(1 time)
--- 2011 Calcium handling in zebrafish ventricular myocytes.
23  calmodulin-dependent protein kinase II with KN-93, reduced I
(1 time)
Cardiology
(1 time)
PCs (1 time)
SAN (1 time)
2007 Simulated ischemia enhances L-type calcium current in pacemaker cells isolated from the rabbit sinoatrial node.
24  CaMKII inhibitor KN-93 fully reversed H(2)O(2)-induced LTF of I
(1 time)
Biochemistry
(1 time)
CaMKII (1 time)
LTF (1 time)
2011 Sustained CaMKII activity mediates transient oxidative stress-induced long-term facilitation of L-type Ca(2+) current in cardiomyocytes.
25  cAMP signals and I
(1 time)
Cardiology
(1 time)
ARVMs (1 time)
PDE (1 time)
2008 Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases.
26  cAMP-dependent stimulation of I
(1 time)
Molecular Biology
(1 time)
--- 2005 Species- and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels.
27  can also decrease I
(1 time)
Physiology
(1 time)
--- 2010 Inhibitory effects of purified antibody against alpha-1 repeat (117-137) on Na(+)-Ca(2+) exchange and L-type Ca(2+) currents in rat cardiomyocytes.
28  can be ascribed mainly to I
(1 time)
Pharmacology
(1 time)
--- 2004 Calcium-antagonizing activity of S-petasin, a hypotensive sesquiterpene from Petasites formosanus, on inotropic and chronotropic responses in isolated rat atria and cardiac myocytes.
29  can be modulated by the baseline sizes of I
(1 time)
Cardiology
(1 time)
sus (1 time)
1998 Mathematical model of an adult human atrial cell: the role of K+ currents in repolarization.
30  can lead to focal, persistent I
(1 time)
Cardiology
(1 time)
E-C (1 time)
2012 Different subcellular populations of L-type Ca2+ channels exhibit unique regulation and functional roles in cardiomyocytes.
31  can modulate I
(1 time)
Cardiology
(1 time)
DHT (1 time)
EST (1 time)
ORCH (1 time)
2002 Effects of gonadal steroids on gender-related differences in transmural dispersion of L-type calcium current.
32  can restore normal responsiveness of I
(1 time)
Drug Therapy
(1 time)
--- 2000 Effects of captopril treatment of renovascular hypertension on beta-adrenergic modulation of L-type Ca(2+) current.
33  can stimulate I
(1 time)
Physiology
(1 time)
APD (1 time)
2011 Influence of pH on Ca⁺ current and its control of electrical and Ca⁺ signaling in ventricular myocytes.
34  capable of reducing I
(1 time)
Cardiology
(1 time)
BAS (1 time)
CPVT (1 time)
DADs (1 time)
2011 Targeting intracellular calcium cycling in catecholaminergic polymorphic ventricular tachycardia: a theoretical investigation.
35  capacitance, current density or voltage-dependent properties of I
(1 time)
Pharmacology
(1 time)
STZ (1 time)
2002 Enhanced inhibition of L-type calcium currents by troglitazone in streptozotocin-induced diabetic rat cardiac ventricular myocytes.
36  captopril improved I
(1 time)
Pharmacology
(1 time)
Ang II (1 time)
MAP (1 time)
PI3K (1 time)
2011 Regulation of L-type inward calcium channel activity by captopril and angiotensin II via the phosphatidyl inositol 3-kinase pathway in cardiomyocytes from volume-overload hypertrophied rat hearts.
37  captopril reduced their basal I
(1 time)
Pharmacology
(1 time)
Ang II (1 time)
MAP (1 time)
PI3K (1 time)
2011 Regulation of L-type inward calcium channel activity by captopril and angiotensin II via the phosphatidyl inositol 3-kinase pathway in cardiomyocytes from volume-overload hypertrophied rat hearts.
