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Abbreviation: PAM
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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
polyacrylamide
(322 times)
Environmental Health
(129 times)
PAC (13 times)
SEM (13 times)
COD (10 times)
2000 Influence of polyacrylamide application to soil on movement of microorganisms in runoff water.
pulmonary alveolar macrophages
(285 times)
Allergy and Immunology
(51 times)
PRRSV (44 times)
LPS (14 times)
BAL (12 times)
1975 Effects of oxygen exposure on it vitro function of pulmonary alveolar macrophages.
positive allosteric modulator
(264 times)
Pharmacology
(96 times)
NAM (15 times)
nAChRs (14 times)
ACh (10 times)
1996 Reversible modification of GABAA receptor subunit mRNA expression during tolerance to diazepam-induced cognition dysfunction.
peptidylglycine alpha-amidating monooxygenase
(245 times)
Biochemistry
(69 times)
PHM (23 times)
PAL (17 times)
CPE (8 times)
1984 Secretion and regulation of two biosynthetic enzyme activities, peptidyl-glycine alpha-amidating monooxygenase and a carboxypeptidase, by mouse pituitary corticotropic tumor cells.
protospacer adjacent motif
(223 times)
Molecular Biology
(39 times)
CRISPR (44 times)
sgRNA (20 times)
crRNA (19 times)
2011 The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli.
pulse amplitude modulation
(167 times)
Environmental Health
(35 times)
PSII (13 times)
NPQ (12 times)
ETR (6 times)
1994 Detection of gaps in sinusoids by frog auditory nerve fibers: importance in AM coding.
primary amoebic meningoencephalitis
(158 times)
Parasitology
(34 times)
CNS (19 times)
GAE (14 times)
CSF (10 times)
1977 Free-living amebic meningoencephalitides: comparative study.
photoacoustic microscopy
(137 times)
Ophthalmology
(49 times)
OCT (18 times)
OR-PAM (9 times)
PA (9 times)
1992 [Development of multicomponent immunoassay and micro-localization analysis by laser-photoacoustic and microscopic image analyzer].
Patient Activation Measure
(129 times)
Nursing
(18 times)
PACIC (6 times)
CS-PAM (3 times)
DSME (3 times)
2004 Development of the Patient Activation Measure (PAM): conceptualizing and measuring activation in patients and consumers.
10  Pulmonary alveolar microlithiasis
(90 times)
Pulmonary Medicine
(26 times)
HRCT (5 times)
CT (4 times)
BAL (3 times)
1987 Pulmonary alveolar microlithiasis in pediatric patients--review of the world literature and two new observations.
11  pregnancy-associated malaria
(80 times)
Allergy and Immunology
(22 times)
CSA (24 times)
IEs (11 times)
VSA (11 times)
2000 Plasma antibodies from malaria-exposed pregnant women recognize variant surface antigens on Plasmodium falciparum-infected erythrocytes in a parity-dependent manner and block parasite adhesion to chondroitin sulfate A.
12  primary acquired melanosis
(75 times)
Ophthalmology
(44 times)
MMC (9 times)
MM (3 times)
AMS (2 times)
1985 Primary acquired melanosis of the conjunctiva.
13  prediction analysis for microarrays
(64 times)
Neoplasms
(22 times)
SAM (14 times)
SVM (7 times)
GO (6 times)
2003 Differentiation of lobular versus ductal breast carcinomas by expression microarray analysis.
14  pamidronate
(58 times)
Neoplasms
(10 times)
ZOL (16 times)
BPs (10 times)
ALN (5 times)
2002 Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts.
15  potential acuity meter
(39 times)
Ophthalmology
(36 times)
BCVA (8 times)
LI (8 times)
BSCVA (3 times)
1985 Retinal acuity evaluation with the potential acuity meter in glaucoma patients.
16  plasma-activated medium
(38 times)
Natural Science Disciplines
(12 times)
CAP (6 times)
ROS (5 times)
NEAPP (4 times)
2015 Plasma-activated medium induces A549 cell injury via a spiral apoptotic cascade involving the mitochondrial-nuclear network.
