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Abbreviation: 5-HT
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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
5-hydroxytryptamine
(7110 times)
Pharmacology
(3062 times)
5-HIAA (614 times)
DA (612 times)
NA (415 times)
1955 Further observations on the action of 5-hydroxytryptamine (5-HT) on the urine flow and chloride excretion in the rat.
5-hydroxytryptophan
(30 times)
Pharmacology
(6 times)
5-HIAA (3 times)
DA (3 times)
5-HI (2 times)
1978 Effect of hypoxia on monoamine synthesis in brains of developing rats. III. Various O2 levels.
hypothesis that 5-hydroxytryptamine
(15 times)
Pharmacology
(7 times)
5-CT (2 times)
5,7-DHT (1 time)
CA (1 time)
1981 The behavioral effects of hallucinogens in rats following 5,7-dihydroxytryptamine administration into the medial forebrain bundle.
5-hydroxytryptamine or serotonin
(9 times)
Pharmacology
(2 times)
DA (4 times)
5-HIAA (3 times)
NA (2 times)
1989 Genetic differences in the effects of voluntary ethanol consumption on brain monoamine levels in inbred strains of mice, C57BL/6J, C3H/He and DBA/2Cr.
hyperreactivity to 5-hydroxytryptamine
(7 times)
Vascular Diseases
(3 times)
DOCA (2 times)
5,6-DHT (1 time)
CAT (1 time)
1978 Increased sensitivity to 5-hydroxytryptamine due to intraventricular administration of 5,6-dihydroxytryptamine.
5-HT(4) serotonin
(6 times)
Chemistry
(2 times)
5-HTP (2 times)
3-D QSARs (1 time)
4-THPI (1 time)
1991 Involvement of serotonergic neuronal systems in the anti-amnesic action of naftidrofuryl oxalate.
5-hydroxytryptamine receptor
(5 times)
Chemistry
(1 time)
alpha-methyl-5-HT (1 time)
BLA (1 time)
EPSCs (1 time)
1988 Effects of various ginseng saponins on 5-hydroxytryptamine release and aggregation in human platelets.
5-HT1A receptors, and the serotonin
(4 times)
Pharmacology
(3 times)
3H-8-OH-DPAT (1 time)
3H-LSD (1 time)
amb (1 time)
1993 Calcineurin inhibits desensitization of cloned rat 5-HT1C receptors.
5-HText
(4 times)
Pharmacology
(3 times)
5-HTP (1 time)
IR (1 time)
KO (1 time)
1996 In vivo effects of the simultaneous blockade of serotonin and norepinephrine transporters on serotonergic function. Microdialysis studies.
10  5-hydroxytryptamine creatine sulfate complex
(4 times)
Neurology
(2 times)
EC (1 time)
EPSPs (1 time)
i.c.v (1 time)
1982 A demonstration that 5-hydroxytryptamine administered peripherally can affect sexual behavior in male rats.
11  5-hydroxytryptamine hydrochloride
(4 times)
Physiology
(2 times)
ACh (1 time)
CCh (1 time)
CGRP (1 time)
1982 The thermoregulatory effects of noradrenaline, serotonin and carbachol injected into the rat spinal subarachnoid space.
12  5-HIAA to serotonin
(3 times)
Neurology
(1 time)
5-HIAA (3 times)
5-HTP (1 time)
5-MeODMT (1 time)
1993 Evidence that corticotropin-releasing factor within the extended amygdala mediates the activation of tryptophan hydroxylase produced by sound stress in the rat.
13  5-HT receptor agonists
(3 times)
Pharmacology
(2 times)
SP (1 time)
1995 Participation of serotonin in capsaicin-induced mouse ear edema.
14  5-HT1A receptor agonist and serotonin
(3 times)
Psychiatry
(2 times)
CGI (2 times)
MDD (2 times)
HAM-D (1 time)
1994 A double-blind comparison of nefazodone, imipramine, and placebo in major depression.
15  8-hydroxy-2-(di-n-propylamino)tetralin ((3H)8-OH-DPAT) binding or 5-hydroxytryptamine
(3 times)
Pharmacology
(2 times)
--- 1985 [3H]8-hydroxy-2-(di-n-propylamino)tetralin binding to pre- and postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain.
