| 1 |
phosphatidylinositol 3-kinase
(15904 times)
|
Neoplasms
(2821 times)
|
mTOR (1486 times)
MAPK (1273 times)
ERK (984 times)
|
1990 Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase.
|
| 2 |
PI3 kinase
(205 times)
|
Cell Biology
(34 times)
|
MAPK (14 times)
VEGF (7 times)
mTOR (6 times)
|
1996 Carbachol inhibits insulin-stimulated phosphatidylinositol 3-kinase activity in SH-SY5Y neuroblastoma cells.
|
| 3 |
PIK3CA
(21 times)
|
Neoplasms
(8 times)
|
3'-UTR (1 time)
AKT1 (1 time)
ASM (1 time)
|
2005 PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma.
|
| 4 |
PI3Kgamma
(7 times)
|
Hematology
(2 times)
|
PI3Ks (2 times)
ADP (1 time)
GPCRs (1 time)
|
1996 Phosphopleckstrin inhibits gbetagamma-activable platelet phosphatidylinositol-4,5-bisphosphate 3-kinase.
|
| 5 |
phosphatidylinositol 3-kinase-dependent
(4 times)
|
Endocrinology
(2 times)
|
MAPK (2 times)
NO (2 times)
ERK (1 time)
|
2005 Gamma-tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor kappaB activity.
|
| 6 |
PI3K/AKT/mTOR
(4 times)
|
Neoplasms
(3 times)
|
EMT (1 time)
PTEN (1 time)
T-ALLs (1 time)
|
2015 Targeting drivers of melanoma with synthetic small molecules and phytochemicals.
|
| 7 |
PIK3R1
(4 times)
|
Molecular Biology
(1 time)
|
GO (1 time)
HFD (1 time)
lepa (1 time)
|
2014 Transcriptional activation of PIK3R1 by PPARgamma in adipocytes.
|
| 8 |
p-PI3K
(2 times)
|
Communicable Diseases
(1 time)
|
ABCA1 (1 time)
|
2018 microRNA-107 inhibits gastric cancer cell proliferation and metastasis by targeting PI3K/AKT pathway.
|
| 9 |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(2 times)
|
Neoplasms
(1 time)
|
MYOD1 (2 times)
GAS5 (1 time)
HIF1A (1 time)
|
2014 Insulin acutely triggers transcription of Slc2a4 gene: participation of the AT-rich, E-box and NFKB-binding sites.
|
| 10 |
PI3K-C2beta
(2 times)
|
Cell Biology
(1 time)
|
HCV (1 time)
LPA (1 time)
PtdIns3P (1 time)
|
2005 Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration.
|
| 11 |
PtdIns-3-kinase
(2 times)
|
Biotechnology
(1 time)
|
FGF (1 time)
MAPK (1 time)
PI3,4,5P3 (1 time)
|
2007 Opposed growth factor signals control protein degradation in muscles of Caenorhabditis elegans.
|
| 12 |
(KIT)-phosphoinositol 3 kinase
(1 time)
|
Cell Biology
(1 time)
|
dpp (1 time)
mTORC1 (1 time)
|
2017 MAPK3/1 participates in the activation of primordial follicles through mTORC1-KITL signaling.
|
| 13 |
3-phosphoinositide-dependent kinase-1
(1 time)
|
Medicine
(1 time)
|
CHBP (1 time)
FOXO3a (1 time)
IRI (1 time)
|
2015 Cyclic helix B peptide inhibits ischemia reperfusion-induced renal fibrosis via the PI3K/Akt/FoxO3a pathway.
|
| 14 |
alpha5beta1-phosphatidylinositol-3-kinase
(1 time)
|
Biomedical Engineering
(1 time)
|
Gel-HA (1 time)
PDA (1 time)
RD (1 time)
|
2018 Mussel-inspired injectable hydrogel and its counterpart for actuating proliferation and neuronal differentiation of retinal progenitor cells.
|
| 15 |
EGFR-Ras-PI 3 kinase
(1 time)
|
Antioxidants
(1 time)
|
CK2 (1 time)
EGFR (1 time)
ER (1 time)
|
2019 Mechanism of Rapid Nuclear Factor-E2-Related Factor 2 (Nrf2) Activation via Membrane-Associated Estrogen Receptors: Roles of NADPH Oxidase 1, Neutral Sphingomyelinase 2 and Epidermal Growth Factor Receptor (EGFR).
