| 1 |
small interfering RNA
(10579 times)
|
Neoplasms
(1764 times)
|
RNAi (983 times)
ROS (278 times)
VEGF (252 times)
|
2001 Post-transcriptional gene silencing in plants.
|
| 2 |
small interfering ribonucleic acid
(122 times)
|
Neoplasms
(17 times)
|
mRNA (8 times)
ELISA (5 times)
HIF-1alpha (5 times)
|
2003 Molecular mechanisms, diagnosis, and rational approaches to management of and therapy for Charcot-Marie-Tooth disease and related peripheral neuropathies.
|
| 3 |
small inhibitory RNA
(81 times)
|
Neoplasms
(16 times)
|
CCT-eta (3 times)
EGFR (3 times)
GR (3 times)
|
2003 IL-1alpha-induced COX-2 expression in human intestinal myofibroblasts is dependent on a PKCzeta-ROS pathway.
|
| 4 |
silencing RNA
(45 times)
|
Neoplasms
(14 times)
|
ER (2 times)
HGF (2 times)
IL (2 times)
|
2003 Induction of G0/G1 cell cycle arrest in ovarian carcinoma cells by the anti-inflammatory drug NS-398, but not by COX-2-specific RNA interference.
|
| 5 |
short interfering RNA duplexes
(33 times)
|
Molecular Biology
(8 times)
|
RNAi (6 times)
RSV (3 times)
dsRNA (2 times)
|
2002 Silencing of Bruton's tyrosine kinase (Btk) using short interfering RNA duplexes (siRNA).
|
| 6 |
small interfering double-stranded RNA
(14 times)
|
Neoplasms
(4 times)
|
RNAi (3 times)
BI-1 (1 time)
BPH (1 time)
|
2002 Isoform-specific knockdown and expression of adaptor protein ShcA using small interfering RNA.
|
| 7 |
silencer RNA
(8 times)
|
Pharmacology
(2 times)
|
Ang II (1 time)
APP (1 time)
CCK-8 (1 time)
|
2003 CUGBP2 plays a critical role in apoptosis of breast cancer cells in response to genotoxic injury.
|
| 8 |
small interfering oligoribonucleotides
(3 times)
|
Medicine
(1 time)
|
CHX (1 time)
DED (1 time)
RCCs (1 time)
|
2005 Reduction of the antiapoptotic protein cFLIP enhances the susceptibility of human renal cancer cells to TRAIL apoptosis.
|
| 9 |
small interfering RNA-mediated
(3 times)
|
Molecular Biology
(1 time)
|
CD2AP (1 time)
ChIP (1 time)
IRF-1 (1 time)
|
2007 RNA interference of interferon regulatory factor-1 gene expression in THP-1 cell line leads to Toll-like receptor-4 overexpression/activation as well as up-modulation of annexin-II.
|
| 10 |
specific interfering RNA
(3 times)
|
Neoplasms
(2 times)
|
CaMK (1 time)
CK (1 time)
HO-1 (1 time)
|
2005 Calcium/calmodulin-dependent kinase I and calcium/calmodulin-dependent kinase kinase participate in the control of cell cycle progression in MCF-7 human breast cancer cells.
|
| 11 |
double-stranded interfering RNA
(2 times)
|
Physicochemical Phenomena
(1 time)
|
RNAi (2 times)
apoB (1 time)
BDNF (1 time)
|
2007 RNA interference-mediated inhibition of brain-derived neurotrophic factor expression increases cocaine's cytotoxicity in cultured cells.
|
| 12 |
double-stranded ribonucleotide
(2 times)
|
Biochemistry
(1 time)
|
shRNA (1 time)
|
2011 General method for labeling siRNA by click chemistry with fluorine-18 for the purpose of PET imaging.
|
| 13 |
silencing interference RNA
(2 times)
|
Cell Biology
(1 time)
|
BAEpC (1 time)
Eph (1 time)
MPM (1 time)
|
2014 Tobacco smoke induces epithelial barrier dysfunction via receptor EphA2 signaling.
|
| 14 |
Silencing of mRNA expression by RNA interference
(2 times)
|
Reproductive Medicine
(1 time)
|
CASP3 (1 time)
COX (1 time)
POU5F1 (1 time)
|
2006 Gene expression of cox5a, 5b, or 6b1 and their roles in preimplantation mouse embryos.
|
| 15 |
small interfering RNA technique
(2 times)
|
Neoplasms
(2 times)
|
AI (1 time)
LASP1 (1 time)
Rb (1 time)
|
2007 Overexpression of LASP-1 mediates migration and proliferation of human ovarian cancer cells and influences zyxin localisation.