38  cardiac L-type calcium current I
(1 time)
Endocrinology
(1 time)
--- 2009 Impact of dihydrotestosterone on L-type calcium channels in human ventricular cardiomyocytes.
39  cardiac myocytes of adult mice reduced I
(1 time)
Cardiology
(1 time)
PI3K (1 time)
2009 Loss of cardiac phosphoinositide 3-kinase p110 alpha results in contractile dysfunction.
40  cardiac repolarization, presumably through its blocking effect on I
(1 time)
Cardiology
(1 time)
--- 2002 Effects of sildenafil on cardiac repolarization.
41  cardiac-cell I
(1 time)
Pharmacology
(1 time)
cAMP (1 time)
2002 Levosimendan increases L-type Ca(2+) current via phosphodiesterase-3 inhibition in human cardiac myocytes.
42  cardiomyocytes displayed increased I
(1 time)
Biochemistry
(1 time)
LTCC (1 time)
2012 Rem-GTPase regulates cardiac myocyte L-type calcium current.
43  cascade; (ii) Src-nPTKs attenuate PKA-dependent stimulation of I
(1 time)
Biochemistry
(1 time)
HAMs (1 time)
L-VDCC (1 time)
PKA (1 time)
2011 Src family protein tyrosine kinases modulate L-type calcium current in human atrial myocytes.
44  case, genistein lead to the same relative increase in I
(1 time)
Pharmacology
(1 time)
AF (1 time)
PTK (1 time)
SR (1 time)
2007 Pharmacological evidence for altered src kinase regulation of I (Ca,L) in patients with chronic atrial fibrillation.
45  caused a significant leftward shift of the I
(1 time)
Cardiology
(1 time)
db-cAMP (1 time)
HVMs (1 time)
ISO (1 time)
2002 L-type Ca2+ channel density and regulation are altered in failing human ventricular myocytes and recover after support with mechanical assist devices.
46  caused a small depolarizing shift in the I
(1 time)
Cell Biology
(1 time)
AA (1 time)
ARVM (1 time)
CS (1 time)
2007 Inhibition of L-type Ca2+ channel current and negative inotropy induced by arachidonic acid in adult rat ventricular myocytes.
47  caused a strong initial increase in basal I
(1 time)
Pharmacology
(1 time)
MANT-ITP (1 time)
2011 Effect of MANT-nucleotides on L-type calcium currents in murine cardiomyocytes.
48  caused a voltage-dependent block of I
(1 time)
Cell Biology
(1 time)
AA (1 time)
ARVM (1 time)
CS (1 time)
2007 Inhibition of L-type Ca2+ channel current and negative inotropy induced by arachidonic acid in adult rat ventricular myocytes.
49  caused down-regulation of I
(1 time)
Cardiology
(1 time)
AF (1 time)
APD (1 time)
Kr (1 time)
2005 Rapid stimulation causes electrical remodeling in cultured atrial myocytes.
50  caveolin-3, whereas beta(1)-AR stimulation (norepinephrine plus prazosin) of I
(1 time)
Science
(1 time)
--- 2006 Localization of cardiac L-type Ca(2+) channels to a caveolar macromolecular signaling complex is required for beta(2)-adrenergic regulation.
51  CCh produced a significant transient stimulation of I
(1 time)
Physiology
(1 time)
8-Br-cGMP (1 time)
Ca.L (1 time)
CCh (1 time)
2002 Cholinergic modulation of the basal L-type calcium current in ferret right ventricular myocytes.
52  cell shortening and supported I
(1 time)
Physiology
(1 time)
ECC (1 time)
NPPB (1 time)
2002 Anion channels influence ECC by modulating L-type Ca(2+) channel in ventricular myocytes.
53  cell surface and thus attenuates I
(1 time)
Cardiology
(1 time)
PI3K (1 time)
