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Abbreviation: iNOS
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Long Form No. Long Form Research Area Co-occurring Abbreviation PubMed/MEDLINE Info. (Year, Title)
inducible nitric oxide synthase
(10802 times)
Pharmacology
(1639 times)
NO (3620 times)
LPS (2262 times)
COX-2 (1584 times)
1993 IL-1 beta induces the coexpression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans: activation of cyclooxygenase by nitric oxide.
inducible NO synthase
(2222 times)
Allergy and Immunology
(379 times)
NO (1663 times)
LPS (607 times)
NF-kappaB (249 times)
1993 Lipopolysaccharide treatment in vivo induces widespread tissue expression of inducible nitric oxide synthase mRNA.
inducible NOS
(1181 times)
Biochemistry
(158 times)
NO (652 times)
NOS (544 times)
eNOS (472 times)
1993 Differential expression of iNOS and cNOS mRNA in human vascular smooth muscle cells and endothelial cells under normal and inflammatory conditions.
isoform of nitric oxide synthase
(197 times)
Biochemistry
(29 times)
NO (66 times)
LPS (40 times)
NF-kappaB (20 times)
1994 Enhancement of inducible-type NO synthase gene transcription by protein synthesis inhibitors. Activation of an intracellular signal transduction pathway by low concentrations of cycloheximide.
isoform of NO synthase
(81 times)
Biochemistry
(14 times)
NO (63 times)
LPS (11 times)
TNF-alpha (7 times)
1994 Argininosuccinate synthetase mRNA and activity are induced by immunostimulants in vascular smooth muscle. Role in the regeneration or arginine for nitric oxide synthesis.
isoform of NOS
(34 times)
Biochemistry
(8 times)
NO (24 times)
NOS (18 times)
eNOS (8 times)
1994 Invited opinion: role of nitric oxide in hemorrhagic, traumatic, and anaphylactic shock and thermal injury.
inducible form of NOS
(32 times)
Pharmacology
(5 times)
NO (17 times)
NOS (14 times)
eNOS (6 times)
1994 Expression of the inducible form of nitric oxide synthase by reactive astrocytes after transient global ischemia.
induced NOS
(15 times)
Complementary Therapies
(2 times)
NOS (10 times)
NO (9 times)
eNOS (6 times)
1999 Endothelium removal induces iNOS in rat aorta in organ culture, leading to tissue damage.
inducible NOS isoform
(11 times)
Biochemistry
(2 times)
NO (10 times)
NOS (6 times)
cNOS (3 times)
1995 Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms.
10  LPS-induced expression of nitric oxide synthase
(11 times)
Allergy and Immunology
(4 times)
COX-2 (5 times)
NO (5 times)
TNF-alpha (3 times)
2002 The Leptospira outer membrane protein LipL32 induces tubulointerstitial nephritis-mediated gene expression in mouse proximal tubule cells.
11  calcium-independent nitric oxide synthase
(7 times)
Neurology
(2 times)
LPS (3 times)
NO (2 times)
BT (1 time)
1994 Nitric oxide synthase expression in glial cells: suppression by tyrosine kinase inhibitors.
12  induction of NO synthase
(7 times)
Medicine
(2 times)
NO (6 times)
ADMA (1 time)
AE-ITU (1 time)
1996 In murine 3T3 fibroblasts, different second messenger pathways resulting in the induction of NO synthase II (iNOS) converge in the activation of transcription factor NF-kappaB.
13  anti-inducible NOS
(5 times)
Otolaryngology
(1 time)
eNOS (3 times)
nNOS (2 times)
NO (2 times)
1996 Immunohistochemical localization of nitric oxide synthase activity in upper respiratory epithelium.
14  inducible oxide nitric synthase
(5 times)
Biochemistry
(1 time)
NO (2 times)
AE (1 time)
cGMP (1 time)
2011 Antidepressant-like and neuroprotective effects of Aloysia gratissima: investigation of involvement of L-arginine-nitric oxide-cyclic guanosine monophosphate pathway.
15  pro-inflammatory mediators, nitric oxide synthase
(5 times)
Physiology
(1 time)
LPS (4 times)
COX-2 (3 times)
NO (2 times)
2004 Sodium salicylate-induced amelioration of experimental autoimmune encephalomyelitis in Lewis rats is associated with the suppression of inducible nitric oxide synthase and cyclooxygenases.
16  cytokine-inducible NOS
(4 times)
Gynecology
(1 time)
NO (3 times)
NOS (2 times)
CaM (1 time)
1995 Altered immune responses in mice lacking inducible nitric oxide synthase.
17  II NO synthase
(4 times)
Neurology
(1 time)
NO (2 times)
IFN-gamma (1 time)
LPS (1 time)
1997 Absence of NO synthase type II expression in fetal liver from pregnant rats under septic shock conditions.
18  immunologic nitric oxide synthase
(4 times)
Molecular Biology
(2 times)
AIDS (1 time)
HAD (1 time)
HIV-1 (1 time)
1998 Herpes simplex virus encephalitis: long-term comparative study of viral load and the expression of immunologic nitric oxide synthase in mouse brain tissue.
