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Abbreviation: Cip1
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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
cyclin-dependent kinase inhibitor p21
(98 times)
Neoplasms
(21 times)
cip1 (17 times)
AMPK (4 times)
ERK (3 times)
1998 Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2.
CDK inhibitor p21
(44 times)
Cell Biology
(14 times)
CDK (6 times)
AD (2 times)
EGFR (2 times)
1996 Adhesion-dependent control of cyclin E/cdk2 activity and cell cycle progression in normal cells but not in Ha-ras transformed NRK cells.
cycle inhibitor p21
(29 times)
Molecular Biology
(7 times)
cip1 (5 times)
SRC3 (2 times)
AML (1 time)
2001 High-intensity p38 kinase activity is critical for p21(cip1) induction and the antiproliferative function of G(i) protein-coupled receptors.
cyclin D1 and p21
(26 times)
Neoplasms
(5 times)
CIP1 (4 times)
DMBA (2 times)
ERK (2 times)
1999 Retinoic acid prevents phosphorylation of pRB in normal human B lymphocytes: regulation of cyclin E, cyclin A, and p21(Cip1).
cyclin D1, p21
(9 times)
Neoplasms
(4 times)
DMBA (2 times)
RT-PCR (2 times)
AR (1 time)
2000 Increased expression of cyclin D1, cyclin E and p21(Cip1) associated with decreased expression of p27(Kip1) in chemically induced rat mammary carcinogenesis.
increase in p21
(8 times)
Neoplasms
(3 times)
CIP1 (3 times)
ACR (1 time)
CAT (1 time)
1999 Expression of the HPV E7 oncoprotein mimics but does not evoke a p53-dependent cellular DNA damage response pathway.
CKIs p21
(5 times)
Biochemistry
(2 times)
CKI (3 times)
CDK2 (1 time)
CDKs (1 time)
1999 A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells.
E-cadherin and p21
(5 times)
Cell Biology
(1 time)
--- 2014 Oncogenic STRAP functions as a novel negative regulator of E-cadherin and p21(Cip1) by modulating the transcription factor Sp1.
Cdk-interacting protein 1
(4 times)
Science
(2 times)
CDK (2 times)
CDK2 (1 time)
PCNA (1 time)
1994 Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme.
10  combined with the accumulation of p21
(4 times)
Allergy and Immunology
(2 times)
CDK (1 time)
CKI (1 time)
DKO (1 time)
2000 Overexpression of wild-type RhoA produces growth arrest by disrupting actin cytoskeleton and microtubules.
11  cyclin kinase inhibitors p21
(4 times)
Cell Biology
(2 times)
bHLH (1 time)
mTOR (1 time)
RA (1 time)
2001 p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest.
12  cdk2 inhibitor, p21
(3 times)
Biochemistry
(2 times)
Cdk2 (1 time)
TCR (1 time)
2001 p27Kip1 regulates T cell proliferation.
13  cells expressing p21
(3 times)
Toxicology
(2 times)
HP1alpha (2 times)
p-Histone H3 (2 times)
ASK1 (1 time)
2003 Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1).
14  cellular proliferation. p21
(3 times)
Science
(1 time)
BMPs (1 time)
CDKs (1 time)
SGZ (1 time)
2001 P21(Cip1) induced by Raf is associated with increased Cdk4 activity in hematopoietic cells.
15  cycle inhibitory protein p21
(3 times)
Molecular Biology
(2 times)
ERK2 (1 time)
2001 Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells.
16  cytoplasmic p21
(3 times)
Biochemistry
(1 time)
ASK1 (1 time)
MAPK (1 time)
MKK (1 time)
2004 Cytoplasmic p21Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/cofilin pathway.
17  induction in p21
(3 times)
Biochemistry
(2 times)
CDK (1 time)
2000 Changes in p21(Cip1) and p27(Kip1) expression are not required for cell cycle entry and progression to S phase in Swiss 3T3 cells.
