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Abbreviation: OAT
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Long forms: 144

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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
organic anion transporter
(244 times)
Pharmacology
(113 times)
OATP (63 times)
OCT (53 times)
MRP (42 times)
1999 Inhibition of initial transport rate of basolateral organic anion carrier in renal PT by BK and phenylephrine.
ornithine aminotransferase
(233 times)
Biochemistry
(40 times)
GA (27 times)
ODC (24 times)
P5CS (15 times)
1981 Effects of arginine-free meals on ureagenesis in cats.
oligoasthenoteratozoospermia
(207 times)
Reproductive Medicine
(107 times)
ICSI (30 times)
FISH (15 times)
MDA (10 times)
1992 Relationship between sperm quality and chromatin condensation measured by sperm DNA fluorescence using flow cytometry.
opioid agonist therapy
(185 times)
Substance-Related Disorders
(84 times)
PWID (46 times)
HCV (40 times)
OUD (40 times)
2004 Variations in evidence-based clinical practices in nine United States Veterans Administration opioid agonist therapy clinics.
oral anticoagulant therapy
(176 times)
Vascular Diseases
(50 times)
INR (33 times)
AF (27 times)
VTE (15 times)
1981 Oral anticoagulation in the secondary prevention of myocardial infarction.
opioid agonist treatment
(174 times)
Substance-Related Disorders
(103 times)
OUD (24 times)
CI (21 times)
PWID (21 times)
2009 Dissolution of a harm reduction track for opiate agonist treatment: longitudinal impact on treatment retention, substance use and service utilization.
oxygen atom transfer
(110 times)
Chemistry
(98 times)
HAT (22 times)
DFT (13 times)
ET (10 times)
2002 Kinetics and mechanism of rhenium-catalyzed oxygen atom transfer from pyridine N-oxides to phosphines.
osteochondral autograft transplantation
(109 times)
Orthopedics
(48 times)
OCD (19 times)
ICRS (16 times)
IKDC (16 times)
1999 [Autologous osteo-chondral grafts in the management of articular cartilage lesions].
oral anticoagulation therapy
(84 times)
Cardiology
(22 times)
AF (27 times)
INR (20 times)
TTR (10 times)
1998 [Value of molecular markers for administration of anticoagulant therapy after heart valve replacement].
10  oral anticoagulant treatment
(52 times)
Hematology
(17 times)
INR (15 times)
AF (5 times)
VTE (5 times)
1994 [Familial thrombophilia due to resistance to activated protein C].
11  Occluded Artery Trial
(35 times)
Cardiology
(25 times)
PCI (21 times)
MI (12 times)
MED (10 times)
2005 Design and methodology of the Occluded Artery Trial (OAT).
12  O-acetyltransferase
(25 times)
Genetics
(10 times)
NAT (5 times)
NR (5 times)
HCAs (3 times)
1989 Polymorphic expression of acetyl coenzyme A-dependent arylamine N-acetyltransferase and acetyl coenzyme A-dependent O-acetyltransferase-mediated activation of N-hydroxyarylamines by human bladder cytosol.
13  o-aminoazotoluene
(22 times)
Neoplasms
(6 times)
TAT (5 times)
3'-Me-DAB (3 times)
DENA (3 times)
1978 [Mechanisms of the immunodepression caused by ortho-aminoazotoluene and its noncarcinogenic analog in mice].
14  optoacoustic tomography
(21 times)
Ophthalmology
(7 times)
FBP (2 times)
MRI (2 times)
GPUs (1 time)
2004 Bioconjugated gold nanoparticles as a molecular based contrast agent: implications for imaging of deep tumors using optoacoustic tomography.