17  passive acoustic monitoring
(30 times)
Speech-Language Pathology
(13 times)
AFSR (1 time)
EDA (1 time)
EIAs (1 time)
2011 Listening to the Deep: live monitoring of ocean noise and cetacean acoustic signals.
18  partitioning around medoids
(29 times)
Medical Informatics
(3 times)
SPME (2 times)
ADCL (1 time)
AEB (1 time)
1997 Validity of using non-pilot subjects to represent pilots in a sustained acceleration environment.
19  pralidoxime
(28 times)
Toxicology
(4 times)
OP (8 times)
AChE (2 times)
ChE (2 times)
1979 Drug uptake into everted intestinal sacs. II. Inhibition of secretion by hypertonicity.
20  pyridine-2-aldoxime methiodide
(24 times)
Pharmacology
(8 times)
AChE (5 times)
DAM (2 times)
DFP (2 times)
1957 Oximes and atropine in sarin poisoning.
21  passive acoustic mapping
(22 times)
Diagnostic Imaging
(7 times)
RCB (4 times)
TEA (4 times)
FUS (3 times)
2013 Real-time temperature estimation and monitoring of HIFU ablation through a combined modeling and passive acoustic mapping approach.
22  periodic acid-methenamine silver
(22 times)
Neurology
(5 times)
SP (4 times)
GBM (3 times)
ATD (2 times)
1975 Periodic acid methenamine silver (pam) staining of the human subcutaneous lymphatic vessel.
23  protein associated with Myc
(20 times)
Cell Biology
(4 times)
mTOR (2 times)
mTORC1 (2 times)
S1P (2 times)
2001 Protein associated with Myc (PAM) is a potent inhibitor of adenylyl cyclases.
24  prematurely aging mice
(17 times)
Geriatrics
(4 times)
NPAM (10 times)
NAC (3 times)
TP (3 times)
2002 A diet supplemented with thiolic anti-oxidants improves leucocyte function in two strains of prematurely ageing mice.
25  palmitic acid
(15 times)
Biochemistry
(9 times)
OLA (4 times)
FA (3 times)
ARA (2 times)
1991 Tumour-necrosis-factor-mediated cytotoxicity is correlated with phospholipase-A2 activity, but not with arachidonic acid release per se.
26  Point Accepted Mutation
(12 times)
Molecular Biology
(5 times)
BLOSUM (4 times)
CAO (1 time)
CPM (1 time)
2001 Evaluation of methods for determination of a reconstructed history of gene sequence evolution.
27  Perception-Action Model
(11 times)
Psychology
(4 times)
GA (2 times)
ML (2 times)
PCM (2 times)
2002 Empathy: Its ultimate and proximate bases.
28  Perceptual Assimilation Model
(11 times)
Speech-Language Pathology
(6 times)
AO (2 times)
AP (1 time)
AV (1 time)
2001 Discrimination of non-native consonant contrasts varying in perceptual assimilation to the listener's native phonological system.
29  Physical Activity Monitor
(11 times)
Sports Medicine
(3 times)
COPD (2 times)
CPAG (2 times)
CI (1 time)
1997 Assessment of ambulatory behavior in nursing home residents who pace or wander: a comparison of four commercially available devices.
30  pressure-assisted microsyringe
(11 times)
Histology
(4 times)
PLGA (2 times)
FDM (1 time)
GRDDSs (1 time)
2003 A comparative study of chemical derivatisation methods for spatially differentiated cell adhesion on 2-dimensional microfabricated polymeric matrices.
31  Pretransplant Assessment of Mortality
(11 times)
Hematology
(7 times)
NRM (5 times)
HCT-CI (4 times)
OS (4 times)
2006 A risk score for mortality after allogeneic hematopoietic cell transplantation.
32  Pan-Asia Menopause
(10 times)
Gynecology
(5 times)
CE (6 times)
MPA (6 times)
BMI (1 time)
2005 Prevalence of menopausal symptoms in different ethnic groups of Asian women and responsiveness to therapy with three doses of conjugated estrogens/medroxyprogesterone acetate: the Pan-Asia Menopause (PAM) study.
33  phosphoramide mustard
(10 times)
Neoplasms
(3 times)
CP (5 times)
MESNA (2 times)
4-HC (1 time)
1981 Investigation on cyclophosphamide treatment during the preimplantation period. II. In vitro studies on the effects of cyclophosphamide and its metabolites 4-OH-cyclophosphamide, phosphoramide mustard, and acrolein on blastulation of four-cell and eight-cell mouse embryos and on their subsequent development during implantation.
