| 1 |
epidermal growth factor receptor
(26071 times)
|
Neoplasms
(10352 times)
|
NSCLC (4904 times)
TKIs (1670 times)
PFS (1330 times)
|
1983 Mapping of the human gene for epidermal growth factor receptor (EGFR) on the p13 leads to q22 region of chromosome 7.
|
| 2 |
EGF receptor
(1710 times)
|
Neoplasms
(408 times)
|
EGF (872 times)
TGF-alpha (94 times)
NSCLC (70 times)
|
1980 Genetic analysis of epidermal growth factor action: assignment of human epidermal growth factor receptor gene to chromosome 7.
|
| 3 |
anti-EGF receptor
(28 times)
|
Neoplasms
(15 times)
|
EGF (10 times)
mCRC (3 times)
NSCLC (3 times)
|
1994 [Growth control of a human glioma cell line by multiple autocrine loop blockade].
|
| 4 |
EGFRvIII
(27 times)
|
Neoplasms
(16 times)
|
GBM (6 times)
mAbs (2 times)
NSCLC (2 times)
|
1997 Epidermal growth factor receptor stimulation of diacylglycerol kinase.
|
| 5 |
EGF and its receptor
(15 times)
|
Neoplasms
(2 times)
|
EGF (15 times)
CNS (1 time)
CNT (1 time)
|
1994 Modulation of epidermal growth factor binding and receptor gene expression by hormones and growth factors in sheep pituitary cells.
|
| 6 |
EGFRwt
(8 times)
|
Neoplasms
(7 times)
|
GBM (3 times)
EGFRvIII (2 times)
OS (2 times)
|
2003 Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme.
|
| 7 |
HB-EGF, the EGF receptor
(7 times)
|
Biochemistry
(1 time)
|
HB-EGF (6 times)
EGF (2 times)
ADAM17 (1 time)
|
1996 Co-expression of heparin-binding EGF-like growth factor and related peptides in human gastric carcinoma.
|
| 8 |
anti-EGFR Affibody molecule, Ac-Cys-Z
(4 times)
|
Neoplasms
(1 time)
|
hEGF (1 time)
HNSCC (1 time)
p.i (1 time)
|
2009 Imaging of EGFR expression in murine xenografts using site-specifically labelled anti-EGFR 111In-DOTA-Z EGFR:2377 Affibody molecule: aspect of the injected tracer amount.
|
| 9 |
early growth factor receptor
(3 times)
|
Neoplasms
(1 time)
|
GNP (1 time)
GNPs (1 time)
|
2015 Amphiregulin Is a Critical Downstream Effector of Estrogen Signaling in ERalpha-Positive Breast Cancer.
|
| 10 |
Economic AnalysisEpidermal Growth Factor Receptor Mutation
(3 times)
|
Biomedical Technology
(3 times)
|
CCO (3 times)
MAS (3 times)
PEPP (3 times)
|
2010 Gene expression profiling for guiding adjuvant chemotherapy decisions in women with early breast cancer: an evidence-based and economic analysis.
|
| 11 |
epidermal GFR
(3 times)
|
Metabolism
(1 time)
|
GFRs (2 times)
DCN (1 time)
ECM (1 time)
|
2011 Mast cell tryptase stimulates production of decorin by human testicular peritubular cells: possible role of decorin in male infertility by interfering with growth factor signaling.
|
| 12 |
epidermal growth receptor factor
(3 times)
|
Respiratory Tract Diseases
(1 time)
|
AC (1 time)
NSCLC (1 time)
PET (1 time)
|
1995 [Proliferation behavior of cholesteatoma].
|
| 13 |
erlotinib, gefitinib
(3 times)
|
Neoplasms
(2 times)
|
NSCLC (3 times)
|
2008 Targeted therapy for the treatment of non-small cell lung cancer: focus on inhibition of epidermal growth factor receptor.
|
| 14 |
EGF and TGF alpha and their common receptor
(2 times)
|
Gastroenterology
(1 time)
|
EGF (1 time)
HP (1 time)
NO (1 time)
|
1992 Adaptation of gastric mucosa to chronic alcohol administration is associated with increased mucosal expression of growth factors and their receptor.
|
| 15 |
EGF receptor gene
(2 times)
|
Neoplasms
(1 time)
|
aa (1 time)
CM (1 time)
GBM (1 time)
|
2013 Construction of an immunotoxin, D2C7-(scdsFv)-PE38KDEL, targeting EGFRwt and EGFRvIII for brain tumor therapy.
|
| 16 |
EGF to its cell surface receptor
(2 times)
|
Neoplasms
(2 times)
|
EGF (2 times)
AP-1 (1 time)
HNSCC (1 time)
|
2008 Fucoidan from Laminaria cichorioides inhibits AP-1 transactivation and cell transformation in the mouse epidermal JB6 cells.