15  oral appliance therapy
(18 times)
Psychophysiology
(8 times)
OSA (8 times)
AHI (6 times)
CPAP (4 times)
2002 Oral Appliance Therapy for the Management of Sleep Disordered Breathing: An Overview.
16  omental adipose tissue
(13 times)
Metabolism
(5 times)
SAT (7 times)
ACEA (1 time)
ADM (1 time)
2002 Ethnic differences in in vitro glyceride synthesis in subcutaneous and omental adipose tissue.
17  O-atom transfer
(10 times)
Chemistry
(8 times)
HAT (3 times)
CHD (1 time)
CO (1 time)
2012 Nonheme Oxoiron(IV) Complexes of Pentadentate N5 Ligands: Spectroscopy, Electrochemistry, and Oxidative Reactivity.
18  osteoarticular tuberculosis
(9 times)
Microbiology
(1 time)
ESR (1 time)
mNGS (1 time)
MRI (1 time)
2003 Peripheral osteoarticular tuberculosis in children: 106 case-reports.
19  one-at-a-time
(8 times)
Environmental Health
(4 times)
AHP (1 time)
DOE (1 time)
EE (1 time)
2012 Sensitivity analysis of ecosystem service valuation in a Mediterranean watershed.
20  Open abdomen treatment
(8 times)
General Surgery
(6 times)
ACS (5 times)
EAF (4 times)
eEVAR (2 times)
2009 10 years of emergency endovascular aneurysm repair for ruptured abdominal aortoiliac aneurysms: lessons learned.
21  omental
(7 times)
Veterinary Medicine
(2 times)
SAT (7 times)
AT (3 times)
DM (2 times)
2010 Regulation of adipokine production in human adipose tissue by propionic acid.
22  L-ornithine:2-oxoacid aminotransferase
(6 times)
Biochemistry
(3 times)
5FMOrn (4 times)
Orn (3 times)
DFMO (1 time)
1987 Ornithine aminotransferase turnover in host tissues of tumor-bearing rats.
23  Object Alternation Task
(6 times)
Psychiatry
(4 times)
OFC (3 times)
OCD (2 times)
BDI (1 time)
1997 The selective breakdown of frontal functions in patients with obsessive-compulsive disorder and in patients with schizophrenia: a double dissociation experimental finding.
24  open-arm time
(6 times)
Behavioral Sciences
(2 times)
OAE (4 times)
EPM (2 times)
LH (2 times)
1999 Effects of glycine or (+/-)-3-amino-1-hydroxy-2-pyrrolidone microinjections along the rostrocaudal axis of the dorsal periaqueductal gray matter on rats' performance in the elevated plus-maze task.
25  overlay autogenous tissue
(6 times)
Gynecology
(3 times)
--- 2004 The overlay autogenous tissue (OAT) patch to control major intraoperative vascular injury in an ovine model.
26  omental AT
(5 times)
Metabolism
(3 times)
AT (5 times)
SAT (3 times)
IR (2 times)
2010 Evidence for osteocalcin production by adipose tissue and its role in human metabolism.
27  oral anticoagulation
(5 times)
Vascular Diseases
(4 times)
DAPT (2 times)
ICH (2 times)
PCI (2 times)
2008 Comparison of the ecarin chromogenic assay and different aPTT assays for the measurement of argatroban concentrations in plasma from healthy individuals and from coagulation factor deficient patients.
28  oral antithrombotic therapy
(5 times)
Neurosurgery
(2 times)
ASDH (1 time)
CI (1 time)
CIs (1 time)
2010 Premorbid oral antithrombotic therapy and risk for reaccumulation, reoperation, and mortality in acute subdural hematomas.
29  other antibiotic therapy
(5 times)
Pharmacology
(2 times)
ARI (2 times)
ARR (2 times)
CT (2 times)
2006 Economic impact of standard antibiotic therapy combined with amikacin, in clinical unit, Lodz, poland--part I.
30  open abdomen therapy
(4 times)
Surgical Procedures, Operative
(2 times)
ACS (1 time)
AIS (1 time)
DCS (1 time)
2021 Prophylactic Onlay Mesh Implantation During Definitive Fascial Closure After Open Abdomen Therapy (PROMOAT): Absorbable or Non-absorbable? Methodical Description and Results of a Feasibility Study.
31  oral anticoagulants
(4 times)
Critical Care
(1 time)
aPCC (1 time)
CHF (1 time)
E-selectin (1 time)
2004 Haemostatic and inflammatory biomarkers in advanced chronic heart failure: role of oral anticoagulants and successful heart transplantation.
32  oral antipsychotic therapy
(4 times)
Medicine
(1 time)
PP (2 times)
10MWT (1 time)
CBHOs (1 time)
2015 Costs and Resource Utilization Among Medicaid Patients with Schizophrenia Treated with Paliperidone Palmitate or Oral Atypical Antipsychotics.
