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Abbreviation: CsA
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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
cyclosporin A
(6915 times)
Pharmacology
(824 times)
P-gp (230 times)
GVHD (193 times)
MMF (189 times)
1979 Cyclosporin A: in vivo and in vitro suppression of rat T-lymphocyte function.
cyclosporine Neoral
(5 times)
Transplantation
(5 times)
AUC (3 times)
TAC (2 times)
CI (1 time)
2004 Baseline immunosuppression is associated with histological findings in early protocol biopsies.
coadministration of cyclosporine
(3 times)
Pharmacology
(1 time)
AUC (1 time)
BUN (1 time)
CAT (1 time)
2001 Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel.
drugs-cyclosporin A
(3 times)
Natural Science Disciplines
(1 time)
EC (1 time)
GC (1 time)
LPS (1 time)
2000 Association of glucocorticoids and cyclosporin A or rapamycin prevents E-selectin and IL-8 expression during LPS- and TNFalpha-mediated endothelial cell activation.
acute-cyclosporin A
(2 times)
Nephrology
(1 time)
ADM (1 time)
DNR (1 time)
FF (1 time)
1989 Acute cyclosporine renal dysfunction reversed by dopamine infusion in healthy subjects.
Chondroitin sulfate
(2 times)
Biomedical Engineering
(1 time)
PLGA (2 times)
CD (1 time)
INS (1 time)
2007 Protein complexed with chondroitin sulfate in poly(lactide-co-glycolide) microspheres.
CNIs: such as cyclosporine
(2 times)
Transplantation
(1 time)
AZA (1 time)
CI (1 time)
ESKD (1 time)
2010 Influence of CYP3A5 and ABCB1 gene polymorphisms on calcineurin inhibitor-related neurotoxicity after hematopoietic stem cell transplantation.
corticosteroids and cyclosporine
(2 times)
Allergy and Immunology
(1 time)
BD (1 time)
DEX (1 time)
EAU (1 time)
1987 Cyclosporine and dexamethasone inhibit T-lymphocyte MHC class II antigens and IL-2 receptor expression in experimental autoimmune uveitis.
corticosteroids, anakinra, and cyclosporine
(2 times)
Medicine
(1 time)
CSF (1 time)
CTLs (1 time)
HLH (1 time)
2017 Hemophagocytic lymphohistiocytosis in an adult kidney transplant recipient successfully treated by plasmapheresis: A case report and review of the literature.
10  corticosteroids, azathioprine, cyclosporine
(2 times)
Transplantation
(1 time)
--- 2004 Optimization of the use of cyclosporine in renal transplantation.
11  cyclosporin A ophthalmic emulsion
(2 times)
Ophthalmology
(2 times)
IL-6 (1 time)
RT-PCR (1 time)
2000 Interleukin-6 levels in the conjunctival epithelium of patients with dry eye disease treated with cyclosporine ophthalmic emulsion.
12  anti-cyclosporine
(1 time)
Allergy and Immunology
(1 time)
--- 1991 Characterization of a monoclonal anti-idiotypic antibody that mimics cyclosporine A in a single binding system.
13  anti-T-cell antibody, cyclophosphamide, cyclosporine
(1 time)
Transplantation
(1 time)
BM (1 time)
BW (1 time)
HSCT (1 time)
2007 In pursuit of the ultimate: the initial Ahmedabad journey toward transplantation tolerance.
14  blocker-cyclosporin A
(1 time)
Biochemistry
(1 time)
AP-1 (1 time)
Con A (1 time)
IFN-gamma (1 time)
2004 Volvariella volvacea lectin activates mouse T lymphocytes by a calcium dependent pathway.
15  cadaveric kidney transplantation using cyclosporine
(1 time)
Health Services Research
(1 time)
AZA (1 time)
ESRD (1 time)
1986 A cost-effectiveness analysis of cyclosporine in cadaveric kidney transplantation.
16  calcineurin activity nor its inhibition by cyclosporine
(1 time)
Transplantation
(1 time)
--- 1997 Calcineurin activity in children with renal transplants receiving cyclosporine.