|
| 16 |
G(alpha)(i3)-Gbetagamma-phosphoinositide 3-kinase
(1 time)
|
Molecular Biology
(1 time)
|
INSL3 (1 time)
RXFP (1 time)
|
2008 Relaxin family peptide receptor (RXFP1) coupling to G(alpha)i3 involves the C-terminal Arg752 and localization within membrane Raft Microdomains.
|
| 17 |
Gi-Gbetagamma-phosphoinositide 3-kinase
(1 time)
|
Drug Therapy
(1 time)
|
beta-AR (1 time)
CaMKII (1 time)
CHF (1 time)
|
2005 Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling.
|
| 18 |
KL-Kit-PI3 kinase
(1 time)
|
Endocrinology
(1 time)
|
GSK-3 (1 time)
|
2007 Phosphorylation and inactivation of glycogen synthase kinase-3 by soluble kit ligand in mouse oocytes during early follicular development.
|
| 19 |
laminin-DGC-Gbetagamma-phosphatidylinositol 3-kinase
(1 time)
|
Cell Biology
(1 time)
|
AP-1 (1 time)
DGC (1 time)
JNK (1 time)
|
2011 Laminin-alpha1 LG4-5 domain binding to dystroglycan mediates muscle cell survival, growth, and the AP-1 and NF-kappaB transcription factors but also has adverse effects.
|
| 20 |
pan-PI3 kinase
(1 time)
|
Pulmonary Medicine
(1 time)
|
BAL (1 time)
IPF (1 time)
mTOR (1 time)
|
2016 Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF.
|
| 21 |
pan-PI3K inhibitors
(1 time)
|
Neoplasms
(1 time)
|
BC (1 time)
ER (1 time)
mTOR (1 time)
|
2014 Managing postmenopausal women with hormone receptor-positive advanced breast cancer who progress on endocrine therapies with inhibitors of the PI3K pathway.
|
| 22 |
pathway, the inositol-3 phosphate kinase
(1 time)
|
Cell Biology
(1 time)
|
---
|
2009 Cyclin A2 confers cisplatin resistance to endometrial carcinoma cells via up-regulation of an Akt-binding protein, periplakin.
|
| 23 |
pathways, i.e., phosphoinositol-3 kinase
(1 time)
|
Hormones
(1 time)
|
HIF-1alpha (1 time)
|
2015 Adipose tissue dysfunction and its effects on tumor metabolism.
|
| 24 |
PDGF-initiated phosphoinositide-3 kinase
(1 time)
|
Neoplasms
(1 time)
|
LOH (1 time)
NHERF1 (1 time)
PDGFR (1 time)
|
2008 Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells.
|
| 25 |
PHB in phophatidylinositol-3-kinase
(1 time)
|
Biochemistry
(1 time)
|
ERK (1 time)
MAPK (1 time)
TGF-beta (1 time)
|
2010 The role of prohibitin in cell signaling.
|
| 26 |
Phosphatidyl-inositol-3,4,5-triphosphate 3-phosphatase and phosphatidylinositol-3 kinase
(1 time)
|
Behavioral Sciences
(1 time)
|
CFC (1 time)
DDR2 (1 time)
PP2A (1 time)
|
2014 Networks of protein kinases and phosphatases in the individual phases of contextual fear conditioning in the C57BL/6J mouse.
|
| 27 |
phosphatidylinositol 3-kinase/serine/threonine kinase
(1 time)
|
Complementary Therapies
(1 time)
|
ELISA (1 time)
ERalpha (1 time)
ERP (1 time)
|
2015 [Effects of acupuncture on PI3K/Akt/mTOR signaling pathway in rats with premature ovarian failure].
|
| 28 |
phosphatidylinositol tallow alcohol 3-kinase
(1 time)
|
Reproductive Medicine
(1 time)
|
DA (1 time)
NO (1 time)
p-AKT (1 time)
|
2017 Icariin improves the sexual function of male mice through the PI3K/AKT/eNOS/NO signalling pathway.
|
| 29 |
phosphatidylinositol-3 kinase p85 subunit
(1 time)
|
Geriatrics
(1 time)
|
CR (1 time)
IRS-1 (1 time)
|
2000 Effect of long-term caloric restriction on GLUT4, phosphatidylinositol-3 kinase p85 subunit, and insulin receptor substrate-1 protein levels in rhesus monkey skeletal muscle.