33  oligoasthenospermia
(3 times)
Reproductive Medicine
(2 times)
ICSI (1 time)
IVF (1 time)
MMP (1 time)
2004 Cinnoxicam and L-carnitine/acetyl-L-carnitine treatment for idiopathic and varicocele-associated oligoasthenospermia.
34  oligozoospermia and/or asthenozoospermia and/or teratozoospermia
(3 times)
Biological Science Disciplines
(1 time)
ICSI (1 time)
IFT (1 time)
IFT140 (1 time)
2007 Is varicocelectomy indicated in subfertile men with clinical varicoceles who have asthenospermia or teratospermia and normal sperm density?
35  opioid analgesic therapy
(3 times)
Orthopedics
(2 times)
CLBP (3 times)
SMT (3 times)
ADEs (1 time)
2021 Initial Choice of Spinal Manipulative Therapy for Treatment of Chronic Low Back Pain Leads to Reduced Long-term Risk of Adverse Drug Events Among Older Medicare Beneficiaries.
36  opioid assisted treatment
(3 times)
Substance-Related Disorders
(2 times)
OUD (2 times)
BUP (1 time)
OR (1 time)
2019 Suboxone Treatment and Recovery Trial (STAR-T): Study Protocol for a Randomised Controlled Trial of Opioid Medication Assisted Treatment with Adjunctive Medication Management Using Therapeutic Drug Monitoring and Contingency Management.
37  oral absorption test
(3 times)
Drug Therapy
(1 time)
--- 2012 A simplified oral flucloxacillin absorption test for patients requiring long-term treatment.
38  oral antiplatelet therapy
(3 times)
Cardiology
(1 time)
HDD (1 time)
MACCEs (1 time)
RARP (1 time)
2011 Non-cardiac surgery in patients with coronary stents: the RECO study.
39  orbital-adipose-tissue
(3 times)
Chemistry
(1 time)
FA (2 times)
GO (2 times)
OAT-GO (2 times)
2020 Distinctive Features of Orbital Adipose Tissue (OAT) in Graves' Orbitopathy.
40  organized atrial tachycardia
(3 times)
Cardiology
(1 time)
AF (2 times)
LMIL (2 times)
SMIL (2 times)
2015 Early recurrence of atrial arrhythmias following pulmonary vein antral isolation: Timing and frequency of early recurrences predicts long-term ablation success.
41  O-acetylation
(2 times)
Neoplasms
(1 time)
NAT (2 times)
2-AF (1 time)
AHAT (1 time)
1989 Metabolism of aromatic amines: relationships of N-acetylation, O-acetylation, N,O-acetyltransfer and deacetylation in human liver and urinary bladder.
42  oat cell carcinoma
(2 times)
General Surgery
(1 time)
INT (2 times)
GRP (1 time)
NSE (1 time)
1986 Subtypes of small cell carcinoma of the lung: morphometric, ultrastructural, and immunohistochemical analyses.
43  object assembly test
(2 times)
Medicine
(1 time)
AMT (1 time)
BDT (1 time)
BNT (1 time)
1997 Cognitive testing of elderly Chinese from selected community clubs in Singapore.
44  octopamine transporter
(2 times)
Biochemistry
(1 time)
AD (1 time)
beta-ARK2-3 (1 time)
CGase (1 time)
2002 A high-affinity octopamine transporter cloned from the central nervous system of cabbage looper Trichoplusia ni.
45  oleanolic acid tablet
(2 times)
Medicine
(1 time)
AMMO (2 times)
AST/ALT (2 times)
BUN (2 times)
2007 [Protective effect of Yigan Fuzheng Paidu capsules combined with ozone on CCl4-induced acute hepatic injury in dogs].
46  omeprazole plus amoxycillin plus tinidazole
(2 times)
Gastroenterology
(1 time)
FAM (1 time)
H. pylori (1 time)
OA (1 time)
1999 Eradication of Helicobacter pylori in routine clinical practice: doubts and uncertainties.
47  omeprazole, amoxicillin, tinidazole
(2 times)
Medicine
(2 times)
OA (1 time)
OAC (1 time)
OCT (1 time)
2005 Gastric acid and salivary bicarbonate. Is there a relationship in duodenal ulcer patients?
48  one factor-at-a-time
(2 times)
Environmental Health
(2 times)
GSA (1 time)
SAs (1 time)
2002 Sensitivity analysis and auto-calibration of an integral dynamic model for river water quality.
49  onset-to-alarm time
(2 times)
Cerebrovascular Disorders
(1 time)
CI (1 time)
IQR (1 time)
OR (1 time)
2016 Help seeking behavior and onset-to-alarm time in patients with acute stroke: sub-study of the preventive antibiotics in stroke study.
