1 |
phosphatidylinositol 3-kinase
(16784 times)
|
Neoplasms (2937 times)
|
mTOR (1614 times) MAPK (1343 times) ERK (1019 times)
|
1990 Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase.
|
2 |
PI3 kinase
(214 times)
|
Cell Biology (34 times)
|
MAPK (14 times) VEGF (7 times) mTOR (6 times)
|
1996 Carbachol inhibits insulin-stimulated phosphatidylinositol 3-kinase activity in SH-SY5Y neuroblastoma cells.
|
3 |
PIK3CA
(21 times)
|
Neoplasms (8 times)
|
3'-UTR (1 time) AKT1 (1 time) ASM (1 time)
|
2005 PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma.
|
4 |
PI3Kgamma
(7 times)
|
Hematology (2 times)
|
PI3Ks (2 times) ADP (1 time) GPCRs (1 time)
|
1996 Phosphopleckstrin inhibits gbetagamma-activable platelet phosphatidylinositol-4,5-bisphosphate 3-kinase.
|
5 |
phosphatidylinositol 3-kinase-dependent
(4 times)
|
Endocrinology (2 times)
|
MAPK (2 times) NO (2 times) ERK (1 time)
|
2005 Gamma-tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor kappaB activity.
|
6 |
PI3K/AKT/mTOR
(4 times)
|
Neoplasms (3 times)
|
EMT (1 time) PTEN (1 time) T-ALLs (1 time)
|
2015 Targeting drivers of melanoma with synthetic small molecules and phytochemicals.
|
7 |
PIK3R1
(4 times)
|
Molecular Biology (1 time)
|
GO (1 time) HFD (1 time) lepa (1 time)
|
2014 Transcriptional activation of PIK3R1 by PPARgamma in adipocytes.
|
8 |
p-PI3K
(2 times)
|
Communicable Diseases (1 time)
|
ABCA1 (1 time)
|
2018 microRNA-107 inhibits gastric cancer cell proliferation and metastasis by targeting PI3K/AKT pathway.
|
9 |
pan-PI3K inhibitors
(2 times)
|
Neoplasms (1 time)
|
BC (1 time) ER (1 time) mTOR (1 time)
|
2014 Managing postmenopausal women with hormone receptor-positive advanced breast cancer who progress on endocrine therapies with inhibitors of the PI3K pathway.
|
10 |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
(2 times)
|
Neoplasms (1 time)
|
MYOD1 (2 times) GAS5 (1 time) HIF1A (1 time)
|
2014 Insulin acutely triggers transcription of Slc2a4 gene: participation of the AT-rich, E-box and NFKB-binding sites.
|
11 |
PI3K-C2beta
(2 times)
|
Cell Biology (1 time)
|
HCV (1 time) LPA (1 time) PtdIns3P (1 time)
|
2005 Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration.
|
12 |
PtdIns-3-kinase
(2 times)
|
Biotechnology (1 time)
|
FGF (1 time) MAPK (1 time) PI3,4,5P3 (1 time)
|
2007 Opposed growth factor signals control protein degradation in muscles of Caenorhabditis elegans.
|
13 |
(KIT)-phosphoinositol 3 kinase
(1 time)
|
Cell Biology (1 time)
|
dpp (1 time) mTORC1 (1 time)
|
2017 MAPK3/1 participates in the activation of primordial follicles through mTORC1-KITL signaling.
|
14 |
3-phosphoinositide-dependent kinase-1
(1 time)
|
Medicine (1 time)
|
CHBP (1 time) FOXO3a (1 time) IRI (1 time)
|
2015 Cyclic helix B peptide inhibits ischemia reperfusion-induced renal fibrosis via the PI3K/Akt/FoxO3a pathway.
|
15 |
alpha5beta1-phosphatidylinositol-3-kinase
(1 time)
|
Biomedical Engineering (1 time)
|
Gel-HA (1 time) PDA (1 time) RD (1 time)
|
2018 Mussel-inspired injectable hydrogel and its counterpart for actuating proliferation and neuronal differentiation of retinal progenitor cells.