|
| 30 |
phospho-PI3 kinase
(1 time)
|
|
MCAO (1 time)
MDA (1 time)
Nrf2 (1 time)
|
2017 RhGLP-1 (7-36) protects diabetic rats against cerebral ischemia-reperfusion injury via up-regulating expression of Nrf2/HO-1 and increasing the activities of SOD.
|
| 31 |
phosphocreatine 3- kinase
(1 time)
|
Medicine
(1 time)
|
PI3Kdelta (1 time)
|
2021 A Review of Phosphocreatine 3 Kinase delta Subtype (PI3Kdelta) and Its Inhibitors in Malignancy.
|
| 32 |
Phosphoenolpyruvate 3-kinases
(1 time)
|
Pharmacology
(1 time)
|
GLUT1 (1 time)
INSR (1 time)
IRS-1 (1 time)
|
2013 Regulation effects of TZQ-F on adipocyte differentiation and insulin action.
|
| 33 |
phosphoinositide 3'-hydroxykinase
(1 time)
|
Biochemistry
(1 time)
|
DMPM (1 time)
PI (1 time)
PIP (1 time)
|
1995 Interfacial catalysis by phosphoinositide 3'-hydroxykinase.
|
| 34 |
Phosphoinositide 3-kinase Class I
(1 time)
|
|
CSC (1 time)
EMT (1 time)
TICs (1 time)
|
2018 Role of Akt Isoforms Controlling Cancer Stem Cell Survival, Phenotype and Self-Renewal.
|
| 35 |
phosphoinositide 3-kinase-related protein kinase
(1 time)
|
Chemistry
(1 time)
|
CP (1 time)
EMT (1 time)
NF-B (1 time)
|
2020 Association of the Epithelial-Mesenchymal Transition (EMT) with Cisplatin Resistance.
|
| 36 |
phosphoinositide 3-kinase/protein kinase B
(1 time)
|
Medicine
(1 time)
|
Cyto C (1 time)
TBI (1 time)
|
2012 Salidroside improves behavioral and histological outcomes and reduces apoptosis via PI3K/Akt signaling after experimental traumatic brain injury.
|
| 37 |
phosphoinositide 3kinaserelated kinase
(1 time)
|
Neoplasms
(1 time)
|
elF4E (1 time)
GB (1 time)
mTOR (1 time)
|
2021 Targeting the mTOR pathway using novel ATP‑competitive inhibitors, Torin1, Torin2 and XL388, in the treatment of glioblastoma.
|
| 38 |
phosphoinositide3kinase regulatory subunit 1
(1 time)
|
Molecular Biology
(1 time)
|
---
|
2018 MicroRNA‑148a inhibition protects against ovariectomy‑induced osteoporosis through PI3K/AKT signaling by estrogen receptor alpha.
|
| 39 |
phosphoinositides by the classIIphosphatidylinositol 3-kinase
(1 time)
|
Biochemistry
(1 time)
|
PX (1 time)
|
2018 Molecular Basis for Membrane Recruitment by the PX and C2 Domains of Class II Phosphoinositide 3-Kinase-C2alpha.
|
| 40 |
phosphorylation including phosphatidylinositol-3-kinase
(1 time)
|
Reproductive Medicine
(1 time)
|
CaMKII (1 time)
PKA (1 time)
PP1 (1 time)
|
2014 PKA and CaMKII mediate PI3K activation in bovine sperm by inhibition of the PKC/PP1 cascade.
|
| 41 |
phosphorylation levels of SOSTDC1,phosphatidylinositol 3 kinase
(1 time)
|
Medicine
(1 time)
|
ERK (1 time)
MAPK (1 time)
miR (1 time)
|
2021 Impact of microRNA-21-5p on the growth of thyroid cancer cells via targeting the recombinant sclerostin domain containing protein 1.