50  ontological addiction theory
(2 times)
Behavior, Addictive
(1 time)
BPD (1 time)
2018 Ontological addiction theory: Attachment to me, mine, and I.
51  Open and Affordable Textbooks
(2 times)
Health Services
(1 time)
OER (1 time)
RU (1 time)
2021 The Rutgers University Libraries Open and Affordable Textbook (OAT) Program.
52  optimized asthma therapy
(2 times)
Allergy and Immunology
(1 time)
GETE (1 time)
OCS (1 time)
OMA (1 time)
2011 Persistency of response to omalizumab therapy in severe allergic (IgE-mediated) asthma.
53  Optometry Admission Test
(2 times)
Optometry
(2 times)
ROC (1 time)
2000 Preoptometry and optometry school grade point average and optometry admissions test scores as predictors of performance on the national board of examiners in optometry part I (basic science) examination.
54  oral antimicrobial therapy
(2 times)
Drug Therapy
(1 time)
APN (1 time)
CRBSI (1 time)
ESBL-PE (1 time)
2019 Clinical effectiveness of oral antimicrobial therapy for acute pyelonephritis caused by extended-spectrum beta-lactamase-producing Enterobacteriales.
55  orthotopic allograft transplantation
(2 times)
Vascular Diseases
(1 time)
BNP (1 time)
DPP-4 (1 time)
EPCs (1 time)
2020 Dipeptidyl Peptidase-4 Inhibitor Decreases Allograft Vasculopathy Via Regulating the Functions of Endothelial Progenitor Cells in Normoglycemic Rats.
56  osteochondral autograft
(2 times)
Cartilage
(1 time)
ACI (2 times)
IKDC (1 time)
KOOS (1 time)
2013 Activity-Related Outcomes of Articular Cartilage Surgery: A Systematic Review.
57  osteochondral transplant
(2 times)
General Surgery
(2 times)
HSS (1 time)
ICRS (1 time)
MF (1 time)
2006 Osteochondral autologous transplantation versus microfracture for the treatment of articular cartilage defects in the knee joint in athletes.
58  Otsu-auto-threshold
(2 times)
Diagnostic Imaging
(2 times)
FWHM (2 times)
LGE (2 times)
HCM (1 time)
2012 Auto-threshold quantification of late gadolinium enhancement in patients with acute heart disease.
59  ovarian ablative therapy
(2 times)
Reproductive Medicine
(1 time)
--- 2012 Impact of obesity on reproductive outcomes after ovarian ablative therapy in PCOS: a collaborative meta-analysis.
60  oxygen atom transfer-reactions
(2 times)
Chemistry
(2 times)
BTSP (1 time)
QALE (1 time)
2005 Rhenium oxo compounds containing eta2-pyrazolate ligands.
61  oxygen transfer atom
(2 times)
Biochemistry
(2 times)
Cor (1 time)
TPC (1 time)
TPFC (1 time)
2016 Visible light-induced formation of corrole-manganese(V)-oxo complexes: Observation of multiple oxidation pathways.
62  1,3-oxazolidine-2-thione
(1 time)
Botany
(1 time)
OAOs (1 time)
2018 Glucosinolate turnover in Brassicales species to an oxazolidin-2-one, formed via the 2-thione and without formation of thioamide.
63  2-oxoacid aminotransferase
(1 time)
Chemistry
(1 time)
Orn (1 time)
1988 Interrelationships between ornithine, glutamate, and GABA. II. Consequences of inhibition of GABA-T and ornithine aminotransferase in brain.
64  astheno- and/or teratozoospermia
(1 time)
Nephrology
(1 time)
PV (1 time)
US (1 time)
Vr (1 time)
2003 [Varicocele and coincidental abacterial prostato-vesiculitis: negative role about the sperm output].