|
| 16 |
small, interfering, hairpin RNA
(2 times)
|
Neurology
(1 time)
|
hpRNA (2 times)
CMV (1 time)
IGF-IR (1 time)
|
2004 Downregulation of uPA, uPAR and MMP-9 using small, interfering, hairpin RNA (siRNA) inhibits glioma cell invasion, angiogenesis and tumor growth.
|
| 17 |
SMS2-silencing RNA
(2 times)
|
Cell Biology
(1 time)
|
ALI (1 time)
HPAECs (1 time)
N2a (1 time)
|
2012 Role of sphingomyelin synthesis in pulmonary endothelial cell cytoskeletal activation and endotoxin-induced lung injury.
|
| 18 |
subjected MCs to RNA interference
(2 times)
|
Nephrology
(2 times)
|
IFN (2 times)
MCs (2 times)
MDA5 (2 times)
|
2016 Interferon-Stimulated Gene 15, a Type I Interferon-Dependent Transcript, Is Involved in a Negative Feedback Loop in Innate Immune Reactions in Human Mesangial Cells.
|
| 19 |
synthetic interfering RNAs
(2 times)
|
Histocytochemistry
(1 time)
|
aiRNAs (1 time)
PCa (1 time)
qRT-PCR (1 time)
|
2011 Silencing USP22 by asymmetric structure of interfering RNA inhibits proliferation and induces cell cycle arrest in bladder cancer cells.
|
| 20 |
Aire-silenced
(1 time)
|
Allergy and Immunology
(1 time)
|
AIRE (1 time)
miRNAs (1 time)
mRNA (1 time)
|
2013 Autoimmune regulator (Aire) controls the expression of microRNAs in medullary thymic epithelial cells.
|
| 21 |
atelocollagen-small interfering RNA
(1 time)
|
Molecular Biology
(1 time)
|
---
|
2005 Fiber molecular model of atelocollagen-small interfering RNA (siRNA) complex.
|
| 22 |
double-stranded RNA interference
(1 time)
|
Biochemistry
(1 time)
|
ILK (1 time)
|
2003 Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation.
|
| 23 |
linc-OIP5-small interfering RNA
(1 time)
|
Molecular Biology
(1 time)
|
lincRNAs (1 time)
qRT-PCR (1 time)
|
2017 Knockdown of linc-OIP5 inhibits proliferation and migration of glioma cells through down-regulation of YAP-NOTCH signaling pathway.
|
| 24 |
pCMV-NF-kappaB-small interference RNA
(1 time)
|
Gastrointestinal Diseases
(1 time)
|
ADM (1 time)
HCC (1 time)
MDR (1 time)
|
2016 Reversal of multidrug resistance of hepatocellular carcinoma cells by metformin through inhibiting NF-kappaB gene transcription.
|
| 25 |
pSilencer-PUMA-small interfering RNA
(1 time)
|
Neoplasms
(1 time)
|
mRNA (1 time)
|
2015 Effect of capilliposide for induction apoptosis in human nasopharyngeal cancer CNE-2 cells through up-regulating PUMA expression.
|
| 26 |
salutary effects were absent in MSC
(1 time)
|
Cardiology
(1 time)
|
AWT (1 time)
ELISA (1 time)
GFP (1 time)
|
2010 Gene manipulated peritoneal cell patch repairs infarcted myocardium.
|
| 27 |
screened and found asmall interfering RNA
(1 time)
|
Nucleic Acids
(1 time)
|
AS (1 time)
FGFR2 (1 time)
P253R (1 time)
|
2018 Adeno-Associated Virus-Mediated RNAi against Mutant Alleles Attenuates Abnormal Calvarial Phenotypes in an Apert Syndrome Mouse Model.
|
| 28 |
secretagogue-small interfering RNA
(1 time)
|
Rheumatology
(1 time)
|
HSG (1 time)
SS (1 time)
|
2011 A secretagogue-small interfering RNA conjugate confers resistance to cytotoxicity in a cell model of Sjogren's syndrome.
|
| 29 |
selective RNA targeting
(1 time)
|
Biochemistry
(1 time)
|
---
|
2015 Dual oxidase 2 generated reactive oxygen species selectively mediate the induction of mucins by epidermal growth factor in enterocytes.
