| 1 |
mitogen-activated protein kinase
(20829 times)
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Biochemistry
(2921 times)
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ERK (2772 times)
JNK (1790 times)
NF-kappaB (1559 times)
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1992 Mitogen-activated-protein-kinase-catalyzed phosphorylation of microtubule-associated proteins, microtubule-associated protein 2 and microtubule-associated protein 4, induces an alteration in their function.
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| 2 |
MAP kinase
(382 times)
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Molecular Biology
(84 times)
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MAP (28 times)
MAPKK (19 times)
PI3K (18 times)
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1990 Stimulation of MAP-2 kinase activity in T lymphocytes by anti-CD3 or anti-Ti monoclonal antibody is partially dependent on protein kinase C.
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| 3 |
microtubule-associated protein kinase
(13 times)
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Biochemistry
(4 times)
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MEK (2 times)
ALDH1 (1 time)
BDNF (1 time)
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1993 Direct stimulation by tyrosine phosphorylation of microtubule-associated protein (MAP) kinase activity by granulocyte-macrophage colony-stimulating factor in human neutrophils.
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| 4 |
mitogen activated kinase-like protein
(6 times)
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Neoplasms
(4 times)
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NF-kappaB (2 times)
AP-1 (1 time)
BCL-2 (1 time)
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1999 p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function.
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| 5 |
mitogen-activated PK
(5 times)
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Pharmacology
(1 time)
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PK (3 times)
TK (2 times)
2-APB (1 time)
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2001 Proadrenomedullin-derived peptides as autocrine-paracrine regulators of cell growth.
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| 6 |
Ras-MAP kinase
(5 times)
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Cell Biology
(2 times)
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7 DIV (1 time)
BCR (1 time)
CREB (1 time)
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1997 v-src-induced cell shape changes in rat fibroblasts require new gene transcription and precede loss of focal adhesions.
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| 7 |
mitogen activated phosphokinase
(4 times)
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Medicine
(2 times)
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COX-2 (1 time)
GA (1 time)
HO-1 (1 time)
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2001 Peroxynitrite induces neuronal cell death in aging and age-associated disorders: A review.
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| 8 |
mitogen-activated phosphorylated kinase
(3 times)
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Molecular Biology
(1 time)
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ALA (1 time)
CM (1 time)
ICAM-1 (1 time)
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2005 The nitrogen mustard melphalan activates mitogen-activated phosphorylated kinases (MAPK), nuclear factor-kappaB and inflammatory response in lung epithelial cells.
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| 9 |
flk-1-mediated activation of p38
(2 times)
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Science
(1 time)
|
---
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2006 VEGF, a prosurvival factor, acts in concert with TGF-beta1 to induce endothelial cell apoptosis.
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| 10 |
metabolism', the 'mitogen-activated protein kinase
(2 times)
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Botany
(1 time)
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BAM (1 time)
KEGG (1 time)
SMRT (1 time)
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2004 Cisplatin-induced apoptosis in human malignant testicular germ cell lines depends on MEK/ERK activation.
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| 11 |
42MAPK
(1 time)
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Natural Science Disciplines
(1 time)
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EGFR (1 time)
LDLR (1 time)
MDA-231 (1 time)
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2021 Regulation of low-density lipoprotein receptor expression in triple negative breast cancer by EGFR-MAPK signaling.
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| 12 |
ERK-MAPK
(1 time)
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Cell Biology
(1 time)
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mTORC1 (1 time)
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2008 Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors.
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| 13 |
interleukin-1beta-mitogen-activated protein kinase
(1 time)
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Allergy and Immunology
(1 time)
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EPS (1 time)
FLSs (1 time)
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2015 Effect of ebosin on modulating interleukin-1beta-induced inflammatory responses in rat fibroblast-like synoviocytes.
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| 14 |
IRS-2-mediated PI 3-kinase activation as well as p42
(1 time)
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Physiology
(1 time)
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2-DG (1 time)
IRS (1 time)
PI 3-kinase (1 time)
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1999 TNF-alpha impairs insulin signaling and insulin stimulation of glucose uptake in C2C12 muscle cells.
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| 15 |
many efforts to develop drugs that target the RAS-RAF-MEK-ERK
(1 time)
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Clinical Medicine
(1 time)
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NSCLC (1 time)
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2015 KRAS mutant lung cancer: progress thus far on an elusive therapeutic target.
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| 16 |
MAP kinase signaling
(1 time)
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Orthopedics
(1 time)
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DMNQ (1 time)
ERK (1 time)
OA (1 time)
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2018 Articular chondrocytes isolated from the knee and ankle joints of human tissue donors demonstrate similar redox-regulated MAP kinase and Akt signaling.