65  INTRODUCTION: Anticoagulantion therapy
(1 time)
Cardiology
(1 time)
AF (1 time)
2018 Incidence of thromboembolic events following atrial fibrillation catheter ablation and rate control strategies according to the kind of oral anticoagulation: A systematic review and meta-analysis.
66  OA and T combined
(1 time)
Biology
(1 time)
OA (1 time)
2015 Colony-specific investigations reveal highly variable responses among individual corals to ocean acidification and warming.
67  OA plus exercise training group
(1 time)
Orthopedics
(1 time)
CG (1 time)
LLLT (1 time)
OAC (1 time)
2015 Aerobic exercise training and low-level laser therapy modulate inflammatory response and degenerative process in an experimental model of knee osteoarthritis in rats.
68  oat beta-glucan
(1 time)
Nutritional Sciences
(1 time)
HFD (1 time)
LGG (1 time)
PUFA (1 time)
2020 Lactobacillus rhamnosus GG and Oat Beta-Glucan Regulated Fatty Acid Profiles along the Gut-Liver-Brain Axis of Mice Fed with High Fat Diet and Demonstrated Antioxidant and Anti-Inflammatory Potentials.
69  oat-enriched diet
(1 time)
Nutritional Sciences
(1 time)
HAB (1 time)
MP (1 time)
SDA (1 time)
2014 Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes.
70  oatmeal agar
(1 time)
Microbiology
(1 time)
CYA (1 time)
YES (1 time)
2007 A method for comparison of growth media in objective identification of Penicillium based on multi-spectral imaging.
71  objective Allen's test
(1 time)
General Surgery
(1 time)
RFFF (1 time)
SAT (1 time)
2000 Preoperative evaluation of the radial forearm free flap patient with the objective Allen's test.
72  Observational Assessment of Teamwork
(1 time)
Cognitive Science
(1 time)
--- 2018 Cyber Teaming and Role Specialization in a Cyber Security Defense Competition.
73  obstacle avoidance task
(1 time)
Brain
(1 time)
CT (1 time)
TT (1 time)
2018 Effect of a cognitive task on online adjustments when avoiding stepping on an obstacle and stepping on a target during walking in young adults.
74  Obstructive Adenotonsillar hypertrophy
(1 time)
Otolaryngology
(1 time)
GHQ-12 (1 time)
OR (1 time)
2015 Impact of emotional distress on caregivers burden among Nigerian children with Obstructive Adenotonsillar hypertrophy.
75  obstructive apnea index
(1 time)
Otolaryngology
(1 time)
AHI (1 time)
BMI (1 time)
MSMSMS (1 time)
2015 [Clinical research on micro-movement sensitive mattress sleep monitoring system in children with obstructive sleep apnea hypopnea syndrome].
76  occult abdominal trauma
(1 time)
Pediatrics
(1 time)
OR (2 times)
CI (1 time)
2009 Screening for occult abdominal trauma in children with suspected physical abuse.
77  occupational activity time
(1 time)
Neoplasms
(1 time)
aOR (1 time)
CIs (1 time)
ESCC (1 time)
2017 Sitting time and occupational and recreational physical activity in relation to the risk of esophageal squamous cell carcinoma.
78  octopamine availability, the octopamine transporter
(1 time)
Nervous System
(1 time)
DAT (1 time)
Dm (1 time)
T. ni (1 time)
2019 Modeling of the Binding of Octopamine and Dopamine in Insect Monoamine Transporters Reveals Structural and Electrostatic Differences.
79  oculo-acupuncture therapy
(1 time)
Complementary Therapies
(1 time)
IBS (1 time)
SERT (1 time)
2011 [Effects of oculo-acupuncture therapy on colonic serotonin reuptake transporter expression in rats with irritable bowel syndrome].
80  odontogenic adenomatoid tumor
(1 time)
Dentistry
(1 time)
--- 1995 Odontogenic adenomatoid tumors associated with orthodontic treatment.
81  Office of Advanced Technology
(1 time)
Health Services
(1 time)
--- 2004 The Office of Advanced Technology: providing focus on the piloting and implementation of new technology.
82  okara-added tofu
(1 time)
Food
(1 time)
--- 2021 Influence of okara with varying particle sizes on the gelling, rheological, and microstructural properties of glucono-δ-lactone-induced tofu.
