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Abbreviation: GCLC
Appearance Frequency: 227 time(s)
Long forms: 22

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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
glutamate-cysteine ligase catalytic subunit
(196 times)
Biochemistry
(30 times)
Nrf2 (67 times)
HO-1 (58 times)
GCLM (44 times)
2000 Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous.
GCL catalytic subunit
(8 times)
Biochemistry
(4 times)
GCL (7 times)
GCLM (2 times)
AP-1 (1 time)
2004 Insulin signaling regulates gamma-glutamylcysteine ligase catalytic subunit expression in primary cultured rat hepatocytes.
GCL holoenzyme is composed of a catalytic
(2 times)
Biochemistry
(1 time)
GCL (2 times)
4HNE (1 time)
beta-NF (1 time)
2001 Cell-type specific differences in glutamate cysteine ligase transcriptional regulation demonstrate independent subunit control.
glutamate-cysteine ligase subunit catalytic
(2 times)
Biology
(1 time)
PCR-RFLP (1 time)
TB (1 time)
2017 Polymorphism of Glutamate-Cysteine Ligase Subunit Catalytic (GCLC) Gene in Pulmonary Tuberculosis Patients.
glutamate-cysteine ligase, which consists of a catalytic subunit
(2 times)
Environmental Health
(1 time)
BeS (1 time)
CBD (1 time)
CI (1 time)
2006 Chronic beryllium disease and glutathione biosynthesis genes.
gamma-GCL catalytic subunit
(1 time)
Toxicology
(1 time)
alpha-LA (1 time)
gamma-GCL (1 time)
2015 alpha-Lipoic acid protects against the oxidative stress and cytotoxicity induced by cadmium in HepG2 cells through regenerating glutathione regulated by glutamate-cysteine ligase.
gamma-glutamylcysteine synthetase, consisting of a heavy, catalytic
(1 time)
Pulmonary Medicine
(1 time)
BAL (1 time)
ELF (1 time)
GCL (1 time)
2003 Glutamate-cysteine ligase modulatory subunit in BAL alveolar macrophages of healthy smokers.
GCL are the catalytic subunit
(1 time)
Toxicology
(1 time)
GCL (1 time)
GCLM (1 time)
2009 Glutamate cysteine ligase (GCL) transgenic and gene-targeted mice for controlling glutathione synthesis.
GCL consists of a catalytic
(1 time)
Biochemistry
(1 time)
GCL (1 time)
HNE (1 time)
2007 Submicromolar concentrations of 4-hydroxynonenal induce glutamate cysteine ligase expression in HBE1 cells.
10  GCL is a heterodimeric protein composed of catalytic
(1 time)
Molecular Biology
(1 time)
--- 2009 Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase.
11  GCL is composed for a catalytic
(1 time)
Molecular Biology
(1 time)
AP-1 (1 time)
ARE (1 time)
GCL (1 time)
2009 Regulation of glutathione synthesis.
12  genes involved in intracellular cysteine metabolism
(1 time)
Environmental Health
(1 time)
--- 2019 Changes in melanocyte RNA and DNA methylation favour pheomelanin synthesis and may avoid systemic oxidative stress after dietary cysteine supplementation in birds.
13  Germinal center B cells
(1 time)
Allergy and Immunology
(1 time)
HEV (1 time)
PNA (1 time)
1983 Germinal center B cells lack homing receptors necessary for normal lymphocyte recirculation.
14  glutamate cysteine ligase c subunit
(1 time)
Pharmacology
(1 time)
GS (1 time)
PN7 (1 time)
RP (1 time)
2015 Neuroprotective actions of progesterone in an in vivo model of retinitis pigmentosa.
15  glutamate-cysteine ligase polymorphism within the catalytic subunit
(1 time)
Cardiology
(1 time)
CV (1 time)
2007 Glutamate-cysteine ligase polymorphism, hypertension, and male sex are associated with cardiovascular events. Biochemical and genetic characterization of Italian subpopulation.
16  glutamate-cysteine ligase synthetase catalytic subunit
(1 time)
Neoplasms
(1 time)
--- 2019 Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers.
17  GSH and the mRNA contents of both the catalytic
(1 time)
Biochemistry
(1 time)
GCL (1 time)
HNE (1 time)
2009 Resveratrol and 4-hydroxynonenal act in concert to increase glutamate cysteine ligase expression and glutathione in human bronchial epithelial cells.
18  GSH biosynthesis and is a heterodimeric holoenzyme composed of catalytic
(1 time)
Pharmacology
(1 time)
GCL (1 time)
WT (1 time)
2010 Manipulation of cellular GSH biosynthetic capacity via TAT-mediated protein transduction of wild-type or a dominant-negative mutant of glutamate cysteine ligase alters cell sensitivity to oxidant-induced cytotoxicity.
19  GSH feedback inhibition or by transcriptional upregulation of the catalytic
(1 time)
Chemistry
(1 time)
2dDR (1 time)
GBM (1 time)
GCL (1 time)
2013 Glycation of glutamate cysteine ligase by 2-deoxy-d-ribose and its potential impact on chemoresistance in glioblastoma.
20  GSH synthesis and is composed of a catalytic subunit
(1 time)
Cardiology
(1 time)
AREs (1 time)
GCL (1 time)
oxLDL (1 time)
2003 Induction of glutathione synthesis in macrophages by oxidized low-density lipoproteins is mediated by consensus antioxidant response elements.
21  GSH synthesis and its catalytic subunit
(1 time)
Complementary Therapies
(1 time)
EGb (1 time)
GCL (1 time)
2008 Extract of Ginkgo biloba induces glutamate cysteine ligase catalytic subunit (GCLC).
22  GSH-regulating enzymes, CSC increased mRNA expression of both catalytic
(1 time)
Pathology
(1 time)
CSC (1 time)
NAC (1 time)
2013 Cigarette smoke-induced differential regulation of glutathione metabolism in bronchial epithelial cells is balanced by an antioxidant tetrapeptide UPF1.