|
| 17 |
EGFR-eGFP
(2 times)
|
Neoplasms
(1 time)
|
EGF (1 time)
ERK (1 time)
GBM (1 time)
|
2004 Expression of cytoplasmic-domain substituted epidermal growth factor receptor inhibits tumorigenicity of EGFR-overexpressed human glioblastoma multiforme.
|
| 18 |
EGFR-siRNA
(2 times)
|
Gastroenterology
(1 time)
|
BE (1 time)
CDX2 (1 time)
EGF (1 time)
|
2012 The role of nitric oxide in the induction of caudal-type homeobox 2 through epidermal growth factor receptor in the development of Barrett's esophagus.
|
| 19 |
EGFR-TKIs
(2 times)
|
Neoplasms
(1 time)
|
NSCLC (2 times)
mOS (1 time)
mPFS (1 time)
|
2015 Experience with erlotinib in the treatment of non-small cell lung cancer.
|
| 20 |
EGFRmut
(2 times)
|
General Surgery
(1 time)
|
IHC (1 time)
MSI2 (1 time)
NSCLC (1 time)
|
2016 Clinical Significance of C-MET Overexpression and Epidermal Growth Factor Receptor Mutation in Platinum-Based Adjuvant Chemotherapy Outcome in Surgically Resected Lung Adenocarcinoma.
|
| 21 |
enhanced growth factor receptor
(2 times)
|
Cell Biology
(1 time)
|
CDDS (1 time)
GPCR (1 time)
MSNs (1 time)
|
2006 Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1.
|
| 22 |
epidermal GF receptor
(2 times)
|
Neurosurgery
(1 time)
|
GF (2 times)
CL (1 time)
DCN (1 time)
|
1999 Inhibition of phospholipase C-gamma1 activation blocks glioma cell motility and invasion of fetal rat brain aggregates.
|
| 23 |
Epidermal growth factor inhibitors
(2 times)
|
Neoplasms
(1 time)
|
HNSCC (1 time)
|
2006 [Treatment of acneiform rash by epidermal growth factor inhibitors with oral tetracyclines].
|
| 24 |
epidermal growth factor-like repeats
(2 times)
|
Neurology
(2 times)
|
CADASIL (2 times)
HR (1 time)
|
2009 Distinct phenotypic and functional features of CADASIL mutations in the Notch3 ligand binding domain.
|
| 25 |
epidermal receptor growth factor
(2 times)
|
Neoplasms
(1 time)
|
BCSS (1 time)
FISH (1 time)
IHC (1 time)
|
2010 Epidermal growth factor receptor and vascular endothelial growth factor receptor 2 are specific biomarkers in triple-negative breast cancer. Results from a controlled randomized trial with long-term follow-up.
|
| 26 |
expression of growth factor receptors
(2 times)
|
Neoplasms
(1 time)
|
FOXD1 (1 time)
|
2000 Immunohistochemical analysis of expression of a 65 kDa oncofetal protein (p65), epidermal growth factor receptor (EGFR), oncogene c-erb B2 and tumor suppressor gene p53 protein products in breast cancer patients.
|
| 27 |
alpha6beta4-EGF receptor
(1 time)
|
Reproductive Medicine
(1 time)
|
AR (1 time)
EGF (1 time)
|
2003 Androgen receptor and prostate cancer invasion.
|
| 28 |
anti-EGFR Ac-Cys-Z
(1 time)
|
Nuclear Medicine
(1 time)
|
---
|
2012 PET of EGFR expression with an 18F-labeled affibody molecule.
|
| 29 |
effective grain-filling rate
(1 time)
|
|
DM (1 time)
GFD (1 time)
KNAR (1 time)
|
2021 Dry Matter Gains in Maize Kernels Are Dependent on Their Nitrogen Accumulation Rates and Duration during Grain Filling.
|
| 30 |
EGF are mediated through the receptor
(1 time)
|
Biochemistry
(1 time)
|
---
|
2011 MAPK scaffold IQGAP1 binds the EGF receptor and modulates its activation.
|
| 31 |
EGF binds to specific receptors
(1 time)
|
Cell Biology
(1 time)
|
---
|
2015 Unconventional EGF-induced ERK1/2-mediated Kv1.3 endocytosis.
|
| 32 |
EGF family member
(1 time)
|
Genes, Neoplasm
(1 time)
|
Ad (1 time)
|
2011 Expression of the Adenovirus Early Gene 1A Transcription-Repression Domain Alone Downregulates HER2 and Results in the Death of Human Breast Cancer Cells Upregulated for the HER2 Proto-Oncogene.
