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Abbreviation: Emax
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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
maximum effect
(100 times)
Pharmacology
(43 times)
PK (15 times)
PD (13 times)
PK/PD (8 times)
1984 [In vitro aggregation of rat platelets by cumulative doses of trypsin: influence of aprotinin].
maximal effect
(51 times)
Pharmacology
(22 times)
NO (4 times)
AUC (3 times)
BMD (2 times)
1987 Pharmacodynamic modeling of the EEG effects of ketamine and its enantiomers in man.
end point was maximum effect
(4 times)
Pharmacology
(2 times)
AEs (1 time)
BUP/SAM (1 time)
COWS (1 time)
2018 A nasal abuse potential randomized clinical trial of REMOXY ER, a high-viscosity extended-release oxycodone formulation.
emission maximum
(3 times)
Chemistry
(2 times)
CV (1 time)
HOMO (1 time)
LUMO (1 time)
2006 Effect of temperature and chain length on the bimodal emission properties of single polyfluorene copolymer molecules.
Efficacy, as assessed by the maximal contractile response
(2 times)
Pharmacology
(2 times)
L-NAME (2 times)
5-CT (1 time)
5-HT (1 time)
1996 Influence of the endothelium and nitric oxide on the contractile responses evoked by 5-HT1D receptor agonists in the rabbit isolated saphenous vein.
estimated maximal stimulations
(2 times)
Orthopedics
(2 times)
FCS (1 time)
PDGF-BB (1 time)
rhIGF-I (1 time)
1991 Recombinant human insulin-like growth factor-I stimulates in vitro matrix synthesis and cell proliferation in rabbit flexor tendon.
Ethanol decreased the maximal amplitude
(2 times)
Molecular Biology
(2 times)
nACh alpha 7 (1 time)
NMDA (1 time)
1994 Differential ethanol sensitivity of recombinant N-methyl-D-aspartate receptor subunits.
evaluated using a sigmoid maximum effect
(2 times)
Pharmacology
(1 time)
AUC (2 times)
HPLC (1 time)
tC0.1 (1 time)
1997 Quantitative relationship between pharmacokinetics of unchanged cisplatin and nephrotoxicity in rats: importance of area under the concentration-time curve (AUC) as the major toxicodynamic determinant in vivo.
concentration-effect modeling, summary pharmacodynamic parameters, including the maximal drug effect
(1 time)
Drug Therapy
(1 time)
--- 1999 Developmental pharmacodynamics of cyclosporine.
10  dose-effect curve shifted to the right significantly, maximum energy
(1 time)
Critical Care
(1 time)
PKC (1 time)
PKG (1 time)
SMA (1 time)
2007 [Regulatory effect of protein kinase C and protein kinase G on calcium sensitivity of vascular smooth muscle cells following hemorrhagic shock].
11  E. maxima
(1 time)
Veterinary Medicine
(1 time)
ACD (1 time)
Eapt (1 time)
VAC (1 time)
2019 Viable Eimeria oocysts in poultry house litter at the time of chick placement.
12  each compound, the mean maximum contractile effect
(1 time)
Vascular Diseases
(1 time)
5-HT (1 time)
Ang II (1 time)
NA (1 time)
1989 Effect of endogenous vasoconstrictors on maternal intramyometrial and fetal stem villous arteries in pre-eclampsia.
13  EC50 at 1.60 0.19 mumolL-1 and maximum effect
(1 time)
Pharmacology
(1 time)
--- 2016 [The structure-activity relationships of novel alpha7 nicotinic acetylcholine receptor agonists based on indolizine scaffold].
14  effect compartment and sigmoid maximum effect
(1 time)
Medicine
(1 time)
AEs (1 time)
ET (1 time)
MTD (1 time)
2016 Dose-escalation study of octanoic acid in patients with essential tremor.
15  effect measured at both muscles included maximum neuromuscular blockade achieved
(1 time)
Anesthesiology
(1 time)
i.v (1 time)
2004 Comparison of the neuromuscular blocking effect of cisatracurium and atracurium on the larynx and the adductor pollicis.
