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Abbreviation: hTERT
Appearance Frequency: 1852 time(s)
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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
human telomerase reverse transcriptase
(1668 times)
Neoplasms
(525 times)
RT-PCR (100 times)
TRAP (71 times)
hTR (60 times)
1998 Telomerase activity exclusively in cervical carcinomas and a subset of cervical intraepithelial neoplasia grade III lesions: strong association with elevated messenger RNA levels of its catalytic subunit and high-risk human papillomavirus DNA.
human telomerase catalytic subunit
(82 times)
Neoplasms
(20 times)
RT-PCR (5 times)
hTR (4 times)
TERT (3 times)
1998 Expression of human telomerase subunits and correlation with telomerase activity in urothelial cancer.
human TERT
(39 times)
Molecular Biology
(15 times)
TERT (28 times)
mTERT (4 times)
TR (3 times)
2000 Telomeres, telomerase, and myc. An update.
human catalytic subunit of telomerase
(5 times)
Molecular Biology
(1 time)
AT (1 time)
FLSs (1 time)
OA (1 time)
2000 Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase.
human telomerase RT
(3 times)
Biochemistry
(1 time)
5-FMO (1 time)
CAT (1 time)
DFMO (1 time)
2001 Human telomerase RNA-protein interactions.
here that expression of the catalytic subunit of telomerase
(2 times)
Neoplasms
(2 times)
AT (1 time)
HSP (1 time)
IR (1 time)
2001 Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression.
Here, we characterize the telomerase catalytic subunit
(2 times)
Allergy and Immunology
(1 time)
CTL (1 time)
TAA (1 time)
1999 The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes.
human protein catalytic subunit
(2 times)
Cell Biology
(1 time)
hTR (1 time)
1999 Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro.
human reverse transcriptase subunit
(2 times)
Cell Biology
(1 time)
HFCs (1 time)
hTR (1 time)
2005 Telomere-independent cellular senescence in human fetal cardiomyocytes.
10  human telomerase catalytic subunit, telomerase reverse transcriptase
(2 times)
Urology
(1 time)
LOH (1 time)
siRNA (1 time)
2002 Prospective evaluation of genetic abnormalities and telomerase expression in exfoliated urinary cells for bladder cancer detection.
11  human telomerase promoter
(2 times)
Neoplasms
(2 times)
CPG2 (1 time)
GDEPT (1 time)
2003 Development of a Conditional Replication Competent Adenovirus, Controlled by the Human Telomerase Promoter (hTERT).
12  hand, the induction of telomerase reverse transcriptase
(1 time)
Hematology
(1 time)
AML (1 time)
ITD (1 time)
2018 MYC-dependent downregulation of telomerase by FLT3 inhibitors is required for their therapeutic efficacy on acute myeloid leukemia.
13  have recently described the enzymatic subunit of telomerase
(1 time)
Neoplasms
(1 time)
--- 2008 Telomere maintenance and dysfunction predict recurrence in paediatric ependymoma.
14  have shown that overexpression of telomerase reverse transcriptase
(1 time)
Neoplasms
(1 time)
--- 2006 Telomere-driven karyotypic complexity concurs with p16INK4a inactivation in TP53-competent immortal endothelial cells.
15  HDAC inhibitor, on the telomerase reverse transcriptase
(1 time)
Molecular Biology
(1 time)
HATs (1 time)
HDACs (1 time)
TSA (1 time)
2004 Inhibition of histone deacetylases.
16  here include the telomerase reverse transcriptase
(1 time)
Cell Biology
(1 time)
--- 2002 Universal tumor antigens as targets for immunotherapy.
17  here that the ectopic expression of the telomerase catalytic subunit
(1 time)
Science
(1 time)
--- 1999 Creation of human tumour cells with defined genetic elements.