|
| 33 |
EGF from EGF receptor
(1 time)
|
Complementary Therapies
(1 time)
|
BPH (1 time)
EGF (1 time)
GM-CSF (1 time)
|
2011 Androgen-independent effects of Serenoa repens extract (Prostasan) on prostatic epithelial cell proliferation and inflammation.
|
| 34 |
EGF, TGF alpha and their receptor
(1 time)
|
Gynecology
(1 time)
|
3beta-HSD (1 time)
SCC (1 time)
|
1995 [Human folliculogenesis and local regulation].
|
| 35 |
EGF/TGF-alpha receptor
(1 time)
|
Molecular Biology
(1 time)
|
wa-1 (1 time)
wa-2 (1 time)
|
1994 The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase.
|
| 36 |
EGF/TGF-alpha tyrosine kinase receptor
(1 time)
|
Cell Biology
(1 time)
|
Cip1 (1 time)
TGF-alpha (1 time)
|
2000 The tetraspanin CD9 associates with transmembrane TGF-alpha and regulates TGF-alpha-induced EGF receptor activation and cell proliferation.
|
| 37 |
EGFR amplification
(1 time)
|
General Surgery
(1 time)
|
GBM (1 time)
TMZ (1 time)
|
2012 Paradoxical relationship between the degree of EGFR amplification and outcome in glioblastomas.
|
| 38 |
EGFR antibodies
(1 time)
|
Neoplasms
(1 time)
|
BUN (1 time)
LP (1 time)
NSCLC (1 time)
|
2014 A cisplatin‑incorporated liposome that targets the epidermal growth factor receptor enhances radiotherapeutic efficacy without nephrotoxicity.
|
| 39 |
EGFR gene
(1 time)
|
General Surgery
(1 time)
|
EGFR-TKIs (1 time)
NSCLC (1 time)
p-EGFR (1 time)
|
2011 The influence of intracellular epidermal growth factor receptor (EGFR) signal activation on the outcome of EGFR tyrosine kinase inhibitor treatment for pulmonary adenocarcinoma.
|
| 40 |
EGFR inhibitor
(1 time)
|
Biochemistry
(1 time)
|
COX (1 time)
E2-BSA-FITC (1 time)
OECs (1 time)
|
2015 Regulation of cyclooxygenase-2 expression in rat oviductal epithelial cells: Evidence for involvement of GPR30/Src kinase-mediated EGFR signaling.
|
| 41 |
EGFR pathway, including erlotinib
(1 time)
|
|
CDX (1 time)
Erl-SiTMR-T (1 time)
HNSCC (1 time)
|
2020 Intracellular paired agent imaging enables improved evaluation of tyrosine kinase inhibitor target engagement.
|
| 42 |
EGFR pharmDX kit
(1 time)
|
Science
(1 time)
|
ATC (1 time)
PDTC (1 time)
|
2005 Epidermal growth factor receptor as a novel therapeutic target in anaplastic thyroid carcinomas.
|
| 43 |
EGFR tyrosine kinase inhibitor
(1 time)
|
Chemistry Techniques, Analytical
(1 time)
|
---
|
2019 Determination of BPI15086 and its metabolite in human plasma by ultra-high performance liquid chromatography-MS/MS and its application to a pharmacokinetic study.
|
| 44 |
EGFR, as pan-Erb
(1 time)
|
Vascular Diseases
(1 time)
|
KSR1 (1 time)
TF (1 time)
|
2010 Modulation of the oncogene-dependent tissue factor expression by kinase suppressor of ras 1.
|
| 45 |
EGFR-mAbs
(1 time)
|
Neoplasms
(1 time)
|
BTC (1 time)
CHT (1 time)
PFS (1 time)
|
2020 Anti-EGFR Monoclonal Antibodies in Advanced Biliary Tract Cancer: A Systematic Review and Meta-analysis.
|
| 46 |
EGFR-mutant
(1 time)
|
Cells
(1 time)
|
NSCLC (1 time)
wtEGFR (1 time)
|
2021 Epidermal Growth Factor Receptor Expression and Resistance Patterns to Targeted Therapy in Non-Small Cell Lung Cancer: A Review.
|
| 47 |
EGFR-targeting protein, the DOTA-Z
(1 time)
|
Nuclear Medicine
(1 time)
|
---
|
2009 Imaging of EGFR expression in murine xenografts using site-specifically labelled anti-EGFR 111In-DOTA-Z EGFR:2377 Affibody molecule: aspect of the injected tracer amount.