18  C-terminal domain of p21
(2 times)
Biochemistry
(1 time)
CaM (1 time)
PCNA (1 time)
2003 The structural plasticity of the C terminus of p21Cip1 is a determinant for target protein recognition.
19  carboxyl-terminal domain of p21
(2 times)
Biochemistry
(2 times)
CDK (1 time)
1999 Calmodulin binds to p21(Cip1) and is involved in the regulation of its nuclear localization.
20  cardiomyocytes in p21
(2 times)
Biochemistry
(2 times)
CKIs (2 times)
2014 CDK inhibitors, p21(Cip1) and p27(Kip1), participate in cell cycle exit of mammalian cardiomyocytes.
21  Cdc2-Tyr-15 phosphorylation and p21
(2 times)
Neoplasms
(1 time)
--- 2002 Enhanced sensitization to taxol-induced apoptosis by herceptin pretreatment in ErbB2-overexpressing breast cancer cells.
22  changes in p21
(2 times)
Cell Biology
(1 time)
IFN-alpha (1 time)
2000 Changes in p21(Cip1) and p27(Kip1) expression are not required for cell cycle entry and progression to S phase in Swiss 3T3 cells.
23  Cip/Kip inhibitors, p21
(2 times)
Biology
(1 time)
AhR (1 time)
CDK2 (1 time)
2005 Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases.
24  cycle-inhibitory role for p21
(2 times)
Drug Therapy
(1 time)
CDK (1 time)
2007 Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells.
25  cycle-regulatory proteins p21
(2 times)
Molecular Biology
(1 time)
AddnSmad4 (1 time)
Cxs (1 time)
TGF-beta (1 time)
2001 Adenovirus-mediated gene transfer of dominant-negative Smad4 blocks TGF-beta signaling in pancreatic acinar cells.
26  cyclin E, CDK2, CDK4, and p21
(2 times)
Cell Biology
(2 times)
HASMCs (2 times)
PDGF (2 times)
EORP (1 time)
2012 Ganoderma lucidum polysaccharides prevent platelet-derived growth factor-stimulated smooth muscle cell proliferation in vitro and neointimal hyperplasia in the endothelial-denuded artery in vivo.
27  cyclin-dependent kinase, p21
(2 times)
Cell Biology
(1 time)
CDK (1 time)
HF (1 time)
VSMC (1 time)
2004 Inhibition of cell cycle progression and migration of vascular smooth muscle cells by prostaglandin D2 synthase: resistance in diabetic Goto-Kakizaki rats.
28  A-CDK activities start to decrease. p21
(1 time)
Biochemistry
(1 time)
CKIs (1 time)
2014 CDK inhibitors, p21(Cip1) and p27(Kip1), participate in cell cycle exit of mammalian cardiomyocytes.
29  A-CDK2, induced by p21
(1 time)
Biochemistry
(1 time)
CDK (1 time)
1999 The protein SET regulates the inhibitory effect of p21(Cip1) on cyclin E-cyclin-dependent kinase 2 activity.
30  activity, increases p21
(1 time)
Neoplasms
(1 time)
TGF-beta (1 time)
2006 Oncogenic function of a novel WD-domain protein, STRAP, in human carcinogenesis.
31  alpha-casein, MAP2c, and p21
(1 time)
Biochemistry
(1 time)
ANS (1 time)
CD (1 time)
FCS (1 time)
2011 Protein disorder prevails under crowded conditions.
32  anti-calmodulin drugs decreases the nuclear accumulation of p21
(1 time)
Biochemistry
(1 time)
--- 1999 Calmodulin binds to p21(Cip1) and is involved in the regulation of its nuclear localization.
33  blocked H(2)O(2)-induced p21
(1 time)
Biochemistry
(1 time)
NES (1 time)
2007 Cytoplasmic localization and ubiquitination of p21(Cip1) by reactive oxygen species.
34  C (PKC) delta suppresses keratinocyte proliferation by increasing p21
(1 time)
Biochemistry
(1 time)
PKC (1 time)
2011 Protein kinase C (PKC) delta suppresses keratinocyte proliferation by increasing p21(Cip1) level by a KLF4 transcription factor-dependent mechanism.