|
16 |
EGFR-Ras-PI 3 kinase
(1 time)
|
Antioxidants (1 time)
|
CK2 (1 time) EGFR (1 time) ER (1 time)
|
2019 Mechanism of Rapid Nuclear Factor-E2-Related Factor 2 (Nrf2) Activation via Membrane-Associated Estrogen Receptors: Roles of NADPH Oxidase 1, Neutral Sphingomyelinase 2 and Epidermal Growth Factor Receptor (EGFR).
|
17 |
G(alpha)(i3)-Gbetagamma-phosphoinositide 3-kinase
(1 time)
|
Molecular Biology (1 time)
|
INSL3 (1 time) RXFP (1 time)
|
2008 Relaxin family peptide receptor (RXFP1) coupling to G(alpha)i3 involves the C-terminal Arg752 and localization within membrane Raft Microdomains.
|
18 |
Gi-Gbetagamma-phosphoinositide 3-kinase
(1 time)
|
Drug Therapy (1 time)
|
beta-AR (1 time) CaMKII (1 time) CHF (1 time)
|
2005 Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling.
|
19 |
KL-Kit-PI3 kinase
(1 time)
|
Endocrinology (1 time)
|
GSK-3 (1 time)
|
2007 Phosphorylation and inactivation of glycogen synthase kinase-3 by soluble kit ligand in mouse oocytes during early follicular development.
|
20 |
laminin-DGC-Gbetagamma-phosphatidylinositol 3-kinase
(1 time)
|
Cell Biology (1 time)
|
AP-1 (1 time) DGC (1 time) JNK (1 time)
|
2011 Laminin-alpha1 LG4-5 domain binding to dystroglycan mediates muscle cell survival, growth, and the AP-1 and NF-kappaB transcription factors but also has adverse effects.
|
21 |
p-FoxO1, 3-kinase
(1 time)
|
|
MCA (1 time) OAA (1 time) PCK (1 time)
|
2022 Exercise postconditioning reduces ischemic injury via suppression of cerebral gluconeogenesis in rats.
|
22 |
pan-PI3 kinase
(1 time)
|
Pulmonary Medicine (1 time)
|
BAL (1 time) IPF (1 time) mTOR (1 time)
|
2016 Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF.
|
23 |
pathway, the inositol-3 phosphate kinase
(1 time)
|
Cell Biology (1 time)
|
---
|
2009 Cyclin A2 confers cisplatin resistance to endometrial carcinoma cells via up-regulation of an Akt-binding protein, periplakin.
|
24 |
pathways andPhosphoinositide 3-kinases
(1 time)
|
Neoplasms (1 time)
|
ERK (1 time) GI50 (1 time) GLI1 (1 time)
|
2022 GANT61/BI-847325 combination: a new hope in lung cancer treatment.
|
25 |
pathways, i.e., phosphoinositol-3 kinase
(1 time)
|
Hormones (1 time)
|
HIF-1alpha (1 time)
|
2015 Adipose tissue dysfunction and its effects on tumor metabolism.
|
26 |
PDGF-initiated phosphoinositide-3 kinase
(1 time)
|
Neoplasms (1 time)
|
LOH (1 time) NHERF1 (1 time) PDGFR (1 time)
|
2008 Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells.
|
27 |
PHB in phophatidylinositol-3-kinase
(1 time)
|
Biochemistry (1 time)
|
ERK (1 time) MAPK (1 time) TGF-beta (1 time)
|
2010 The role of prohibitin in cell signaling.
|
28 |
Phosphatidyl-inositol-3,4,5-triphosphate 3-phosphatase and phosphatidylinositol-3 kinase
(1 time)
|
Behavioral Sciences (1 time)
|
CFC (1 time) DDR2 (1 time) PP2A (1 time)
|
2014 Networks of protein kinases and phosphatases in the individual phases of contextual fear conditioning in the C57BL/6J mouse.
|
29 |
phosphatidylinositol 3-kinase/serine/threonine kinase
(1 time)
|
Complementary Therapies (1 time)
|
ELISA (1 time) ERalpha (1 time) ERP (1 time)
|
2015 [Effects of acupuncture on PI3K/Akt/mTOR signaling pathway in rats with premature ovarian failure].
