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Abbreviation: IRS-1
Appearance Frequency: 1828 time(s)
Long forms: 18

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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
insulin receptor substrate-1
(1772 times)
Biochemistry
(436 times)
PI3K (177 times)
IR (164 times)
PI 3-kinase (110 times)
1992 YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase.
IR substrate-1
(31 times)
Endocrinology
(11 times)
IR (27 times)
PI3K (9 times)
GH (2 times)
1995 Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain.
insulin receptor-1
(5 times)
Pharmacology
(2 times)
aPKC (1 time)
AR (1 time)
BUN (1 time)
2003 Oestrogen improves glucose metabolism and insulin signal transduction in HepG2 cells.
INS receptor substrate-1
(3 times)
Neoplasms
(1 time)
ROS (2 times)
ACC (1 time)
AMPK (1 time)
1993 Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase.
insulin-receptor substrate, type 1
(3 times)
Gastroenterology
(2 times)
PCNA (2 times)
Tg (2 times)
AAH (1 time)
1998 Ethanol inhibition of insulin signaling in hepatocellular carcinoma cells.
insulin substrate 1
(2 times)
Drug Therapy
(1 time)
IR (1 time)
MOR (1 time)
SREBP (1 time)
2003 Morphine induces desensitization of insulin receptor signaling.
insulin receptor cellular substrate p185
(1 time)
Biochemistry
(1 time)
PI 3-kinase (1 time)
1993 Differential effects of okadaic acid on insulin-stimulated glucose and amino acid uptake and phosphatidylinositol 3-kinase activity.
insulin receptor is a 185-kDa phosphoprotein
(1 time)
Biochemistry
(1 time)
PI3K (1 time)
1992 Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers.
Insulin receptor tyrosine kinase activity and substrate 1
(1 time)
Gynecology
(1 time)
IR (1 time)
2005 Insulin receptor tyrosine kinase activity and substrate 1 (IRS-1) expression in human myometrium and leiomyoma.
10  insulin receptor→insulin receptor substrate-1
(1 time)
Dementia
(1 time)
AD (1 time)
aMCI (1 time)
GLP-1 (1 time)
2014 The nature, significance, and glucagon-like peptide-1 analog treatment of brain insulin resistance in Alzheimer's disease.
11  insulin substrate 1 protein
(1 time)
Cell Biology
(1 time)
MAPK (1 time)
1996 Overexpression of human insulin receptor substrate 1 induces cellular transformation with activation of mitogen-activated protein kinases.
12  insulin substrate receptor-1
(1 time)
Endocrinology
(1 time)
FFA (1 time)
PI (1 time)
2002 Female rats do not exhibit free fatty acid-induced insulin resistance.
13  insulin-resistant substrate-1
(1 time)
Biochemistry
(1 time)
ADEs (1 time)
BMDM (1 time)
EMSA (1 time)
2018 Adipocyte-Derived Exosomes Carrying Sonic Hedgehog Mediate M1 Macrophage Polarization-Induced Insulin Resistance via Ptch and PI3K Pathways.
14  IRS-1 delta PH
(1 time)
Biochemistry
(1 time)
PH (1 time)
1995 The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling.
15  IRS-1 mutants S332A
(1 time)
Biochemistry
(1 time)
GSK-3 (1 time)
WT (1 time)
2005 Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling.
16  IRS-1pSer
(1 time)
Medicine
(1 time)
AD (1 time)
2012 An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Abeta oligomers.
17  IRS-CAAX
(1 time)
Cell Biology
(1 time)
PI 3'-kinase (1 time)
2000 Cellular compartmentalization in insulin action: altered signaling by a lipid-modified IRS-1.
18  its substrate 1
(1 time)
Biochemistry
(1 time)
IR (1 time)
2000 Development and comparison of two 3T3-L1 adipocyte models of insulin resistance: increased glucose flux vs glucosamine treatment.