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| 17 |
MAP/Erk kinase
(1 time)
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Allergy and Immunology
(1 time)
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IL (1 time)
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1996 Interleukin-7 induces T cell proliferation in the absence of Erk/MAP kinase activity.
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| 18 |
MAPK-activated protein kinase-2, a well-known downstream effector of p38
(1 time)
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Biochemistry
(1 time)
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---
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2000 Activation of p38 mitogen-activated protein kinase and mitochondrial Ca(2+)-mediated oxidative stress are essential for the enhanced expression of grp78 induced by the protein phosphatase inhibitors okadaic acid and calyculin A.
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| 19 |
MAPK/ERK
(1 time)
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Endocrinology
(1 time)
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MEK (1 time)
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2011 The Akt inhibitor MK2206 synergizes, but perifosine antagonizes, the BRAF(V600E) inhibitor PLX4032 and the MEK1/2 inhibitor AZD6244 in the inhibition of thyroid cancer cells.
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| 20 |
MAPKAPK-2, that lie upstream and downstream of p38
(1 time)
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Biochemistry
(1 time)
|
HEK (1 time)
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2008 Activation of p38(MAPK) mediates the angiostatic effect of the chemokine receptor CXCR3-B.
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| 21 |
MAPkinases ERK-1/-2, p38
(1 time)
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Pulmonary Medicine
(1 time)
|
ERK (1 time)
T-bet (1 time)
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2006 IL-12-induced T-bet expression and IFNgamma release in lymphocytes from asthmatics--role of MAPkinases ERK-1/-2, p38(MAPK) and effect of dexamethasone.
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| 22 |
may promote NF-kappaB signaling via activation of mitogen-activated kinase
(1 time)
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Cell Biology
(1 time)
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BDNF (1 time)
IKK (1 time)
NF-kappaB (1 time)
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2008 Ankyrin-rich membrane spanning protein plays a critical role in nuclear factor-kappa B signaling.
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| 23 |
Meanwhile, PMK-1
(1 time)
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Cell Biology
(1 time)
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MAPKK (1 time)
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2020 Caenorhabditis elegans mounts a p38 MAPK pathway-mediated defence to Cutibacterium acnes infection.
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| 24 |
mechanism for TGFbeta and Alk5-dependent Erk1/2
(1 time)
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Cell Biology
(1 time)
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---
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2015 Endocytic deficiency induced by ITSN-1s knockdown alters the Smad2/3-Erk1/2 signaling balance downstream of Alk5.
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| 25 |
mechanism for TPA-induced ERK
(1 time)
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Medicine
(1 time)
|
AS (1 time)
ODN (1 time)
TPA (1 time)
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2005 Activation of protein kinase C alpha is required for TPA-triggered ERK (MAPK) signaling and growth inhibition of human hepatoma cell HepG2.
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| 26 |
mediated by NADPH oxidase involving PI 3-K and p42/44
(1 time)
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Pharmacology
(1 time)
|
11-keto-BAs (1 time)
AA (1 time)
LT (1 time)
|
2003 Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes.
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| 27 |
MEK-1, prevented the dual phosphorylation of p42/44
(1 time)
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Biochemistry
(1 time)
|
HGF/SF (1 time)
PtdIns3K (1 time)
Rama (1 time)
|
2001 Hepatocyte growth factor/scatter factor stimulates migration of rat mammary fibroblasts through both mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt pathways.
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| 28 |
MEK-ERK1/2-pathway independent of p38
(1 time)
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Cell Biology
(1 time)
|
MK (1 time)
OSMR (1 time)
SOCS (1 time)
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2015 Oncostatin M regulates SOCS3 mRNA stability via the MEK-ERK1/2-pathway independent of p38(MAPK)/MK2.
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| 29 |
microkeratome-assisted posterior keratoplasty
(1 time)
|
Ophthalmology
(1 time)
|
CH (1 time)
CRF (1 time)
HTH PK (1 time)
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2015 [Evaluation of corneal biomechanics before and after up-to-date keratoplasty in patients with bullous keratopathy].
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| 30 |
Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38
(1 time)
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Biochemistry
(1 time)
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---
|
2008 Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38(MAPK) inhibitor RO3201195 for study in Werner syndrome cells.