35  c-Jun N-terminal kinase (JNK). p21
(1 time)
Allergy and Immunology
(1 time)
AP-1 (1 time)
CDK (1 time)
IL-2 (1 time)
2010 p21(Cip1) up-regulated during histone deacetylase inhibitor-induced CD4(+) T-cell anergy selectively associates with mitogen-activated protein kinases.
36  c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21
(1 time)
Molecular Biology
(1 time)
ERK (1 time)
JNK (1 time)
PKC (1 time)
2002 Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells.
37  c-Jun N-terminal kinase, which was associated with p21
(1 time)
Allergy and Immunology
(1 time)
--- 2003 Gene transfer of a cell cycle modulator exerts anti-inflammatory effects in the treatment of arthritis.
38  c-Myc in established tumors leads to the up-regulation of p21
(1 time)
Molecular Biology
(1 time)
--- 2006 Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene.
39  c-Myc-mediated repression of p21
(1 time)
Molecular Biology
(1 time)
--- 2006 Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene.
40  C-terminal p21
(1 time)
Biotechnology
(1 time)
PCNA (1 time)
2000 Essential interaction between the fission yeast DNA polymerase delta subunit Cdc27 and Pcn1 (PCNA) mediated through a C-terminal p21(Cip1)-like PCNA binding motif.
41  C14-inhibiting protein-1
(1 time)
Microbiology
(1 time)
Pto DC3000 (1 time)
2016 Screen of Non-annotated Small Secreted Proteins of Pseudomonas syringae Reveals a Virulence Factor That Inhibits Tomato Immune Proteases.
42  C33A inhibits UV-induced expression of p21
(1 time)
Virology
(1 time)
--- 2012 The human papillomavirus type 16 E7 oncoprotein targets Myc-interacting zinc-finger protein-1.
43  calmodulin and p21
(1 time)
Biochemistry
(1 time)
--- 1999 Calmodulin binds to p21(Cip1) and is involved in the regulation of its nuclear localization.
44  Calmodulin binds to p21
(1 time)
Biochemistry
(1 time)
--- 1999 Calmodulin binds to p21(Cip1) and is involved in the regulation of its nuclear localization.
45  calmodulin interaction with p21
(1 time)
Biochemistry
(1 time)
--- 1999 Calmodulin binds to p21(Cip1) and is involved in the regulation of its nuclear localization.
46  can be effectively treated by local gene transfer of p21
(1 time)
Allergy and Immunology
(1 time)
--- 2000 Adenoviral transfer of cyclin-dependent kinase inhibitor genes suppresses collagen-induced arthritis in mice.
47  can induce p21
(1 time)
Biochemistry
(1 time)
--- 2002 Drm/Gremlin transcriptionally activates p21(Cip1) via a novel mechanism and inhibits neoplastic transformation.
48  can interact with p21
(1 time)
Molecular Biology
(1 time)
HPVs (1 time)
1997 The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2.
49  can progress to the S phase without downregulation of p21
(1 time)
Cell Biology
(1 time)
--- 2000 Changes in p21(Cip1) and p27(Kip1) expression are not required for cell cycle entry and progression to S phase in Swiss 3T3 cells.
50  can repress Miz-1-induced p21
(1 time)
Virology
(1 time)
--- 2012 The human papillomavirus type 16 E7 oncoprotein targets Myc-interacting zinc-finger protein-1.
51  can then result in increased p21
(1 time)
Biochemistry
(1 time)
--- 2015 KLF10 affects pancreatic function via the SEI-1/p21Cip1 pathway.
