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Abbreviation: Isc
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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
increase in short-circuit current
(401 times)
Physiology
(195 times)
cAMP (24 times)
VIP (16 times)
TTX (15 times)
1975 Bile salt alteration of ion transport across jejunal mucosa.
amiloride-sensitive short-circuit current
(33 times)
Physiology
(22 times)
ENaC (4 times)
CF (3 times)
cAMP (2 times)
1989 Segmental heterogeneity of basal and aldosterone-induced electrogenic Na transport in human colon.
equivalent short-circuit current
(20 times)
Physiology
(12 times)
Rt (5 times)
CCh (3 times)
Rte (3 times)
1982 A cytotoxin of Pseudomonas aeruginosa acts directly on the cortical thick ascending limb of Henle's loop of rabbit kidney.
ischemia
(16 times)
Physiology
(3 times)
FF (2 times)
FP (2 times)
LBP (2 times)
1986 Long term model for evaluation of myocardial metabolic recovery following global ischemia.
Ion transport was measured as the short-circuit current
(7 times)
Physiology
(4 times)
ATP (1 time)
CaCC (1 time)
CFTR (1 time)
1987 Vasoactive intestinal peptide stimulates ion transport in avian salt gland.
1-EBIO-induced short-circuit current
(5 times)
Physiology
(3 times)
1-EBIO (1 time)
AMPK (1 time)
BBM (1 time)
1996 Modulation of Cl- secretion by benzimidazolones. I. Direct activation of a Ca(2+)-dependent K+ channel.
increased the cellular short circuit current
(4 times)
Physiology
(2 times)
DIDS (2 times)
NPPB (2 times)
CTAL (1 time)
1984 Substrate utilization in the isolated perfused cortical thick ascending limb of rabbit nephron.
increase in amiloride-sensitive short-circuit current
(3 times)
Physiology
(2 times)
ENaC (2 times)
NHMEE (1 time)
SGK1 (1 time)
2004 Extracellular Ca2+ regulates the stimulation of Na+ transport in A6 renal epithelia.
outward-directed short-circuit current
(3 times)
Physiology
(2 times)
--- 1990 The chloride-stimulated K(+)-secretion by insect midgut and its modification in the presence of osmotic gradients: a short-circuit current and noise-analysis study.
10  bicarbonate secretion, short-circuit current
(2 times)
Physiology
(1 time)
dbcAMP (1 time)
PD (1 time)
PGE2 (1 time)
1981 Alkaline secretion by amphibian duodenum. II. Short-circuit current and Na+ and Cl- fluxes.
11  chloride-dependent short-circuit current
(2 times)
Biochemistry
(1 time)
--- 2002 Action of palytoxin on apical H+/K+-ATPase in rat colon.
12  continuous short circuit current
(2 times)
Pharmacology
(1 time)
CCD (1 time)
ENaC (1 time)
PAF (1 time)
1989 Platelet activating factor is a potent colonic secretagogue with actions independent of specific PAF receptors.
13  CT-induced changes in short-circuit current
(2 times)
Medicine
(1 time)
AC (1 time)
AC6 (1 time)
CFTR (1 time)
2017 Chronic social stress in pigs impairs intestinal barrier and nutrient transporter function, and alters neuro-immune mediator and receptor expression.
14  difference, short-circuit current
(2 times)
Physiology
(1 time)
AAD (1 time)
CTCs (1 time)
OVA (1 time)
1987 Aldosterone-induced, amiloride-inhibitable short-circuit current in the avian ileum.
15  increased potential difference and short-circuit current
(2 times)
Biochemistry
(1 time)
BB (1 time)
GRP (1 time)
NMB (1 time)
1988 Actions of gastrin-releasing peptide and related mammalian and amphibian peptides on ion transport in the porcine proximal jejunum.