|
| 48 |
EGFRlow
(1 time)
|
Neoplasms
(1 time)
|
PC (1 time)
TKI (1 time)
|
2011 Epidermal Growth Factor Receptor (EGFR) mutation analysis, gene expression profiling and EGFR protein expression in primary prostate cancer.
|
| 49 |
elegans identified CDT-2 as an attenuator of LET-23
(1 time)
|
Embryology
(1 time)
|
---
|
2010 The Caenorhabditis elegans CDT-2 ubiquitin ligase is required for attenuation of EGFR signalling in vulva precursor cells.
|
| 50 |
elements of the EV/EP cargo, including oncoproteins
(1 time)
|
Nanotechnology
(1 time)
|
AFM (1 time)
EP (1 time)
EV (1 time)
|
2019 Mapping Subpopulations of Cancer Cell-Derived Extracellular Vesicles and Particles by Nano-Flow Cytometry.
|
| 51 |
encoding the whole isoform a
(1 time)
|
Neoplasms
(1 time)
|
Ext-Ab (1 time)
|
2011 Adult diffuse gliomas produce mRNA transcripts encoding EGFR isoforms lacking a tyrosine kinase domain.
|
| 52 |
endothelial growth factor receptors expression
(1 time)
|
Chemistry
(1 time)
|
LNCs (1 time)
|
2013 EGFR siRNA lipid nanocapsules efficiently transfect glioma cells in vitro.
|
| 53 |
endothelial-GF receptor
(1 time)
|
Male Urogenital Diseases
(1 time)
|
CG (1 time)
EG (1 time)
FG (1 time)
|
2015 The effect of penile urethral fat graft application on urethral angiogenesis.
|
| 54 |
enrolled CRC patients treated with antiepidermal growth factor receptor
(1 time)
|
Medicine
(1 time)
|
CI (1 time)
CRC (1 time)
HR (1 time)
|
2017 Prognostic value of KRAS codon 13 gene mutation for overall survival in colorectal cancer: Direct and indirect comparison meta-analysis.
|
| 55 |
epidermal factor growth receptor
(1 time)
|
Gastroenterology
(1 time)
|
IRFA (1 time)
PDX (1 time)
|
2021 Insufficient Radiofrequency Ablation Promotes Hepatocellular Carcinoma Metastasis Through N6-Methyladenosine mRNA Methylation-Dependent Mechanism.
|
| 56 |
epidermal growth factor and its transmembrane receptor
(1 time)
|
Neoplasms
(1 time)
|
---
|
2008 Developments in epidermal growth factor receptor-targeting therapy for solid tumors: focus on matuzumab (EMD 72000).
|
| 57 |
epidermal growth factor of upstream receptor
(1 time)
|
Medicine
(1 time)
|
---
|
2011 [Identification of K-RAS mutations in colorectal cancer patients in Israel].
|
| 58 |
epidermal growth factor tyrosine kinase receptors
(1 time)
|
Biochemistry
(1 time)
|
---
|
2002 Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH.
|
| 59 |
epidermal growth factor urothelial receptor
(1 time)
|
Urology
(1 time)
|
EGF (1 time)
|
1994 [Quantitative determination of epidermal growth factor urothelial receptor (EGFR) in superficial and invasive bladder carcinoma].
|
| 60 |
epidermal growth factor receptor
(1 time)
|
Biology
(1 time)
|
EPP (1 time)
HGF (1 time)
NSCLC (1 time)
|
2022 The Root Extract of Peucedanum praeruptorum Dunn Exerts Anticancer Effects in Human Non-Small-Cell Lung Cancer Cells with Different EGFR Mutation Statuses by Suppressing MET Activity.
|
| 61 |
epithelial changes after using epidermal
(1 time)
|
Ophthalmology
(1 time)
|
FGFR (1 time)
IRB (1 time)
|
2020 Markedly increased ocular side effect causing severe vision deterioration after chemotherapy using new or investigational epidermal or fibroblast growth factor receptor inhibitors.