|
30 |
phosphatidylinositol tallow alcohol 3-kinase
(1 time)
|
Reproductive Medicine (1 time)
|
DA (1 time) NO (1 time) p-AKT (1 time)
|
2017 Icariin improves the sexual function of male mice through the PI3K/AKT/eNOS/NO signalling pathway.
|
31 |
phosphatidylinositol-3 kinase p85 subunit
(1 time)
|
Geriatrics (1 time)
|
CR (1 time) IRS-1 (1 time)
|
2000 Effect of long-term caloric restriction on GLUT4, phosphatidylinositol-3 kinase p85 subunit, and insulin receptor substrate-1 protein levels in rhesus monkey skeletal muscle.
|
32 |
phospho-PI3 kinase
(1 time)
|
|
MCAO (1 time) MDA (1 time) Nrf2 (1 time)
|
2017 RhGLP-1 (7-36) protects diabetic rats against cerebral ischemia-reperfusion injury via up-regulating expression of Nrf2/HO-1 and increasing the activities of SOD.
|
33 |
phosphocreatine 3- kinase
(1 time)
|
Medicine (1 time)
|
PI3Kdelta (1 time)
|
2021 A Review of Phosphocreatine 3 Kinase delta Subtype (PI3Kdelta) and Its Inhibitors in Malignancy.
|
34 |
Phosphoenolpyruvate 3-kinases
(1 time)
|
Pharmacology (1 time)
|
GLUT1 (1 time) INSR (1 time) IRS-1 (1 time)
|
2013 Regulation effects of TZQ-F on adipocyte differentiation and insulin action.
|
35 |
phosphoinositide 3'-hydroxykinase
(1 time)
|
Biochemistry (1 time)
|
DMPM (1 time) PI (1 time) PIP (1 time)
|
1995 Interfacial catalysis by phosphoinositide 3'-hydroxykinase.
|
36 |
Phosphoinositide 3-kinase Class I
(1 time)
|
|
CSC (1 time) EMT (1 time) TICs (1 time)
|
2018 Role of Akt Isoforms Controlling Cancer Stem Cell Survival, Phenotype and Self-Renewal.
|
37 |
phosphoinositide 3-kinase-related protein kinase
(1 time)
|
Chemistry (1 time)
|
CP (1 time) EMT (1 time) NF-B (1 time)
|
2020 Association of the Epithelial-Mesenchymal Transition (EMT) with Cisplatin Resistance.
|
38 |
phosphoinositide 3-kinase/protein kinase B
(1 time)
|
Medicine (1 time)
|
Cyto C (1 time) TBI (1 time)
|
2012 Salidroside improves behavioral and histological outcomes and reduces apoptosis via PI3K/Akt signaling after experimental traumatic brain injury.
|
39 |
phosphoinositide 3kinaserelated kinase
(1 time)
|
Neoplasms (1 time)
|
elF4E (1 time) GB (1 time) mTOR (1 time)
|
2021 Targeting the mTOR pathway using novel ATP‑competitive inhibitors, Torin1, Torin2 and XL388, in the treatment of glioblastoma.
|
40 |
phosphoinositide3kinase regulatory subunit 1
(1 time)
|
Molecular Biology (1 time)
|
---
|
2018 MicroRNA‑148a inhibition protects against ovariectomy‑induced osteoporosis through PI3K/AKT signaling by estrogen receptor alpha.
|
41 |
phosphoinositides by the classIIphosphatidylinositol 3-kinase
(1 time)
|
Biochemistry (1 time)
|
PX (1 time)
|
2018 Molecular Basis for Membrane Recruitment by the PX and C2 Domains of Class II Phosphoinositide 3-Kinase-C2alpha.
|
42 |
Phosphoinositol-3-kinase enzyme
(1 time)
|
|
PI3Kalpha (1 time) SAR (1 time)
|
2020 Elaborating piperazinyl-furopyrimidine based scaffolds as phosphoinositol-3-kinase enzyme alpha (PI3Kalpha) inhibitors to combat pancreatic cancer.
|
43 |
phospholipids acylinositide 3-kinase
(1 time)
|
Neoplasms (1 time)
|
CCK-8 (1 time) EMT (1 time) RT-PCR (1 time)
|
2022 [Effect of miR1290 on the growth of endometrial cancer and the related mechanism].