18  Here we evaluate the role of the telomerase
(1 time)
Genetics, Medical
(1 time)
CRC (1 time)
LS (1 time)
MMR (1 time)
2013 Genetic variant in the telomerase gene modifies cancer risk in Lynch syndrome.
19  Here we report that the telomerase gene
(1 time)
Hematology
(1 time)
ATLL (1 time)
HTLV-I (1 time)
NF-kappaB (1 time)
2004 Transcriptional activation of hTERT through the NF-kappaB pathway in HTLV-I-transformed cells.
20  Here, we investigated the cooperativity of telomerase reverse transcriptase
(1 time)
Neoplasms
(1 time)
AE (1 time)
HSPC (1 time)
2016 Immortalization of human AE pre-leukemia cells by hTERT allows leukemic transformation.
21  Heterozygous carriers for mutations in either the telomerase reverse transcriptase
(1 time)
Genetics
(1 time)
--- 2012 Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes.
22  HGPS patients are frequently resistant to immortalization with telomerase
(1 time)
Genetics
(1 time)
HGPS (2 times)
LMNA (1 time)
2005 Molecular cytogenetic insights into the ageing syndrome Hutchinson-Gilford Progeria (HGPS).
23  High-level expression of the telomerase reverse transcriptase
(1 time)
Neoplasms
(1 time)
--- 2004 Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes.
24  histone deacetylase inhibitor trichostatin A derepresses the telomerase reverse transcriptase
(1 time)
Cell Biology
(1 time)
HDAC (1 time)
TSA (1 time)
2002 The histone deacetylase inhibitor trichostatin A derepresses the telomerase reverse transcriptase (hTERT) gene in human cells.
25  homology to the human ortholog
(1 time)
Molecular Biology
(1 time)
mTERT (1 time)
1998 Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation.
26  hormones, separately increases telomerase
(1 time)
Medicine
(1 time)
--- 2017 Synergistic Effects of Resistin and Visfatin as Adipocyte Derived Hormones on Telomerase Gene Expression in AGS Gastric Cancer Cell Line.
27  Hotspot activating mutations of the telomerase reverse transcriptase
(1 time)
Pathology
(1 time)
--- 2017 Study of hTERT and Histone 3 Mutations in Medulloblastoma.
28  HPV-16 E6, E7, and the reverse transcriptase component of telomerase
(1 time)
Virology
(1 time)
HPV (1 time)
2005 Amplification of the chromosome 20q region is associated with expression of HPV-16 E7 in human airway and anogenital epithelial cells.
29  hTERT gene mRNA
(1 time)
Neoplasms
(1 time)
TP1 (1 time)
2001 Clinicopathologic significance of telomerase activity and hTERT mRNA expression in non-small cell lung cancer.
30  hTERT promoter
(1 time)
General Surgery
(1 time)
cHCC-CCA (1 time)
CLC (1 time)
DPM (1 time)
2019 Cholangiolocellular Carcinoma With "Ductal Plate Malformation" Pattern May Be Characterized by ARID1A Genetic Alterations.
31  human catalytic fraction of reverse telomerase
(1 time)
Neoplasms
(1 time)
AFP (1 time)
ELISA (1 time)
HCC (1 time)
2008 PAI-1, t-PA and circulating hTERT DNA as related to virus infection in liver carcinogenesis.
32  human catalytic subunit of telomerase, the reverse transcriptase
(1 time)
Radiology
(1 time)
--- 2004 Reconstitution of active telomerase in primary human foreskin fibroblasts: effects on proliferative characteristics and response to ionizing radiation.
33  human diploid fibroblasts expressing telomerase
(1 time)
Biochemistry
(1 time)
--- 2006 Identification of p38MAPK-dependent genes with changed transcript abundance in H2O2-induced premature senescence of IMR-90 hTERT human fibroblasts.
34  human fibroblasts require telomerase reverse transcriptase
(1 time)
Neoplasms
(1 time)
ALT (1 time)
2005 Immortal ALT+ human cells do not require telomerase reverse transcriptase for malignant transformation.
35  human fibroblasts that were transduced with telomerase reverse transcriptase
(1 time)
Molecular Biology
(1 time)
--- 2009 Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase.