|
| 30 |
several challenges associated with the cargo
(1 time)
|
Drug Delivery Systems
(1 time)
|
---
|
2012 Delivery and biodistribution of siRNA for cancer therapy: challenges and future prospects.
|
| 31 |
shell and core, facilitating the independent encapsulations of large
(1 time)
|
Biomedical Engineering
(1 time)
|
---
|
2017 Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer.
|
| 32 |
short dsRNA oligonucleotides
(1 time)
|
Neoplasms
(1 time)
|
HIF (1 time)
IAA (1 time)
NDRG1 (1 time)
|
2012 Inhibition of N-Myc down regulated gene 1 in in vitro cultured human glioblastoma cells.
|
| 33 |
short hairpin RNA
(1 time)
|
Medicine
(1 time)
|
Bcl-2 (1 time)
RT-PCR (1 time)
|
2015 Overexpression of RLIP76 Required for Proliferation in Meningioma Is Associated with Recurrence.
|
| 34 |
short inhibitory RNA duplexes
(1 time)
|
Cell Biology
(1 time)
|
NES (1 time)
|
2002 Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation.
|
| 35 |
short interfering 21-23 mer double-stranded RNA
(1 time)
|
Biochemistry
(1 time)
|
LTR (1 time)
RNAi (1 time)
|
2005 Lentiviral-mediated delivery of combined HIV-1 decoy TAR and Vif siRNA as a single RNA molecule that cleaves to inhibit HIV-1 in transduced cells.
|
| 36 |
show that knockdown of N-CoR either transiently
(1 time)
|
Cell Biology
(1 time)
|
---
|
2007 A critical role for the co-repressor N-CoR in erythroid differentiation and heme synthesis.
|
| 37 |
show, usingsmall interfering RNA
(1 time)
|
Biological Science Disciplines
(1 time)
|
ER (1 time)
V-ATPase (1 time)
|
2018 IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes.
|
| 38 |
SHP-2 genes were knocked down by interference RNA
(1 time)
|
Ophthalmology
(1 time)
|
HCE (1 time)
HGF (1 time)
PTPs (1 time)
|
2008 Association of protein tyrosine phosphatases (PTPs)-1B with c-Met receptor and modulation of corneal epithelial wound healing.
|
| 39 |
signaling pathway, RNA interference
(1 time)
|
Allergy and Immunology
(1 time)
|
MyD88 (1 time)
NF (1 time)
PGRPs (1 time)
|
2008 RNAi suppression of zebrafish peptidoglycan recognition protein 6 (zfPGRP6) mediated differentially expressed genes involved in Toll-like receptor signaling pathway and caused increased susceptibility to Flavobacterium columnare.
|
| 40 |
signaling pathways involved, we performed RNA interference
(1 time)
|
Breast Neoplasms
(1 time)
|
---
|
2008 G-Protein Inwardly Rectifying Potassium Channel 1 (GIRK1) Knockdown Decreases Beta-Adrenergic, MAP Kinase and Akt Signaling in the MDA-MB-453 Breast Cancer Cell Line.
|
| 41 |
significantly attenuated in IR
(1 time)
|
Biochemistry
(1 time)
|
FBPase (1 time)
G6Pase (1 time)
HPTC (1 time)
|
2017 Reduced Insulin Receptor Expression Enhances Proximal Tubule Gluconeogenesis.
|
| 42 |
significantly increased, compared with CCNY knockdown
(1 time)
|
Medicine
(1 time)
|
CCNY (1 time)
HCC (1 time)
qRT-PCR (1 time)
|
2018 Cyclin Y Modulates the Proliferation, Invasion, and Metastasis of Hepatocellular Carcinoma Cells.
|
| 43 |
significantly inhibited by catalase or by inhibiting the expression
(1 time)
|
Cardiology
(1 time)
|
DAPT (1 time)
si (1 time)
TACE (1 time)
|
2011 Cyclic stretch stimulates vascular smooth muscle cell alignment by redox-dependent activation of Notch3.
|
| 44 |
silence of RBPMS using RNA interference
(1 time)
|
Pharmacology
(1 time)
|
CRC (1 time)
miR-21-3p (1 time)
|
2018 Inhibition of microRNA-21-3p suppresses proliferation as well as invasion and induces apoptosis by targeting RNA-binding protein with multiple splicing through Smad4/extra cellular signal-regulated protein kinase signalling pathway in human colorectal cancer HCT116 cells.