17  calcineurin inhibitors, tacrolimus or modified cyclosporine
(1 time)
Transplantation
(1 time)
USRDS (1 time)
2005 Renal graft survival and calcineurin inhibitor.
18  calcineurin phosphatase inhibitors, cyclosporine
(1 time)
Biochemistry
(1 time)
--- 2003 Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes.
19  calcium antagonist may have a renoprotective against cyclosporin
(1 time)
Nephrology
(1 time)
BP (1 time)
FF (1 time)
GFR (1 time)
1998 The effect of felodipine on renal function and blood pressure in cyclosporin-treated renal transplant recipients during the first three months after transplantation.
20  Calcium antagonists may reduce the nephrotoxicity of cyclosporine
(1 time)
Nephrology
(1 time)
ATG (1 time)
ATGAM (1 time)
1997 A randomized trial comparing cyclosporine induction with sequential therapy in renal transplant recipients.
21  Campath-1H and received sirolimus or cyclosporine
(1 time)
Nephrology
(1 time)
Treg (1 time)
2007 Regulatory T cells and T cell depletion: role of immunosuppressive drugs.
22  can antagonize the cyclosporine
(1 time)
Transplantation
(1 time)
--- 1997 Investigation of a possible interaction between ciprofloxacin and cyclosporine in renal transplant patients.
23  can reduce the dosage of cyclosporine
(1 time)
Pharmacology
(1 time)
--- 2015 Diltiazem augments the influence of MDR1 genotype status on cyclosporine concentration in Chinese patients with renal transplantation.
24  capsid stability were assessed using a cyclosporine
(1 time)
Virology
(1 time)
CTL (1 time)
2016 Changes in HIV-1 Capsid Stability Induced by Common Cytotoxic-T-Lymphocyte-Driven Viral Sequence Mutations.
25  carbamazepine and cyclosporine
(1 time)
Drug Therapy
(1 time)
--- 1995 Effects of carbamazepine on cyclosporine metabolism in pediatric renal transplant recipients.
26  carboxylic acid, was in clinical development in combination with cyclosporine
(1 time)
Pharmacology
(1 time)
BQR (1 time)
1997 Phase I safety and pharmacokinetic studies of brequinar sodium after single ascending oral doses in stable renal, hepatic, and cardiac allograft recipients.
27  cardiac allograft survival and is synergistic with cyclosporine
(1 time)
General Surgery
(1 time)
BN (1 time)
LEW (1 time)
LPS (1 time)
1993 Lipopolysaccharide pretreatment of cyclosporine-treated rats enhances cardiac allograft survival.
28  cardiac allografts and has demonstrated synergy with cyclosporine
(1 time)
General Surgery
(1 time)
RPM (1 time)
1994 Efficacy of rapamycin and FK 506 in prolonging rat hind limb allograft survival.
29  cardiac allografts in rats treated with cyclosporine
(1 time)
Transplantation
(1 time)
Th (1 time)
1985 Phenotype, activation status, and suppressor activity of host lymphocytes during acute rejection and after cyclosporine-induced unresponsiveness of rat cardiac allografts.
30  cardiovascular risk factors in two phase II studies comparing cyclosporine
(1 time)
Transplantation
(1 time)
--- 2003 Cardiovascular risk factors of sirolimus compared with cyclosporine: early experience from two randomized trials in renal transplantation.
31  cardiovascular toxicity by cyclosporine
(1 time)
Nephrology
(1 time)
CAT-1 (1 time)
eNOS (1 time)
HUVEC (1 time)
2013 Cyclosporine attenuates arginine transport, in human endothelial cells, through modulation of cationic amino acid transporter-1.
32  carried out, particularly focussing our attention on cyclosporine
(1 time)
Transplantation
(1 time)
DKG (1 time)
MMF (1 time)
MPA (1 time)
2000 The kidney transplant program at the Bergamo Center.
33  carvedilol and cyclosporine
(1 time)
Transplantation
(1 time)
CVR (1 time)
1997 Elevation of cyclosporin A blood levels during carvedilol treatment in renal transplant patients.
34  cases and to cyclosporine
(1 time)
Transplantation
(1 time)
--- 2006 Tacrolimus-related neurologic and renal complications in liver transplantation: A single-center experience.