16  induced a rapid, monophasic, concentration- and chloride-dependent, bumetanide-sensitive short-circuit current
(2 times)
Physiology
(1 time)
NK-1 (1 time)
NT (1 time)
SP (1 time)
1999 Effects of substance P on human colonic mucosa in vitro.
17  intestinal short-circuit current
(2 times)
Gastroenterology
(1 time)
Gal1-R (1 time)
GI (1 time)
1994 Lipid peroxidation and electrogenic ion transport in the jejunum of the vitamin E deficient rat.
18  iron-sulfur cluster
(2 times)
Biochemical Phenomena
(1 time)
CDI (1 time)
2014 The importance of iron in the biosynthesis and assembly of [NiFe]-hydrogenases.
19  ouabain-sensitive component of the short-circuit current
(2 times)
Biochemistry
(2 times)
DC (1 time)
MC (1 time)
TC (1 time)
1999 Tetracyclines reduce Na+/K+ pump capacity in Calu-3 human airway cells.
20  (CT)-induced Cl- secretion
(1 time)
Medicine
(1 time)
BFA (1 time)
CT (1 time)
1993 Entry of cholera toxin into polarized human intestinal epithelial cells. Identification of an early brefeldin A sensitive event required for A1-peptide generation.
21  adenosine-induced anion secretion, measured by short-circuit current
(1 time)
Cell Biology
(1 time)
2-APB (1 time)
CFTR (1 time)
2008 Apical adenosine regulates basolateral Ca2+-activated potassium channels in human airway Calu-3 epithelial cells.
22  agonist-induced electrolyte transport by the short circuit current
(1 time)
Dermatology
(1 time)
--- 2007 A preliminary study of the short circuit current (Isc) responses of sweat gland cells from normal and anhidrotic horses to purinergic and adrenergic agonists.
23  amiloride, short-circuit current
(1 time)
Physiology
(1 time)
--- 1988 Complex response of epithelial cells to inhibition of Na+ transport by amiloride.
24  Amiloride-insensitive baseline short-circuit current
(1 time)
Physiology
(1 time)
cAMP (1 time)
CFTR (1 time)
DIDS (1 time)
1995 Role of CFTR in chloride secretion across human tracheal epithelium.
25  charybdotoxin-sensitive short-circuit current
(1 time)
Gastroenterology
(1 time)
ATPase (1 time)
PDECs (1 time)
1998 Calcium-activated potassium conductances on cultured nontransformed dog pancreatic duct epithelial cells.
26  conjunctival short-circuit current
(1 time)
Drug Therapy
(1 time)
--- 1996 Cyclic AMP modulation of active ion transport in the pigmented rabbit conjunctiva.
27  continuously short-circuited to measure tissue conductance, short-circuit current
(1 time)
Drug Therapy
(1 time)
--- 1993 Secretin and somatostatin as modulators of electrolyte transport in guinea pig gallbladder epithelium.
28  elicited significant changes in mucosal short-circuit current
(1 time)
Allergy and Immunology
(1 time)
EIEC (1 time)
1995 Identification and cloning of a novel plasmid-encoded enterotoxin of enteroinvasive Escherichia coli and Shigella strains.
29  eliminates short circuit currents
(1 time)
Physiology
(1 time)
--- 1990 Intestinal transport of potassium. Effects of changing apical and basolateral influx of sodium in the isolated mucosa of the hen (Gallus domesticus) colon.
30  fluid, since short-circuit current
(1 time)
Cell Biology
(1 time)
--- 1989 Stimulation by aldosterone of a conductive chloride pathway in toad skin.
31  forskolin-stimulated chloride secretion, as measured by the short-circuit current
(1 time)
Biochemistry
(1 time)
MAPK (1 time)
MLCK (1 time)
PI3K (1 time)
2000 Wortmannin inhibition of forskolin-stimulated chloride secretion by T84 cells.
32  Gly-Sar-induced short-circuit
(1 time)
Gastroenterology
(1 time)
PEG (1 time)
WT (1 time)
2018 Luminal Na+ homeostasis has an important role in intestinal peptide absorption in vivo.
33  highly significant correlation between short-circuit current
(1 time)
Physiology
(1 time)
--- 1991 Apical and basolateral conductance in cultured A6 cells.