83  oligo(amide-triazole)s
(1 time)
Chemistry
(1 time)
--- 2013 From nongelating to gelating: synthesis and structural self-assembling property relationships of a homologous series of oligo(amide-triazole)s.
84  oligo-, astheno- and/or terato-zoospermia
(1 time)
Nephrology
(1 time)
--- 2005 [Unilateral testicular cancer: incidence and effects of a contralateral testiculopathy on the sperm output].
85  oligoasthenoteratozoospermia syndrome
(1 time)
Nephrology
(1 time)
ED (1 time)
IIEF (1 time)
2015 Improvement of seminal quality and sexual function of men with oligoasthenoteratozoospermia syndrome following supplementation with L-arginine and Pycnogenol.
86  oligoasthenoteratozoospermic ejaculates
(1 time)
Reproductive Medicine
(1 time)
DNMTs (1 time)
2019 Relation between sperm protamine transcripts with global sperm DNA methylation and sperm DNA methyltransferases mRNA in men with severe sperm abnormalities.
87  oligonecrozoospermia, and oligoasthenoteratozoospermia
(1 time)
Reproductive Medicine
(1 time)
SNPs (1 time)
2011 Should TSPYL1 mutation screening be included in routine diagnostics of male idiopathic infertility?
88  oligopyrimidine/AUG tandem
(1 time)
Biotechnology
(1 time)
TMEV (1 time)
1996 Modification of translational control elements as a new approach to design of attenuated picornavirus strains.
89  oligospermia with/without astheno- or teratozoospermia
(1 time)
Neoplasms
(1 time)
DNA (1 time)
FSH (1 time)
MMP (1 time)
2021 Effect of the oral intake of astaxanthin on semen parameters in patients with oligo-astheno-teratozoospermia: a randomized double-blind placebo-controlled trial.
90  oligospermic, asthenospermic, oligoasthenoteratospermic
(1 time)
OR (1 time)
PCR-RFLP (1 time)
2016 Association of the MTHFR C677T (rs1801133) polymorphism with idiopathic male infertility in a local Pakistani population.
91  omega-aminotransferase
(1 time)
Microbiology
(1 time)
AATs (1 time)
ALDH (1 time)
2007 A high-throughput and generic assay method for the determination of substrate specificities of thermophilic alpha-aminotransferases.
92  omental-derived AT
(1 time)
Obesity
(1 time)
AT (1 time)
ATM (1 time)
EVs (1 time)
2013 Human adipocyte extracellular vesicles in reciprocal signaling between adipocytes and macrophages.
93  Oncology Acuity Tool
(1 time)
Nursing
(1 time)
--- 2013 The oncology acuity tool: a reliable, valid method for measuring patient acuity for nurse assignment decisions.
94  onset-admission time
(1 time)
Neurology
(1 time)
rt-PA (1 time)
2010 Effect of daytime, weekday and year of admission on outcome in acute ischaemic stroke patients treated with thrombolytic therapy.
95  ontology annotation treebrowser
(1 time)
Medical Informatics
(1 time)
GO (1 time)
MeSH (1 time)
2006 Ontology annotation treebrowser : an interactive tool where the complementarity of medical subject headings and gene ontology improves the interpretation of gene lists.
96  open access technique
(1 time)
General Surgery
(1 time)
DTI (1 time)
2019 Laparoscopic Access: Direct Trocar Insertion Versus Open Technique.
97  open adductor longus tenotomy
(1 time)
Orthopedics
(1 time)
HA (1 time)
PAT (1 time)
2010 Is percutaneous adductor tenotomy as effective and safe as the open procedure?
98  ophthalmic artery trunk
(1 time)
Neurosurgical Procedures
(1 time)
SAH (1 time)
2017 Aneurysms of the Intracranial Segment of the Ophthalmic Artery Trunk: Case Report and Systematic Literature Review.
99  opinions about treatment
(1 time)
Behavioral Sciences
(1 time)
ABFT (1 time)
WAI (1 time)
2021 Implementing Attachment-Based Family Therapy for Depressed and Suicidal Adolescents and Young Adults in LGBTQ+ Services.
100  opioid agonist
(1 time)
Substance-Related Disorders
(1 time)
--- 2017 The costs of crime associated with stimulant use in a Canadian setting.