|
44 |
phosphorylation including phosphatidylinositol-3-kinase
(1 time)
|
Reproductive Medicine (1 time)
|
CaMKII (1 time) PKA (1 time) PP1 (1 time)
|
2014 PKA and CaMKII mediate PI3K activation in bovine sperm by inhibition of the PKC/PP1 cascade.
|
45 |
phosphorylation levels of SOSTDC1,phosphatidylinositol 3 kinase
(1 time)
|
Medicine (1 time)
|
ERK (1 time) MAPK (1 time) miR (1 time)
|
2021 Impact of microRNA-21-5p on the growth of thyroid cancer cells via targeting the recombinant sclerostin domain containing protein 1.
|
46 |
phosphorylation, IRS/phosphatidylinositol 3-kinase
(1 time)
|
Gastroenterology (1 time)
|
CRP (1 time) ERK (1 time) IRS (1 time)
|
2010 C-reactive protein impairs hepatic insulin sensitivity and insulin signaling in rats: role of mitogen-activated protein kinases.
|
47 |
PI3 kinase p85
(1 time)
|
Medicine (1 time)
|
---
|
2021 Poly(I:C)-Induced Mesenchymal Stem Cells Protect the Kidney Against Ischemia/Reperfusion Injury via the TLR3/PI3K Pathway.
|
48 |
PI3K activation, we used p85alpha
(1 time)
|
Medicine (1 time)
|
PKA (1 time)
|
2014 The p85 regulatory subunit of PI3K mediates cAMP-PKA and insulin biological effects on MCF-7 cell growth and motility.
|
49 |
PI3K derived from a thymic lymphoma, p65
(1 time)
|
Biology (1 time)
|
---
|
2000 Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo.
|
50 |
PI3K p110delta
(1 time)
|
Pulmonary Medicine (1 time)
|
BM-Eos (1 time)
|
2012 The p110delta subunit of PI3K regulates bone marrow-derived eosinophil trafficking and airway eosinophilia in allergen-challenged mice.
|
51 |
PI3K regulatory subunit, p65
(1 time)
|
Biology (1 time)
|
---
|
2002 A Role for phosphoinositide 3-kinase in the control of cell division and survival during retinal development.
|
52 |
PI3K, AKT, mTOR, PTEN
(1 time)
|
Cell Biology (1 time)
|
PRMT5 (1 time)
|
2020 Protein Arginine Methyltransferase 5 (PRMT5) and the ERK1/2 & PI3K Pathways: A Case for PRMT5 Inhibition and Combination Therapies in Cancer.
|
53 |
PI3K-based immune therapies for transplantation.Phosphatidylinositol-3-kinases
(1 time)
|
Biology (1 time)
|
---
|
2017 Regulation of T cell alloimmunity by PI3Kgamma and PI3Kdelta.
|
54 |
PI3K-C2 alpha
(1 time)
|
Biochemistry (1 time)
|
PI3Ks (1 time)
|
2002 Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities.
|
55 |
PI3K-C2alpha and PI3K-C2beta
(1 time)
|
|
---
|
2003 Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation.
|
56 |
PI3K-Deltap85
(1 time)
|
Biochemistry (1 time)
|
---
|
2004 Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42.
|
57 |
PI3K-DN
(1 time)
|
Allergy and Immunology (1 time)
|
A/E (1 time) CTL (1 time) FasL (1 time)
|
2003 Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression.
|
58 |
PI3K-H1047R
(1 time)
|
Molecular Biology (1 time)
|
---
|
2012 Autophagy restricts proliferation driven by oncogenic phosphatidylinositol 3-kinase in three-dimensional culture.
|
59 |
PI3K-IR
(1 time)
|
Psychopharmacology (1 time)
|
ASODN (1 time) i.c.v (1 time) MOR (1 time)
|
2003 [Direct involvement of the supraspinal phosphoinositide 3-kinase/phospholipase C gamma 1 pathway in the mu-opioid receptor agonist-induced supraspinal antinociception in the mouse].
|
60 |
PI3K/Akt
(1 time)
|
Chemistry (1 time)
|
Guo (1 time)
|
2021 Neuroprotective Effects of Guanosine in Ischemic Stroke-Small Steps towards Effective Therapy.
|
61 |
PI3K/Akt pathway through recruitment of Grb2/Gab2 followed by p85
(1 time)
|
Biochemistry (1 time)
|
GDNF (1 time)
|
2000 Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase.
|
62 |
PI3K/mTOR
(1 time)
|
Molecular Biology (1 time)
|
NB (1 time)
|
2014 Detection of PI3K inhibition in human neuroblastoma using multiplex luminex bead immunoassay: a targeted approach for pathway analysis.