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| 31 |
migration through a G(i)-linked and a PI3-K coupled, p38
(1 time)
|
General Surgery
(1 time)
|
EGF (1 time)
PI3K (1 time)
S1P (1 time)
|
2003 Sphingosine-1-phosphate stimulates smooth muscle cell migration through galpha(i)- and pi3-kinase-dependent p38(MAPK) activation.
|
| 32 |
migration through galpha(i)- and pi3-kinase-dependent p38
(1 time)
|
General Surgery
(1 time)
|
EGF (1 time)
PI3K (1 time)
S1P (1 time)
|
2003 Sphingosine-1-phosphate stimulates smooth muscle cell migration through galpha(i)- and pi3-kinase-dependent p38(MAPK) activation.
|
| 33 |
mitogen activated protein/extracellular signal-regulated kinase
(1 time)
|
Neoplasms
(1 time)
|
EGFR (1 time)
GBM (1 time)
mTOR (1 time)
|
2020 mTOR Inhibition Leads to Src-Mediated EGFR Internalisation and Degradation in Glioma Cells.
|
| 34 |
mitogen protein-activated kinase
(1 time)
|
Neurology
(1 time)
|
IL (1 time)
LDH (1 time)
MMP-9 (1 time)
|
2011 Mild stretch-induced injury increases susceptibility to interleukin-1beta-induced release of matrix metalloproteinase-9 from astrocytes.
|
| 35 |
mitogen-activated protein kinase-related proteins
(1 time)
|
Biochemistry
(1 time)
|
COX-2 (1 time)
IL-6 (1 time)
iNOS (1 time)
|
2021 Anti-inflammatory Effects of Sanhuang-Siwu-Tang in Lipopolysaccharide-Stimulated RAW264.7 Macrophages and BV2 Microglial Cells.
|
| 36 |
mitogen-activated protein/extracellular signal-regulated kinase inhibitor, mitogen activated kinase
(1 time)
|
Dentistry
(1 time)
|
NOD (1 time)
P. gingivalis (1 time)
PD-L1 (1 time)
|
2021 Porphyromonas gingivalis induced up-regulation of PD-L1 in colon carcinoma cells.
|
| 37 |
mitogen-activated/extracellular signal-regulated protein kinase
(1 time)
|
Chemistry
(1 time)
|
IGF-I (1 time)
IRS-2 (1 time)
|
2001 Inhibition of insulin-like growth factor-1 receptor and IRS-2 signaling by ethanol in SH-SY5Y neuroblastoma cells.
|
| 38 |
mitogene-activated kinases pathway
(1 time)
|
Pediatrics
(1 time)
|
LCH (1 time)
|
2019 [Vemurafenib in refractory langerhans histiocytosis].
|
| 39 |
Mitotic-Associated Protein Kinase
(1 time)
|
Biotechnology
(1 time)
|
ERK7 (1 time)
TORC1 (1 time)
|
2011 ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association.
|
| 40 |
MKP-1 was a target in vivo and in vitro for p42
(1 time)
|
Science
(1 time)
|
MAP (1 time)
MKP (1 time)
|
2000 Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation.
|
| 41 |
MKP-1's intrinsic ability to dephosphorylate p44
(1 time)
|
Science
(1 time)
|
MAP (1 time)
MKP (1 time)
|
2000 Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation.
|
| 42 |
modulation of PKC-alpha and -beta-mitogen-activated protein kinase
(1 time)
|
Chemistry
(1 time)
|
ERK (1 time)
PKC (1 time)
STZ (1 time)
|
2012 Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: possible involvement of PKC-MAPK signaling pathway.
|
| 43 |
modulation via ROS-dependent ASK1-p38
(1 time)
|
Neurology
(1 time)
|
ASK1 (1 time)
beta-Ecd (1 time)
DN (1 time)
|
2016 beta-Ecdysterone Protects SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Apoptosis via Mitochondria-Dependent Mechanism: Involvement of p38(MAPK)-p53 Signaling Pathway.
|
| 44 |
multiple factors of the KIT-RAS-RAF-MEK-ERK
(1 time)
|
Neoplasms
(1 time)
|
AML (1 time)
|
2018 Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia.
|
| 45 |
mutant kinase inhibited IL-1beta-induced p38
(1 time)
|
Biochemistry
(1 time)
|
IL-1beta (1 time)
iNOS (1 time)
NO (1 time)
|
1999 Both p38alpha(MAPK) and JNK/SAPK pathways are important for induction of nitric-oxide synthase by interleukin-1beta in rat glomerular mesangial cells.
|
| 46 |
myelin basic protein kinases
(1 time)
|
Biochemistry
(1 time)
|
---
|
1998 Stimulation of MAP kinase and S6 kinase by vanadium and selenium in rat adipocytes.
|
| 47 |
p38-MAP kinase
(1 time)
|
Endocrinology
(1 time)
|
MAP (1 time)
|
2001 Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death.
|
| 48 |
pheromone-mediated-mitogen activated protein kinase
(1 time)
|
Cell Biology
(1 time)
|
---
|
1998 Saccharomyces cerevisiae STE11 may contribute to the stabilities of a scaffold protein, STE5, in the pheromone signaling pathway.
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