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Abbreviation: a,d
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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo
(153 times)
Neurology
(65 times)
NMDA (83 times)
CNQX (16 times)
AMPA (15 times)
1987 MK-801 blocks NMDA receptor-mediated synaptic transmission and long term potentiation in rat hippocampal slices.
affect the binding of (3H)(+)-5-methyl-10,11-dihydro-5H-dibenzo
(4 times)
Chemistry
(2 times)
NMDA (4 times)
AMPA (1 time)
Glu (1 time)
1993 Excitatory amino acid receptor binding in hippocampus of gerbils with transient global brain ischemia.
antagonists, DL-2-amino-5-phosphonovaleric acid and (+)-5-methyl-10,11-dihydro-5H-dibenzo
(4 times)
Neurology
(3 times)
AMPA (1 time)
AP5 (1 time)
AP7 (1 time)
1990 Role of excitatory amino acid receptors in K+- and glutamate-evoked release of endogenous adenosine from rat cortical slices.
N-methyl-D-aspartate (NMDA) receptor, (5R,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo
(4 times)
Pharmacology
(2 times)
AMPA (2 times)
NMDA (2 times)
CNQX (1 time)
1992 NMDA-receptor blockers but not NBQX, an AMPA-receptor antagonist, inhibit spreading depression in the rat brain.
acid (D-AP5) and (+)-5-methyl-10,11-dihydro-5-H-dibenzo
(3 times)
Pharmacology
(2 times)
D-AP5 (3 times)
NMDA (3 times)
AMPA (1 time)
1992 N-methyl-D-aspartic acid (NMDA) and non-NMDA receptors regulating hippocampal norepinephrine release. II. Evidence for functional cooperation and for coexistence on the same axon terminal.
4-amine (3-N,N-dimethylpropylamine)-10,11-dihydro-5H-dibenzo
(2 times)
Psychopharmacology
(1 time)
ADDCH2 (2 times)
FST (1 time)
TST (1 time)
2007 Antidepressant-like profile of action of two 4-amine derivatives of 10,11-dihydro-5H-dibenzo [a,d] cycloheptane in mice evaluated in the forced swimming test.
4-amine derivatives of 10,11-dihydro-5H-dibenzo
(2 times)
Psychopharmacology
(1 time)
ADDCH2 (2 times)
FST (1 time)
TST (1 time)
2007 Antidepressant-like profile of action of two 4-amine derivatives of 10,11-dihydro-5H-dibenzo [a,d] cycloheptane in mice evaluated in the forced swimming test.
5-aminocarbonyl-10, 11-dihydro-5h-dibenzo
(2 times)
Psychopharmacology
(2 times)
NMDA (1 time)
1994 Evaluation of ADCI against convulsant and locomotor stimulant effects of cocaine: comparison with the structural analogs dizocilpine and carbamazepine.
5-aminodibenzo
(2 times)
Pharmacology
(2 times)
--- 1972 Hydrolysis of certain 5-aminodibenzo[a,d]cycloheptanes.
10  analogues of (+-)-10,11-dihydro-5H-dibenzo
(2 times)
Chemistry
(1 time)
NMDA (1 time)
1990 Synthesis and structure-activity relationship of C5-substituted analogues of (+-)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine [(+-)-desmethyl-MK801]: ligands for the NMDA receptor-coupled phencyclidine binding site.
11  antagonist (+-)-5-aminocarbonyl-10,11-dihydro-5H-dibenzo
(2 times)
Drug Therapy
(2 times)
NMDA (1 time)
1991 Anticonvulsant activity of the low-affinity uncompetitive N-methyl-D- aspartate antagonist (+-)-5-aminocarbonyl-10,11-dihydro-5H- dibenzo[a,d]cyclohepten-5,10-imine (ADCI): comparison with the structural analogs dizocilpine (MK-801) and carbamazepine.