35  cases singular or complicated cyclosporine
(1 time)
Transplantation
(1 time)
--- 1998 Is kidney graft biopsy indicated in recipients with newly developed, microscopic hematuria?
36  catalyzing the site-specific hydroxylation of the immunosuppressant cyclosporine
(1 time)
Microbiology
(1 time)
CsA-4-OH (1 time)
CTAB (1 time)
2015 Reconstitution of the In Vitro Activity of the Cyclosporine-Specific P450 Hydroxylase from Sebekia benihana and Development of a Heterologous Whole-Cell Biotransformation System.
37  cell activity by cyclosporine
(1 time)
Transplantation
(1 time)
--- 1986 Modulation of host defenses against pyogenic microorganisms by cyclosporine.
38  cell-mediated and relatively resistant to cyclosporine
(1 time)
Transplantation
(1 time)
IFN-gamma (1 time)
IL (1 time)
NOD (1 time)
1997 Combination therapy with cyclosporine and interleukin-4 or interleukin-10 prolongs survival of synergeneic pancreatic islet grafts in nonobese diabetic mice: islet graft survival does not correlate with mRNA levels of type 1 or type 2 cytokines, or transforming growth factor-beta in the islet grafts.
39  cells and maintenance suppression with low-dose cyclosporine
(1 time)
Transplantation
(1 time)
AZ (1 time)
CP (1 time)
1988 Low-dose cyclosporine maintenance therapy after immunosuppressive induction in a rat cardiac transplant model.
40  cells are inhibited by cyclosporine
(1 time)
Antineoplastic Agents
(1 time)
DFMO (1 time)
1988 Differential sensitivity of pancreatic and colon cancer to cyclosporine and alpha-difluoromethylornithine in vivo.
41  cells suggest that cyclosporin
(1 time)
Dentistry
(1 time)
--- 1997 [Cytokines and cytokine receptors in mouth mucosa of immune suppressed patients].
42  cells, addition of cyclosporine
(1 time)
Microbiology
(1 time)
EBV (1 time)
IRF4 (1 time)
KSHV (1 time)
2014 Murine gammaherpesvirus M2 protein induction of IRF4 via the NFAT pathway leads to IL-10 expression in B cells.
43  cessation of long-term cyclosporin
(1 time)
General Surgery
(1 time)
--- 1993 Extended survival and function of peripheral nerve allografts after cessation of long-term cyclosporin administration in rats.
44  changed; specifically, the cyclosporine
(1 time)
Transplantation
(1 time)
AZA (1 time)
BP (1 time)
BW (1 time)
2004 Effect of mycophenolate mofetil on kidney graft function and body weight in patients with chronic allograft nephropathy.
45  changes; an alternate hypothesis, however, may be that cyclosporine
(1 time)
Toxicology
(1 time)
--- 1993 An in vitro model of cyclosporine-induced nephrotoxicity.
46  channel antagonists on the metabolism of cyclosporine
(1 time)
Pharmacology
(1 time)
--- 1989 Calcium channel antagonists and cyclosporine metabolism: in vitro studies with human liver microsomes.
47  characterize a possible plasma membrane receptor for cyclosporine
(1 time)
Allergy and Immunology
(1 time)
--- 1983 Binding of cyclosporine by human lymphocytes and phospholipid vesicles.
48  characterized a series of cyclosporine
(1 time)
Gastroenterology
(1 time)
CN (1 time)
Cyps (1 time)
HBV (1 time)
2017 Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity.
49  chemosensitizer, such as cyclosporin A
(1 time)
Neoplasms
(1 time)
ADR (1 time)
CsH (1 time)
IC50 (1 time)
1994 Secondary combined resistance to the multidrug-resistance-reversing activity of cyclosporin A in the cell line F4-6RADR-CsA.
50  chitosan aerogel
(1 time)
Carbohydrates
(1 time)
--- 2016 An environment-friendly and multi-functional absorbent from chitosan for organic pollutants and heavy metal ion.
51  Cholestatic effects have been reported for cyclosporine
(1 time)
Transplantation
(1 time)
BADF (1 time)
BAIF (1 time)
BASR (1 time)
1999 Influence of tacrolimus on bile acid and lipid composition in continuously drained bile using a rat model. Comparative study with cyclosporine.
