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Abbreviation: MEK
Appearance Frequency: 2579 time(s)
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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
mitogen-activated protein kinase kinase
(1017 times)
Neoplasms
(185 times)
ERK (454 times)
PI3K (160 times)
MAPK (89 times)
1994 Partial purification of a mitogen-activated protein kinase kinase activator from bovine brain. Identification as B-Raf or a B-Raf-associated activity.
mitogen-activated protein kinase/extracellular signal-regulated kinase kinase
(342 times)
Neoplasms
(90 times)
ERK (85 times)
MAPK (57 times)
PI3K (46 times)
1995 Molecular characterization of Ste20p, a potential mitogen-activated protein or extracellular signal-regulated kinase kinase (MEK) kinase kinase from Saccharomyces cerevisiae.
MAPK kinase
(313 times)
Biochemistry
(62 times)
MAPK (154 times)
ERK (56 times)
PKC (36 times)
1994 Regulation of mitogen-activated protein kinase cascade in adult rat heart preparations in vitro.
MAPK/ERK kinase
(295 times)
Neoplasms
(66 times)
ERK (129 times)
MAPK (87 times)
MAP (32 times)
1994 Chemotactic peptides induce phosphorylation and activation of MEK-1 in human neutrophils.
methyl ethyl ketone
(231 times)
Environmental Health
(85 times)
MIBK (22 times)
VOCs (21 times)
DMF (10 times)
1976 Peripheral nerve changes induced by methyl n-butyl ketone and potentiation by methyl ethyl ketone.
MAP kinase kinase
(213 times)
Biochemistry
(44 times)
MAP (85 times)
ERK (53 times)
MAPK (19 times)
1994 Transforming growth factor beta 2 stimulates acute and chronic activation of the mitogen-activated protein kinase cascade in rat renal mesangial cells.
mitogen-induced extracellular kinase
(34 times)
Hematology
(11 times)
ERK (16 times)
MAPK (9 times)
PI3K (7 times)
2000 cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway.
mitogen-activated ERK-activating kinase
(19 times)
Physiology
(4 times)
ERK (12 times)
HCC (5 times)
MAPK (4 times)
1999 Inhibitory guanine nucleotide regulatory protein activation of mitogen-activated protein kinase in experimental hepatocellular carcinoma in vitro.
MAPK/ERK
(15 times)
Biochemistry
(3 times)
ERK (6 times)
MAPK (5 times)
PI3K (2 times)
2002 Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation.
10  methionine-enkephalin
(15 times)
Biochemistry
(4 times)
beta-EP (6 times)
L-Ek (5 times)
AVP (4 times)
1988 Opioid peptides in pituitary gland, brain regions and peripheral tissues of spontaneously hypertensive and Wistar-Kyoto normotensive rats.
11  Met-enkephalin
(13 times)
Physiology
(5 times)
LEK (4 times)
beta-EP (2 times)
EA (2 times)
1983 Enkephalins and the secretion of pancreatic somatostatin and insulin in the dog: studies in vitro.
12  MAPK or ERK kinase
(12 times)
Physiology
(3 times)
ERK (7 times)
MAPK (6 times)
JNK (4 times)
1995 [MAP kinase cascade in cultured rat mesangial cells].
13  mitogen-activated protein extracellular kinase
(8 times)
Pharmacology
(3 times)
ERK (4 times)
AA (1 time)
ACC (1 time)
1996 Reduced phosphorylation of mitogen-activated protein kinase kinase in response to insulin in cells with truncated C-terminal domain of insulin receptor.
14  MAPK/ERK activity kinase
(4 times)
Neoplasms
(2 times)
MAPK (2 times)
NB (2 times)
NF-kappaB (2 times)
1995 Gi2-mediated activation of the MAP kinase cascade.
15  Raf-MAPK/ERK kinase
(3 times)
Science
(1 time)
ERK (2 times)
ENaC (1 time)
GEFs (1 time)
2003 Apoptosis of granulosa cells: a review on the role of MAPK-signalling modules.
16  marker extraction kernel
(2 times)
Neoplasms
(1 time)
MU (1 time)
2000 Detection of fiducial gold markers for automatic on-line megavoltage position verification using a marker extraction kernel (MEK).
17  methyl ketone
(2 times)
Occupational Medicine
(1 time)
FTIR (1 time)
HRXRD (1 time)
MONS (1 time)
1981 [Retention of organic solvent vapors in plastic bags. Part 5. A basic study about correction methods of concentration of organic solvent vapors in plastic bags (author's transl)].
18  microtubule-associated protein kinase kinase
(2 times)
Biochemistry
(1 time)
AhR (1 time)
DA (1 time)
ERK (1 time)
2006 Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons.
19  mitogen/ERK kinase
(2 times)
Biochemistry
(1 time)
alpha1A-AR (1 time)
ERK (1 time)
LDLR (1 time)
1999 Induction of low density lipoprotein receptor (LDLR) transcription by oncostatin M is mediated by the extracellular signal-regulated kinase signaling pathway and the repeat 3 element of the LDLR promoter.
20  mouse epidermal keratinocytes
(2 times)
Molecular Biology
(1 time)
AA (1 time)
HEK (1 time)
PG (1 time)
1992 Tumour promoter-induced release and metabolism of arachidonic acid: Comparison between mouse and human epidermal cells.
21  II-mediated growth, cells were pretreated with the selective ERK kinase
(1 time)
Vascular Diseases
(1 time)
Ang II (1 time)
ERK (1 time)
1999 Angiotensin II stimulates DNA and protein synthesis in vascular smooth muscle cells from human arteries: role of extracellular signal-regulated kinases.
22  MAP kinase kinase of the ERK group
(1 time)
Biochemistry
(1 time)
AA (1 time)
ERK (1 time)
2000 Basal cPLA(2) phosphorylation is sufficient for Ca(2+)-induced full activation of cPLA(2) in A549 epithelial cells.
23  MAP kinase kinase, also called ERK kinase
(1 time)
Biochemistry
(1 time)
--- 1999 Nonspecific inhibition of myogenic tone by PD98059, a MEK1 inhibitor, in rat middle cerebral arteries.
24  MAP kinase pathway
(1 time)
Neurology
(1 time)
hnRNA (1 time)
LC (1 time)
NET (1 time)
2005 Differential effects of forskolin on tyrosine hydroxylase gene transcription in identified brainstem catecholaminergic neuronal subtypes in organotypic culture.
25  MAP kinase/Erk kinase kinase
(1 time)
Biochemistry
(1 time)
ID (1 time)
ZFDBD (1 time)
2005 Transcriptional activity of Sp1 is regulated by molecular interactions between the zinc finger DNA binding domain and the inhibitory domain with corepressors, and this interaction is modulated by MEK.
26  MAP-K/Erk
(1 time)
Biochemistry
(1 time)
IRS-1 (1 time)
MAPK (1 time)
PI3K (1 time)
1998 Insulin-stimulated cell growth in insulin receptor substrate-1-deficient ZR-75-1 cells is mediated by a phosphatidylinositol-3-kinase-independent pathway.
27  MAP-kinase activating kinase
(1 time)
Cell Biology
(1 time)
HSPs (1 time)
2000 Chaperones in cell cycle regulation and mitogenic signal transduction: a review.
28  MAP-kinase-kinase activity
(1 time)
Biochemistry
(1 time)
BSA (1 time)
DHT (1 time)
VSMC (1 time)
2009 Dihydrotestosterone and estradiol-17beta mutually neutralize their inhibitory effects on human vascular smooth muscle cell growth in vitro.
29  MAPK kinase inhibitor
(1 time)
Neoplasms
(1 time)
FN (1 time)
GBM (1 time)
MAPK (1 time)
2009 Rho/ROCK and MAPK signaling pathways are involved in glioblastoma cell migration and proliferation.
30  MAPK(Erk) kinase
(1 time)
Neoplasms
(1 time)
Erk (1 time)
NF-kappaB (1 time)
PI3K (1 time)
2004 Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine.
31  MAPkinase/ERK
(1 time)
Brain
(1 time)
CBF (1 time)
ERK (1 time)
IL (1 time)
2011 Blockade of the MEK/ERK pathway with a raf inhibitor prevents activation of pro-inflammatory mediators in cerebral arteries and reduction in cerebral blood flow after subarachnoid hemorrhage in a rat model.
32  MCP-1 expression was reversed by the MAPK
(1 time)
Kidney Diseases
(1 time)
hs-CRP (1 time)
MAPK (1 time)
MCP-1 (1 time)
2012 Plasma leptin concentrations are greater in type II diabetic patients and stimulate monocyte chemotactic peptide-1 synthesis via the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway.
33  meiosis-specific serine/threonine kinase
(1 time)
Cardiology
(1 time)
APN (1 time)
APN-KO (1 time)
CCL (1 time)
2013 Adiponectin protects against Toll-like receptor 4-mediated cardiac inflammation and injury.
34  MEK inhibitor
(1 time)
Neoplasms
(1 time)
BEV (1 time)
PDXs (1 time)
PTX (1 time)
2017 Combination of paclitaxel, bevacizumab and MEK162 in second line treatment in platinum-relapsing patient derived ovarian cancer xenografts.
35  MEK/ERK
(1 time)
Endocrinology
(1 time)
--- 2001 Discovery of a novel Raf kinase inhibitor.