52  canonical E-box sequences found in the TrkB and p21
(1 time)
Cell Biology
(1 time)
bHLH (1 time)
RA (1 time)
2004 Basic helix-loop-helix proteins bind to TrkB and p21(Cip1) promoters linking differentiation and cell cycle arrest in neuroblastoma cells.
53  canonical PCNA binding motif first identified in the mammalian p21
(1 time)
Biotechnology
(1 time)
PCNA (1 time)
2000 Essential interaction between the fission yeast DNA polymerase delta subunit Cdc27 and Pcn1 (PCNA) mediated through a C-terminal p21(Cip1)-like PCNA binding motif.
54  capability to repress p21
(1 time)
Virology
(1 time)
--- 2012 The human papillomavirus type 16 E7 oncoprotein targets Myc-interacting zinc-finger protein-1.
55  capable of regulating the normal turnover of p21
(1 time)
Biochemistry
(1 time)
IR (1 time)
2009 Ionizing radiation induces ATM-independent degradation of p21Cip1 in transformed cells.
56  capacity of the HPV E7 oncoprotein to overcome p21
(1 time)
Molecular Biology
(1 time)
HPVs (1 time)
1997 The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2.
57  capacity to inactivate p21
(1 time)
Neoplasms
(1 time)
HPV (1 time)
2009 Human papillomavirus E7 oncoprotein overrides the tumor suppressor activity of p21Cip1 in cervical carcinogenesis.
58  carcinogen 6-nitrochrysene on p53 and p21
(1 time)
Biochemistry
(1 time)
1,2-DHD-6-NHOH-C (1 time)
6-NC (1 time)
BaP (1 time)
2007 Effects of the environmental mammary carcinogen 6-nitrochrysene on p53 and p21(Cip1) protein expression and cell cycle regulation in MCF-7 and MCF-10A cells.
59  carcinogenesis and that p21
(1 time)
Neoplasms
(1 time)
HPV (1 time)
2009 Human papillomavirus E7 oncoprotein overrides the tumor suppressor activity of p21Cip1 in cervical carcinogenesis.
60  carcinoma were immunostained using specific antibodies against ErbB2, p21
(1 time)
Neoplasms
(1 time)
CMF (1 time)
DFS (1 time)
Tyr (1 time)
2003 ErbB2 overexpression in human breast carcinoma is correlated with p21Cip1 up-regulation and tyrosine-15 hyperphosphorylation of p34Cdc2: poor responsiveness to chemotherapy with cyclophoshamide methotrexate, and 5-fluorouracil is associated with Erb2 overexpression and with p21Cip1 overexpression.
61  cardiomyocytes and whether p21
(1 time)
Biochemistry
(1 time)
CKIs (1 time)
2015 Two inhibitory systems and CKIs regulate cell cycle exit of mammalian cardiomyocytes after birth.
62  cardiomyocytes increased significantly in p21
(1 time)
Biochemistry
(1 time)
CKIs (1 time)
2015 Two inhibitory systems and CKIs regulate cell cycle exit of mammalian cardiomyocytes after birth.
63  cardiomyocytes, and that the M-phase inhibitory system and p21
(1 time)
Biochemistry
(1 time)
CKIs (1 time)
2015 Two inhibitory systems and CKIs regulate cell cycle exit of mammalian cardiomyocytes after birth.
64  cardiotoxicity via p21
(1 time)
Cardiology
(1 time)
DOX (1 time)
FAK (1 time)
MFKO (1 time)
2014 Focal adhesion kinase antagonizes doxorubicin cardiotoxicity via p21(Cip1.).
65  cascade and rapamycin-induced apoptosis are suppressed by p53/p21
(1 time)
Cell Biology
(1 time)
ASK1 (1 time)
mTOR (1 time)
2003 Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1).
66  cascade in p21
(1 time)
Biochemistry
(1 time)
CDK (1 time)
2005 Cyclin-dependent kinase inhibitors uncouple cell cycle progression from mitochondrial apoptotic functions in DNA-damaged cancer cells.