|
| 45 |
silencing approach
(1 time)
|
Gastroenterology
(1 time)
|
THTR (1 time)
|
2012 Relative contribution of THTR-1 and THTR-2 in thiamin uptake by pancreatic acinar cells: studies utilizing Slc19a2 and Slc19a3 knockout mouse models.
|
| 46 |
silencing inhibitory RNA
(1 time)
|
Nephrology
(1 time)
|
DA (1 time)
l-DOPA (1 time)
LAT2 (1 time)
|
2004 The dopamine precursor L-dihydroxyphenylalanine is transported by the amino acid transporters rBAT and LAT2 in renal cortex.
|
| 47 |
silencing RhoA expression
(1 time)
|
Vascular Diseases
(1 time)
|
M3G (1 time)
M6G (1 time)
MNTX (1 time)
|
2006 Methylnaltrexone inhibits opiate and VEGF-induced angiogenesis: role of receptor transactivation.
|
| 48 |
Slc52a2-small interfering RNA
(1 time)
|
Pharmacology
(1 time)
|
---
|
2013 Involvement of riboflavin transporter RFVT2/Slc52a2 in hepatic homeostasis of riboflavin in mice.
|
| 49 |
small inducible RNA
(1 time)
|
Molecular Biology
(1 time)
|
Chk1 (1 time)
|
2006 Dissecting the roles of checkpoint kinase 1/CDC2 and mitogen-activated protein kinase kinase 1/2/extracellular signal-regulated kinase 1/2 in relation to 7-hydroxystaurosporine-induced apoptosis in human multiple myeloma cells.
|
| 50 |
small inhibitor ribonucleic acid
(1 time)
|
Otolaryngology
(1 time)
|
CTGF (1 time)
TGF (1 time)
|
2016 The role of Smad3 in the fibrotic phenotype in human vocal fold fibroblasts.
|
| 51 |
small inhibitory hairpin RNA
(1 time)
|
Anatomy
(1 time)
|
DRG (1 time)
NRP-1 (1 time)
|
2004 Functional knockdown of neuropilin-1 in the developing chick nervous system by siRNA hairpins phenocopies genetic ablation in the mouse.
|
| 52 |
small inhibitory RNA duplex
(1 time)
|
Medicine
(1 time)
|
AFAP1L1 (1 time)
Sp (1 time)
|
2013 The transcription factor Sp3 regulates the expression of a metastasis-related marker of sarcoma, actin filament-associated protein 1-like 1 (AFAP1L1).
|
| 53 |
small inhibitory RNA molecules
(1 time)
|
Ophthalmology
(1 time)
|
IE-3 (1 time)
MCMV (1 time)
|
2014 Decrease of murine cytomegalovirus-induced retinitis by intravenous delivery of immediate early protein-3-specific siRNA.
|
| 54 |
small interfering complementary RNA
(1 time)
|
Biochemistry
(1 time)
|
ECFCs (1 time)
mRNA (1 time)
RNAi (1 time)
|
2008 Inhibition of alpha-globin gene expression by RNAi.
|
| 55 |
small interfering double-stranded RNA molecules
(1 time)
|
Biochemistry
(1 time)
|
CS-HOBT (1 time)
MWs (1 time)
|
2010 Nucleic acid delivery with chitosan hydroxybenzotriazole.
|
| 56 |
small interfering ribonucleic acid duplexes
(1 time)
|
Dermatology
(1 time)
|
DPC (1 time)
|
2012 Effect of HSPC016 gene expression on the aggregative growth of dermal papillae cells.
|
| 57 |
small interfering RNA of MRTF-A
(1 time)
|
Brain
(1 time)
|
---
|
2011 Myocardin-related transcription factor-A promoting neuronal survival against apoptosis induced by hypoxia/ischemia.
|
| 58 |
small interfering RNA sequences against
(1 time)
|
Neoplasms
(1 time)
|
lncRNA (1 time)
PCa (1 time)
PCGEM1 (1 time)
|
2014 Reciprocal regulation of PCGEM1 and miR-145 promote proliferation of LNCaP prostate cancer cells.
|
| 59 |
small interfering RNA-mediated posttranscriptional knockdown
(1 time)
|
Genetics, Medical
(1 time)
|
Q-ON (1 time)
|
2005 Engineered Streptomyces quorum-sensing components enable inducible siRNA-mediated translation control in mammalian cells and adjustable transcription control in mice.