2009 Loss of cardiac phosphoinositide 3-kinase p110 alpha results in contractile dysfunction.
54  cells by enhancing I
(1 time)
Cardiology
(1 time)
PKC (1 time)
SA (1 time)
2000 Effect of hydrogen peroxide on the membrane currents of sinoatrial node cells from rabbit heart.
55  cells displayed both I
(1 time)
Cardiology
(1 time)
AF (1 time)
APD (1 time)
Kr (1 time)
2005 Rapid stimulation causes electrical remodeling in cultured atrial myocytes.
56  cells on laminin restored ACh-induced stimulation of I
(1 time)
Physiology
(1 time)
--- 2000 Laminin acts via beta 1 integrin signalling to alter cholinergic regulation of L-type Ca(2+) current in cat atrial myocytes.
57  cells yielded double-peaked I
(1 time)
Cardiology
(1 time)
AP (1 time)
ENDO (1 time)
EPI (1 time)
2003 Endocardial versus epicardial differences in L-type calcium current in canine ventricular myocytes studied by action potential voltage clamp.
58  cells, also produced a significant inhibition of I
(1 time)
Science
(1 time)
EPA (1 time)
PUFAs (1 time)
1997 Suppression of voltage-gated L-type Ca2+ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes.
59  cells, but it did not increase I
(1 time)
Cardiology
(1 time)
ISO (1 time)
MbetaCD (1 time)
2008 Cholesterol depletion modulates basal L-type Ca2+ current and abolishes its -adrenergic enhancement in ventricular myocytes.
60  cells, quercetin suppressed the amplitude of I
(1 time)
Cell Biology
(1 time)
--- 2003 Differential effects of quercetin, a natural polyphenolic flavonoid, on L-type calcium current in pituitary tumor (GH3) cells and neuronal NG108-15 cells.
61  cells, respectively, and I
(1 time)
Cardiology
(1 time)
SVA (1 time)
2007 Effects of atorvastatin and simvastatin on atrial plateau currents.
62  cells, the NO generating agent SIN-1 inhibited I
(1 time)
Cardiology
(1 time)
ES (1 time)
NOS (1 time)
PTX (1 time)
1999 Galpha(i2), Galpha(i3)and Galpha(o) are all required for normal muscarinic inhibition of the cardiac calcium channels in nodal/atrial-like cultured cardiocytes.
63  cells, voltage-dependent processes appear to be reset, such that I
(1 time)
Cardiology
(1 time)
APs (1 time)
EBZ (1 time)
REM (1 time)
2004 Dynamic remodeling of K+ and Ca2+ currents in cells that survived in the epicardial border zone of canine healed infarcted heart.
64  cGMP-dependent pathway is responsible for I
(1 time)
Pharmacology
(1 time)
APD (1 time)
NO (1 time)
2004 Nitric oxide-dependent modulation of the delayed rectifier K+ current and the L-type Ca2+ current by ginsenoside Re, an ingredient of Panax ginseng, in guinea-pig cardiomyocytes.
65  CGP12177 which also is a beta1-AR/beta2-AR antagonist on I
(1 time)
Molecular Biology
(1 time)
beta3-AR (1 time)
HVMs (1 time)
2014 beta₃-Adrenergic regulation of L-type Ca⁺ current and force of contraction in human ventricle.
66  challenge induced biphasic changes of I
(1 time)
Pharmacology
(1 time)
PKA (1 time)
PKC (1 time)
PKG (1 time)
2010 Hyposmotic challenge modulates function of L-type calcium channel in rat ventricular myocytes through protein kinase C.
