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Abbreviation: MeIQx
Appearance Frequency: 99 time(s)
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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
mutagens 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(47 times)
Neoplasms
(20 times)
PhIP (12 times)
4NQO (2 times)
5-HO-MeIQx (2 times)
1987 Formation of mutagens, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (4,8-DiMeIQx), in heated fish meats.
mutagenic component has been identified as 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(3 times)
Genetics
(2 times)
--- 1984 Formation of 2-amino-3,7,8-trimethylimidazo [4,5-f]quinoxaline, a new mutagen, by heating a mixture of creatinine, glucose and glycine.
mutagenic heterocyclic amines 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(3 times)
Nutritional Sciences
(2 times)
PhIP (3 times)
BOP (1 time)
HCAs (1 time)
1994 Effect of cooking time and temperature on the heterocyclic amine content of fried beef patties.
Male F344 rats were administered 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(2 times)
Neoplasms
(2 times)
GST-P (2 times)
1996 Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, at low dose levels.
medium-term liver bioassay, combined treatment with 0.03% 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(2 times)
Neoplasms
(1 time)
DMH (2 times)
GST-P (2 times)
HCA (2 times)
1999 Chemoprevention of heterocyclic amine-induced carcinogenesis by phenolic compounds in rats.
metabolism and disposition of the food-borne carcinogen 2-amino-3,8-dimethylimidazo(4,5-f) quinoxaline
(2 times)
Neoplasms
(1 time)
HNOH-MeIQx (1 time)
PCB (1 time)
1991 The effect of dose and cytochrome P450 induction on the metabolism and disposition of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx) in the rat.
more effectively than 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(2 times)
Environmental Health
(1 time)
MeIQ (1 time)
PhIP (1 time)
1988 A model system for studying covalent binding of food carcinogens MeIQx, MeIQ and IQ to DNA and protein.
most relevant heterocyclic aromatic amines in food: 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(2 times)
Nutritional Sciences
(2 times)
PhIP (1 time)
SCE (1 time)
1996 Cytogenetic results from a chronic feeding study of MeIQx in mice.
mutagenesis in hepatocarcinogenesis induced by 2-amino-3,8-dimethylimidazo(4,5-f)-quinoxaline
(2 times)
Neoplasms
(1 time)
--- 1999 Carcinogenicity and mutagenicity of heterocyclic amines in transgenic mouse models.
10  2-amino-3-methylimidazo(4,5-f)quinoline and 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Neoplasms
(1 time)
LCEC (1 time)
1985 Quantification of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in beef extracts by liquid chromatography with electrochemical detection (LCEC).
11  major HAs were found: 2-amino-3,8-dimethyl-imidazo(4,5-F)Quinoxaline
(1 time)
Nutritional Sciences
(1 time)
HAs (1 time)
PhIP (1 time)
TriMeIQx (1 time)
2013 Dietary vitamin E effects on the formation of heterocyclic amines in grilled lean beef.
12  male F344/DuCrj rats were fed 200 ppm 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Pathology
(1 time)
ACF (1 time)
2009 Ethanol Does Not Promote MeIQx-initiated Rat Colon Carcinogenesis Based on Evidence from Analysis of a Colon Cancer Surrogate Marker.
13  male rats were administered 14C-labeled 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Neoplasms
(1 time)
--- 1992 Tissue distribution of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in two strains of male rats.
14  mammary carcinogenesis in female rats and on 2-amino-3, 8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Neoplasms
(1 time)
DEN (1 time)
GST-P (1 time)
PhIP (1 time)
2000 Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague-Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats.
15  material is identified as 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Neoplasms
(1 time)
--- 1984 Isolation and characterization of new mutagens from fried ground beef.
16  material present in cooked beef is accounted for by 2-Amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Toxicology
(1 time)
PhIP (1 time)
1996 Chemical methods for assessing systemic exposure to dietary heterocyclic amines in man.
17  MCF-7, we investigated 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Toxicology
(1 time)
HA (1 time)
2004 Modulation of cytochrome P450 1A1 by food-derived heterocyclic aromatic amines.
18  meal and urinary excretion of the HA 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Neoplasms
(1 time)
HA (1 time)
PhIP (1 time)
2001 Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man.
19  means to separate 2-amino-3,8-dimethylimidazo-(4,5-f)quinoxaline
(1 time)
Medical Oncology
(1 time)
blue-cotton (1 time)
1983 Characterization of mutagenic fractions in beef extract and in cooked ground beef. Use of blue-cotton for efficient extraction.
20  measure DNA adducts of the carcinogen 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Toxicology
(1 time)
CT-DNA (1 time)
SRM (1 time)
2002 Analysis and quantification of DNA adducts of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in liver of rats by liquid chromatography/electrospray tandem mass spectrometry.
21  meat products, include 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Nutritional Sciences
(1 time)
AOB (1 time)
HAAs (1 time)
2013 Formation and mitigation of heterocyclic aromatic amines in fried pork.
22  MeIgQx is an isomer of 2-amino-3,8-dimethylmidazo(4,5-f)quinoxaline
(1 time)
Toxicology
(1 time)
HAA (1 time)
2011 Cytochrome P450-mediated metabolism and DNA binding of 2-amino-1,7-dimethylimidazo[4,5-g]quinoxaline and its carcinogenic isomer 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in mice.