34  plasminogen-binding group A streptococcal M protein
(9 times)
Biochemistry
(6 times)
GAS (6 times)
HPg (2 times)
Pg (2 times)
2004 Natural selection and evolution of streptococcal virulence genes involved in tissue-specific adaptations.
35  pre-arrest morbidity
(9 times)
Geriatrics
(3 times)
CPR (6 times)
AMI (1 time)
CHF (1 time)
1989 Pre-arrest morbidity and other correlates of survival after in-hospital cardiopulmonary arrest.
36  presequence translocase-associated motor
(9 times)
Cell Biology
(7 times)
mtHsp70 (4 times)
IM (1 time)
mtDNA (1 time)
2003 A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria.
37  pneumatic artificial muscle
(8 times)
Biomedical Engineering
(3 times)
BOLD (1 time)
DOF (1 time)
EMG (1 time)
2008 Hip orthosis powered by pneumatic artificial muscle: voluntary activation in absence of myoelectrical signal.
38  polyamide membrane
(8 times)
Chemistry Techniques, Analytical
(5 times)
RTP (9 times)
AA (5 times)
AA-SS-RTP (4 times)
2006 Determination of trace mercury by solid substrate-room temperature phosphorimetry quenching method based on catalytic effect of Hg2+ on formation of the ion association complex [Sn(XO)6]4+.[(Fin)4].
39  postapproval monitoring
(8 times)
Laboratory Animal Science
(7 times)
IACUC (5 times)
ACUP (1 time)
IACUCs (1 time)
2008 The institutional official and postapproval monitoring: the view from 10,000 feet.
40  potassium-aggravated myotonia
(8 times)
Neurology
(4 times)
HyperPP (3 times)
PC (3 times)
PMC (2 times)
1996 Paramyotonia congenita: genotype to phenotype correlations in two families and report of a new mutation in the sodium channel gene.
41  primary ammonium monocarboxylate
(8 times)
Chemistry
(8 times)
SXRD (3 times)
MS (2 times)
NSAID (2 times)
2011 Supramolecular synthons in designing low molecular mass gelling agents: L-amino acid methyl ester cinnamate salts and their anti-solvent-induced instant gelation.
42  Psychosis Attachment Measure
(8 times)
Psychiatry
(6 times)
ChM (1 time)
CTQ (1 time)
2007 Attachment styles, earlier interpersonal relationships and schizotypy in a non-clinical sample.
43  pancreatic acinar metaplasia
(7 times)
Gastroenterology
(3 times)
BO (2 times)
GOJ (2 times)
IM (2 times)
1996 Prevalence and significance of pancreatic acinar metaplasia at the gastroesophageal junction.
44  peptidylglycine alpha-monooxygenase
(7 times)
Pharmacology
(3 times)
PBA (5 times)
PGL (3 times)
COX (2 times)
1991 Functional and structural characterization of peptidylamidoglycolate lyase, the enzyme catalyzing the second step in peptide amidation.
45  phenylalanine aminomutase
(7 times)
Biochemistry
(4 times)
MIO (3 times)
PAL (2 times)
HAL (1 time)
2004 Cloning, heterologous expression, and characterization of a phenylalanine aminomutase involved in Taxol biosynthesis.
46  post-assembly modification
(7 times)
Chemistry
(6 times)
IEDDA (2 times)
AIE (1 time)
MOFs (1 time)
2015 Understanding the Adsorption of PFOA on MIL-101(Cr)-Based Anionic-Exchange Metal-Organic Frameworks: Comparing DFT Calculations with Aqueous Sorption Experiments.
47  programmable array microscope
(7 times)
Diagnostic Imaging
(3 times)
CLSM (2 times)
FRAP (1 time)
FWHM (1 time)
1999 An optical sectioning programmable array microscope implemented with a digital micromirror device.
48  protocerebral anterior medial
(7 times)
Genetics
(2 times)
DA (3 times)
MB (2 times)
PD (2 times)
2012 A subset of dopamine neurons signals reward for odour memory in Drosophila.
49  pharmacologically active microcarriers
(6 times)
Biomedical Engineering
(4 times)
MSC (2 times)
NGF (2 times)
PLGA (2 times)
2004 In vivo evaluation of pharmacologically active microcarriers releasing nerve growth factor and conveying PC12 cells.