52  chromatography estimations of trough plasma cyclosporin
(1 time)
Nephrology
(1 time)
--- 1988 Is there a therapeutic range for monitoring plasma cyclosporin in renal allograft recipients?
53  Chromosome-type aberrations
(1 time)
Toxicology
(1 time)
Cd (1 time)
MN (1 time)
1994 Comparison of chromosome aberrations and micronuclei in testing genotoxicity in humans.
54  chronic allograft dysfunction even in the absence of cyclosporine
(1 time)
Transplantation
(1 time)
ET-1 (1 time)
2002 Inhibition of endothelin-1 improves survival and vasculopathy in rat cardiac transplants treated with cyclosporine.
55  chronic allograft liver rejection model induced by low-dose immunosuppressive cyclosporine
(1 time)
Biology
(1 time)
BN (1 time)
DA (1 time)
2012 Humoral immunity-mediated chronic rejection in liver transplantation is associated with predominant IL-10 expression.
56  chronic allograft nephropathy, and cyclosporine
(1 time)
Nephrology
(1 time)
GPT (1 time)
2005 Long-term beneficial effect of tacrolimus conversion on renal transplant recipients.
57  chronic liver disease and the use of cyclosporin
(1 time)
Transplantation
(1 time)
--- 2002 Nocardiosis in tropical renal transplant recipients.
58  chronically administered low doses of cyclosporine
(1 time)
Pharmacology
(1 time)
--- 1994 The effect of neonatal immunoregulatory cells and cyclosporine on the heart allograft survival in rats.
59  ciclosporin A group
(1 time)
Complementary Therapies
(1 time)
BrdU (1 time)
DC (1 time)
MSCA (1 time)
2009 Mesenchymal stem cells transplantation mildly ameliorates experimental diabetic nephropathy in rats.
60  ciclosporin A modified
(1 time)
Health Services
(1 time)
--- 2010 Healthcare costs in renal transplant recipients using branded versus generic ciclosporin.
61  cimetidine and cyclosporine
(1 time)
Gastroenterology
(1 time)
--- 1992 The effect of cimetidine on cyclosporine A levels in liver transplant recipients: a preliminary report.
62  circumstances force some stable renal transplant recipients to discontinue cyclosporine
(1 time)
Nephrology
(1 time)
NORD (1 time)
1996 Benefits of continued cyclosporine through an indigent drug program.
63  clearly attributable to cyclosporine
(1 time)
Nephrology
(1 time)
--- 2005 Hyperuricemia in kidney transplantation.
64  clinical applications in the United States: cyclosporine
(1 time)
Chemistry, Clinical
(1 time)
LC (1 time)
MEIA (1 time)
MPA (1 time)
2001 Therapeutic drug monitoring for immunosuppressants.
65  clinical aspects after kidney transplantation using cyclosporine
(1 time)
General Surgery
(1 time)
AZ (1 time)
1986 Improved outcome of renal transplantation with cyclosporine compared with azathioprine--experience in 33 recipients followed for over one year.
66  clinical settings as cyclosporine
(1 time)
Transplantation
(1 time)
IGF-I (1 time)
2003 Insulin-like growth factor-I enhances choleretic action of FK506 in rats.
67  clinical significance of cyclosporine
(1 time)
Biochemistry
(1 time)
AP (1 time)
AUC (1 time)
2006 Is absorption profile of cyclosporine really important for effective immunosuppression?
68  closely correlated with the level of P-450
(1 time)
Pharmacology
(1 time)
NF (1 time)
1989 Metabolism of cyclosporin A. IV. Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily.
69  CMV and intravenous cyclosporine
(1 time)
Gastroenterology
(1 time)
--- 2011 A case of ulcerative colitis accompanied with myelodysplastic syndrome successfully treated by cyclosporine.
70  CN, as demonstrated by CN inhibition with cyclosporine
(1 time)
Cell Biology
(1 time)
NFAT (1 time)
PE (1 time)
PKC (1 time)
2009 Effects of thapsigargin and phenylephrine on calcineurin and protein kinase C signaling functions in cardiac myocytes.