34  I(-) efflux and short-circuit current
(1 time)
Cell Biology
(1 time)
CDCA (1 time)
CFTR (1 time)
2013 Chenodeoxycholic acid stimulates Cl(-) secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells.
35  IBMX, on short-circuit current
(1 time)
Endocrinology
(1 time)
FW (1 time)
GH (1 time)
IBMX (1 time)
1985 Hormonal effects on L-proline transport in coho salmon (Oncorhynchus kisutch) intestine.
36  ibuprofen and salicylic acid on cAMP-mediated Cl- secretion
(1 time)
Medicine
(1 time)
HBE (1 time)
MTE (1 time)
1998 Ibuprofen inhibits cystic fibrosis transmembrane conductance regulator-mediated Cl- secretion.
37  ICC was determined by measuring short-circuit current
(1 time)
Biology
(1 time)
Ala (1 time)
Gln (1 time)
GLU (1 time)
1992 Cotransport of sodium with glutamine, alanine and glucose in the isolated rabbit ileal mucosa.
38  identical HCO3-/CO2-containing, Cl- -free Na+ media exhibit a short-circuit current
(1 time)
Biochemistry
(1 time)
IBMX (1 time)
1982 Effect of 3-isobutyl-1-methylxanthine on HCO3- transport in turtle bladder. Evidence for electrogenic HCO3- secretion.
39  identification and analysis of two genes encoding critical FeS cluster
(1 time)
Biology
(1 time)
HGT (1 time)
2004 The iron-sulfur cluster assembly genes iscS and iscU of Entamoeba histolytica were acquired by horizontal gene transfer.
40  identified two opposing short-circuit current
(1 time)
Medicine
(1 time)
ENaC (1 time)
KCC (1 time)
NKCC (1 time)
2017 Bumetanide increases Cl--dependent short-circuit current in late distal colon: Evidence for the presence of active electrogenic Cl- absorption.
41  II did have a bimodal effect on short-circuit current
(1 time)
Physiology
(1 time)
Ang II (1 time)
1998 Losartan antagonism of angiotensin-II-induced potassium secretion across rat colon.
42  IL-1 alpha significantly enhanced T84 short-circuit current
(1 time)
Physiology
(1 time)
COX (1 time)
IL-1 (1 time)
PGE2 (1 time)
1996 IL-1 stimulates intestinal myofibroblast COX gene expression and augments activation of Cl- secretion in T84 cells.
43  ileal short-circuit
(1 time)
Communicable Diseases
(1 time)
--- 1997 Cryptosporidiosis-induced impairment of ion transport and Na+-glucose absorption in adult immunocompromised mice.
44  ileum had a higher short-circuit current
(1 time)
Allergy and Immunology
(1 time)
PD (1 time)
2004 Parenteral immunization to beta-lactoglobulin modifies the intestinal structure and mucosal electrical parameters in rabbit.
45  ileum had a significantly greater short-circuit current
(1 time)
Physiology
(1 time)
--- 1991 Ion transport across the chick ileum: a good model for transport studies.
46  immediate effect on the short-circuit current
(1 time)
Physiology
(1 time)
--- 1980 Suppression of gastric acid secretion by furosemide in isolated gastric mucosa of guinea pig.
47  impaled with microelectrodes and experiments were done under short-circuit current
(1 time)
Biology
(1 time)
PCP (1 time)
1999 Effect of pentachlorophenol (PCP) on frog cornea epithelium.
48  in vivo and short-circuit current
(1 time)
Pulmonary Medicine
(1 time)
CFTR (1 time)
NPD (1 time)
2017 Roflumilast reverses CFTR-mediated ion transport dysfunction in cigarette smoke-exposed mice.
49  increase in serosa-positive short-circuit current
(1 time)
Pharmacology
(1 time)
--- 1991 Modulation of Na+, Cl- and HCO3- transport by carbachol in pig distal jejunum.
50  increase in short current circuit
(1 time)
Microbiology
(1 time)
beta-LG (1 time)
2015 Protective effect of Enterococcus faecalis DAPTO 512 on the intestinal tract and gut mucosa: milk allergy application.