50  polyphosphate-accumulating metabolism
(6 times)
Environmental Health
(5 times)
GAM (6 times)
COD (3 times)
EBPR (3 times)
2002 Effects of pH on enhanced biological phosphorus removal metabolisms.
51  posterior auricular muscle
(6 times)
Medicine
(3 times)
HFS (2 times)
AMR (1 time)
AS (1 time)
1993 The effect of acupuncture stimulation of the middle latency auditory evoked potential.
52  pregnancy-associated alpha-macroglobulin
(6 times)
Neoplasms
(2 times)
CEA (2 times)
AFP (1 time)
GGT (1 time)
1975 Correlation of the blood-level of a pregnancy-associated alpha-macroglobulin with the clinical course of cancer patients.
53  pressure application measurement
(6 times)
Pharmacology
(2 times)
AIA (1 time)
EPM (1 time)
EVF (1 time)
2007 Pressure application measurement (PAM): a novel behavioural technique for measuring hypersensitivity in a rat model of joint pain.
54  penicillin G in oil with aluminum monostearate
(5 times)
Sexually Transmitted Diseases
(3 times)
APPG (1 time)
CSF (1 time)
1954 A WHO study of treatment schedules for early syphilis in use throughout the world.
55  periarbuscular membrane
(5 times)
Botany
(3 times)
AM (3 times)
ARK1 (1 time)
Pi (1 time)
2014 The H+-ATPase HA1 of Medicago truncatula Is Essential for Phosphate Transport and Plant Growth during Arbuscular Mycorrhizal Symbiosis.
56  periodic acid-silver methenamine
(5 times)
Histology
(1 time)
AMF (1 time)
AT1aKO (1 time)
BSE (1 time)
1990 Features of the aperiodic microfibrils associated with mouse dental basement membrane demonstrated by ultrastructural histochemistry.
57  photoacoustic mammography
(5 times)
Science
(1 time)
MRI (2 times)
PA (2 times)
CAIX (1 time)
2013 Dedicated 3D photoacoustic breast imaging.
58  plasma membrane associated membranes
(5 times)
Biochemistry
(3 times)
ER (2 times)
CRISPR-Cas9 (1 time)
ERAD (1 time)
2001 A subfraction of the yeast endoplasmic reticulum associates with the plasma membrane and has a high capacity to synthesize lipids.
59  porous alumina membrane
(5 times)
Nanotechnology
(3 times)
AAM (1 time)
AAO (1 time)
CAH (1 time)
2008 In situ GISAXS study of the formation of mesostructured phases within the pores of anodic alumina membranes.
60  positive assortative mating
(5 times)
Genetics
(4 times)
BP (4 times)
PP (2 times)
MCM (1 time)
2003 Positive assortative mating with selection restrictions on group coancestry enhances gain while conserving genetic diversity in long-term forest tree breeding.
61  potential aerosol mass
(5 times)
Environmental Health
(4 times)
SOA (3 times)
HOA (1 time)
LV-OOA (1 time)
2014 Secondary organic aerosol formation from in-use motor vehicle emissions using a potential aerosol mass reactor.
62  protective apoptosis-mediated
(5 times)
Dose-Response Relationship, Drug
(2 times)
LET (3 times)
LNT (1 time)
PPI (1 time)
2004 A biological-based model that links genomic instability, bystander effects, and adaptive response.
63  psoriatic arthritis mutilans
(5 times)
Rheumatology
(3 times)
CI (1 time)
DIP (1 time)
PARS (1 time)
2013 Psoriatic arthritis mutilans (PAM) in the Nordic countries: demographics and disease status. The Nordic PAM study.
64  pulse-amplitude modulated fluorometry
(5 times)
Environmental Health
(2 times)
GA (1 time)
PAR (1 time)
PEA (1 time)