16  5-HIAA, a metabolite of serotonin
(2 times)
Physiology
(1 time)
5-HIAA (2 times)
DA (1 time)
DOPAC (1 time)
1994 Hypothalamic monoaminergic activity in 11-week-old cold-exposed female lean (Fa/Fa) and obese (fa/fa) Zucker rats.
17  5-HT1A subtype of serotonin
(2 times)
Chemistry
(1 time)
5,7-DHT (1 time)
TFMPP (1 time)
1989 Alterations in serotonin binding sites after 5,7-dihydroxytryptamine treatment in the rat spinal cord.
18  5-HT1A-R agonist, and serotonin
(2 times)
Psychiatry
(1 time)
mPFC (1 time)
SSRI (1 time)
vHPC (1 time)
1996 Responders to antidepressant drug treatment: a study comparing nefazodone, imipramine, and placebo in patients with major depression.
19  5-HTpls
(2 times)
Cardiology
(1 time)
CaHD (1 time)
CS (1 time)
2013 Circulating plasma and platelet 5-hydroxytryptamine in carcinoid heart disease: a pilot study.
20  5-hydroxyindoleacetic acid
(2 times)
Brain
(1 time)
DA (3 times)
ACC (1 time)
DOPAC (1 time)
1992 Interactions of fluoxetine with metabolism of dopamine and serotonin in rat brain regions.
21  5-hydroxyindoleacetic acid to serotonin
(2 times)
Pharmacology
(1 time)
BDNF (1 time)
DA (1 time)
NGF (1 time)
1986 Phencyclidine-induced wet-dog shakes observed in rats after withdrawal from reserpine treatment.
22  5-hydroxythalidomide
(2 times)
Biochemistry
(2 times)
ATRA (1 time)
HUVEC (1 time)
N-HT (1 time)
2005 Enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by thalidomide and its metabolites.
23  head-twitch response and the 5-hydroxytryptamine
(2 times)
Psychopharmacology
(1 time)
5-MeODMT (1 time)
CPP (1 time)
NMDA (1 time)
1985 Circadian variation in behavioural responses to central 5-HT receptor stimulation in the mouse.
24  (4-(5-methoxy-7-bromo-benzofuranyl)2-piperidine-HCl) inhibited serotonin
(1 time)
Pharmacology
(1 time)
PEA (1 time)
1983 The monoamine oxidase inhibiting properties of CGP 11305 A.
25  (5-HT(2A)) receptor, serotonin
(1 time)
Chemistry
(1 time)
SWS (1 time)
2010 Discovery of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (nelotanserin) and related 5-hydroxytryptamine2A inverse agonists for the treatment of insomnia.
26  (5-HTT-/-) mice, extracellular serotonin
(1 time)
Neurology
(1 time)
REMS (1 time)
2006 Early life blockade of 5-hydroxytryptamine 1A receptors normalizes sleep and depression-like behavior in adult knock-out mice lacking the serotonin transporter.
27  2-methyl-5-HT, a selective serotonin
(1 time)
Pharmacology
(1 time)
BJR (1 time)
1995 Characteristics of inhibitory effects of serotonin (5-HT)3-receptor antagonists, YM060 and YM114 (KAE-393), on the von Bezold-Jarisch reflex induced by 2-Methyl-5-HT, veratridine and electrical stimulation of vagus nerves in anesthetized rats.