51  increase in the current
(1 time)
Animal Population Groups
(1 time)
DON (1 time)
2007 Influence of deoxynivalenol on the D-glucose transport across the isolated epithelium of different intestinal segments of laying hens.
52  increase in transepithelial short-circuit current
(1 time)
Molecular Biology
(1 time)
--- 1994 Antidiuretic hormone action in A6 cells: effect on apical Cl and Na conductances and synergism with aldosterone for NaCl reabsorption.
53  increase the amplitude of the short-circuit current
(1 time)
Biochemistry
(1 time)
--- 1988 Catecholamine stimulation of ion transport in the toad urinary bladder.
54  increased Cai concentration and transepithelial short-circuit current
(1 time)
Physiology
(1 time)
--- 1992 Intracellular Ca2+ and regulation of ion transport across rabbit Clara cells.
55  increased electrical conductance across epithelial membrane (G), short-circuit current
(1 time)
Physiology
(1 time)
GO (1 time)
SOD (1 time)
1995 Oxidants affect permeability and repair of the cultured human tracheal epithelium.
56  increased mouse duodenal short-circuit current
(1 time)
Pharmacology
(1 time)
IECs (1 time)
RyR (1 time)
2019 Molecular mechanisms of caffeine-mediated intestinal epithelial ion transports.
57  increased TDH binding, higher short-circuit currents
(1 time)
Microbiology
(1 time)
TDH (1 time)
2001 Chloride secretion induced by thermostable direct haemolysin of Vibrio parahaemolyticus depends on colonic cell maturation.
58  increased the electrical parameters short-circuit current
(1 time)
Toxicology
(1 time)
CBZ (1 time)
PD (1 time)
2006 The antiepileptic drug carbamazepine affects sodium transport in toad epithelium.
59  increased the electrogenic Cl- secretion measured as the short-circuit current
(1 time)
Physiology
(1 time)
L-NAME (1 time)
TTX (1 time)
1994 Enterotoxin Escherichia coli STa activates a nitric oxide-dependent myenteric plexus secretory reflex in the rat ileum.
60  increased transmonolayer short-circuit current
(1 time)
Physiology
(1 time)
PGE2 (1 time)
1986 Evidence that prostaglandin E2 stimulates chloride secretion in cultured A6 renal epithelial cells.
61  increased, and calculated short-circuit current
(1 time)
Molecular Biology
(1 time)
RT (1 time)
1985 Effects of anions on cellular volume and transepithelial Na+ transport across toad urinary bladder.
62  increases the magnitude of the TEP, the short-circuit current
(1 time)
Physiology
(1 time)
PGE2 (1 time)
TEP (1 time)
1992 Bidirectional ion transport in thyroid: secretion of anions by monolayer cultures that absorb sodium.
63  increases the negative short-circuiting current
(1 time)
Biochemistry
(1 time)
--- 1984 Chloride-induced increment in short-circuiting current of the turtle bladder. Effects of in-vivo acid-base state.
64  indicated by an elevated baseline short-circuit current
(1 time)
Gastroenterology
(1 time)
p.i (1 time)
1995 Role of T lymphocytes in secretory response to an enteric nematode parasite. Studies in athymic rats.
65  indicated by baseline and stimulated short-circuit current
(1 time)
Gastroenterology
(1 time)
HPA (1 time)
HRP (1 time)
MS (1 time)
2007 Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation.
66  indicated the presence of a biphasic short-circuit current
(1 time)
Science
(1 time)
P2Y2R (1 time)
2015 Infection by Toxoplasma gondii, a severe parasite in neonates and AIDS patients, causes impaired anion secretion in airway epithelia.
67  indicating the maximum values of short circuit current
(1 time)
Biology
(1 time)
--- 2015 Enhanced photocatalytic activity of sprayed Au doped ferric oxide thin films for salicylic acid degradation in aqueous medium.
68  indomethacin on short-circuit current
(1 time)
Gastroenterology
(1 time)
--- 2006 Indomethacin reduces short-circuit current and oxygen consumption in normal and chronically hypoxic rat colon.