2007 Study of photosystem 2 heterogeneity in the sulfur-deficient green alga Chlamydomonas reinhardtii.
65  paraxial mesoderm
(4 times)
Molecular Biology
(3 times)
IM (1 time)
MSCs (1 time)
TCF (1 time)
2006 Zebrafish protocadherin 10 is involved in paraxial mesoderm development and somitogenesis.
66  periodic Anderson model
(4 times)
Nanotechnology
(2 times)
eff (1 time)
2010 Effective low-energy model for f-electron delocalization.
67  peronea arteria magna
(4 times)
General Surgery
(4 times)
dPR (1 time)
FFF (1 time)
MRA (1 time)
1994 The need for preoperative leg angiography in fibula free flaps.
68  phenylacetic acid mustard
(4 times)
Neoplasms
(1 time)
CLB (2 times)
AUC (1 time)
BER (1 time)
1984 Effect of food on pharmacokinetics of chlorambucil and its main metabolite, phenylacetic acid mustard.
69  plasmid artificial modification
(4 times)
Bacteriology
(1 time)
R-M (3 times)
MRSA (1 time)
2011 Plasmid artificial modification: a novel method for efficient DNA transfer into bacteria.
70  platelet aggregating material
(4 times)
Vascular Diseases
(1 time)
GFP (1 time)
PAT (1 time)
1981 Platelet-aggregating immune complexes and intraplatelet serotonin in idiopathic glomerulonephritis and systemic lupus.
71  posterior adductor muscle
(4 times)
Toxicology
(2 times)
DG (1 time)
MHC (1 time)
p.i (1 time)
2006 Catalytic subunit of cAMP-dependent protein kinase from a catch muscle of the bivalve mollusk Mytilus galloprovincialis: purification, characterization, and phosphorylation of muscle proteins.
72  Pralidoxime chloride
(4 times)
Toxicology
(3 times)
OP (1 time)
TBA (1 time)
1970 Pralidoxime iodide (PAM) and toxogonin as antidotes in acute malathion intoxication in the dog.
73  prasugrel active metabolite
(4 times)
Hematology
(4 times)
ADP (2 times)
AA (1 time)
cAMP (1 time)
2011 In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation.
74  Precision Addiction Management
(4 times)
GARS (3 times)
RDS (2 times)
BRC (1 time)
2018 Promoting Precision Addiction Management (PAM) to Combat the Global Opioid Crisis.
75  pulmonary macrophages
(4 times)
Toxicology
(2 times)
IFN-gamma (1 time)
IL-6 (1 time)
PGE2 (1 time)
1979 Induction of ouabain-resistant mutation and sister chromatid exchanges in Chinese hamster cells with chemical carcinogens mediated by human pulmonary macrophages.
76  4-phenylazophenyl maleimide
(3 times)
Biochemistry
(2 times)
UV (2 times)
VIS (2 times)
CaM (1 time)
2007 Photocontrol of kinesin ATPase activity using an azobenzene derivative.
77  palmitic
(3 times)
Biochemistry
(2 times)
DHA (3 times)
EPA (3 times)
ALA (2 times)
2013 Fatty acids with in vitro binding affinity for human opioid receptors from the fungus Emericella nidulans.
78  paracetamol
(3 times)
Environmental Health
(2 times)
AFB1 (1 time)
gamma-GT (1 time)
GST (1 time)
2005 The effect of modulation of glutathione levels on markers for aflatoxin B1-induced cell damage.
79  performing arts medicine
(3 times)
Occupational Medicine
(3 times)
PAMA (1 time)
2011 Development and implementation of an in-house healthcare program for university-level performing artists.
80  phagocytic activity of macrophages
(3 times)
Medicine
(1 time)
ADC (1 time)
MEF (1 time)
MPS (1 time)
1985 Role of macrophages in the pathogenesis of experimental tick-borne encephalitis in mice.
81  phenylacetylene macrocycle
(3 times)
Chemistry, Organic
(2 times)
PDAs (1 time)
SEM (1 time)
XRD (1 time)
2011 H-bonding-driven gel formation of a phenylacetylene macrocycle.
82  phenylalanine-2,3-aminomutase
(3 times)
Biochemistry
(3 times)
MIO (2 times)
beta-Phe (1 time)
2014 Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from Taxus chinensis.