12  disposition and metabolism of (+)-5-methyl-10,11-dihydro-5H-dibenzo
(2 times)
Pharmacology
(1 time)
rat (1 time)
1983 Disposition and metabolism of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine in rats, dogs, and monkeys.
13  (5-dibenzosuberyl) and 5H-dibenzo
(1 time)
Biochemistry
(1 time)
--- 1997 New mild acid-labile protecting groups for the guanidino function of N alpha-fluorenylmethoxycarbonyl-L-arginine in solid-phase peptide synthesis: 10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl, 2-methoxy-10,11-dihydoro-5H-dibenzo[a,d]cyclohepten-5-yl and 5H-dibenzo[a,d]cyclohepten-5-yl groups.
14  1-amino-3,5-dimethyladamantane (memantine) and (+)-5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Biochemistry
(1 time)
NMDA (1 time)
2008 Ca2+ inhibits the association of memantine with N-methyl-D-aspartate (NMDA) receptor-gated ion channels.
15  1-N-methylamino-3,5-dimethyl-adamantane as well as (+)-5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Pharmacology
(1 time)
ScN2 a cells (1 time)
1993 Cytoprotective effect of NMDA receptor antagonists on prion protein (PrionSc)-induced toxicity in rat cortical cell cultures.
16  2-substituted-5-aminomethyl-10,11-dihydrodibenzo
(1 time)
Biochemistry
(1 time)
AMDH (2 times)
2003 Ring substituted analogues of 5-aminomethyl-10,11-dihydro-dibenzo[a,d]cycloheptene (AMDH): potential modes of binding to the 5-HT(2A) receptor.
17  3-ASP plus diazepam, 5S,10R-(+)-5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Brain
(1 time)
3-ASP (1 time)
AA (1 time)
AChE (1 time)
2009 Anticonvulsant and antioxidant effects of 3-alkynyl selenophene in 21-day-old rats on pilocarpine model of seizures.
18  3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline) and MK-801 (dizocilpine, (+)-5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Brain
(1 time)
--- 1999 Postmortem elevation in extracellular glutamate in the rat hippocampus when brain temperature is maintained at physiological levels: implications for the use of human brain autopsy tissues.
19  5-amino-5H-dibenzo
(1 time)
Chemistry
(1 time)
--- 2004 Amine olefin rhodium(I) complexes: pKa and NH bond strength.
20  5-aminomethyl-10,11-dihydro-dibenzo
(1 time)
Biochemistry
(1 time)
AMDH (2 times)
2003 Ring substituted analogues of 5-aminomethyl-10,11-dihydro-dibenzo[a,d]cycloheptene (AMDH): potential modes of binding to the 5-HT(2A) receptor.
21  7-Chloro-5-cyclo-propyl-9-methyl-5H-4,5,6,10-tetra-aza-dibenzo
(1 time)
Crystallography
(1 time)
--- 2011 7-Chloro-5-cyclo-propyl-9-methyl-5H-4,5,6,10-tetra-aza-dibenzo[a,d]cyclo-hepten-11(10H)-one.
22  ability to displace (+)-10,11-dihydro-5-methyl-5H-dibenzo
(1 time)
Chemistry
(1 time)
NMDA (1 time)
1990 Synthesis and pharmacological evaluation of a series of dibenzo[a,d]cycloalkenimines as N-methyl-D-aspartate antagonists.
23  Ac-D-10,11-dihydro-5H-dibenzo
(1 time)
Pharmacology
(1 time)
--- 2000 Enhanced endothelin ET(B) receptor down-regulation in human tumor cells.
24  accomplished via alkylation of (+-)-10,11-dihydro-5H-dibenzo
(1 time)
Nuclear Medicine
(1 time)
--- 1990 Synthesis of 11C-labeled (+-)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imin e [(+-)-[11C]MK801].
25  achieved by injection of (+)-5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Brain
(1 time)
AD (1 time)
APH (1 time)
CSD (1 time)
1992 The effect of glutamate receptor blockade on anoxic depolarization and cortical spreading depression.
26  acid (CPP), 0.1 mg/kg (+)5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Behavioral Sciences
(1 time)
CPP (1 time)
NMDA (1 time)
2000 NMDA glutamate receptor role in the development of context-dependent and independent sensitization of the induction of stereotypy by amphetamine or apomorphine.