67  cascade to increase p53 levels and p53 drives p21
(1 time)
Biochemistry
(1 time)
--- 2014 p38delta regulates p53 to control p21Cip1 expression in human epidermal keratinocytes.
68  cascade, decreased expression of p21
(1 time)
Biochemistry
(1 time)
Cav-1 (1 time)
MEFs (1 time)
2004 Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia.
69  caspase activity is partially regulated by p21
(1 time)
Allergy and Immunology
(1 time)
CO (1 time)
HO-1 (1 time)
2004 Carbon monoxide inhibits T lymphocyte proliferation via caspase-dependent pathway.
70  caspase pathways, the B-Raf and extracellular signal-regulated kinase pathway, p21
(1 time)
Antineoplastic Agents
(1 time)
HDACi (1 time)
2007 Proapoptotic ability of oncogenic H-Ras to facilitate apoptosis induced by histone deacetylase inhibitors in human cancer cells.
71  catalytic subunit expression, and upregulation of p53, p21
(1 time)
Neoplasms
(1 time)
iNOS (1 time)
NF-kappaB (1 time)
2004 Inhibition of nuclear factor-kappaB and nitric oxide by curcumin induces G2/M cell cycle arrest and apoptosis in human melanoma cells.
72  caused a G2 /M arrest by the induction of p21
(1 time)
Cell Biology
(1 time)
MDR (1 time)
2013 Defective autophagy in multidrug resistant cells may lead to growth inhibition by BH3-mimetic gossypol.
73  caused a moderate increase in p21
(1 time)
Biochemistry
(1 time)
AR (1 time)
pRb (1 time)
RB (1 time)
2010 A novel anticancer agent, retigeric acid B, displays proliferation inhibition, S phase arrest and apoptosis activation in human prostate cancer cells.
74  caused an associated increase in the p21
(1 time)
Neoplasms
(1 time)
PCNA (1 time)
RG (1 time)
SG (1 time)
2010 KG-135, enriched with selected ginsenosides, inhibits the proliferation of human prostate cancer cells in culture and inhibits xenograft growth in athymic mice.
75  caused an increase in p21
(1 time)
Cell Biology
(1 time)
mpc (1 time)
2008 p21(Cip1) expression is increased in ambient oxygen, compared to estimated physiological (5%) levels in rat muscle precursor cell culture.
76  caused by altered intracellular localization of p21
(1 time)
Cell Biology
(1 time)
--- 2001 Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells.
77  caused increased cellular levels of p21
(1 time)
Pathology
(1 time)
CO (1 time)
2005 Carbon monoxide suppresses bleomycin-induced lung fibrosis.
78  causes a transient p53- and p21
(1 time)
Biochemistry
(1 time)
MKK4 (1 time)
2012 Delayed cell cycle progression in selenoprotein W-depleted cells is regulated by a mitogen-activated protein kinase kinase 4-p38/c-Jun NH2-terminal kinase-p53 pathway.
79  causes G(2)/M arrest associated with the modulation of p21
(1 time)
Biochemistry
(1 time)
--- 2009 Apigenin causes G(2)/M arrest associated with the modulation of p21(Cip1) and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 cells.
80  causes transcriptional upregulation of p21
(1 time)
Virology
(1 time)
CDK (1 time)
MHV (1 time)
pRb (1 time)
2004 Murine coronavirus nonstructural protein p28 arrests cell cycle in G0/G1 phase.
81  CCND3 and was negatively regulated by p21
(1 time)
Science
(1 time)
CCND3 (1 time)
CDKs (1 time)
2007 Functional characterization of human PFTK1 as a cyclin-dependent kinase.
82  cdc2 and upregulating p-p53 and p21
(1 time)
Cell Biology
(1 time)
HCC (1 time)
MTT (1 time)
2013 Corilagin inhibits hepatocellular carcinoma cell proliferation by inducing G2/M phase arrest.
83  Cdc2 on Tyr-15, and down-regulated the expression of p21
(1 time)
Neoplasms
(1 time)
--- 2002 Enhanced sensitization to taxol-induced apoptosis by herceptin pretreatment in ErbB2-overexpressing breast cancer cells.