69  induce a sustained Cl- secretory current
(1 time)
Physiology
(1 time)
1-EBIO (1 time)
cAMP (1 time)
KCa (1 time)
1997 Inhibition of intestinal Cl- secretion by clotrimazole: direct effect on basolateral membrane K+ channels.
70  induced a biphasic short-circuit current
(1 time)
Reproductive Medicine
(1 time)
--- 2009 Stimulating effects of dopamine on chloride transport across the rat caudal epididymal epithelium in culture.
71  induced a rapid, transient, bumetanide-sensitive, dose- and chloride-dependent short-circuit current
(1 time)
Gastroenterology
(1 time)
NK-1 (1 time)
SP (1 time)
1999 Substance P causes a chloride-dependent short-circuit current response in rabbit colonic mucosa in vitro.
72  induced transient short-circuit current
(1 time)
Physiology
(1 time)
--- 1996 P2u-purinoceptor regulation of chloride secretion in cultured human tracheal submucosal glands.
73  infection did not alter the short-circuit current
(1 time)
Physiology
(1 time)
DBcAMP (1 time)
PD (1 time)
1989 Electrolyte transport in rabbit cecum. I. Effect of RDEC-1 infection.
74  infection significantly decreased short-circuit current
(1 time)
Physiology
(1 time)
EPEC (1 time)
1999 Enteropathogenic E. coli attenuates secretagogue-induced net intestinal ion transport but not Cl- secretion.
75  infection significantly reduced CFTR short circuit currents
(1 time)
Biology
(1 time)
CFTR (1 time)
GFP (1 time)
HEK (1 time)
2015 Influenza virus M2 targets cystic fibrosis transmembrane conductance regulator for lysosomal degradation during viral infection.
76  influence of four opioid antagonists on short circuit current
(1 time)
Pharmacology
(1 time)
nor-BNI (1 time)
Pdo (1 time)
1991 Voltage-clamp experiments reveal receptor type-dependent modulation of chloride secretion in the guinea pig colonic mucosa by intestinal opioids.
77  influence of norepinephrine on the short-circuit current
(1 time)
Physiology
(1 time)
EFS (1 time)
PHI (1 time)
VIP (1 time)
1989 Noradrenergic influence on epithelial responses of rabbit ileum to secretagogues.
78  inhibit the majority of forskolin-stimulated secretory short-circuit current
(1 time)
Physiology
(1 time)
BCECF (1 time)
NKCC1 (1 time)
2001 Expression and role of sodium, potassium, chloride cotransport (NKCC1) in mouse inner medullary collecting duct (mIMCD-K2) epithelial cells.
79  inhibited water absorption and short-circuit current
(1 time)
Physiology
(1 time)
GN (1 time)
MI (1 time)
NCC (1 time)
2014 Mechanisms of guanylin action on water and ion absorption at different regions of seawater eel intestine.
80  inhibiting CFTR mediated Cl- secretion
(1 time)
Biochemistry
(1 time)
--- 2006 Arsenic inhibits CFTR-mediated chloride secretion by killifish (Fundulus heteroclitus) opercular membrane.
81  inhibiting the absorptive short-circuit current
(1 time)
Physiology
(1 time)
GCC (1 time)
ppt (1 time)
RGN (1 time)
2015 The differential role of renoguanylin in osmoregulation and apical Cl-/HCO3- exchange activity in the posterior intestine of the Gulf toadfish (Opsanus beta).
82  inhibition of forskolin-stimulated short-circuit current
(1 time)
Physiology
(1 time)
--- 1998 The bumetanide-resistant part of forskolin-induced anion secretion in rat colon.
83  inhibits the Na+ moiety of the short-circuiting current
(1 time)
Biochemistry
(1 time)
--- 1980 Vanadate-induced inhibition of sodium transport and of sodium-independent anion transport in turtle bladder.