16  effect on the calculated maximal contractile response
(1 time)
Drug Therapy
(1 time)
CRCs (1 time)
ET-1 (1 time)
PE (1 time)
1998 Endothelin-1-induced alterations in phenylephrine-induced contractile responses are largely additive in physiologically diverse rabbit vasculature.
17  effect was modeled as obeying a maximum
(1 time)
Drug Therapy
(1 time)
--- 1991 A pharmacokinetic-pharmacodynamic model of heart rate during cocaine administration in humans.
18  Effects including statistically greater maximum effect
(1 time)
Psychopharmacology
(1 time)
VAS (1 time)
2017 Randomized, Double-Blind, Placebo- and Active Comparator-Controlled Crossover Study Evaluating the Abuse Potential of the Antiepileptic Drug Lacosamide in Healthy Recreational Drug Users.
19  effects were accompanied by an increase in maximal isometric tension
(1 time)
Gynecology
(1 time)
--- 1993 Venous placental reactivity to serotonin in normal and preeclamptic gestants.
20  efficacious venodilator across the age range; the average maximal response
(1 time)
Drug Therapy
(1 time)
--- 1995 H1- and H2-histamine receptor-mediated vasodilation varies with aging in humans.
21  efficacy: maximum antibacterial effect
(1 time)
Anti-Bacterial Agents
(1 time)
CI (1 time)
TKC (1 time)
2010 Generic vancomycin products fail in vivo despite being pharmaceutical equivalents of the innovator.
22  efficiency as the maximal efficiency
(1 time)
Molecular Biology
(1 time)
--- 2008 Critical evaluation of methods used to determine amplification efficiency refutes the exponential character of real-time PCR.
23  EFS-induced contraction with a maximal effect
(1 time)
Urinary Bladder, Neurogenic
(1 time)
5-HT (1 time)
EFS (1 time)
2017 Ketanserin and Naftopidil Enhance the Potentiating Effect of Alpha-Methyl-Serotonin on the Neurally-Induced Contraction of Human Isolated Urinary Bladder Muscle Strips.
24  ehdothelium-independent vaasoconstriction similar to CRE, maximal constriction
(1 time)
General Surgery
(1 time)
Cre (1 time)
CyA (1 time)
1998 [The vasoconstrictor effect of cyclosporine on the pulmonary vein is mediated by its vehicle: the cremophor].
25  elasticity indices of the maximum
(1 time)
Neoplasms
(1 time)
ER (1 time)
SWE (1 time)
TIRADS (1 time)
2017 Shear wave elastography combined with the thyroid imaging reporting and data system for malignancy risk stratification in thyroid nodules.
26  elasticity, including the maximum Young's modulus
(1 time)
Radiology
(1 time)
GS (1 time)
PCa (1 time)
PSA (1 time)
2019 Stiffness of prostate gland measured by transrectal real-time shear wave elastography for detection of prostate cancer: a feasibility study.
27  eliciting half of maximum effect
(1 time)
Drug Therapy
(1 time)
--- 1999 Altered plasma and brain disposition and pharmacodynamics of methadone in abstinent rats.
28  Emax = -0.8 x
(1 time)
Cardiology
(1 time)
EF (1 time)
1990 [Evaluation of left ventricular mechanical energy efficiency and ventriculo-arterial coupling in humans using the conductance catheter technique].
29  Emax model revealed that the maximum drug response
(1 time)
Drug Therapy
(1 time)
--- 1990 Pharmacodynamic characterization of posture-related diuretic and saluretic responses to furosemide in humans.
