| 1 |
mutant huntingtin
(225 times)
|
Neurology
(69 times)
|
HD (187 times)
HTT (22 times)
WT (9 times)
|
2002 Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions.
|
| 2 |
mutant huntingtin protein
(61 times)
|
Neurology
(20 times)
|
HD (50 times)
HTT (14 times)
BDNF (7 times)
|
2009 Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons.
|
| 3 |
mutant HTT
(50 times)
|
Medicine
(11 times)
|
HD (46 times)
HTT (43 times)
NPCs (4 times)
|
2012 Crosstalk between the UPR and autophagy pathway contributes to handling cellular stress in neurodegenerative disease.
|
| 4 |
mutant HTT protein
(7 times)
|
Cell Biology
(2 times)
|
HD (7 times)
HTT (3 times)
aa (1 time)
|
2013 A critical role of astrocyte-mediated nuclear factor-kappaB-dependent inflammation in Huntington's disease.
|
| 5 |
mutant huntingtin gene
(3 times)
|
Neurology
(1 time)
|
HD (3 times)
HTT (3 times)
ASO (1 time)
|
2015 Aberrant astrocytes impair vascular reactivity in Huntington disease.
|
| 6 |
mutated HTT
(2 times)
|
Molecular Biology
(1 time)
|
HTT (2 times)
AGA (1 time)
HD (1 time)
|
2014 Advances in huntington disease drug discovery: novel approaches to model disease phenotypes.
|
| 7 |
misfolded form of the huntingtin protein
(1 time)
|
Stem Cells
(1 time)
|
HD (1 time)
|
2020 Prion-like mechanisms in neurodegenerative disease: Implications for Huntington's disease therapy.
|
| 8 |
mutant forms of the huntingtin protein
(1 time)
|
Molecular Biology
(1 time)
|
scFv (1 time)
|
2015 Structure of a single-chain Fv bound to the 17 N-terminal residues of huntingtin provides insights into pathogenic amyloid formation and suppression.
|
| 9 |
mutant HTT mRNA
(1 time)
|
Molecular Biology
(1 time)
|
AAV (1 time)
AAV9 (1 time)
HD (1 time)
|
2014 Intrajugular vein delivery of AAV9-RNAi prevents neuropathological changes and weight loss in Huntington's disease mice.
|
| 10 |
mutation in the HTT gene
(1 time)
|
Brain
(1 time)
|
DRN (1 time)
DRv (1 time)
HD (1 time)
|
2015 Viral vector mediated expression of mutant huntingtin in the dorsal raphe produces disease-related neuropathology but not depressive-like behaviors in wildtype mice.
|
| 11 |
mutation of the huntingtin gene
(1 time)
|
Neurology
(1 time)
|
BE (1 time)
DS (1 time)
HD (1 time)
|
2019 Lack of mutant huntingtin in cortical efferents improves behavioral inflexibility and corticostriatal dynamics in Huntington's disease mice.
|
| 12 |
mutation of the N-terminal polyglutamine of huntingtin
(1 time)
|
Science
(1 time)
|
cGAS (1 time)
HD (1 time)
|
2020 Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease.
|
| 13 |
mutations within this gene
(1 time)
|
Neurology
(1 time)
|
GE (1 time)
GNE (1 time)
HD (1 time)
|
2019 Abnormal brain development in child and adolescent carriers of mutant huntingtin.
|
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