27  acid receptors by 5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Neurology
(1 time)
CNQX (1 time)
2000 Inhibition of Na(+),K(+)-ATPase activity in cultured rat cerebellar granule cells prevents the onset of apoptosis induced by low potassium.
28  acid receptors, such as (3H)(+)-5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Chemistry
(1 time)
NMDA (1 time)
1993 Potentiation by polyamines of an interaction of noncompetitive antagonists at the N-methyl-D-aspartate receptor ionophore complex with phosphatidylserine.
29  acid to give quantitatively 10-phenyl-5H-dibenzo
(1 time)
Chemistry
(1 time)
HPLC (1 time)
PAL (1 time)
PALs (1 time)
2006 Chiral phosphane alkenes (PALs): simple synthesis, applications in catalysis, and functional hemilability.
30  acid, ifenprodil, memantine, (5R,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Drug Therapy
(1 time)
HEK (1 time)
NMDA (1 time)
2007 Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits.
31  ACPC enhanced 3H-labelled (+)-5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Chemistry
(1 time)
ACPC (1 time)
1989 1-Aminocyclopropane carboxylic acid: a potent and selective ligand for the glycine modulatory site of the N-methyl-D-aspartate receptor complex.
32  active compounds were 10,11-dihydro-5H-dibenzo
(1 time)
Chemistry
(1 time)
--- 1979 Dibenzotropone- and dibenzosuberonecarboxylic acids with bronchodilator activity.
33  administering glutamate receptor antagonists, (+)-5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Anatomy
(1 time)
ALS (1 time)
CNQX (1 time)
MN (1 time)
2013 Differential pattern of neuroprotection in lumbar, cervical and thoracic spinal cord segments in an organotypic rat model of glutamate-induced excitotoxicity.
34  administration of (+)-10,11-dihydro-5-methyl-5H-dibenzo
(1 time)
Neurology
(1 time)
ACh (1 time)
NMDA (1 time)
1993 MK-801 increases endogenous acetylcholine release in the rat parietal cortex: a study using brain microdialysis.
35  affinity ligand, (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Chemistry
(1 time)
--- 1994 An electrophilic affinity ligand based on (+)-MK801 distinguishes PCP site 1 from PCP site 2.
36  affinity toward the receptor: (3H)(+)-5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Pharmacology
(1 time)
NMDA (1 time)
1990 Distinctive structural requirement for the binding of uncompetitive blockers (phencyclidine-like drugs) to the NMDA receptor.
37  afford dibenzo
(1 time)
Biochemistry
(1 time)
--- 2019 Synthesis of dibenzo[a,d]cycloheptanoids via aryne insertion into 2-arylidene-1,3-indandiones.
38  aliphatic-substituted L
(1 time)
Molecular Biology
(1 time)
ATP (1 time)
2003 Recognition promoted by Zn2+ between phenanthroline bridging polyaza ligands and nucleotides--Zn2+ acts as 'messenger' between the receptor and substrate.
39  alkylamides, characterized by a dibenzo
(1 time)
Chemistry
(1 time)
MLT (1 time)
2004 Tricyclic alkylamides as melatonin receptor ligands with antagonist or inverse agonist activity.
40  alkylidenedibenzo
(1 time)
Chemistry
(1 time)
--- 2015 Construction of dibenzo-fused seven- to nine-membered carbocycles via Bronsted acid-promoted intramolecular Friedel-Crafts-type alkenylation.
41  amygdala kindled seizure, (3H)(+)-5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Brain
(1 time)
EAA (1 time)
NMDA (1 time)
1992 Ionotropic excitatory amino acid receptors in discrete brain regions of kindled rats.
42  analysis of 10,10',11,11'-tetrahydro-5,5'-bidibenzo
(1 time)
Chemistry
(1 time)
AIE (1 time)
BDBA (1 time)
RIM (1 time)
2014 Restriction of intramolecular motions: the general mechanism behind aggregation-induced emission.
43  antagonist 10,11-dihydro-5-methyl-5H-dibenzo
(1 time)
Drug Therapy
(1 time)
AMPA (1 time)
CNQX (1 time)
CYZ (1 time)
2001 Insights into the mechanisms of ifosfamide encephalopathy: drug metabolites have agonistic effects on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors and induce cellular acidification in mouse cortical neurons.