30  Emax modelling to derive; maximum effect
(1 time)
Pharmaceutical Preparations
(1 time)
DDP-4 (1 time)
DPP-4 (1 time)
EC50 (1 time)
2017 Is the Inhibition of Dipeptidyl Peptidase-4 (DDP-4) Enzyme Route Dependent and/or Driven by High Peak Concentration?- Seeking Answers with ZYDPLA1, a Novel Long Acting DPP-4 Inhibitor, in a Rodent Model.
31  Empiric application of a maximal-effect
(1 time)
Medicine
(1 time)
PD (1 time)
PK (1 time)
RA (1 time)
2018 A Pilot Dose-Finding Study of Etanercept in Rheumatoid Arthritis.
32  empirical maximum effect
(1 time)
Drug Therapy
(1 time)
AUEC (1 time)
FDA (1 time)
1999 Development of in vivo bioequivalence methodology for dermatologic corticosteroids based on pharmacodynamic modeling.
33  end points included mean maximum drug liking
(1 time)
Pain
(1 time)
IR (1 time)
2019 A Randomized, Double-Blind, Double-Dummy, Placebo-Controlled, Intranasal Human Abuse Potential Study of Oxycodone ARIR, a Novel, Immediate-Release, Abuse-Deterrent Formulation.
34  end-systolic maximal elastance
(1 time)
Transplantation
(1 time)
CO (1 time)
CPB (1 time)
LVP (1 time)
2004 Effects of adding P38 mitogen-activated protein-kinase inhibitor to celsior solution in canine heart transplantation from non-heart-beating donors.
35  end-systolic pressure-minor axis diameter relationships
(1 time)
General Surgery
(1 time)
LV (1 time)
1988 Myocardial protection with blood cardioplegia in ischemically injured hearts: reduction of reoxygenation injury with allopurinol.
36  end-systolic volume and attains its maximum value
(1 time)
Cardiology
(1 time)
ESPVRs (1 time)
Vom (1 time)
Vop (1 time)
1987 The development of the entire end-systolic pressure-volume and ejection fraction-afterload relations: a new concept of systolic myocardial stiffness.
37  endothelium removal produced a significant increase of the maximal contraction
(1 time)
Pharmacology
(1 time)
--- 1991 Modulation of alpha-adrenergic-induced contractions by endothelium-derived relaxing factor in rat aorta.
38  endpoint to assess abuse potential was the maximum effect
(1 time)
Behavioral Sciences
(1 time)
CBD (1 time)
CNS (1 time)
VAS (1 time)
2018 Abuse potential assessment of cannabidiol (CBD) in recreational polydrug users: A randomized, double-blind, controlled trial.
39  energetic parameters and the maximum P-V ratio
(1 time)
Physiology
(1 time)
LV (1 time)
P-V (1 time)
PVA (1 time)
1991 Stability of myocardial O2 consumption-pressure-volume area relation in red cell-perfused rabbit heart.
40  energy at maximum absorption
(1 time)
Chemistry
(1 time)
--- 2009 On the origin of small band gaps in alternating thiophene-thienopyrazine oligomers.
41  enhanced dopamine-mediated maximal stimulation
(1 time)
Cell Biology
(1 time)
GPCRs (1 time)
TM (1 time)
2015 Functional importance of two conserved residues in intracellular loop 1 and transmembrane region 2 of Family A GPCRs: insights from ligand binding and signal transduction responses of D1 and D5 dopaminergic receptor mutants.
42  enhanced the maximal vasoconstrictor response
(1 time)
Medicine
(1 time)
NOS (1 time)
PTX (1 time)
SOD (1 time)
2014 Isoproterenol induces vascular oxidative stress and endothelial dysfunction via a Gialpha-coupled beta2-adrenoceptor signaling pathway.
43  enzyme inhibition were characterized in terms of the maximum effect
(1 time)
Vascular Diseases
(1 time)
Ce50 (1 time)
1990 Kinetic-dynamic relations and individual responses to enalapril.
44  EOLA (100-1000 mug/mL) induced relaxation, where the maximal effect
(1 time)
Pharmacology
(1 time)
EOLA (1 time)
GC/MS (1 time)
NIF (1 time)
2011 Chemical composition and vasorelaxant effect induced by the essential oil of Lippia alba (Mill.) N.E. Brown. (Verbenaceae) in rat mesenteric artery.
