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Abbreviation: pVHL
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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
VHL protein
(49 times)
Neoplasms
(26 times)
VHL (43 times)
HIF (14 times)
RCC (10 times)
1995 Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C.
protein von Hippel-Lindau
(5 times)
Neoplasms
(2 times)
PHDs (2 times)
alpha-KG (1 time)
ASC (1 time)
2011 Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death.
protein VHL
(3 times)
Neoplasms
(1 time)
VHL (3 times)
CCCP (1 time)
DCM (1 time)
2002 VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells.
suppressor von Hippel-Lindau protein
(3 times)
Biochemistry
(2 times)
HIF (1 time)
HSCs (1 time)
2006 pVHL function is essential for endothelial extracellular matrix deposition.
pathway including the von Hippel-Lindau tumor suppressor protein
(2 times)
Biochemistry
(1 time)
HIF (2 times)
DMBA (1 time)
HIF-PH (1 time)
2001 Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.
genotype-phenotype correlation based on alterations in VHL protein
(1 time)
Genetics, Medical
(1 time)
CHB (1 time)
HM (1 time)
HMTR (1 time)
2018 Genotype and phenotype correlation in von Hippel-Lindau disease based on alteration of the HIF-alpha binding site in VHL protein.
paralog of the von Hippel-Lindau tumor suppressor protein
(1 time)
Biochemistry
(1 time)
VLP (1 time)
2019 Insights into the molecular features of the von Hippel-Lindau-like protein.
partner of von Hippel-Lindau
(1 time)
Molecular Biology
(1 time)
HAT (1 time)
2016 Jade-1: its structure, regulation and functions in the renal cancer.
pathways related to the VHL protein
(1 time)
Medicine
(1 time)
RCC (1 time)
VHL (1 time)
2009 Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma.
10  patterns of transcription factor HIF-1alpha and von Hippel Lindau protein
(1 time)
Molecular Biology
(1 time)
--- 2014 Etaypoxia-inducible factor-1alpha, von Hippel-Lindau protein, and heat shock protein expression in ophthalmic pterygium and normal conjunctiva.
11  patterns of VHL protein
(1 time)
Neoplasms
(1 time)
ccRCC (1 time)
HIF (1 time)
VHL (1 time)
2015 pVHL/HIF-regulated CD70 expression is associated with infiltration of CD27+ lymphocytes and increased serum levels of soluble CD27 in clear cell renal cell carcinoma.
12  perfectly correlated with a gradient of VHL protein
(1 time)
Neoplasms
(1 time)
VHL (1 time)
2014 Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis.
13  PHD1-3 and von Hippel-Lindau protein
(1 time)
Biochemistry
(1 time)
Spry (1 time)
Spry2 (1 time)
2011 Regulation of cellular levels of Sprouty2 protein by prolyl hydroxylase domain and von Hippel-Lindau proteins.
14  phosphorylation. von Hippel-Lindau protein
(1 time)
Neoplasms
(1 time)
HDACs (1 time)
HIF-1alpha (1 time)
2008 Protein kinase CK2 is a key activator of histone deacetylase in hypoxia-associated tumors.
15  played by the VHL protein
(1 time)
Neoplasms
(1 time)
PARs (1 time)
VHL (1 time)
2004 von Hippel-Lindau tumor suppressor protein stimulation by thrombin involves RhoA activation.
16  polyubiquitin chains on the lysine residues of von Hippel-Lindau protein
(1 time)
Medicine
(1 time)
UCP (1 time)
UCPC118A (1 time)
2016 E2-EPF UCP Possesses E3 Ubiquitin Ligase Activity via Its Cysteine 118 Residue.
17  polyubiquitination by a complex containing the von Hippel-Lindau protein
(1 time)
Cell Biology
(1 time)
HIF (1 time)
2009 A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo.
18  potential competitive inhibitor for von Hippel-Lindau
(1 time)
Neoplasms
(1 time)
GRIM-19 (1 time)
HIF-1alpha (1 time)
2013 GRIM-19 opposes reprogramming of glioblastoma cell metabolism via HIF1alpha destabilization.
19  potential role of the VHL protein
(1 time)
General Surgery
(1 time)
mRNA (1 time)
VHL (1 time)
2011 Reduced expression of von Hippel-Lindau protein correlates with decreased apoptosis and high chondrosarcoma grade.
20  predicted to involve the von Hippel Lindau protein
(1 time)
Hematology
(1 time)
--- 2006 Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis.
21  presence of von Hippel-Lindau tumor suppressor
(1 time)
Nephrology
(1 time)
ccRCC (1 time)
RCC (1 time)
2018 Metabolomics and Metabolic Reprogramming in Kidney Cancer.
22  presence of wild-type VHL protein
(1 time)
Neoplasms
(1 time)
CCRC (1 time)
OXPHOS (1 time)
VHL (1 time)
2005 A new role for the von Hippel-Lindau tumor suppressor protein: stimulation of mitochondrial oxidative phosphorylation complex biogenesis.
23  present study, VHL protein
(1 time)
Molecular Biology
(1 time)
CDDR (1 time)
VHL (1 time)
2003 von Hippel-Lindau protein complex is regulated by cell density.