|
| 60 |
small interfering RNA-negative
(1 time)
|
Biomedical Engineering
(1 time)
|
CLSM (1 time)
FTIR (1 time)
GPC (1 time)
|
2012 A mPEG-PLGA-b-PLL copolymer carrier for adriamycin and siRNA delivery.
|
| 61 |
Small interfering synthetic double-stranded RNA
(1 time)
|
Biotechnology
(1 time)
|
hCTLA4Ig (1 time)
PEI (1 time)
|
2009 Enhanced delivery of siRNA complexes by sonoporation in transgenic rice cell suspension cultures.
|
| 62 |
small ribonuclear acid
(1 time)
|
Cell Biology
(1 time)
|
FABP (1 time)
|
2015 Expression and function of fatty acid-binding protein 4 in epithelial cell of uterine endometrium.
|
| 63 |
small-interfering oligos
(1 time)
|
Neoplasms
(1 time)
|
CRY2 (1 time)
|
2010 Phenotypic effects of the circadian gene Cryptochrome 2 on cancer-related pathways.
|
| 64 |
smokers with and without COPD, along with RelB knock-down
(1 time)
|
Pulmonary Medicine
(1 time)
|
CSE (1 time)
|
2015 Decreased expression of the NF-kappaB family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression.
|
| 65 |
specific small EGR-1 interfering RNA
(1 time)
|
Neoplasms
(1 time)
|
FCM (1 time)
MTT (1 time)
RT-PCR (1 time)
|
2009 Down-regulation of Egr-1 by siRNA inhibits growth of human prostate carcinoma cell line PC-3.
|
| 66 |
stabilized AgNPs-Qe with a layer of molecules
(1 time)
|
Biomimetics
(1 time)
|
AgNPs-Qe (1 time)
N/P (1 time)
Qe (1 time)
|
2016 Silver nanoparticles-quercetin conjugation to siRNA against drug-resistant Bacillus subtilis for effective gene silencing: in vitro and in vivo.
|
| 67 |
study was to inhibit alphaV-mediated angiogenesis in vitro using RNAs
(1 time)
|
Hematology
(1 time)
|
asON (1 time)
HUVEC (1 time)
|
2005 Use of RNA interference to inhibit integrin subunit alphaV-mediated angiogenesis.
|
| 68 |
subjected the cells to RNA interference
(1 time)
|
Medicine
(1 time)
|
BA (1 time)
dsRNA (1 time)
ELISA (1 time)
|
2017 CCL5 is induced by TLR 3 signaling in HuCCT1 human biliary epithelial cells: possible involvement in the pathogenesis of biliary atresia.
|
| 69 |
such effects, RNA interference
(1 time)
|
Zoology
(1 time)
|
LPS (1 time)
NF (1 time)
QT-PCR (1 time)
|
2009 Zebrafish peptidoglycan recognition protein SC (zfPGRP-SC) mediates multiple intracellular signaling pathways.
|
| 70 |
supported by ER-alpha downregulation
(1 time)
|
Medicine
(1 time)
|
DIM (1 time)
|
2011 Estrogen induced metastatic modulators MMP-2 and MMP-9 are targets of 3,3'-diindolylmethane in thyroid cancer.
|
| 71 |
suppressed by RNA interference
(1 time)
|
Pathology
(1 time)
|
HCCs (1 time)
|
2006 PIN1 expression contributes to hepatic carcinogenesis.
|
| 72 |
survival experiments after molecular
(1 time)
|
Neoplasms
(1 time)
|
ATM (1 time)
HRS (1 time)
|
2007 Transition in survival from low-dose hyper-radiosensitivity to increased radioresistance is independent of activation of ATM Ser1981 activity.
|
| 73 |
synthetic 21-23 nt RNAs
(1 time)
|
Biochemistry
(1 time)
|
ES (1 time)
RNAi (1 time)
|
2002 Small interfering RNA and gene silencing in transgenic mice and rats.
|
| 74 |
synthetic RNA
(1 time)
|
Molecular Biology
(1 time)
|
CJD (1 time)
FAD (1 time)
rpAD (1 time)
|
2017 Strain-Specific Altered Regulatory Response of Rab7a and Tau in Creutzfeldt-Jakob Disease and Alzheimer's Disease.
|
| 75 |
synthetic RNA oligonucleotides
(1 time)
|
Cell Biology
(1 time)
|
hESC (1 time)
|
2010 Efficient, high-throughput transfection of human embryonic stem cells.
|
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