28  5-HIAA, the major 5-hydroxytryptophan
(1 time)
Substance-Related Disorders
(1 time)
5-HIAA (1 time)
DA (1 time)
HMPG (1 time)
1983 The effect of alcoholism on salsolinol and biogenic amines in human brain.
29  5-HIAA/serotonin
(1 time)
Psychopharmacology
(1 time)
5-HIAA (1 time)
DA (1 time)
DE-2 (1 time)
1998 Monoaminergic dysregulation on diestrus-2 and estrus through high emotional reactivity.
30  5-HT and GTN
(1 time)
Transplantation
(1 time)
--- 1994 Temperature-dependent coronary reactivity after perfusion with University of Wisconsin solution in the isolated rat heart.
31  5-HT application, I
(1 time)
Neurology
(1 time)
TG (1 time)
2004 Potentiation of 5-HT3 receptor function by the activation of coexistent 5-HT2 receptors in trigeminal ganglion neurons of rats.
32  5-HT communication through terminal
(1 time)
Neurology
(1 time)
5-HT2A (1 time)
1998 On the relationship of 5-hydroxytryptamine neurons to 5-hydroxytryptamine 2A receptor-immunoreactive neuronal processes in the brain stem of rats. A double immunolabelling analysis.
33  5-HT levels, resulting from serotonin
(1 time)
Psychiatry
(1 time)
NA (1 time)
OCD (1 time)
SSRIs (1 time)
2007 The importance of serotonin and noradrenaline in anxiety.
34  5-HT turnover index
(1 time)
Pharmacology
(1 time)
--- 2010 [Effects of amitriptyline, fluoxetine, and tianeptine on the content of monoamines and their metabolites in Wistar rat brain structures].
35  5-HT(1A) receptors decreases serotonin
(1 time)
Chemistry
(1 time)
SSRIs (1 time)
2008 Flesinoxan challenge suggests that chronic treatment with paroxetine in rats does not desensitize receptors controlling 5-HT synthesis.
36  5-HT(1A)R-ir in serotonergic
(1 time)
Neurology
(1 time)
IML (1 time)
ir (1 time)
PPR (1 time)
1997 Immunocytochemical studies of the 5-HT(1A) receptor in ventral medullaryneurons that project to the intermediolateral cell column and contain serotonin or tyrosine hydroxylase immunoreactivity.
37  5-HT(1B) receptor regulation of serotonin
(1 time)
Neurology
(1 time)
SNr (1 time)
2010 5-HT(1B) receptor regulation of serotonin (5-HT) release by endogenous 5-HT in the substantia nigra.
38  5-HT(3) receptor antagonists
(1 time)
Anesthesiology
(1 time)
PONV (1 time)
2004 The efficacy of the 5-HT3 receptor antagonists combined with droperidol for PONV prophylaxis is similar to their combination with dexamethasone. A meta-analysis of randomized controlled trials.
39  5-HT(3) receptors were 9.9 microM
(1 time)
Pharmacology
(1 time)
2-Me-5-HT (1 time)
mCPBG (1 time)
2006 Molecular cloning and pharmacological characterization of serotonin 5-HT(3A) receptor subtype in dog.
40  5-HT(4)-mediated potentiating effect of serotonin
(1 time)
Urology
(1 time)
EFS (1 time)
2005 Piboserod (SB 207266), a selective 5-HT4 receptor antagonist, reduces serotonin potentiation of neurally-mediated contractile responses of human detrusor muscle.
41  5-HT1 and 5-HT2 receptors
(1 time)
Pharmacology
(1 time)
i.v (1 time)
IA (1 time)
NKA (1 time)
1989 Capillary permeability induced by intravenous neurokinins. Receptor characterization and mechanism of action.
42  5-HT1 receptor
(1 time)
Pharmacology
(1 time)
5,7-DHT (1 time)
1983 Selective destruction of the serotonergic fibers of the fornix-fimbria and cingulum bundle increases 5-HT1 but not 5-HT2 receptors in rat midbrain.
43  5-HT1A agonists, serotonin
(1 time)
Brain
(1 time)
--- 1990 NAN-190: agonist and antagonist interactions with brain 5-HT1A receptors.