|
| 62 |
ErbB family consists of four proteins including
(1 time)
|
Neoplasms
(1 time)
|
CRC (1 time)
pEGFR (1 time)
pErbB2 (1 time)
|
2014 Localization of phosphorylated ErbB1-4 and heregulin in colorectal cancer.
|
| 63 |
erlotinib, gefitinib, afatinib, osimertinib
(1 time)
|
Neoplasms
(1 time)
|
CI (1 time)
ROR (1 time)
SVT (1 time)
|
2021 Pharmacovigilance Analysis of Cardiac Toxicities Associated With Targeted Therapies for Metastatic NSCLC.
|
| 64 |
erlotinib, gefitinib, cetuximab
(1 time)
|
Neoplasms
(1 time)
|
NSCLC (1 time)
VEGF (1 time)
|
2009 Investigational agents in the management of non-small cell lung cancer.
|
| 65 |
erlotinib, gefitinib, lapatinib
(1 time)
|
Clinical Trials as Topic
(1 time)
|
---
|
2015 Novel targeted therapies in chordoma: an update.
|
| 66 |
established targeted therapies such as antiepidermal growth factor receptor
(1 time)
|
Neoplasms
(1 time)
|
ctDNA (1 time)
|
2022 Mind the target: circulating tumour DNA in gastrointestinal malignancies.
|
| 67 |
evaluate the gamma-imaging properties of an antiepidermal growth factor receptor
(1 time)
|
Nuclear Medicine
(1 time)
|
DTPA (1 time)
PEG (1 time)
ROIs (1 time)
|
2001 Conjugation with (111)In-DTPA-poly(ethylene glycol) improves imaging of anti-EGF receptor antibody C225.
|
| 68 |
evaluate the possibility of treatment with antiepidermal growth factor receptor
(1 time)
|
Neoplasms
(1 time)
|
ADCC (1 time)
SCC (1 time)
TGF (1 time)
|
2006 Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinoma.
|
| 69 |
evident that growth factor receptors
(1 time)
|
Cell Biology
(1 time)
|
CTGF (1 time)
ECM (1 time)
PAI-1 (1 time)
|
2010 Linking cell structure to gene regulation: signaling events and expression controls on the model genes PAI-1 and CTGF.
|
| 70 |
expression of growth factor
(1 time)
|
Dentistry
(1 time)
|
---
|
2006 Expression of p53, Ki-67, and EGFR in odontogenic keratocysts before and after decompression.
|
| 71 |
expression of oncogenic markers
(1 time)
|
Chemistry
(1 time)
|
4-AAQB (1 time)
CRC (1 time)
EFGR (1 time)
|
2021 4-Acetyl-Antroquinonol B Improves the Sensitization of Cetuximab on Both Kras Mutant and Wild Type Colorectal Cancer by Modulating the Expression of Ras/Raf/miR-193a-3p Signaling Axis.
|
| 72 |
expression profiles of five parameters as potential mediators in neoangiogenesis
(1 time)
|
Gastroenterology
(1 time)
|
---
|
2009 Haemorrhoids are related to changes of cell function in mucosa and submucosa.
|
| 73 |
Gurken-EGF receptor
(1 time)
|
Embryology
(1 time)
|
EGF (1 time)
|
2020 Signaling between somatic follicle cells and the germline patterns the egg and embryo of Drosophila.
|
| 74 |
HB-EGF processing or EGF receptor
(1 time)
|
Science
(1 time)
|
14,15-EET (1 time)
HB-EGF (1 time)
|
2002 Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells.
|
| 75 |
include growth factors and their receptors
(1 time)
|
Gynecology
(1 time)
|
---
|
2009 [Expression of selected angiogenesis markers and modulators in pre-, peri- and postmenopausal women with ovarian cancer].
|
| 76 |
measured, glomerular filtration rate
(1 time)
|
Biomedical Research
(1 time)
|
CRP (1 time)
|
2020 Effect of Different Hemodialysis Methods on Microbiota in Uremic Patients.
|
| 77 |
pathways--Epithelial Growth Factor Receptor
(1 time)
|
Neoplasms
(1 time)
|
GC (1 time)
MAPK (1 time)
MSI (1 time)
|
2010 Oncogenic mutations in gastric cancer with microsatellite instability.
|
| 78 |
phospho-EGF receptor
(1 time)
|
Cell Biology
(1 time)
|
EGF (1 time)
ROS (1 time)
|
2020 Epiregulin promotes hair growth via EGFR-medicated epidermal and ErbB4-mediated dermal stimulation.
|
| 79 |
SignificanceEpidermal growth factor receptor
(1 time)
|
Science
(1 time)
|
HGS (1 time)
|
2022 O-GlcNAcylation regulates epidermal growth factor receptor intracellular trafficking and signaling.
|
| 80 |
STAT3-EGF receptor
(1 time)
|
Neoplasms
(1 time)
|
CCND1 (1 time)
HA (1 time)
MMP (1 time)
|
2013 A novel inhibitor of STAT3 homodimerization selectively suppresses STAT3 activity and malignant transformation.
|
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