67  change in basal I
(1 time)
Cardiology
(1 time)
CMs (1 time)
2007 Chronic verapamil treatment remodels ICa,L in mouse ventricle.
68  changes in Q(r) might affect release and I
(1 time)
Cell Biology
(1 time)
DHPR (1 time)
E-C (1 time)
GBP (1 time)
2002 Dissociation of charge movement from calcium release and calcium current in skeletal myotubes by gabapentin.
69  channel currents including I
(1 time)
Pharmacology
(1 time)
Pro (1 time)
2000 Electrophysiological effects of protopine in cardiac myocytes: inhibition of multiple cation channel currents.
70  Channel function was increased in voltage-clamp recordings of I
(1 time)
Cardiology
(1 time)
PK (1 time)
2009 Physical and functional interaction between calcineurin and the cardiac L-type Ca2+ channel.
71  channel mRNAs and I
(1 time)
Cardiology
(1 time)
CMs (1 time)
2007 Chronic verapamil treatment remodels ICa,L in mouse ventricle.
72  channel subunit expression and the regulation of I
(1 time)
Pharmacology
(1 time)
AF (1 time)
PTK (1 time)
SR (1 time)
2007 Pharmacological evidence for altered src kinase regulation of I (Ca,L) in patients with chronic atrial fibrillation.
73  channel subunits reduces I
(1 time)
Cardiology
(1 time)
mRNA (1 time)
RAP (1 time)
2003 Molecular mechanisms of early electrical remodeling: transcriptional downregulation of ion channel subunits reduces I(Ca,L) and I(to) in rapid atrial pacing in rabbits.
74  channels and increases I
(1 time)
Drug Therapy
(1 time)
beta2AR (1 time)
HF (1 time)
ZIN (1 time)
2001 Enhanced cardiac L-type calcium current response to beta2-adrenergic stimulation in heart failure.
75  channels in addition to I
(1 time)
Pharmacology
(1 time)
AF (1 time)
2007 Cardiomyocyte Ca2+ overload in atrial tachycardia: is blockade of L-type Ca2+ channels a promising approach to prevent electrical remodeling and arrhythmogenesis?
76  channels rather than I
(1 time)
Pharmacology
(1 time)
APD (1 time)
hERG (1 time)
2013 Effect of azelastine on cardiac repolarization of guinea-pig cardiomyocytes, hERG K⁺ channel, and human L-type and T-type Ca⁺ channel.
77  channels were completely blocked, I
(1 time)
Molecular Biology
(1 time)
EADs (1 time)
2008 Contribution of L-type Ca2+ channels to early afterdepolarizations induced by I Kr and I Ks channel suppression in guinea pig ventricular myocytes.
78  CHF, respectively: peak I
(1 time)
Cardiology
(1 time)
CHF (1 time)
2002 Normal contractions triggered by I(Ca,L) in ventricular myocytes from rats with postinfarction CHF.
79  chiefly accounted for by inhibition of I
(1 time)
Pharmacology
(1 time)
--- 2008 Electromechanical characterization of cinnamophilin, a natural thromboxane A2 receptor antagonist with anti-arrhythmic activity, in guinea-pig heart.
80  cholesterol inhibited either basal and BAY-stimulated I
(1 time)
Pharmacological Phenomena
(1 time)
--- 2010 Testosterone and cholesterol vasodilation of rat aorta involves L-type calcium channel inhibition.
81  chronic ethanol consumption with an increased I
(1 time)
Pharmacology
(1 time)
--- 2003 Sex differences in L-type calcium current after chronic ethanol consumption in rats.
82  chronic GDPbetaS dialysis accelerated the rundown of I
(1 time)
Cardiology
(1 time)
FSK (1 time)
GDP (1 time)
GTP (1 time)
2000 Agonist-independent modulation of L-type Ca currents by basal Gs protein activities in single guinea pig ventricular myocytes.
83  cilnidipine strongly shifted the steady-state inactivation curve of I
(1 time)
Pharmacology
(1 time)
Ca,N (1 time)
1999 Selectivity of dihydropyridines for cardiac L-type and sympathetic N-type Ca2+ channels.
84  Cisapride also delayed the kinetics of recovery of I
(1 time)
Medicine
(1 time)
--- 2004 Inhibition of L-type Ca(2+) current in Guinea pig ventricular myocytes by cisapride.