84  Cdc2-Tyr-15 and down-regulation of p21
(1 time)
Neoplasms
(1 time)
--- 2002 Enhanced sensitization to taxol-induced apoptosis by herceptin pretreatment in ErbB2-overexpressing breast cancer cells.
85  Cdc25A degradation and p21
(1 time)
Cell Biology
(1 time)
IR (1 time)
2010 The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage.
86  Cdc25B and an increase in the protein expression of p21
(1 time)
Neoplasms
(1 time)
AML (1 time)
mRNA (1 time)
2010 The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia.
87  Cdelta (PKCdelta) inhibitor rottlerin also blocked the induction of p21
(1 time)
Biochemistry
(1 time)
PDGF (1 time)
PKCdelta (1 time)
RASMC (1 time)
2001 Peroxisome proliferator-activated receptor gamma ligands inhibit mitogenic induction of p21(Cip1) by modulating the protein kinase Cdelta pathway in vascular smooth muscle cells.
88  Cdk 1, 4, and 6 and increase in p21
(1 time)
Biochemistry
(1 time)
RDGN (1 time)
2012 DACH1 regulates cell cycle progression of myeloid cells through the control of cyclin D, Cdk 4/6 and p21Cip1.
89  Cdk activity by p21
(1 time)
Cell Biology
(1 time)
--- 2001 Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells.
90  CDK-2, and decreased inhibitory binding of CDK-2 to p21
(1 time)
Biochemistry
(1 time)
CDK-2 (1 time)
2004 Mevalonate promotes the growth of tumors derived from human cancer cells in vivo and stimulates proliferation in vitro with enhanced cyclin-dependent kinase-2 activity.
91  Cdk-inhibitory activity and expression of both p21
(1 time)
Cell Biology
(1 time)
CDKs (1 time)
ER (1 time)
pRb (1 time)
2001 Multifaceted regulation of cell cycle progression by estrogen: regulation of Cdk inhibitors and Cdc25A independent of cyclin D1-Cdk4 function.
92  CDK2 activity, which is mediated by p21
(1 time)
Neoplasms
(1 time)
IRF-1 (1 time)
2000 Molecular determinants of UCN-01-induced growth inhibition in human lung cancer cells.
93  Cdk2 are both less susceptible to inhibition by p21
(1 time)
Biochemistry
(1 time)
CDKs (1 time)
2001 Differential regulation of Cdc2 and Cdk2 by RINGO and cyclins.
94  cdk2 association of p21
(1 time)
Cell Biology
(1 time)
--- 1996 Adhesion-dependent control of cyclin E/cdk2 activity and cell cycle progression in normal cells but not in Ha-ras transformed NRK cells.
95  Cdk2 inhibitory activity of p21
(1 time)
Cell Biology
(1 time)
--- 2001 Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells.
96  Cdk2 is dispensable for p21
(1 time)
Neoplasms
(1 time)
--- 2005 Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1).
97  cdk2 kinase activity despite high levels of p21
(1 time)
Molecular Biology
(1 time)
HPVs (1 time)
1997 The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2.
98  CDK2 overexpression elicits a p21
(1 time)
Pathology
(1 time)
--- 2008 CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development.
99  CDK2 was also reduced with increased expression of p21
(1 time)
Neoplasms
(1 time)
YB-1 (1 time)
2010 Y-box binding protein-1 (YB-1) promotes cell cycle progression through CDC6-dependent pathway in human cancer cells.
100  CDK2, as well as increased the expression of p21
(1 time)
Pharmacology
(1 time)
CDK (1 time)
PCNA (1 time)
PDGF (1 time)
2015 Apamin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and migration through suppressions of activated Akt and Erk signaling pathway.