83  picolinamide
(3 times)
Pharmacology
(1 time)
NAM (3 times)
ACM (2 times)
2ABAM (1 time)
2003 ECNI GC-MS analysis of picolinic and quinolinic acids and their amides in human plasma, CSF, and brain tissue.
84  point mutations
(3 times)
Science
(1 time)
IDAM (1 time)
IDAMs (1 time)
REH (1 time)
1981 Simulation of protein evolution by random fixation of allowed codons.
85  poly(allylamine)
(3 times)
Chemistry
(2 times)
PAA (2 times)
PDA (1 time)
PEO (1 time)
2006 Two-site ionic labeling with pyranine: implications for structural dynamics studies of polymers and polypeptides by time-resolved fluorescence anisotropy.
86  Pomeranian Medical Academy
(3 times)
Tropical Medicine
(2 times)
--- 1996 [Bacterial flora of acne lesions in diagnostic material of the Microbiology and Immunology Department, Pomeranian Medical Academy (PAM) in Szczecin].
87  Pomeranian Medical University
(3 times)
Rheumatology
(1 time)
PAN (1 time)
pSS (1 time)
2007 Comparative analysis of informative support in lactation in lying-in women hospitalized in rooming-in system.
88  post-anoxic myoclonus
(3 times)
Tremor
(1 time)
CA (1 time)
CGI-S (1 time)
CPC (1 time)
2000 Antimyoclonic effect of levetiracetam.
89  preadmission medication
(3 times)
Drug Therapy
(2 times)
GP (1 time)
2011 Sources of pre-admission medication information: observational study of accuracy and availability.
90  primary acquired melanosis of the conjunctiva
(3 times)
Immune System
(1 time)
PCA (1 time)
Se (1 time)
Sp (1 time)
2013 Imaging microscopic pigment chemistry in conjunctival melanocytic lesions using pump-probe laser microscopy.
91  procaine benzylpenicillin in oil with aluminium monostearate
(3 times)
Public Health
(2 times)
--- 1961 Blood-level duration limit test of procaine benzylpenicillin in sheep.
92  professionals allied to medicine
(3 times)
Nephrology
(1 time)
BLS (1 time)
ESRD (1 time)
1997 Subordinate appraisal of managers: "testing the theory".
93  protein A Mimetic
(3 times)
Allergy and Immunology
(2 times)
SPR (1 time)
2000 Protein A mimetic (PAM) affinity chromatography. Immunoglobulins purification.
94  Protein aggregate myopathies
(3 times)
Genetic Testing
(1 time)
DRM (1 time)
2005 Protein aggregate myopathies.
95  protospacer-associated motif
(3 times)
Molecular Biology
(2 times)
Cas (1 time)
CRISPR (1 time)
crRNA (1 time)
2012 Structure and mechanism of the CMR complex for CRISPR-mediated antiviral immunity.
96  cis-platinum, adriamycin and mitomycin C
(2 times)
Antineoplastic Agents
(2 times)
--- 1986 [Combination chemotherapy with cis-platinum, adriamycin and mitomycin C (PAM) in the treatment of non-small cell carcinoma of the lung].
97  pamidronate disodium
(2 times)
Orthopedics
(1 time)
ACLT (1 time)
ALN (1 time)
OA (1 time)
2014 Effects of pamidronate disodium on the loss of osteoarthritic subchondral bone and the expression of cartilaginous and subchondral osteoprotegerin and RANKL in rabbits.
98  particle-associated microorganisms
(2 times)
Veterinary Medicine
(2 times)
PAB (1 time)
PAP (1 time)
PB (1 time)
1994 Improved techniques for dissociating particle-associated mixed ruminal microorganisms from ruminal digesta solids.
99  pathogen-associated molecules
(2 times)
Neoplasms
(2 times)
RT-PCR (1 time)
TAP (1 time)
TNF (1 time)
2010 The effect of NSC-631570 (ukrain) alone and in combination with pathogen-associated molecules on cell cycle distribution and apoptosis induction of mouse melanoma cells with different biological properties.
100  pathway-activation model
(2 times)
Medicine
(1 time)
DBS (2 times)
DTI (1 time)
MADRS (1 time)
2017 Creating and parameterizing patient-specific deep brain stimulation pathway-activation models using the hyperdirect pathway as an example.