|
63 |
PI3K/PTEN signaling axis through dual regulation of both p110
(1 time)
|
Cell Biology (1 time)
|
---
|
2010 p85 plays a critical role in controlling flux through the PI3K/PTEN signaling axis through dual regulation of both p110 (PI3K) and PTEN.
|
64 |
PI3Kalpha
(1 time)
|
Neoplasms (1 time)
|
PDAC (1 time)
|
2019 Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer.
|
65 |
PI3Kbeta
(1 time)
|
Hematology (1 time)
|
---
|
2012 The proline-rich tyrosine kinase Pyk2 regulates platelet integrin alphaIIbbeta3 outside-in signaling.
|
66 |
PI3KCA
(1 time)
|
Geriatrics (1 time)
|
DEGs (1 time) MI/R (1 time)
|
2021 The protective effect of allicin on myocardial ischemia-reperfusion by inhibition of Ca2+ overload-induced cardiomyocyte apoptosis via the PI3K/GRK2/PLC-gamma/IP3R signaling pathway.
|
67 |
PI3Kdelta
(1 time)
|
Allergy and Immunology (1 time)
|
CLL (1 time)
|
2019 The PI3K p110delta Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function.
|
68 |
PI3Kp110alpha
(1 time)
|
Neoplasms (1 time)
|
OSCC (1 time)
|
2020 Selective inhibition of PI3K110alpha as a novel therapeutic strategy for cetuximab‑resistant oral squamous cell carcinoma.
|
69 |
PIK3CA, AKT1, and PTEN
(1 time)
|
Neoplasms (1 time)
|
GIST (1 time) LOH (1 time) OG (1 time)
|
2019 Driver gene alterations and activated signaling pathways toward malignant progression of gastrointestinal stromal tumors.
|
70 |
PIK3CA, AKT1, PIK3CG
(1 time)
|
Neoplasms (1 time)
|
MCC (1 time) MCV (1 time) TIL (1 time)
|
2015 UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas.
|
71 |
PIK3CA, TSC1 and ATM
(1 time)
|
Neoplasms (1 time)
|
NGS (1 time) PC (1 time)
|
2019 Genetic profiling as a clinical tool in advanced parathyroid carcinoma.
|
72 |
PIK3CG, PDK1, PLK1
(1 time)
|
|
AMD (1 time) ESCs (1 time) MMP (1 time)
|
2020 Reversed Senescence of Retinal Pigment Epithelial Cell by Coculture With Embryonic Stem Cell via the TGFbeta and PI3K Pathways.
|
73 |
PIK3R1 and PIK3CA genes, respectively
(1 time)
|
Neoplasms (1 time)
|
BRAF (1 time) OS (1 time) SNPs (1 time)
|
2017 Impact of phosphoinositide-3-kinase and vitamin D3 nuclear receptor single-nucleotide polymorphisms on the outcome of malignant melanoma patients.
|
74 |
prediction identified phosphoinositide-3 kinases
(1 time)
|
Medicine (1 time)
|
IDD (1 time) NP (1 time)
|
2013 MiR-27a regulates apoptosis in nucleus pulposus cells by targeting PI3K.
|
75 |
Shc-PI-3 kinase
(1 time)
|
Hematology (1 time)
|
GM-CSF (1 time) IL-3 (1 time) SHIP (1 time)
|
2007 The Shc-binding site of the betac subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis.
|
76 |
species-phosphoinositide3-kinase
(1 time)
|
Diabetes Mellitus (1 time)
|
CUR (1 time) IL (1 time) TAECs (1 time)
|
2017 Curcumin attenuates high glucose-induced inflammatory injury through the reactive oxygen species-phosphoinositide 3-kinase/protein kinase B-nuclear factor-kappaB signaling pathway in rat thoracic aorta endothelial cells.
|
77 |
TNF-alpha-mediated-phosphatidylinositol-3-kinase
(1 time)
|
Chemistry (1 time)
|
CDDO-Me (1 time) eNOS (1 time) NF-kappaB (1 time)
|
2019 CDDO-Me Attenuates Vasogenic Edema and Astroglial Death by Regulating NF-kappaB p65 Phosphorylations and Nrf2 Expression Following Status Epilepticus.
|