|
| 42 |
phosphorylation, IRS/phosphatidylinositol 3-kinase
(1 time)
|
Gastroenterology
(1 time)
|
CRP (1 time)
ERK (1 time)
IRS (1 time)
|
2010 C-reactive protein impairs hepatic insulin sensitivity and insulin signaling in rats: role of mitogen-activated protein kinases.
|
| 43 |
PI3 kinase p85
(1 time)
|
Medicine
(1 time)
|
---
|
2021 Poly(I:C)-Induced Mesenchymal Stem Cells Protect the Kidney Against Ischemia/Reperfusion Injury via the TLR3/PI3K Pathway.
|
| 44 |
PI3K activation, we used p85alpha
(1 time)
|
Medicine
(1 time)
|
PKA (1 time)
|
2014 The p85 regulatory subunit of PI3K mediates cAMP-PKA and insulin biological effects on MCF-7 cell growth and motility.
|
| 45 |
PI3K derived from a thymic lymphoma, p65
(1 time)
|
Biology
(1 time)
|
---
|
2000 Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo.
|
| 46 |
PI3K p110delta
(1 time)
|
Pulmonary Medicine
(1 time)
|
BM-Eos (1 time)
|
2012 The p110delta subunit of PI3K regulates bone marrow-derived eosinophil trafficking and airway eosinophilia in allergen-challenged mice.
|
| 47 |
PI3K regulatory subunit, p65
(1 time)
|
Biology
(1 time)
|
---
|
2002 A Role for phosphoinositide 3-kinase in the control of cell division and survival during retinal development.
|
| 48 |
PI3K, AKT, mTOR, PTEN
(1 time)
|
Cell Biology
(1 time)
|
PRMT5 (1 time)
|
2020 Protein Arginine Methyltransferase 5 (PRMT5) and the ERK1/2 & PI3K Pathways: A Case for PRMT5 Inhibition and Combination Therapies in Cancer.
|
| 49 |
PI3K-based immune therapies for transplantation.Phosphatidylinositol-3-kinases
(1 time)
|
Biology
(1 time)
|
---
|
2017 Regulation of T cell alloimmunity by PI3Kgamma and PI3Kdelta.
|
| 50 |
PI3K-C2 alpha
(1 time)
|
Biochemistry
(1 time)
|
PI3Ks (1 time)
|
2002 Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities.
|
| 51 |
PI3K-C2alpha and PI3K-C2beta
(1 time)
|
|
---
|
2003 Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation.
|
| 52 |
PI3K-Deltap85
(1 time)
|
Biochemistry
(1 time)
|
---
|
2004 Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42.
|
| 53 |
PI3K-DN
(1 time)
|
Allergy and Immunology
(1 time)
|
A/E (1 time)
CTL (1 time)
FasL (1 time)
|
2003 Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression.
|
| 54 |
PI3K-H1047R
(1 time)
|
Molecular Biology
(1 time)
|
---
|
2012 Autophagy restricts proliferation driven by oncogenic phosphatidylinositol 3-kinase in three-dimensional culture.
|
| 55 |
PI3K-IR
(1 time)
|
Psychopharmacology
(1 time)
|
ASODN (1 time)
i.c.v (1 time)
MOR (1 time)
|
2003 [Direct involvement of the supraspinal phosphoinositide 3-kinase/phospholipase C gamma 1 pathway in the mu-opioid receptor agonist-induced supraspinal antinociception in the mouse].
|
| 56 |
PI3K/Akt
(1 time)
|
Chemistry
(1 time)
|
Guo (1 time)
|
2021 Neuroprotective Effects of Guanosine in Ischemic Stroke-Small Steps towards Effective Therapy.
|
| 57 |
PI3K/Akt pathway through recruitment of Grb2/Gab2 followed by p85
(1 time)
|
Biochemistry
(1 time)
|
GDNF (1 time)
|
2000 Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase.
|
| 58 |
PI3K/mTOR
(1 time)
|
Molecular Biology
(1 time)
|
NB (1 time)
|
2014 Detection of PI3K inhibition in human neuroblastoma using multiplex luminex bead immunoassay: a targeted approach for pathway analysis.