45  equal maximum effects
(1 time)
Antineoplastic Agents
(1 time)
C-E (1 time)
UE (1 time)
2017 Method to Assess Interactivity of Drugs with Nonparallel Concentration Effect Relationships.
46  equal to the individual maximal metabolic power
(1 time)
Occupational Medicine
(1 time)
AnS (1 time)
BPT (1 time)
MAP (1 time)
1999 Physiological determinants of best performances in human locomotion.
47  equation for maximum effect
(1 time)
Anti-Bacterial Agents
(1 time)
PK/PD (1 time)
2016 In Vivo Pharmacodynamic Target Assessment of Delafloxacin against Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumoniae in a Murine Lung Infection Model.
48  equation to compute maximum effect
(1 time)
Communicable Diseases
(1 time)
API (1 time)
BD (1 time)
CLSI (1 time)
2010 In vitro and in vivo comparison of the anti-staphylococcal efficacy of generic products and the innovator of oxacillin.
49  ESDU measured on B-mode images, as well as maximum elasticity
(1 time)
Natural Science Disciplines
(1 time)
AUC (1 time)
ESDE (1 time)
SWE (1 time)
2017 Application of 3D and 2D quantitative shear wave elastography (SWE) to differentiate between benign and malignant breast masses.
50  established, and crucial pharmacodynamic parameters, such as maximal efficacy
(1 time)
Neoplasms
(1 time)
--- 2019 Quantitative comparison of drug efficacy in treating hot flashes in patients with breast cancer.
51  estimate of maximum predicted effect
(1 time)
Pharmacology
(1 time)
CNS (1 time)
DSS (1 time)
EC50 (1 time)
1990 Simultaneous modeling of the pharmacokinetic and pharmacodynamic properties of benzodiazepines. I: Lorazepam.
52  estimated concizumab-free TFPI exposure-response
(1 time)
Hematology
(1 time)
PK/PD (1 time)
TFPI (1 time)
TG (1 time)
2019 Concizumab restores thrombin generation potential in patients with haemophilia: Pharmacokinetic/pharmacodynamic modelling results of concizumab phase 1/1b data.
53  estimates of both maximal effect
(1 time)
Pharmacology
(1 time)
CNS (1 time)
EEG (1 time)
1987 Pharmacodynamic modeling of the EEG effects of ketamine and its enantiomers in man.
54  Estimates of maximal improvement
(1 time)
Pharmacology
(1 time)
ED (1 time)
EF (1 time)
IIEF (1 time)
2004 Population dose-response model for tadalafil in the treatment of male erectile dysfunction.
55  ET-1 produced a maximum contraction
(1 time)
Pharmacology
(1 time)
ET (1 time)
RT-PCR (1 time)
1996 Plasticity of contractile endothelin-B receptors in human arteries after organ culture.
56  evaluate the correlations of maximum stiffness
(1 time)
Radiology
(1 time)
SWE (1 time)
2015 Shear-wave elastography and immunohistochemical profiles in invasive breast cancer: evaluation of maximum and mean elasticity values.
57  exception, which produces the same maximal contraction
(1 time)
Pharmacology
(1 time)
NE (1 time)
pD2S (1 time)
1998 Alpha 1-adrenergic and 5-HT2-serotonergic effects of some beta-alkoxy-beta-phenylethylamines on isolated rat thoracic aorta.
58  exchange during maximal exercise
(1 time)
Pulmonary Medicine
(1 time)
IPF (1 time)
1988 Different patterns of gas exchange response to exercise in asbestosis and idiopathic pulmonary fibrosis.
59  Excursion max
(1 time)
Medicine
(1 time)
DOB (1 time)
Esd (1 time)
IMR (1 time)
2015 [Real-time Three-dimensional Dobutamine Stress Echocardiography for the Evaluation of Ischemic Mitral Regurgitation].