85  clamp experiments revealed that the decay of I
(1 time)
Cardiology
(1 time)
AP (1 time)
ENDO (1 time)
EPI (1 time)
2003 Endocardial versus epicardial differences in L-type calcium current in canine ventricular myocytes studied by action potential voltage clamp.
86  clamp recording revealed that LIF maximally increased the I
(1 time)
Cardiology
(1 time)
LIF (1 time)
1999 Leukemia inhibitory factor, a potent cardiac hypertrophic cytokine, enhances L-type Ca2+ current and [Ca2+]i transient in cardiomyocytes.
87  clamp studies demonstrated a markedly blunted increase in I
(1 time)
Cardiology
(1 time)
beta-AR (1 time)
HF (1 time)
2005 Crosstalk of beta-adrenergic receptor subtypes through Gi blunts beta-adrenergic stimulation of L-type Ca2+ channels in canine heart failure.
88  clamp studies revealed a significant increase of I
(1 time)
Cell Biology
(1 time)
ANP (1 time)
EB (1 time)
ES (1 time)
2008 Retinoid acid-induced effects on atrial and pacemaker cell differentiation and expression of cardiac ion channels.
89  clamp technique was performed to assess I
(1 time)
Cardiology
(1 time)
DHT (1 time)
EST (1 time)
ORCH (1 time)
2002 Effects of gonadal steroids on gender-related differences in transmural dispersion of L-type calcium current.
90  clamped voltage at peak I
(1 time)
Physiology
(1 time)
--- 2013 [Metabolites of long-time preserved-acutely isolated rat cardiomyocytes affect L-type Ca(2+) channel current].
91  clear that by reducing I
(1 time)
Science
(1 time)
EPA (1 time)
PUFAs (1 time)
1997 Suppression of voltage-gated L-type Ca2+ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes.
92  combined with the isoflurane-induced acceleration of I
(1 time)
Anesthesiology
(1 time)
AP (1 time)
APD (1 time)
2002 Biphasic effects of isoflurane on the cardiac action potential: an ionic basis for anesthetic-induced changes in cardiac electrophysiology.
93  compared with wild-type I
(1 time)
Biochemistry
(1 time)
LTCC (1 time)
2012 Rem-GTPase regulates cardiac myocyte L-type calcium current.
94  compartmentalized regulation of I
(1 time)
Cardiology
(1 time)
E-C (1 time)
2012 Different subcellular populations of L-type Ca2+ channels exhibit unique regulation and functional roles in cardiomyocytes.
95  completely blocked the AA-induced suppression of I
(1 time)
Cell Biology
(1 time)
AA (1 time)
ARVM (1 time)
CS (1 time)
2007 Inhibition of L-type Ca2+ channel current and negative inotropy induced by arachidonic acid in adult rat ventricular myocytes.
96  completely deactivate I
(1 time)
Molecular Biology
(1 time)
EADs (1 time)
2008 Contribution of L-type Ca2+ channels to early afterdepolarizations induced by I Kr and I Ks channel suppression in guinea pig ventricular myocytes.
97  complex alteration in the kinase/phosphatase balance leads to I
(1 time)
Pharmacology
(1 time)
AF (1 time)
PTK (1 time)
SR (1 time)
2007 Pharmacological evidence for altered src kinase regulation of I (Ca,L) in patients with chronic atrial fibrillation.
98  computed a virtual I
(1 time)
Physiology
(1 time)
EADs (1 time)
SCD (1 time)
VF (1 time)
2011 Shaping a new Ca⁺ conductance to suppress early afterdepolarizations in cardiac myocytes.
99  concentration but significantly inhibited I
(1 time)
Physiology
(1 time)
ECC (1 time)
NPPB (1 time)
2002 Anion channels influence ECC by modulating L-type Ca(2+) channel in ventricular myocytes.
100  concentration-dependent block of peak I
(1 time)
Medicine
(1 time)
--- 2004 Inhibition of L-type Ca(2+) current in Guinea pig ventricular myocytes by cisapride.