24  present study, we identified von Hippel-Lindau protein
(1 time)
Biochemistry
(1 time)
--- 2009 Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner.
25  preventing binding of the von Hippel-Lindau protein
(1 time)
Metabolism
(1 time)
HIF-2alpha (1 time)
N-TAD (1 time)
NOXs (1 time)
2010 The hypoxia-inducible factor-2alpha is stabilized by oxidative stress involving NOX4.
26  previous observations that deletion of the von Hippel-Lindau protein
(1 time)
Nephrology
(1 time)
HIF-2alpha (1 time)
JG (1 time)
2015 Chronic hypoxia-inducible transcription factor-2 activation stably transforms juxtaglomerular renin cells into fibroblast-like cells in vivo.
27  Previous research has revealed that the von-Hippel-Lindau tumor suppressor protein
(1 time)
Neoplasms
(1 time)
HIF-alpha (1 time)
NEK8 (1 time)
2018 Never-in-mitosis A-related kinase 8, a novel target of von-Hippel-Lindau tumor suppressor protein, promotes gastric cancer cell proliferation.
28  proliferation of normal cells. von Hippel-Lindau protein
(1 time)
Cell Biology
(1 time)
HIF-1alpha (1 time)
2012 pVHL-mediated transcriptional repression of c-Myc by recruitment of histone deacetylases.
29  prolyl hydroxylation and resultant von Hippel-Lindau protein
(1 time)
Biochemistry
(1 time)
HIF (1 time)
PI3K (1 time)
2003 The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism.
30  prolyl hydroxylation causes recognition by von Hippel-Lindau tumor suppressor protein
(1 time)
Genetics, Medical
(1 time)
CRM1 (1 time)
HIFs (1 time)
NES (1 time)
2015 Nuclear-cytoplasmatic shuttling of proteins in control of cellular oxygen sensing.
31  promotes interaction with the von Hippel-Lindau tumour suppressor protein
(1 time)
Biochemistry
(1 time)
FIH (1 time)
HIF (1 time)
2004 HIF hydroxylation and cellular oxygen sensing.
32  proteasomal degradation by the von Hippel-Lindau tumor suppressor protein
(1 time)
Nephrology
(1 time)
AIF (1 time)
HIFs (1 time)
2007 Hypoxia and podocyte-specific Vhlh deletion confer risk of glomerular disease.
33  protein degradation by the von Hippel Lindau
(1 time)
Medicine
(1 time)
17-AAG (1 time)
HIFs (1 time)
2009 COMMD1 Promotes pVHL and O2-Independent Proteolysis of HIF-1alpha via HSP90/70.
34  protein encoded by VHL
(1 time)
Cell Biology
(1 time)
ccRCC (1 time)
HIF-alpha (1 time)
NF-kappaB (1 time)
2005 Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor kappa B activity.
35  protein is regulated either by attenuating von Hippel-Lindau protein
(1 time)
Biochemistry
(1 time)
HIF-1 (1 time)
Hsp90 (1 time)
MAPKK (1 time)
2004 PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation.
36  protein is targeted for degradation by the von Hippel-Lindau
(1 time)
Biochemistry
(1 time)
HIF-1alpha (1 time)
N-TAD (1 time)
2003 Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor gene product.
37  protein stabilizes hypoxia-inducible factor-1alpha through competition with von Hippel-Lindau protein
(1 time)
Biochemistry
(1 time)
CD31 (1 time)
HIF-1alpha (1 time)
ODDD (1 time)
2012 Runx2 protein stabilizes hypoxia-inducible factor-1alpha through competition with von Hippel-Lindau protein (pVHL) and stimulates angiogenesis in growth plate hypertrophic chondrocytes.
38  protein-protein interaction between HIF-1alpha and the von Hippel-Lindau protein
(1 time)
--- 2016 Discovery of novel inhibitors disrupting HIF-1alpha/von Hippel-Lindau interaction through shape-based screening and cascade docking.
39  proteins, and von Hippel-Lindau protein
(1 time)
Pathology
(1 time)
HIF (1 time)
VEGF (1 time)
2003 Peritubular capillary loss after mouse acute nephrotoxicity correlates with down-regulation of vascular endothelial growth factor-A and hypoxia-inducible factor-1 alpha.
40  proteins, including von Hippel Lindau
(1 time)
Biology
(1 time)
ccRCC (1 time)
LRR-1 (1 time)
PRAME (1 time)
2020 The Roles of Cullin-2 E3 Ubiquitin Ligase Complex in Cancer.
41  proteolysis via the von Hippel-Lindau protein
(1 time)
Biochemistry
(1 time)
HIF-1alpha (1 time)
2011 von Hippel-Lindau protein adjusts oxygen sensing of the FIH asparaginyl hydroxylase.
42  PTHrP expression is negatively regulated by the VHL gene products
(1 time)
Neoplasms
(1 time)
PTH1R (1 time)
PTHrP (1 time)
RCCs (1 time)
2006 Antitumor effect of parathyroid hormone-related protein neutralizing antibody in human renal cell carcinoma in vitro and in vivo.
43  wild-type von Hippel-Lindau protein
(1 time)
Cell Biology
(1 time)
MEFs (1 time)
1998 The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix.