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Abbreviation: MTX
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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
methotrexate
(8454 times)
Rheumatology
(1834 times)
RA (1927 times)
DHFR (370 times)
ALL (332 times)
0 [15 years experience with biological therapy of inflammatory rheumatic diseases in Czech national register ATTRA].
mitoxantrone
(113 times)
Pharmacology
(17 times)
MS (13 times)
DOX (9 times)
AML (5 times)
1984 Comparative microscopic study of cardiotoxicity and skin toxicity of anthracycline analogs.
maitotoxin
(104 times)
Pharmacology
(22 times)
CTX (3 times)
L-VDCC (3 times)
NSCC (3 times)
1983 Contractile response of the rabbit aorta to maitotoxin, the most potent marine toxin.
methoxamine
(27 times)
Cardiology
(9 times)
eNOS (4 times)
NO (4 times)
PVL (4 times)
1985 Contribution of extracellular and intracellular calcium to the enhanced effect of an alpha-adrenergic agonist on amylase release from dispersed rat parotid cells.
Maurotoxin
(22 times)
Biochemistry
(15 times)
CTX (2 times)
Abu (1 time)
AgTx2 (1 time)
1997 Maurotoxin, a four disulfide bridge toxin from Scorpio maurus venom: purification, structure and action on potassium channels.
mosquitocidal toxin
(12 times)
Microbiology
(5 times)
ADPRTs (1 time)
btx (1 time)
EF-Tu (1 time)
1993 Cytotoxicity and ADP-ribosylating activity of the mosquitocidal toxin from Bacillus sphaericus SSII-1: possible roles of the 27- and 70-kilodalton peptides.
medical treatment with methotrexate
(9 times)
Gynecology
(3 times)
EP (4 times)
beta-hCG (1 time)
CL (1 time)
1999 Electrical stimulation prolongs the survival days of leukemic mice treated with methotrexate.
MTX group
(7 times)
Rheumatology
(6 times)
RA (5 times)
CrI (3 times)
RCTs (3 times)
2005 Modification of pro- and antiinflammatory cytokines and vascular-related molecules by tumor necrosis factor-a blockade in patients with rheumatoid arthritis.
maintenance therapy with methotrexate
(6 times)
Neoplasms
(4 times)
ALL (4 times)
6-MP (2 times)
BFM (1 time)
1976 [Pulmonary disease during mtx therapy in a.l.l. (author's transl)].
10  marine toxin maitotoxin
(6 times)
Drug Therapy
(2 times)
CBF (1 time)
fMLP (1 time)
ROCC (1 time)
1983 Excitatory effect of the most potent marine toxin, maitotoxin, on the guinea-pig vas deferens.
11  methotrexate sodium
(5 times)
Dermatology
(1 time)
HTCC (1 time)
MTX-SCPP-PS (1 time)
NASH (1 time)
1978 Methotrexate-induced renal failure and ineffectiveness of peritoneal dialysis.
12  methoxychlor
(4 times)
Biochemistry
(1 time)
DA (2 times)
ME (2 times)
5-HIAA (1 time)
2000 Possible estrogenic and/or antiandrogenic effects of methoxychlor on prolactin release in male rats.
13  methylxanthines
(4 times)
Biochemistry
(2 times)
CAF (2 times)
PTX (2 times)
TH (2 times)
1986 Methylxanthine, alcohol-free diet and fibrocystic breast disease: a factorial clinical trial.
14  high-dose-methotrexate
(3 times)
Radiology
(1 time)
CRT (1 time)
GC-MS (1 time)
MTXCL (1 time)
2001 Favorable outcome for children and adolescents with T-cell lymphoblastic lymphoma with an intensive ALL-type therapy without local radiotherapy.
15  metaxin gene
(3 times)
Genetics
(1 time)
psGBA (1 time)
psMTX (1 time)
THBS3 (1 time)
1996 Structure and organization of the human metaxin gene (MTX) and pseudogene.
16  methohexital
(3 times)
Pharmacology
(1 time)
ED (1 time)
GABAAR (1 time)
GCS (1 time)
1986 Barbiturates block divalent cation action potentials in leech nociceptive cells.
17  methotrexate alone
(3 times)
Rheumatology
(3 times)
ACR Pedi 75 (1 time)
COMBO (1 time)
DMARD (1 time)
2003 Elucidation of the relationship between synovitis and bone damage: a randomized magnetic resonance imaging study of individual joints in patients with early rheumatoid arthritis.
18  methotrexate-treated
(3 times)
Sexually Transmitted Diseases
(1 time)
FUdR (1 time)
PCNSL (1 time)
WBRT (1 time)
1988 Natural and Chang liver cell cytotoxic studies of methotrexate-treated psoriatic patients with liver cirrhosis.
19  polymer-methotrexate
(3 times)
Biocompatible Materials
(1 time)
3,4-DHBA (1 time)
FUdR (1 time)
HaCaT (1 time)
1987 Comparison of the inhibitory effects of hydroxyurea, 5-fluorodeoxyuridine, 3,4-dihydroxybenzylamine, and methotrexate on human squamous cell carcinoma.
20  anti-methotrexate
(2 times)
Allergy and Immunology
(1 time)
AMF (1 time)
AMI (1 time)
i.p (1 time)
1982 Lysis of hapten-labeled cells by anti-hapten IgG and complement: effect of cell surface hapten density.
21  cytostatics--methotrexate
(2 times)
Medicine
(2 times)
DXR (2 times)
1998 Central action of some cytostatics--methotrexate (MTX) and doxorubicin (DXR). I. Long-term influence on the pain sensitivity and activity of brain dopaminergic system in mice.
22  drug-methotrexate
(2 times)
Neoplasms
(1 time)
CV (1 time)
HA (1 time)
LRET (1 time)
1985 [Radioimmunoassay of the antitumor drug--methotrexate (MTX)].
23  margatoxin
(2 times)
Reproductive Medicine
(1 time)
CC (1 time)
CTX (1 time)
EC (1 time)
2002 Potassium channel antagonists influence porcine granulosa cell proliferation, differentiation, and apoptosis.
24  matrix size
(2 times)
Radiology
(2 times)
MR (2 times)
CNR (1 time)
COC (1 time)
2002 Technical parameters affecting image characteristics in in vivo MR microscopy of the mouse.
25  maximal tolerated dose of methotrexate
(2 times)
Rheumatology
(2 times)
RA (2 times)
HAQ (1 time)
HAQ-DI (1 time)
2000 Divergent effect of cyclosporine on Th1/Th2 type cytokines in patients with severe, refractory rheumatoid arthritis.
26  mediating transfer of methotrexate
(2 times)
Biochemistry
(1 time)
PGE2 (1 time)
TCA (1 time)
1991 Evidence for the facilitated transport of methotrexate polyglutamates into lysosomes derived from S180 cells. Basic properties and specificity for polyglutamate chain length.
27  metaxin
(2 times)
Genetics
(1 time)
GBA (2 times)
SCAMP37 (1 time)
THBS3 (1 time)
1997 Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease.
28  methoxetrate
(2 times)
Rheumatology
(2 times)
FACS (1 time)
IL (1 time)
JCA (1 time)
2002 Folinic acid antagonizes methotrexate-induced differentiation of monocyte progenitors.
29  modify toxicity of methotrexate
(2 times)
Rheumatic Diseases
(1 time)
MTHFR (2 times)
ATIC (1 time)
FPGS (1 time)
2006 Methylenetetrahydrofolate reductase and thymidylate synthase genotypes and risk of acute graft-versus-host disease following hematopoietic cell transplantation for chronic myelogenous leukemia.
30  modulate the cytotoxicity of methotrexate
(2 times)
Neoplasms
(2 times)
DP (1 time)
HX (1 time)
1987 Phase II trial of oral methotrexate and dipyridamole in colorectal carcinoma.
31  MTX and calcium folinate (leucovorin) rescue therapy
(2 times)
Pharmacology
(1 time)
CL (1 time)
1999 Electrical stimulation prolongs the survival days of leukemic mice treated with methotrexate.
32  post-methotrexate
(2 times)
Dermatology
(1 time)
MRI (1 time)
1976 The relation of HL-A antigens to liver histology in methotrexate-treated psoriatics.
33  5-deoxy-5-methylthio-xylofuranose
(1 time)
Chemistry
(1 time)
LAM (1 time)
MSX (1 time)
2006 The 5-deoxy-5-methylthio-xylofuranose residue in mycobacterial lipoarabinomannan. absolute stereochemistry, linkage position, conformation, and immunomodulatory activity.
34  5-methylthio-d-xylofuranose
(1 time)
Microbiology
(1 time)
CI (1 time)
LAM (1 time)
TB (1 time)
2018 A Novel Sensitive Immunoassay Targeting the 5-Methylthio-d-Xylofuranose-Lipoarabinomannan Epitope Meets the WHO's Performance Target for Tuberculosis Diagnosis.
35  ABCG2-mediated transport of methotrexate
(1 time)
Biochemistry
(1 time)
ABC (1 time)
MDR (1 time)
TKI (1 time)
2009 Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters.
36  dendrimer-methotrexate
(1 time)
Biochemistry
(1 time)
CHO (1 time)
DCC (1 time)
DHFR (1 time)
2006 Activity of dendrimer-methotrexate conjugates on methotrexate-sensitive and -resistant cell lines.
37  dsDNA-methotrexate
(1 time)
Biophysics
(1 time)
AFM (1 time)
HOPG (1 time)
2011 In situ evaluation of anticancer drug methotrexate-DNA interaction using a DNA-electrochemical biosensor and AFM characterization.
38  etanercept-methotrexate
(1 time)
Rheumatology
(1 time)
DAS28 (1 time)
NRI (1 time)
2010 Two-year clinical and radiographic results with combination etanercept-methotrexate therapy versus monotherapy in early rheumatoid arthritis: a two-year, double-blind, randomized study.
39  glycan-methotrexate
(1 time)
Biochemistry
(1 time)
DHFR (1 time)
2006 High-mannose-type glycan modifications of dihydrofolate reductase using glycan-methotrexate conjugates.
40  insulin-methotrexate
(1 time)
Gastroenterology
(1 time)
--- 2004 Receptor binding characteristics and cytotoxicity of insulin-methotrexate.
41  lipid-PEG-methotrexate
(1 time)
Biomedical Engineering
(1 time)
CPT (1 time)
NRs (1 time)
NSs (1 time)
2015 Self-Targeted, Shape-Assisted, and Controlled-Release Self-Delivery Nanodrug for Synergistic Targeting/Anticancer Effect of Cytoplasm and Nucleus of Cancer Cells.
42  macrophages treated with methotrexate
(1 time)
Complementary Therapies
(1 time)
IL (1 time)
RANTES (1 time)
WPG (1 time)
2010 Wild Panax ginseng (Panax ginseng C.A. Meyer) protects against methotrexate-induced cell regression by enhancing the immune response in RAW 264.7 macrophages.
43  magnitude than methotrexate
(1 time)
Chemistry
(1 time)
--- 1991 Novel pyrrolo[2,3-d]pyrimidine antifolates: synthesis and antitumor activities.
44  major target of methotrexate
(1 time)
Hematology
(1 time)
ALL (1 time)
CCND1 (1 time)
DHFR (1 time)
2008 DNA variants in the dihydrofolate reductase gene and outcome in childhood ALL.
45  major toxic effects of methotrexate
(1 time)
Pediatrics
(1 time)
--- 1999 The extended oligoarticular subtype is the best predictor of methotrexate efficacy in juvenile idiopathic arthritis.
46  marrow to specific methotrexate
(1 time)
Neoplasms
(1 time)
--- 1977 The relative contribution of drug concentration and duration of exposure to mouse bone marrow toxicity during continuous methotrexate infusion.
47  MBD therapy with methotrexate
(1 time)
Urology
(1 time)
PEP (1 time)
1992 [Repair of skin defect after extensive resection for penile cancer: report of two cases, and clinical observation of patients with penile cancer at Mie University hospital].
48  measure the effect of methotrexate
(1 time)
Rheumatology
(1 time)
IL-1 beta (1 time)
mRNA (1 time)
RA (1 time)
1994 Mechanisms of methotrexate action in rheumatoid arthritis. Selective decrease in synovial collagenase gene expression.
49  mechanisms that underlie the methotrexate
(1 time)
Antineoplastic Agents
(1 time)
TJ (1 time)
ZO-1 (1 time)
2010 Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats.
50  mediating the majority of methotrexate
(1 time)
Biochemistry
(1 time)
--- 1995 Structural preferences among folate compounds and their analogues for ATPase-mediated efflux by inside-out plasma membrane vesicles derived from L1210 cells.
51  medical therapy combining multidose methotrexate
(1 time)
Medicine
(1 time)
CSP (1 time)
2015 Novel Medical Therapy of Cesarean Scar Pregnancy With a Viable Embryo Combining Multidose Methotrexate and Mifepristone: A Case Report.
52  medical treatment with intramuscular methotrexate
(1 time)
Medicine
(1 time)
EGFR (1 time)
hCG (1 time)
tEP (1 time)
2013 Phase II single arm open label multicentre clinical trial to evaluate the efficacy and side effects of a combination of gefitinib and methotrexate to treat tubal ectopic pregnancies (GEM II): study protocol.
53  medical treatment with systemic methotrexate
(1 time)
Gynecology
(1 time)
ECA (1 time)
2015 The efficacy of the systemic methotrexate treatment in caesarean scar ectopic pregnancy: A quantitative review of English literature.
54  medium-term effects of methotrexate
(1 time)
Pharmacology
(1 time)
--- 1999 Additive effect of indomethacin and methotrexate on suppression of growth in rats.
55  metabolic turnover of methotrexate
(1 time)
Biochemistry
(1 time)
--- 1992 Metabolic turnover of methotrexate polyglutamates in lysosomes derived from S180 cells. Definition of a two-step process limited by mediated lysosomal permeation of polyglutamates and activating reduced sulfhydryl compounds.
56  metaphylaxis
(1 time)
Therapeutics
(1 time)
BRD (1 time)
2008 Evaluation of on-arrival versus prompted metaphylaxis regimes using ceftiofur crystalline free acid for feedlot heifers at risk of developing bovine respiratory disease.
57  method to facilitate methotrexate
(1 time)
Pharmacology
(1 time)
--- 1988 Effects of combination of vasodilator drugs and hypertonic solutions on methotrexate distribution into the rat brain.
58  method to monitor methotrexate
(1 time)
Chemistry Techniques, Analytical
(1 time)
CE (1 time)
CSF (1 time)
DAMPA (1 time)
2010 Analysis of methotrexate and its eight metabolites in cerebrospinal fluid by solid-phase extraction and triple-stacking capillary electrophoresis.
59  methodology to calculate methotrexate
(1 time)
Drug Therapy
(1 time)
--- 1996 A limited sampling method to estimate methotrexate pharmacokinetics in patients with rheumatoid arthritis using a Bayesian approach and the population data modeling program P-PHARM.
60  methohexital sodium
(1 time)
Emergency Medicine
(1 time)
--- 1991 The efficacy and safety of methohexital in the emergency department.
61  Methortrexatum
(1 time)
Dentistry
(1 time)
5-FU (1 time)
E-ADM (1 time)
PYM (1 time)
2002 [Chemosensitivity testing of oral and maxillofacial cancer with biopsy specimens].
62  methotrexate formulations
(1 time)
Nanotechnology
(1 time)
AIA (1 time)
LDE (1 time)
2013 Intra-articular methotrexate associated to lipid nanoemulsions: anti-inflammatory effect upon antigen-induced arthritis.
63  methotrexate is correlated with the Ki
(1 time)
Biochemistry
(1 time)
--- 1990 Transfection of DHFR- and DHFR+ mammalian cells using methotrexate-resistant mutants of mouse dihydrofolate reductase.
64  methotrexate tablets
(1 time)
Complementary Therapies
(1 time)
DD (1 time)
ESR (1 time)
Fbg (1 time)
2018 [Acupuncture combined with western medicine on rheumatoid arthritis and effects on blood stasis].
65  methotrexate/week
(1 time)
Rheumatology
(1 time)
--- 1988 Severe reversible interstitial pneumonitis induced by low dose methotrexate: report of a case and review of the literature.
66  Methoxamine hydrochloride
(1 time)
Biomedical Engineering
(1 time)
ASC (1 time)
HPLC (1 time)
LLOQ (1 time)
2007 Pharmacokinetic study of three cardiovascular drugs by high-performance liquid chromatography using pre-column derivatization with 9,10-anthraquinone-2-sulfonyl chloride.
67  methoxsalen
(1 time)
Physiology
(1 time)
Ca (1 time)
CFTR (1 time)
2002 Methoxsalen stimulates electrogenic Cl- secretion in the mouse jejunum.
68  Methoxyflurane
(1 time)
Emergency Medicine
(1 time)
INF (1 time)
2011 Inhaled methoxyflurane and intranasal fentanyl for prehospital management of visceral pain in an Australian ambulance service.
69  methylthio-d-xylose
(1 time)
Biochemistry
(1 time)
DP-MTX (1 time)
LAM (1 time)
2017 Biosynthesis of the Methylthioxylose Capping Motif of Lipoarabinomannan in Mycobacterium tuberculosis.
70  mg/kg. concentration-time profiles of methotrexate
(1 time)
Pharmacology
(1 time)
--- 1995 The use of intracerebral microdialysis for the determination of pharmacokinetic profiles of anticancer drugs in tumor-bearing rat brain.
71  microencapsulation, the composite methotrexate
(1 time)
Nanotechnology
(1 time)
--- 2012 Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO2.
72  mini-methorexate
(1 time)
Hematology
(1 time)
allo-SCT (1 time)
AML/MDS (1 time)
AUC (1 time)
2011 Clofarabine fludarabine with once daily i.v. busulfan as pretransplant conditioning therapy for advanced myeloid leukemia and MDS.
73  minimize toxicity of high-dose methotrexate
(1 time)
Biochemistry
(1 time)
--- 2013 Discordance between urine pH measured by dipstick and pH meter: implications for methotrexate administration protocols.
74  mitoxantrone dihydrochloride
(1 time)
Biomedical Engineering
(1 time)
PSi (1 time)
2013 Engineering porous silicon nanostructures as tunable carriers for mitoxantrone dihydrochloride.
75  Mitoxantrone HCl
(1 time)
Biology
(1 time)
FA (1 time)
2015 Folic acid-conjugated TiO2-doped mesoporous carbonaceous nanocomposites loaded with Mitoxantrone HCl for chemo-photodynamic therapy.
76  Mixture 2-treated group, methotrexate
(1 time)
Complementary Therapies
(1 time)
CIA (1 time)
RA (1 time)
TNF-alpha (1 time)
2008 [Effects of Tongbi Mixture 2 on expressions of CD28 and CD152 and content of tumor necrosis factor-alpha in peripheral blood in rats with collagen-induced arthritis].
77  molecular target of methotrexate
(1 time)
Allergy and Immunology
(1 time)
--- 2005 Modulation of orphan nuclear receptor NURR1 expression by methotrexate in human inflammatory joint disease involves adenosine A2A receptor-mediated responses.
78  monocytostatic treatment trial with Methotrexat
(1 time)
Neoplasms
(1 time)
BLM (1 time)
1979 Combined regional chemotherapy and radiation therapy in the treatment of epidermoid carcinoma in the oro-facial region.
79  monotherapy, ETN+methotrexate
(1 time)
Rheumatology
(1 time)
CDAI (1 time)
DMARD (1 time)
ETN (1 time)
2015 Discontinuation of disease-modifying anti-rheumatic drugs and clinical outcomes in the Rheumatoid Arthritis DMARD Intervention and Utilisation Study 2 (RADIUS 2).
80  more than a decade, methotrexate
(1 time)
Rheumatology
(1 time)
DM (1 time)
2005 The effectiveness of treating juvenile dermatomyositis with methotrexate and aggressively tapered corticosteroids.
81  MTX (n = 129) or IV golimumab 2-4 mg/kg
(1 time)
Rheumatology
(1 time)
LTE (1 time)
RA (1 time)
s.c (1 time)
2011 Maintenance of efficacy and safety with subcutaneous golimumab among patients with active rheumatoid arthritis who previously received intravenous golimumab.
82  MTX after high-dose methotrexate
(1 time)
Antineoplastic Agents
(1 time)
CAVH (1 time)
CF (1 time)
CH (1 time)
1995 [Delayed clearance of methotrexate in a patient with malignant lymphoma who developed renal failure].
83  MTX and medium
(1 time)
Biochemistry
(1 time)
--- 1992 Methotrexate transport in the human intestine. Evidence for heterogeneity.
84  MTX arm
(1 time)
Rheumatology
(1 time)
PMR (1 time)
1996 Methotrexate in polymyalgia rheumatica: preliminary results of an open, randomized study.
85  MTX disposition, emphasizing the need to monitor
(1 time)
Neoplasms
(1 time)
--- 1989 Variability in the disposition of intraventricular methotrexate: a proposal for rational dosing.
86  MTX dose, patient age
(1 time)
Neoplasms
(1 time)
--- 1989 Variability in the disposition of intraventricular methotrexate: a proposal for rational dosing.
87  MTX from suspensions of methotrexate
(1 time)
Gynecology
(1 time)
EP (1 time)
LPD (1 time)
MTX-LPD (1 time)
1995 A new approach to methotrexate and lipiodol suspensions for ectopic pregnancy: preliminary in vitro and animal experiments.
88  MTX plasma concentrations
(1 time)
Antineoplastic Agents
(1 time)
HD-MTX (1 time)
2015 Delayed methotrexate excretion in infants and young children with primary central nervous system tumors and postoperative fluid collections.
89  MTX plasma concentrations to target the prespecified AUC
(1 time)
Pharmacology
(1 time)
HD-MTX (1 time)
PCNSL (1 time)
2012 Dosing algorithm to target a predefined AUC in patients with primary central nervous system lymphoma receiving high dose methotrexate.
90  MTX rats
(1 time)
Gastroenterology
(1 time)
--- 2009 Effect of oral glutamine on enterocyte turnover during methotrexate-induced mucositis in rats.
91  MTX use
(1 time)
Rheumatology
(1 time)
RA (1 time)
TKA (1 time)
TNF (1 time)
2015 Concomitant Methotrexate Protects Against Total Knee Arthroplasty in Patients with Rheumatoid Arthritis Treated with Tumor Necrosis Factor Inhibitors.
92  MTX versus active comparator
(1 time)
Health Services Research
(1 time)
CI (1 time)
CrI (1 time)
HAQ (1 time)
2017 Biologics or tofacitinib for people with rheumatoid arthritis unsuccessfully treated with biologics: a systematic review and network meta-analysis.
93  MTX without TNF blockers
(1 time)
Rheumatology
(1 time)
DMARDs (1 time)
GMT (1 time)
HI (1 time)
2007 Influenza vaccination as model for testing immune modulation induced by anti-TNF and methotrexate therapy in rheumatoid arthritis patients.
94  MTX, Cnoga Medical Ltd
(1 time)
--- 2018 Post marketing study of hemodynamic and hematological noninvasive readings in a blood bank.
95  MTX-glutamine rats
(1 time)
Gastroenterology
(1 time)
--- 2009 Effect of oral glutamine on enterocyte turnover during methotrexate-induced mucositis in rats.
96  MTX-IRs
(1 time)
Arthritis
(1 time)
MBDA (1 time)
RA (1 time)
2017 A Multi-Biomarker Disease Activity Score and the Choice of Second-Line Therapy in Early Rheumatoid Arthritis After Methotrexate Failure.
97  MTX-only
(1 time)
Rheumatology
(1 time)
ATTRACT (1 time)
RA (1 time)
2004 Infliximab in active early rheumatoid arthritis.
98  MTX-treated group
(1 time)
Cell Biology
(1 time)
EBV (1 time)
LPD (1 time)
RA (1 time)
2013 Mature T/NK-cell lymphoproliferative disease and Epstein-Barr virus infection are more frequent in patients with rheumatoid arthritis treated with methotrexate.
99  much larger change in influx at low
(1 time)
Biochemistry
(1 time)
--- 1997 Impact of overexpression of the reduced folate carrier (RFC1), an anion exchanger, on concentrative transport in murine L1210 leukemia cells.
100  multimodality therapy, and methotrexate
(1 time)
Emergency Medicine
(1 time)
ALL (1 time)
2017 A Stroke Mimic: Methotrexate-induced Neurotoxicity in the Emergency Department.