84  insect saline on both sides the outward-directed short-circuit current
(1 time)
Physiology
(1 time)
--- 1986 Current-noise analysis of the basolateral route for K+ ions across a K+-secreting insect midgut epithelium (Manduca sexta).
85  instantaneous short-circuit current
(1 time)
Nanotechnology
(1 time)
TENG (1 time)
2013 Integrated multilayered triboelectric nanogenerator for harvesting biomechanical energy from human motions.
86  integrity and the short-circuit current
(1 time)
Animal Population Groups
(1 time)
SCFA (1 time)
2018 Effects of dissolved carbon dioxide on the integrity of the rumen epithelium: An agent in the development of ruminal acidosis.
87  interface of polyacrylamide gels and electrolyte secretion as short-circuit current
(1 time)
Molecular Biology
(1 time)
--- 1994 ATP-stimulated electrolyte and mucin secretion in the human intestinal goblet cell line HT29-Cl.16E.
88  Intestinal electrogenic Cl- secretion was determined by measuring short-circuit current
(1 time)
Gastroenterology
(1 time)
cAMP (1 time)
cGK (1 time)
STa (1 time)
1997 Guanosine 3',5'-cyclic monophosphate-dependent protein kinase II mediates heat-stable enterotoxin-provoked chloride secretion in rat intestine.
89  Intestinal electrolyte movement was assessed using short-circuit current
(1 time)
Pharmacology
(1 time)
ENTs (1 time)
PE (1 time)
SBT (1 time)
2006 Acute denervation alters the epithelial response to adrenoceptor activation through an increase in alpha1-adrenoceptor expression on villus enterocytes.
90  intestinal mucosal guanylate cyclase and Na-K-ATPase activities, short-circuit current
(1 time)
Physiology
(1 time)
MP (1 time)
PD (1 time)
1981 Effects of methylprednisolone on electrolyte transport by in vitro rat ileum.
91  Intestinal secretion was monitored electrophysiologically as transmucosal short circuit current
(1 time)
Biochemistry
(1 time)
STa (1 time)
2001 In vitro effects of wood creosote on enterotoxin-induced secretion measured electrophysiologically in the rat jejunum and colon.
92  intestine reduced the short-circuit current
(1 time)
Biology
(1 time)
FW (1 time)
SW (1 time)
2007 Regulation of ion transport in eel intestine by the homologous guanylin family of peptides.
93  intestines were mounted on Ussing chambers, and short-circuit current
(1 time)
Physiological Phenomena
(1 time)
COX (1 time)
TRPA1 (1 time)
2016 Effects of epsilon-viniferin, a dehydrodimer of resveratrol, on transepithelial active ion transport and ion permeability in the rat small and large intestinal mucosa.
94  into a K-free ouabain Ringer solution and short-circuit current
(1 time)
Physiology
(1 time)
--- 1990 Net basolateral potassium flux and short-circuit current in ouabain-treated frog skin.
95  intracellular K+ activity ((K+)i), and short-circuit current
(1 time)
Physiology
(1 time)
--- 1990 Basal membrane uptake in potassium-secreting cells of midgut of tobacco hornworm (Manduca sexta).
96  investigate permeability, apoptosis, electrogenic ion transport
(1 time)
Physiology
(1 time)
GI (1 time)
2014 Acute exercises induce disorders of the gastrointestinal integrity in a murine model.
97  investigation of basal short-circuit current
(1 time)
Physiology
(1 time)
--- 1998 Evidence that Calu-3 human airway cells secrete bicarbonate.
98  ion concentrations on the stimulated epithelial short-circuit current
(1 time)
Physiology
(1 time)
--- 1989 Mechanism of chloride uptake in rabbit corneal epithelium.
99  ion fluxes significantly different from the short-circuit current
(1 time)
Physiology
(1 time)
--- 1986 Sodium and chloride transport by the tracheal epithelium of fetal, new-born and adult sheep.
100  ion fluxes, short-circuit current
(1 time)
Physiology
(1 time)
DDPC (1 time)
RNAE (1 time)
1996 Effects of a short-chain phospholipid on ion transport pathways in rabbit nasal airway epithelium.