|
| 59 |
PI3K/PTEN signaling axis through dual regulation of both p110
(1 time)
|
Cell Biology
(1 time)
|
---
|
2010 p85 plays a critical role in controlling flux through the PI3K/PTEN signaling axis through dual regulation of both p110 (PI3K) and PTEN.
|
| 60 |
PI3Kalpha
(1 time)
|
Neoplasms
(1 time)
|
PDAC (1 time)
|
2019 Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer.
|
| 61 |
PI3Kbeta
(1 time)
|
Hematology
(1 time)
|
---
|
2012 The proline-rich tyrosine kinase Pyk2 regulates platelet integrin alphaIIbbeta3 outside-in signaling.
|
| 62 |
PI3KCA
(1 time)
|
Geriatrics
(1 time)
|
DEGs (1 time)
MI/R (1 time)
|
2021 The protective effect of allicin on myocardial ischemia-reperfusion by inhibition of Ca2+ overload-induced cardiomyocyte apoptosis via the PI3K/GRK2/PLC-gamma/IP3R signaling pathway.
|
| 63 |
PI3Kdelta
(1 time)
|
Allergy and Immunology
(1 time)
|
CLL (1 time)
|
2019 The PI3K p110delta Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function.
|
| 64 |
PI3Kp110alpha
(1 time)
|
Neoplasms
(1 time)
|
OSCC (1 time)
|
2020 Selective inhibition of PI3K110alpha as a novel therapeutic strategy for cetuximab‑resistant oral squamous cell carcinoma.
|
| 65 |
PIK3CA, AKT1, and PTEN
(1 time)
|
Neoplasms
(1 time)
|
GIST (1 time)
LOH (1 time)
OG (1 time)
|
2019 Driver gene alterations and activated signaling pathways toward malignant progression of gastrointestinal stromal tumors.
|
| 66 |
PIK3CA, AKT1, PIK3CG
(1 time)
|
Neoplasms
(1 time)
|
MCC (1 time)
MCV (1 time)
TIL (1 time)
|
2015 UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas.
|
| 67 |
PIK3CA, TSC1 and ATM
(1 time)
|
Neoplasms
(1 time)
|
NGS (1 time)
PC (1 time)
|
2019 Genetic profiling as a clinical tool in advanced parathyroid carcinoma.
|
| 68 |
PIK3CG, PDK1, PLK1
(1 time)
|
|
AMD (1 time)
ESCs (1 time)
MMP (1 time)
|
2020 Reversed Senescence of Retinal Pigment Epithelial Cell by Coculture With Embryonic Stem Cell via the TGFbeta and PI3K Pathways.
|
| 69 |
PIK3R1 and PIK3CA genes, respectively
(1 time)
|
Neoplasms
(1 time)
|
BRAF (1 time)
OS (1 time)
SNPs (1 time)
|
2017 Impact of phosphoinositide-3-kinase and vitamin D3 nuclear receptor single-nucleotide polymorphisms on the outcome of malignant melanoma patients.
|
| 70 |
prediction identified phosphoinositide-3 kinases
(1 time)
|
Medicine
(1 time)
|
IDD (1 time)
NP (1 time)
|
2013 MiR-27a regulates apoptosis in nucleus pulposus cells by targeting PI3K.
|
| 71 |
Shc-PI-3 kinase
(1 time)
|
Hematology
(1 time)
|
GM-CSF (1 time)
IL-3 (1 time)
SHIP (1 time)
|
2007 The Shc-binding site of the betac subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis.
|
| 72 |
species-phosphoinositide3-kinase
(1 time)
|
Diabetes Mellitus
(1 time)
|
CUR (1 time)
IL (1 time)
TAECs (1 time)
|
2017 Curcumin attenuates high glucose-induced inflammatory injury through the reactive oxygen species-phosphoinositide 3-kinase/protein kinase B-nuclear factor-kappaB signaling pathway in rat thoracic aorta endothelial cells.
|
| 73 |
TNF-alpha-mediated-phosphatidylinositol-3-kinase
(1 time)
|
Chemistry
(1 time)
|
CDDO-Me (1 time)
eNOS (1 time)
NF-kappaB (1 time)
|
2019 CDDO-Me Attenuates Vasogenic Edema and Astroglial Death by Regulating NF-kappaB p65 Phosphorylations and Nrf2 Expression Following Status Epilepticus.
|
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