44  5-HT1A receptor-mediated autoinhibition of serotonin
(1 time)
Pharmacology
(1 time)
5-HTP (1 time)
DRN (1 time)
2013 Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis.
45  5-HT1A response to serotonin
(1 time)
Science
(1 time)
--- 1998 Structural requirements for 5-HT2A and 5-HT1A serotonin receptor potentiation by the biologically active lipid oleamide.
46  5-HT1A, 5-HT1B, 5-HT2A
(1 time)
Pharmacology
(1 time)
L-5-HTP (1 time)
1997 EMD 57445, the selective sigma receptor ligand, has no effect on the 5-hydroxytryptamine system.
47  5-HT1A-like serotonin
(1 time)
Neurology
(1 time)
2-AG (1 time)
AEA (1 time)
OA (1 time)
2017 Cannabinoids Activate Monoaminergic Signaling to Modulate Key C. elegans Behaviors.
48  5-HT1B receptors modulate synaptic serotonin
(1 time)
Nervous System
(1 time)
--- 2019 5-HT1B Receptor-Mediated Activation of ERK1/2 Requires Both Galphai/o and beta-Arrestin Proteins.
49  5-HT1B/1D receptors control serotonin
(1 time)
Psychopharmacology
(1 time)
--- 2008 In vivo/ex vivo and behavioural study on central effects of 5-HT1B/1D and 5-HT1A antagonists in guinea pigs.
50  5-HT2 and 5-HT1c respectively
(1 time)
Anatomy
(1 time)
--- 1992 D1-receptor antagonists: comparison of [3H]SCH39166 to [3H]SCH23390.
51  5-HT2A
(1 time)
Pharmacology
(1 time)
5-HT2A (1 time)
1998 Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist.
52  5-HT3 agonist
(1 time)
Pharmacology
(1 time)
SP (1 time)
1995 Participation of serotonin in capsaicin-induced mouse ear edema.
53  5-HT4 receptor subtype of serotonin
(1 time)
Biology
(1 time)
--- 2004 [Feeding disorders in 5-HT4 receptor knockout mice].
54  5-HTir
(1 time)
Neurology
(1 time)
THir (1 time)
1992 Monoaminergic systems in the brainstem and spinal cord of the turtle Pseudemys scripta elegans as revealed by antibodies against serotonin and tyrosine hydroxylase.
55  5-HTP decarboxylase activity, serotonin
(1 time)
Chemistry
(1 time)
AADC (1 time)
HPLC-ED (1 time)
l-5-HTP (1 time)
1982 Demonstration of aromatic l-amino acid decarboxylase activity in human brain with l-dopa and l-5-hydroxytryptophan as substrates by high-performance liquid chromatography with electrochemical detection.
56  5-HTP to L-5-hydroxytryptamine
(1 time)
Toxicology
(1 time)
5-HTP (1 time)
DFMD (1 time)
1980 Inhibition of 5-hydroxytryptophan nephrotoxicity by alpha-difluoromethyl-dopa, an inhibitor or L-amino acid decarboxylase.
57  5-HTT knockout mice, serotonin
(1 time)
Brain
(1 time)
DA (1 time)
VTA (1 time)
2002 Serotonin uptake into dopamine neurons via dopamine transporters: a compensatory alternative.
58  5-HTTLPR genotype, whole blood serotonin
(1 time)
Genetics, Medical
(1 time)
--- 2002 Serotonin transporter promoter polymorphism, peripheral indexes of serotonin function, and personality measures in families with alcoholism.
59  5-HTTLPR genotypes and platelet serotonin
(1 time)
Psychiatry
(1 time)
PTSD (1 time)
2019 The Association between Serotonin Transporter Polymorphism, Platelet Serotonin Concentration and Insomnia in Non-Depressed Veterans with Posttraumatic Stress Disorder.