60  exercise and at maximal effort
(1 time)
Pharmacology
(1 time)
MHPG (1 time)
PNE (1 time)
1991 Influence of beta-blockade on circulating plasma levels of 3-methoxy-4-hydroxy phenylethylene glycol (MHPG) during exercise in moderate hypertension.
61  exhibited regional heterogeneity in the magnitude of cyclic AMP accumulation
(1 time)
Pharmacology
(1 time)
5-CT (1 time)
5-HT (1 time)
5-MeOT (1 time)
1997 Identification of 5-hydroxytryptamine receptors positively coupled to adenylyl cyclase in rat cultured astrocytes.
62  exhibited the strongest NO inhibition with the average maximum inhibition
(1 time)
Chemistry
(1 time)
LPS (1 time)
NO (1 time)
2013 Anti-inflammatory components from the root of Solanum erianthum.
63  experimental arteries had a significantly decreased maximum contraction
(1 time)
Vascular Diseases
(1 time)
--- 1989 Balloon catheter injury to rabbit carotid artery. II. Selective increase in reactivity to some vasoconstrictor drugs.
64  experimental regimens, the maximum clinical response to levodopa
(1 time)
Psychopharmacology
(1 time)
CI (1 time)
CURS (1 time)
1998 Pharmacodynamics of levodopa coadministered with apomorphine in parkinsonian patients with end-of-dose motor fluctuations.
65  experiments, and the average values of PE maximum efficacy
(1 time)
Critical Care
(1 time)
Gln (1 time)
HSP70 (1 time)
IL-6 (1 time)
2007 Glutamine induces heat-shock protein and protects against Escherichia coli lipopolysaccharide-induced vascular hyporeactivity in rats.
66  exploitation producing maximum relative yield per recruit
(1 time)
Zoology
(1 time)
--- 2019 Demographics of Lagocephalus inermis in the Arabian Sea unveils complex conservation challenges.
67  exponential, or maximum response
(1 time)
Pharmacology
(1 time)
CL (1 time)
Vd (1 time)
1998 Population pharmacokinetics and pharmacodynamics of cisplatin in patients with cancer: analysis with the NONMEM program.
68  exposure were related to hematological toxicity by a sigmoid-maximum effect
(1 time)
Neoplasms
(1 time)
--- 2002 Gemcitabine, epirubicin and paclitaxel: pharmacokinetic and pharmacodynamic interactions in advanced breast cancer.
69  expressed as a percentage of the maximum carbachol-evoked contraction
(1 time)
General Surgery
(1 time)
rEPO (1 time)
2006 Erythropoietin restores bowel damage and hypoperistalsis in gastroschisis.
70  expression and maximal relaxation response
(1 time)
Toxicology
(1 time)
eNOS (1 time)
TNF (1 time)
2012 Endothelial dysfunction in the pulmonary artery induced by concentrated fine particulate matter exposure is associated with local but not systemic inflammation.
71  extensively washed crude cerebrocortical membranes, the maximal effect
(1 time)
Substance-Related Disorders
(1 time)
NMDA (1 time)
1995 [3H]MK-801 binding in various brain regions of rat lines selected for differential alcohol sensitivity.
72  extent maximum of superprecipitation
(1 time)
Biochemistry
(1 time)
--- 1978 Studies on the superprecipitation of actomyosin in isoproterenol-induced cardiac hypertrophy.
73  extent of inhibition of striatal ((11) C)ORM-13070 uptake
(1 time)
Neurology
(1 time)
--- 2015 Validation of [(11) C]ORM-13070 as a PET tracer for alpha2c -adrenoceptors in the human brain.
74  extent of topoisomerase I redistribution
(1 time)
Cell Biology
(1 time)
--- 1998 Characterization of topotecan-mediated redistribution of DNA topoisomerase I by digital imaging microscopy.