36  Human gastric cancer MKN-45 telomerase reverse transcriptase
(1 time)
Complementary Therapies
(1 time)
--- 2010 Study on the mechanism of xiaotan sanjie recipe for inhibiting proliferation of gastric cancer cells.
37  human keratocytes and in telomerase
(1 time)
Ophthalmology
(1 time)
alpha-SMA (1 time)
PDGF (1 time)
2003 Myofibroblast differentiation of normal human keratocytes and hTERT, extended-life human corneal fibroblasts.
38  human reverse transcriptase telomerase
(1 time)
Genomics
(1 time)
--- 2016 Therapeutic Targeting of Telomerase.
39  Human telomerase comprises a catalytic protein subunit
(1 time)
Pathology
(1 time)
--- 2008 Cytoplasmic expression of human telomerase catalytic protein (hTERT) in neutrophils: an immunoelectron microscopy study.
40  Human telomerase consists minimally of a catalytic protein
(1 time)
Biochemistry
(1 time)
--- 2006 The biochemical role of the heat shock protein 90 chaperone complex in establishing human telomerase activity.
41  human telomerase protein
(1 time)
Science
(1 time)
--- 2011 Separation of telomerase functions by reverse genetics.
42  human telomerase transfected immortalized
(1 time)
Biotechnology
(1 time)
--- 2009 A hierarchical response of cells to perpendicular micro- and nanometric textural cues.
43  Human telomerase, a cellular reverse transcriptase
(1 time)
Science
(1 time)
APL (1 time)
ATRA (1 time)
RAR (1 time)
2001 Retinoids down-regulate telomerase and telomere length in a pathway distinct from leukemia cell differentiation.
44  human TERT gene
(1 time)
Medicine
(1 time)
HPV (1 time)
Pap (1 time)
PCR (1 time)
2017 Correlation of hTERT Expression with Cervical Cytological Abnormalities and Human Papillomavirus Infection.
45  human TERT gene promoter
(1 time)
Biological Science Disciplines
(1 time)
5FC (1 time)
ARE (1 time)
2017 A Novel Hybrid Promoter ARE-hTERT for Cancer Gene Therapy.
46  human TERT protein
(1 time)
Neoplasms
(1 time)
alTERC (1 time)
CR4 (1 time)
mTERC (1 time)
2016 Expression of functional alternative telomerase RNA component gene in mouse brain and in motor neurons cells protects from oxidative stress.
47  human tumors activate the catalytic component of telomerase
(1 time)
Molecular Biology
(1 time)
--- 2005 Telomere maintenance and tumorigenesis: an "ALT"ernative road.
48  human tumors stabilize their telomeres through activation of telomerase
(1 time)
Biochemistry
(1 time)
ALT (1 time)
2008 Alternative lengthening of telomeres (ALT) and chromatin: is there a connection?
49  human tumors the gene of the key subunit of telomerase
(1 time)
Biochemistry
(1 time)
--- 2003 The tumor cell and telomerase.
50  human uterine myocyte cell line
(1 time)
Endocrinology
(1 time)
CASP3 (1 time)
2012 Antiapoptotic signaling via MCL1 confers resistance to caspase-3-mediated apoptotic cell death in the pregnant human uterine myocyte.
51  humans, the enzyme telomerase
(1 time)
Molecular Biology
(1 time)
PER (1 time)
2011 Transcriptional repression by the proximal exonic region at the human TERT gene.
52  humans, the protein component
(1 time)
Molecular Biology
(1 time)
shRNA (1 time)
siRNA (1 time)
TERT (1 time)
2014 Global expression profile of telomerase-associated genes in HeLa cells.
53  humans, this enzyme is composed of the telomerase reverse transcriptase
(1 time)
Biochemistry
(1 time)
NoLD (1 time)
RNPs (1 time)
2002 The nucleolar localization domain of the catalytic subunit of human telomerase.
54  mechanism, telomerase enzymatic activity and telomerase reverse transcriptase
(1 time)
Hematology
(1 time)
MDS (1 time)
2013 Naive T-cells in myelodysplastic syndrome display intrinsic human telomerase reverse transcriptase (hTERT) deficiency.