60  5-hydroxy-thymide
(1 time)
Reproductive Medicine
(1 time)
NE (1 time)
2004 Calcium homeostasis and contraction of the uterine artery: effect of pregnancy and chronic hypoxia.
61  5-hydroxy-tryptamine-induced
(1 time)
Endocrinology
(1 time)
HUA (1 time)
1988 Inhibition of the oxygen-induced contraction of the isolated human umbilical artery by indomethacin, flurbiprofen, aspirin and drugs modifying Ca2+ disposition.
62  5-hydroxyindole acetic acid
(1 time)
Biology
(1 time)
DA (1 time)
GSH-Px (1 time)
MDA (1 time)
2012 The influence of microwave radiation from cellular phone on fetal rat brain.
63  5-hydroxyindoleacetic acid:5-hydroxytryptamine
(1 time)
Brain
(1 time)
OB (1 time)
PCPA (1 time)
1985 Progesterone stimulates sexual behaviour in female rats by increasing 5-HT activity on 5-HT2 receptors.
64  5-Hydroxytryptamine-containing
(1 time)
Neurology
(1 time)
--- 1985 Intracerebroventricular administration of 5,7-dihydroxytryptamine to mice increases both head-twitch response and the number of cortical 5-HT2 receptors.
65  5-hydroxytryptamine-mediated
(1 time)
Pharmacology
(1 time)
--- 1982 beta-Adrenoceptor agonists enhance 5-hydroxytryptamine-mediated behavioural responses.
66  5-hydroxytryptophan a precursor of serotonin
(1 time)
Endocrinology
(1 time)
CA (1 time)
GnRH (1 time)
2001 Changes in the control of gonadotrophin secretion by neurotransmitters during sexual development in rats.
67  5-hydroxytryptophan, L-tryptophan, or serotonin
(1 time)
Psychopharmacology
(1 time)
--- 2009 The effect of increased serotonergic neurotransmission on aggression: a critical meta-analytical review of preclinical studies.
68  5-hydroxytyrosol
(1 time)
Virology
(1 time)
CTE (1 time)
EAL (1 time)
RT (1 time)
2017 5-Hydroxytyrosol inhibits HIV-1 replication in primary cells of the lower and upper female reproductive tract.
69  5-tryptophan hydroxylase
(1 time)
Endocrinology
(1 time)
APECED (1 time)
autoAbs (1 time)
CSF (1 time)
2019 Reduction of Total Brain and Cerebellum Volumes Associated With Neuronal Autoantibodies in Patients With APECED.
70  5HTlym
(1 time)
Science
(1 time)
G protein (1 time)
1993 Serotonin receptor cDNA cloned from Lymnaea stagnalis.
71  alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid, serotonin
(1 time)
Psychopharmacology
(1 time)
AD (1 time)
ChAT (1 time)
FTD (1 time)
2008 Imbalance of a serotonergic system in frontotemporal dementia: implication for pharmacotherapy.
72  alpha-methyl-5-HT potentiation of I
(1 time)
Neurology
(1 time)
TG (1 time)
2004 Potentiation of 5-HT3 receptor function by the activation of coexistent 5-HT2 receptors in trigeminal ganglion neurons of rats.
73  alpha-methyl-5-HT pretreatment, the maximal I
(1 time)
Neurology
(1 time)
TG (1 time)
2004 Potentiation of 5-HT3 receptor function by the activation of coexistent 5-HT2 receptors in trigeminal ganglion neurons of rats.
74  alpha7-nACh-5-hydroxytryptamine
(1 time)
Drug Therapy
(1 time)
2-AG (1 time)
Delta9-THC (1 time)
nACh (1 time)
2004 Differential effects of endogenous and synthetic cannabinoids on alpha7-nicotinic acetylcholine receptor-mediated responses in Xenopus Oocytes.