71  co-administered with cyclosporin
(1 time)
Pharmacy
(1 time)
AUC (1 time)
MMF (1 time)
MPA (1 time)
2006 Comparison of mycophenolic acid pharmacokinetic parameters in kidney transplant patients within the first 3 months post-transplant.
72  Coadministration of diltiazem with cyclosporine
(1 time)
Cardiology
(1 time)
--- 1992 Cost containment: coadministration of diltiazem with cyclosporine after heart transplantation.
73  Coadministration of the calcineurin inhibitor cyclosporine
(1 time)
Toxicology
(1 time)
ROS (1 time)
SRL (1 time)
2010 Immunosuppressant neurotoxicity in rat brain models: oxidative stress and cellular metabolism.
74  coefficients of variation ranged between 3.0-4.1
(1 time)
Chemistry, Clinical
(1 time)
ACMIA (1 time)
CLIA (1 time)
ECLIA (1 time)
2017 Analytical performance evaluation of the Elecsys Cyclosporine and Elecsys Tacrolimus assays on the cobas e411 analyzer.
75  collections among patients treated with sirolimus-cyclosporine
(1 time)
Transplantation
(1 time)
--- 2002 Incidence, therapy, and consequences of lymphocele after sirolimus-cyclosporine-prednisone immunosuppression in renal transplant recipients.
76  combined with a triple immunosuppressive protocol including prednisolone,cyclosporine microemulsion
(1 time)
Kidney Diseases
(1 time)
MMF (1 time)
2012 Efficacy of anti-interleukin-2 receptor antibody (daclizumab) in reducing the incidence of acute rejection after renal transplantation.
77  common adverse effect of cyclosporine
(1 time)
Cardiology
(1 time)
--- 2007 Possible everolimus-induced, severe, reversible encephalopathy after cardiac transplantation.
78  common after heart transplantation, and is related to ciclosporin
(1 time)
Nephrology
(1 time)
AZA (1 time)
SRL (1 time)
2009 Transfer from ciclosporin to mycophenolate-sirolimus immunosuppression for chronic renal disease after heart transplantation: safety and efficacy of two regimens.
79  common and clinically important side effect of cyclosporine
(1 time)
Pharmacology
(1 time)
BUN (1 time)
ROS (1 time)
TBARS (1 time)
2001 Quercetin, a bioflavonoid, protects against oxidative stress-related renal dysfunction by cyclosporine in rats.
80  common and important side-effect of cyclosporin
(1 time)
Nephrology
(1 time)
ANF (1 time)
GFR (1 time)
RBF (1 time)
1994 Prevention of acute cyclosporin nephrotoxicity by verapamil and atrial natriuretic factor in the rat.
81  comparators administered with a cyclosporine
(1 time)
Transplantation
(1 time)
AZA (1 time)
PRED (1 time)
2003 Two-year results of multicenter phase III trials on the effect of the addition of sirolimus to cyclosporine-based immunosuppressive regimens in renal transplantation.
82  compare outcomes in patients receiving either cyclosporine
(1 time)
Transplantation
(1 time)
CI (1 time)
CMV (1 time)
DFI (1 time)
1995 Major infectious complications after orthotopic liver transplantation and comparison of outcomes in patients receiving cyclosporine or FK506 as primary immunosuppression.
83  compared the pharmacokinetic parameters obtained from cyclosporine
(1 time)
Transplantation
(1 time)
AUC (1 time)
TLs (1 time)
1995 Reduced inter- and intrasubject variability in cyclosporine pharmacokinetics in renal transplant recipients treated with a microemulsion formulation in conjunction with fasting, low-fat meals, or high-fat meals.
84  comparing sirolimus versus cyclosporine
(1 time)
Transplantation
(1 time)
MMF (1 time)
2005 Bone metabolism in renal transplant patients treated with cyclosporine or sirolimus.
85  comparing SRL and cyclosporin A
(1 time)
Transplantation
(1 time)
MCV (1 time)
MMF (1 time)
SRL (1 time)
2006 Marked erythrocyte microcytosis under primary immunosuppression with sirolimus.
86  comparison of single and repeated peroral administration of cyclosporine
(1 time)
Medicine
(1 time)
AChE (1 time)
MEOTA (1 time)
2002 Antiacetylcholinesterase activity of cyclosporine--a comparison of single and repeated administration and effect of 7-methoxytacrine.