23  men and 65,875 women, intake of the HCAs 2-amino-3,8-dimethylimidazo(4,5-j)quinoxaline
(1 time)
Environmental Health
(1 time)
CIs (1 time)
CRC (1 time)
HCAs (1 time)
2016 A Prospective Analysis of Meat Mutagens and Colorectal Cancer in the Nurses' Health Study and Health Professionals Follow-up Study.
24  metabolic activation of 14C-labelled food carcinogens 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Pharmacology
(1 time)
--- 1992 Covalent binding of food carcinogens MeIQx, MeIQ and IQ to DNA and protein in microsomal incubations and isolated rat hepatocytes.
25  Metabolism of the food-derived carcinogen 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Neoplasms
(1 time)
NHOH-MeIQx (1 time)
1995 Metabolism of the food-derived carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in nonhuman primates.
26  metabolizing enzymes on DNA adduct formation by 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Neoplasms
(1 time)
AIA (1 time)
BNF (1 time)
PB (1 time)
1990 Role of metabolism on the DNA binding of MeIQx in mice and bacteria.
27  mice are not susceptible to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Neoplasms
(1 time)
HCAs (1 time)
1999 Heterozygous p53-deficient mice are not susceptible to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) carcinogenicity.
28  mice given a carcinogenic heterocyclic amine, 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Genetics
(1 time)
PhIP (1 time)
2011 Anti-genotoxic activity of Vitis coignetiae Pulliat towards heterocyclic amines and isolation and identification of caftaric acid as an antimutagenic component from the juice.
29  mice were fed a diet supplemented with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Molecular Biology
(1 time)
--- 2009 Enhancing effects of a high fat diet on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced lung tumorigenesis in female A/J mice.
30  mice were given a diet containing 300 ppm of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Toxicology
(1 time)
--- 2010 Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
31  micronucleated erythrocytes by 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Genetics
(1 time)
PhIP (1 time)
SCEs (1 time)
1989 In vivo cytogenetic effects of cooked food mutagens.
32  modes, was established to profile 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Toxicology
(1 time)
4'-HO-PhIP (1 time)
HONH-PhIP (1 time)
IQx-8-COOH (1 time)
2010 A comprehensive approach to the profiling of the cooked meat carcinogens 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, and their metabolites in human urine.
33  monoclonal antibodies to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Environmental Health
(1 time)
PhIP (1 time)
1993 Immunoaffinity purification of dietary heterocyclic amine carcinogens.
34  Monoclonal antibodies, previously selected to bind either 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Neoplasms
(1 time)
PhIP (1 time)
1991 Immunochemical detection of rodent hepatic and urinary metabolites of cooking-induced food mutagens.
35  most abundant HCA, followed by 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Nutritional Sciences
(1 time)
HCA (1 time)
PhIP (1 time)
1995 Airborne mutagens produced by frying beef, pork and a soy-based food.
36  most Japanese people, was found to contain 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Neoplasms
(1 time)
--- 1986 The presence of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in smoked dry bonito (katsuobushi).
37  muscle, being 4.2 and 5.3 ng/g, followed by 2-amino-3,4-dimethylimidazo(4,5-f) quinoxaline
(1 time)
Genetics
(1 time)
HCAs (1 time)
PhIP (1 time)
2002 Mutagenic and carcinogenic heterocyclic amines as affected by muscle types/skin and cooking in pan-roasted mackerel.
38  mutagen 2-nitro derivative of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Neoplasms
(1 time)
AF-2 (1 time)
HTHQ (1 time)
MNNG (1 time)
1995 Strong anti-mutagenic activity of the novel lipophilic antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone against heterocyclic amine-induced mutagenesis in the Ames assay and its effect on metabolic activation of 2-amino-6-methyldipyrido[1,2-a:3',2'-d] imidazole (Glu-p-1).
39  mutagen 3,8-dimethyl-3H-imidazo(4,5-f)quinoxaline-2-amine
(1 time)
Nutritional Sciences
(1 time)
--- 1992 Reversible binding of the cooked food mutagen MeIQx to lignin-enriched preparations from wheat bran.
40  mutagenicity and hepatocarcinogenicity of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Neoplasms
(1 time)
--- 1999 In vivo mutagenicity and hepatocarcinogenicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in bitransgenic c-myc/lambda lacZ mice.
41  mutagens formed, but did affect the yield of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Neoplasms
(1 time)
--- 1993 Effects of edible oils and fatty acids on the formation of mutagenic heterocyclic amines in a model system.
42  mutagens/carcinogens and all but one contained 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Genetics
(1 time)
PhIP (1 time)
2003 Mutagenic activity and heterocyclic amine carcinogens in commercial pet foods.
43  mutants exposed to colon carcinogen, 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
(1 time)
Environmental Health
(1 time)
AFB1 (1 time)
2017 An in vitro system for measuring genotoxicity mediated by human CYP3A4 in Saccharomyces cerevisiae.