75  H-tropan-3-yl-3, 5-dichlorobenzoate at 5-hydroxytryptamine
(1 time)
Neurology
(1 time)
DR (1 time)
SCG (1 time)
1987 Further studies on the blockade of 5-HT depolarizations of rabbit vagal afferent and sympathetic ganglion cells by MDL 72222 and other antagonists.
76  histamine, tele-methylhistamine, 5-hydroxytryptamine
(1 time)
Gastroenterology
(1 time)
5-HIAA (1 time)
EEG (1 time)
PCA (1 time)
1999 Brain histamine levels and neocortical slow-wave activity in rats with portacaval anastomosis.
77  hydroxylase (TH), 5-hydroxytryptamine
(1 time)
Urinary Bladder, Neurogenic
(1 time)
TH (1 time)
TPH (1 time)
2018 Dexmedetomidine Ameliorates Sleep Deprivation-Induced Depressive Behaviors in Mice.
78  hyperreactivity to acetylcholine, 5-hydroxytryptamine
(1 time)
Pharmacology
(1 time)
--- 1990 Induction of non-specific airway hyperreactivity by potassium channel blockade in rat isolated trachea.
79  hypothalamic and striatal (5-HIAA)
(1 time)
Psychopharmacology
(1 time)
i.c.v (1 time)
OX1 (1 time)
OX2 (1 time)
2001 Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity.
80  hypothalamic TRP, 5-hydroxytryptamine
(1 time)
Veterinary Medicine
(1 time)
5-HIAA (1 time)
CAT (1 time)
GSH-Px (1 time)
2015 Effects of tryptophan supplementation on growth performance, antioxidative activity, and meat quality of ducks under high stocking density.
81  hypothalamus tissues and hippocampal 5-hydroxytryptamine
(1 time)
Complementary Therapies
(1 time)
CUMS (1 time)
EA (1 time)
SP (1 time)
2014 [Effect of electroacupuncture stimulation of "Ganshu" (BL 18) on locomotor, gastric mucosal and hypothalamic SP immunoactivity and hippocampal 5-HT content in rats with depression and gastric ulcer].
82  hypothesis that endogenous 5-hydroxytryptamine
(1 time)
Physiology
(1 time)
--- 1962 Physiological control of molluscan gill cilia by 5-hydroxytryptamine.
83  hypothesis that neurotransmitters 5-hydroxytryptamine
(1 time)
Nutritional Sciences
(1 time)
5-HT3R (1 time)
NK1R (1 time)
SP (1 time)
2019 Role of neurotransmitters 5-hydroxytryptamine and substance P in anorexia induction following oral exposure to the trichothecene T-2 toxin.
84  hypothesis that systemically administered 5-hydroxytryptamine
(1 time)
Psychopharmacology
(1 time)
--- 1987 The anorectic action of peripheral 5-HT examined in the runway: evidence for an action on satiation.
85  hypothesis that the peripheral 5-hydroxytryptamine
(1 time)
Neurology
(1 time)
FLI (1 time)
i.pl (1 time)
2005 The contribution of peripheral 5-hydroxytryptamine2A receptor to carrageenan-evoked hyperalgesia, inflammation and spinal Fos protein expression in the rat.
86  L-5-hydroxytryptophan, considerably increasing the serotonin
(1 time)
Pharmacology
(1 time)
--- 1979 The effect of L-DOPA and L-5-hydroxytryptophan on the pentetrazole seizures in rats after lesions of the median raphe nucleus and substantia nigra.
87  monoamines-5-hydroxy tryptamine
(1 time)
Pharmacology
(1 time)
AS (1 time)
CUS (1 time)
DA (1 time)
2011 Influence of Momordica charantia on oxidative stress-induced perturbations in brain monoamines and plasma corticosterone in albino rats.
88  tryptophan-5-hydroxylase activity and decreased serotonin
(1 time)
Physiology
(1 time)
OM (1 time)
1982 Alterations of tryptophan metabolism in a rat strain (Osborne-Mendel) predisposed to obesity.