44  antagonists 6,7-initroquinoxaline-2,3-dione (DNQX) or (5R,2S)-(1)-5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Chemistry
(1 time)
DNQX (1 time)
SVCT-2 (1 time)
2009 Glutamate receptors modulate sodium-dependent and calcium-independent vitamin C bidirectional transport in cultured avian retinal cells.
45  antagonists having dibenzo
(1 time)
Chemistry
(1 time)
--- 1995 Novel angiotensin II receptor antagonists. Design, synthesis, and in vitro evaluation of dibenzo[a,d]cycloheptene and dibenzo[b,f]oxepin derivatives. Searching for bioisosteres of biphenylyltetrazole using a three-dimensional search technique.
46  antagonists phencyclidine or 5R,10S-(+)-5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Pharmacology
(1 time)
AMPA (1 time)
d-CPPene (1 time)
GABA (1 time)
2009 Pharmacological characterization of harmaline-induced tremor activity in mice.
47  antagonists, gamma-D-glutamylamino-methylsulfonate (GAMS) or (+)-5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Cell Biology
(1 time)
GAMS (1 time)
GMP (1 time)
KA (1 time)
2002 Neuroprotective effect of GMP in hippocampal slices submitted to an in vitro model of ischemia.
48  anticataleptic effect of (+)-5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Pharmacology
(1 time)
NMDA (1 time)
1997 MK 801 reverses haloperidol-induced catalepsy from both striatal and extrastriatal sites in the rat brain.
49  anticonvulsant 10,11-dihydro-5H-dibenzo
(1 time)
Biochemistry
(1 time)
--- 1971 Metabolism of the anticonvulsant 10,11-dihydro-5H-dibenzo(a,d)cycloheptene-5-carboxamide. I. Metabolic fate of (14C)cyheptamide in animals and man.
50  assay for (3H)(+)-5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Pharmacology
(1 time)
--- 1996 Pharmacological characterization of [3H]MK-801 binding in the rat spinal cord.
51  autoradiography, using tritiated 5-methyl-10, 11-dihydro-5H-dibenzo
(1 time)
Brain
(1 time)
ALA (1 time)
NMDA (1 time)
2005 Effect of delta-aminolevulinic acid treatment on N-methyl-D-aspartate receptor at different ages in the rat brain.
52  D-2-amino-5-phosphonopentanoate (D-AP5), Mg2+, (+)-5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Pharmacology
(1 time)
7-Cl-KYNA (1 time)
D-AP5 (1 time)
NMDA (1 time)
1990 Release-enhancing glycine-dependent presynaptic NMDA receptors exist on noradrenergic terminals of hippocampus.
53  D-2-amino-7-phosphonoheptanoate, dextromethorphan and (+)-5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Neurology
(1 time)
NMDA (1 time)
1989 N-methyl-D-aspartate promotes the survival of cerebellar granule cells: pharmacological characterization.
54  di- and sesterterpenes with dicyclopenta
(1 time)
Biology
(1 time)
--- 2005 Studies towards the total synthesis of di- and sesterterpenes with dicyclopenta[a,d]cyclooctane skeletons. Three-component approach to the A/B rings building block.
55  N-methyl-d-aspartate (NMDA) receptor blocker (+)-10,11-dihydro-5-methyl-5H-dibenzo
(1 time)
Behavioral Sciences
(1 time)
DEX (1 time)
EPI (1 time)
GLU (1 time)
1999 Memory-enhancing treatments do not reverse the impairment of inhibitory avoidance retention induced by NMDA receptor blockade.
56  N-methyl-D-aspartate (NMDA) receptors, cyclopentenophenanthrene, (+)-5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Drug Therapy
(1 time)
CO (1 time)
NMDA (1 time)
1992 Effects of N-methyl-D-aspartate receptor antagonists on carbon monoxide-induced brain damage in mice.
57  receptor-associated 5-methyl-10,11-dihydro-5H-dibenzo
(1 time)
Chemistry
(1 time)
--- 1990 (+)-[3H]MK-801 binding sites in postmortem human brain.