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Abbreviation: DKO
Appearance Frequency: 708 time(s)
Long forms: 28

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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
double knockout
(566 times)
Cell Biology
(55 times)
WT (97 times)
KO (45 times)
DMD (21 times)
1995 Targeted disruption of CD44 in MDAY-D2 lymphosarcoma cells has no effect on subcutaneous growth or metastatic capacity.
double KO
(81 times)
Biochemistry
(16 times)
KO (55 times)
WT (17 times)
APOE (9 times)
2000 Acute hepatotoxicant exposure induces TNFR-mediated hepatic injury and cytokine/apoptotic gene expression.
double knockout mice
(35 times)
Neurology
(7 times)
WT (4 times)
ACEI (2 times)
ACs (2 times)
2003 Type 8 adenylyl cyclase is targeted to excitatory synapses and required for mossy fiber long-term potentiation.
double knockout mouse model
(2 times)
Cardiology
(1 time)
AMD (1 time)
CaMKII (1 time)
CNV (1 time)
2016 Inducible cardiomyocyte-specific deletion of CaM kinase II protects from pressure overload-induced heart failure.
ApoE-double KO
(1 time)
Biochemistry
(1 time)
ATGL (1 time)
CGI-58 (1 time)
2014 Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis.
ATF3-double-KO
(1 time)
Heart Diseases
(1 time)
IRF7 (2 times)
ATF3 (1 time)
DTG (1 time)
2014 Interferon regulatory factor 7 protects against vascular smooth muscle cell proliferation and neointima formation.
cell-depleted RAG1-/- mice or RAG2-/-IL2rgamma-/-double knock-out
(1 time)
aGVHD (1 time)
HSCT (1 time)
2019 Induction of acute graft vs. host disease in lymphopenic mice.
deficient for Bax, Bak
(1 time)
Biochemistry
(1 time)
ER (1 time)
2003 Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members.
delta-subunit knockout
(1 time)
Drug Therapy
(1 time)
TSPO (1 time)
2015 Antiseizure Activity of Midazolam in Mice Lacking delta-Subunit Extrasynaptic GABA(A) Receptors.
10  desmin knockout
(1 time)
Genetics, Medical
(1 time)
AAV (1 time)
AAV-Des (1 time)
DKI (1 time)
2020 AAV-mediated cardiac gene transfer of wild-type desmin in mouse models for recessive desminopathies.
11  DKO-hu
(1 time)
Hematology
(1 time)
pDCs (1 time)
2011 Efficient infection, activation, and impairment of pDCs in the BM and peripheral lymphoid organs during early HIV-1 infection in humanized rag2⁻/⁻gamma C⁻/⁻ mice in vivo.
12  domain knockout mice on an apolipoprotein E knockout background
(1 time)
Biochemistry
(1 time)
NASH (1 time)
NMR (1 time)
2018 Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model.
13  don't know option
(1 time)
Education
(1 time)
FS (1 time)
NR (1 time)
2015 The don't know option in progress testing.
14  double gene knock-outs
(1 time)
Cell Biology
(1 time)
2-APB (1 time)
COX-2 (1 time)
G proteins (1 time)
2003 Galphaq signaling is required for Rho-dependent transcriptional activation of the cyclooxygenase-2 promoter in fibroblasts.
15  double knockout animals
(1 time)
Neoplasms
(1 time)
ABCA1 (1 time)
apoA-I (1 time)
HDL (1 time)
2017 Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer.
16  double knockout of FXR and SHP signaling
(1 time)
Gastroenterology
(1 time)
FXR (1 time)
SHP (1 time)
2017 Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice.
17  double KO of Akita/MMP-9(-/-)
(1 time)
Biochemistry
(1 time)
Cxs (1 time)
ECM (1 time)
MMP-9 (1 time)
2015 MMP-9- and NMDA receptor-mediated mechanism of diabetic renovascular remodeling and kidney dysfunction: hydrogen sulfide is a key modulator.
18  Double receptor knockout
(1 time)
Psychopharmacology
(1 time)
MCR (1 time)
WT (1 time)
2010 Effect of serotonergic anorectics on food intake and induction of Fos in brain of mice with disruption of melanocortin 3 and/or 4 receptors.
19  double-mutant knockout
(1 time)
Genetics, Medical
(1 time)
--- 2006 Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy.
20  double-receptor knockout mice
(1 time)
Cardiology
(1 time)
I/R (1 time)
MIP (1 time)
MPG (1 time)
2001 Brief murine myocardial I/R induces chemokines in a TNF-alpha-independent manner: role of oxygen radicals.
21  GPR40-double knockout
(1 time)
Diabetes Mellitus
(1 time)
GIP (1 time)
GPR (1 time)
2019 Free fatty acid receptors, Gprotein-coupled receptor120 and Gprotein-coupled receptor40, are essential for oil-induced gastric inhibitory polypeptide secretion.
22  H2-D(b)-double knockout
(1 time)
Allergy and Immunology
(1 time)
Tg (1 time)
2002 Human MHC class I transgenic mice deficient for H2 class I expression facilitate identification and characterization of new HLA class I-restricted viral T cell epitopes.
23  Nrf2-Ucp2-double knockout
(1 time)
Biochemistry
(1 time)
NRF2 (1 time)
Nrf2-KO (1 time)
UCP2 (1 time)
2016 The role of nuclear factor E2-Related factor 2 and uncoupling protein 2 in glutathione metabolism: Evidence from an invivo gene knockout study.
24  Pbx3-deficient genetic background
(1 time)
Anatomy
(1 time)
HSPCs (1 time)
2016 Spleen hypoplasia leads to abnormal stress hematopoiesis in mice with loss of Pbx homeoproteins in splenic mesenchyme.
25  PKCdelta-double knockout
(1 time)
Allergy and Immunology
(1 time)
BAFF-R (1 time)
BCR (1 time)
PKCdelta (1 time)
2006 Double knockout mice show BASH and PKCdelta have different epistatic relationships in B cell maturation and CD40-mediated activation.
26  Ptpro-double-KO
(1 time)
Neurology
(1 time)
KO (1 time)
PTPRJ (1 time)
Ptprj-KO (1 time)
2018 Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) Regulates Retinal Axonal Projections by Inhibiting Eph and Abl Kinases in Mice.
27  TLR9-IRF3-double-KO
(1 time)
Molecular Biology
(1 time)
DCs (1 time)
IFN (1 time)
KO (1 time)
2010 TLR9 and IRF3 cooperate to induce a systemic inflammatory response in mice injected with liposome:DNA.
28  utrophin-double-knockout
(1 time)
Cell Biology
(1 time)
DMD (1 time)
WT (1 time)
2014 Immunoproteasome in animal models of Duchenne muscular dystrophy.