75  extracellular MAC with maximal microbial kill
(1 time)
Anti-Bacterial Agents
(1 time)
HFS-MAC (1 time)
MAC (1 time)
2017 The discovery of ceftazidime/avibactam as an anti-Mycobacterium avium agent.
76  extracellular maximal relative efficacy
(1 time)
Natural Science Disciplines
(1 time)
CFU (1 time)
2018 Increased intracellular activity of MP1102 and NZ2114 against Staphylococcus aureus in vitro and in vivo.
77  extract in organ baths significantly reduced the maximal contractile responses
(1 time)
Physiology
(1 time)
OA (1 time)
2010 Effects of aqueous leaf extract of Bryophyllum pinnatum on guinea pig tracheal ring contractility.
78  linear model and a maximum effect
(1 time)
Hematology
(1 time)
AF (1 time)
OS (1 time)
PD (1 time)
2012 A combined pharmacometric analysis of dabigatran etexilate in healthy volunteers and patients with atrial fibrillation or undergoing orthopaedic surgery.
79  manoeuvre (MVV) and the maximum ventilation V
(1 time)
Pulmonary Medicine
(1 time)
MVV (1 time)
2008 Ventilatory capacity and its utilisation during exercise.
80  maxillary expansion efficacy
(1 time)
Dentistry
(1 time)
Nt (1 time)
Qx (1 time)
2004 A clinical comparison of the quadhelix appliance and the nickel titanium (tandem loop) palatal expander: a preliminary, prospective investigation.
81  maximal effect of insulin
(1 time)
Metabolism
(1 time)
ACE (1 time)
BK (1 time)
EC50 (1 time)
1999 Insulin resistance in adipocytes from spontaneously hypertensive rats: effect of long-term treatment with enalapril and losartan.
82  maximal efficacy
(1 time)
Signal Transduction
(1 time)
pMHCs (1 time)
TCRs (1 time)
2011 Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation.
83  maximal elastance
(1 time)
Cardiology
(1 time)
Ees (1 time)
LA (1 time)
P-V (1 time)
1994 In vivo assessment of left atrial contractile performance in normal and pathological conditions using a time-varying elastance model.
84  maximally effective doses
(1 time)
Physiology
(1 time)
ACh (1 time)
DAG (1 time)
LES (1 time)
1994 Differential signal transduction pathways in cat lower esophageal sphincter tone and response to ACh.
85  maximum effect induced by phenylephrine
(1 time)
Pharmacology
(1 time)
eNOS (1 time)
NO (1 time)
2008 Ethanol consumption increases blood pressure and alters the responsiveness of the mesenteric vasculature in rats.
86  maximum elasticity
(1 time)
Diagnostic Imaging
(1 time)
AD (1 time)
AF (1 time)
SWE (1 time)
2018 Ultrasound shear wave elastography of breast lesions: correlation of anisotropy with clinical and histopathological findings.
87  maximum energy
(1 time)
Complementary Therapies
(1 time)
DEX (1 time)
MAP (1 time)
MIF (1 time)
2007 [Role of macrophage migration inhibitory factor in septic shock-induced cardiovascular dysfunction: experiment with rats].
88  Maximum exercise testing
(1 time)
Physiology
(1 time)
BL (1 time)
CAO (1 time)
DS (1 time)
1984 Exercise performance with added dead space in chronic airflow obstruction.
89  rh-EPO was analyzed using the maximum effect
(1 time)
Pharmacology
(1 time)
sigmoid Emax (1 time)
2001 Pharmacokinetics and pharmacodynamics of recombinant human erythropoietin in rats.
90  sigmoid-Emax model were the maximal effect
(1 time)
Anti-Bacterial Agents
(1 time)
LN (1 time)
1997 Modeling of the change in CD4 lymphocyte counts in patients before and after administration of the human immunodeficiency virus protease inhibitor indinavir.