36  methyl ethyl ketone-ethyl alcohol
(1 time)
Chemistry
(1 time)
--- 2005 Rheological behavior of organic suspensions of fluorapatite.
37  mice, as was activation of ERK kinase
(1 time)
Vascular Diseases
(1 time)
Ang (1 time)
ERK (1 time)
MKP (1 time)
2003 Angiotensin II-induced ventricular hypertrophy and extracellular signal-regulated kinase activation are suppressed in mice overexpressing brain natriuretic peptide in circulation.
38  microcyst-like epithelial keratopathy
(1 time)
Ophthalmology
(1 time)
--- 2018 Clinical and Histological Characterization of Toxic Keratopathy From Depatuxizumab Mafodotin (ABT-414), an Antibody-Drug Conjugate: [RETRACTED].
39  min with the ERK kinase
(1 time)
Chemistry
(1 time)
ERK (1 time)
MBP (1 time)
OLGs (1 time)
1997 Role of extracellular signal-regulated protein kinases 1 and 2 in oligodendroglial process extension.
40  mitogen and extracellularly-activated protein kinase kinase
(1 time)
Neoplasms
(1 time)
JNK (1 time)
MKP (1 time)
2003 Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer.
41  mitogen protein-activated kinase
(1 time)
Medicine
(1 time)
bFGF (1 time)
2008 Effect of exogenous bFGF on the proliferation of human adenoid cystic carcinoma ACC-2 cells.
42  mitogen signal-regulated kinase
(1 time)
Gastroenterology
(1 time)
HIF (1 time)
LCECs (1 time)
PCNA (1 time)
2010 ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice.
43  mitogen-activated ERK
(1 time)
Toxicology
(1 time)
BBB (1 time)
ERK (1 time)
MCEC (1 time)
2016 Roles of NMDARs in maintenance of the mouse cerebrovascular endothelial cell-constructed tight junction barrier.
44  mitogen-activated signal-regulated protein kinase
(1 time)
Neoplasms
(1 time)
ERK (1 time)
IKK (1 time)
NF-kappaB (1 time)
2005 Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway.
45  Mobile Exchange of Knowledge
(1 time)
EDIPS (1 time)
2014 Enhancing knowledge flow in a health care context: a mobile computing approach.
46  modified, equalized kidney
(1 time)
Medicine
(1 time)
PCR (1 time)
SHR (1 time)
2000 Cloning a novel metallophosphoesterase gene from a kidney cDNA library of hypertensive rat.
47  molecule MAPK kinase
(1 time)
Biotechnology
(1 time)
D-raf (1 time)
DER (1 time)
1994 Genetic and molecular analyses of mutations involved in Drosophila raf signal transduction.
48  monkey embryo kidney
(1 time)
Microbiology
(1 time)
CRFK (1 time)
FCV (1 time)
PV (1 time)
2003 The effect of bovine lactoferrin and lactoferricin B on the ability of feline calicivirus (a norovirus surrogate) and poliovirus to infect cell cultures.
49  monopolar electrocautery knife
(1 time)
FA (1 time)
2009 Destructive effect of monopolar electrocautery knife usage on femoral artery endothelium during spine surgery: experimental study.
50  morphine equivalents per kilogram
(1 time)
Cardiology
(1 time)
PICU (1 time)
2013 Opioid withdrawal signs and symptoms in children: frequency and determinants.
51  phospho-MAPK kinase
(1 time)
Neoplasms
(1 time)
ERK (1 time)
MAPK (1 time)
TGF-beta (1 time)
2010 The TGF-beta co-receptor endoglin modulates the expression and transforming potential of H-Ras.
52  Raf-MAPK/ERK
(1 time)
HGF (1 time)
IL (1 time)
PDGFR (1 time)
2014 Overview of fundamental study of pazopanib in cancer.
53  RAS-RAF-MAP/ERK kinase
(1 time)
Neoplasms
(1 time)
PI3K (1 time)
RPPA (1 time)
2010 Basal and treatment-induced activation of AKT mediates resistance to cell death by AZD6244 (ARRY-142886) in Braf-mutant human cutaneous melanoma cells.
54  Ras-Raf-MAPkinase/Erk-kinase
(1 time)
Cell Biology
(1 time)
PDGF (1 time)
PI3K (1 time)
2004 Dephosphorylation of cofilin is regulated through Ras and requires the combined activities of the Ras-effectors MEK and PI3K.
55  Sur8-mediated regulations of differentiation, as the treatment of ERK kinase
(1 time)
Cell Biology
(1 time)
bFGF (1 time)
ERK (1 time)
NPC (1 time)
2011 Sur8/Shoc2 involves both inhibition of differentiation and maintenance of self-renewal of neural progenitor cells via modulation of extracellular signal-regulated kinase signaling.