87  complication associated with cyclosporine
(1 time)
Transplantation
(1 time)
EMT (1 time)
2015 MicroRNA-494 promotes cyclosporine-induced nephrotoxicity and epithelial to mesenchymal transition by inhibiting PTEN.
88  complications, and duration of effect of a cyclosporine
(1 time)
Ophthalmology
(1 time)
ERU (1 time)
2010 Long-term outcome after implantation of a suprachoroidal cyclosporine drug delivery device in horses with recurrent uveitis.
89  compounds such as Cyclosporine A
(1 time)
Pharmacology
(1 time)
Con A (1 time)
Cyp A (1 time)
IL-2 (1 time)
2016 Identification of Spongionella compounds as cyclosporine A mimics.
90  concentration ranges of 0.1-10.0 ng/mL
(1 time)
Drug Therapy
(1 time)
MPA (1 time)
TDM (1 time)
2017 Simultaneous Determination of Protein-Unbound Cyclosporine A and Mycophenolic Acid in Kidney Transplant Patients Using Liquid Chromatography-Tandem Mass Spectrometry.
91  concentrations (IC(50)'s) ranged from 511-771 ng/ml
(1 time)
Allergy and Immunology
(1 time)
TRL (1 time)
2004 In vitro evaluation of the effects of candidate immunosuppressive drugs: flow cytometry and quantitative real-time PCR as two independent and correlated read-outs.
92  concentrations 100-fold lower than cyclosporine
(1 time)
Allergy and Immunology
(1 time)
--- 1990 Effect of FK-506 and cyclosporine on human T and B lymphoproliferative responses.
93  CONCEPT study, a prospective randomized study comparing a cyclosporine
(1 time)
Nephrology
(1 time)
MMF (1 time)
SRL (1 time)
VEGF (1 time)
2012 Sirolimus-based regimen is associated with decreased expression of glomerular vascular endothelial growth factor.
94  conclusion, both low and high
(1 time)
Cell Biology
(1 time)
--- 2000 Protective effects of low and high doses of cyclosporin A against reoxygenation injury in isolated rat cardiomyocytes are associated with differential effects on mitochondrial calcium levels.
95  concomitant azathioprine and cyclosporine
(1 time)
Transplantation
(1 time)
DSTs (1 time)
1984 The effect of donor-specific transfusions on rat heart allograft survival.
96  conditioning and cyclosporine
(1 time)
Medicine
(1 time)
aGVHD (1 time)
CR (1 time)
HSCT (1 time)
2014 Treatment difficulty with acute GVHD - frequent cause of mortality after allogeneic hematopoietic stem cell transplantation.
97  conditioning, and GVHD prophylaxis was with cyclosporine
(1 time)
Transplantation
(1 time)
allo-BMT (1 time)
AML (1 time)
AML M4 Eo (1 time)
1999 Three AML patients with existing or pre-existing intracerebral granulocytic sarcomas who were successfully treated with allogeneic bone marrow transplantations.
98  conducted a prospective study to compare the efficacy of cyclosporine
(1 time)
Pediatrics
(1 time)
MMF (1 time)
NS (1 time)
RTX (1 time)
2013 Cyclosporine versus mycophenolate mofetil for maintenance of remission of steroid-dependent nephrotic syndrome after a single infusion of rituximab.
99  considerable debate about whether maintenance cyclosporin
(1 time)
Nephrology
(1 time)
--- 1997 Maintenance cyclosporin monotherapy after renal transplantation--clinical predictors of long-term outcome.
100  contrast, adjunctive cyclosporine
(1 time)
Transplantation
(1 time)
ADCC (1 time)
DBM (1 time)
LMC (1 time)
1989 Promotion of incompatible allograft acceptance in rhesus monkeys given posttransplant antithymocyte globulin and donor bone marrow. II. Effects of adjuvant immunosuppressive drugs.