19  inflammatory nitric oxide synthase
(4 times)
Neurology
(3 times)
AD (2 times)
APP (1 time)
betaAPP (1 time)
2002 Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation: implications for Alzheimer's disease.
20  isoform of the enzyme
(4 times)
Allergy and Immunology
(1 time)
NOS (2 times)
CHS (1 time)
DNFB (1 time)
1998 Involvement of NO in contact hypersensitivity.
21  immunological NOS
(3 times)
Pharmacology
(1 time)
eNOS (2 times)
nNOS (2 times)
AMD (1 time)
1997 Neuronal (type I) nitric oxide synthase regulates nuclear factor kappaB activity and immunologic (type II) nitric oxide synthase expression.
22  inducible form of the enzyme NOS
(3 times)
Urology
(2 times)
NOS (3 times)
ICP (2 times)
NO (2 times)
1995 Modulation of nitric oxide synthase activity in macrophages.
23  Inhibition of iNO synthase
(3 times)
Cardiology
(1 time)
NO (2 times)
AG (1 time)
i.p (1 time)
1998 Inducible nitric oxide: an autoregulatory feedback inhibitor of vascular inflammation.
24  inhibition of the inducible isoform
(3 times)
Allergy and Immunology
(1 time)
NO (2 times)
NOS (2 times)
7-NI (1 time)
1996 Macula densa derived nitric oxide in regulation of glomerular capillary pressure.
25  calcium-independent NO synthase
(2 times)
Critical Care
(1 time)
NO (2 times)
ALI (1 time)
EB (1 time)
1999 Regulation of inducible nitric oxide synthase gene expression in vascular smooth muscle cells.
26  calcium-independent NOS
(2 times)
Physiology
(1 time)
AR (1 time)
ATV (1 time)
cNOS (1 time)
2004 Protective mechanisms during ischemic tolerance in skeletal muscle.
27  eicosanoids, nitric oxide oxydase
(2 times)
Rheumatology
(2 times)
IL-1RAcP (2 times)
RANKL (2 times)
IL-1 (1 time)
2002 Evidence for the biological modulation of IL-1 activity: the role of IL-1Ra.
28  II NOS
(2 times)
Pharmacology
(1 time)
NOS (2 times)
CI (1 time)
cNOS (1 time)
2001 A rapid and transient synthesis of nitric oxide (NO) by a constitutively expressed type II NO synthase in the guinea-pig suprachiasmatic nucleus.
29  in situ hybridization
(2 times)
Reproductive Medicine
(1 time)
NO (1 time)
NOS (1 time)
1999 The contribution of inducible nitric oxide and cytomegalovirus to the stability of complex carotid plaque.
30  induce mRNA and protein expressions of nitric oxide synthase
(2 times)
Nutritional Sciences
(2 times)
COX-2 (2 times)
IL-1beta (2 times)
LPS (2 times)
2015 Glycyrrhiza glabra L. Extract Inhibits LPS-Induced Inflammation in RAW Macrophages.
31  inducible NO synthase expression
(2 times)
Pharmacology
(1 time)
IFN (1 time)
ISRE (1 time)
LPS (1 time)
2014 Novel molecular aspects of ghrelin and leptin in the control of adipobiology and the cardiovascular system.
32  inducible NO synthase inhibitor
(2 times)
Nutritional Sciences
(1 time)
AG (2 times)
ARF (1 time)
i.p (1 time)
2008 Reversal of iron-induced nephrotoxicity in rats by molsidomine, a nitric oxide donor.
33  inducible NOS isoenzyme
(2 times)
Nephrology
(1 time)
NO (2 times)
cNOS (1 time)
ecNOS (1 time)
1997 Renal and systemic nitric oxide synthesis in rats with renal mass reduction.
34  inducible synthase of nitric oxide
(2 times)
Neoplasms
(1 time)
5-LOG (1 time)
COG (1 time)
LPS (1 time)
2006 Effect of IL-18 on leukocyte expression of iNOS and phospho-IkB in patients with squamous cell carcinoma of the oral cavity.
35  induction of NOS
(2 times)
Brain
(1 time)
DA (1 time)
L-NIO (1 time)
LDH (1 time)
1998 Persistent induction of nitric oxide synthase in tumours from mice treated with the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid.
36  inhibitory effect of FGLE on nitric oxide synthase
(2 times)
Allergy and Immunology
(2 times)
COX-2 (2 times)
HK (2 times)
IL-1beta (2 times)
2015 Flavonoid fraction of guava leaf extract attenuates lipopolysaccharide-induced inflammatory response via blocking of NF-kappaB signalling pathway in Labeo rohita macrophages.
37  (LPS)-induced NO-synthase
(1 time)
Biochemistry
(1 time)
DHICA (1 time)
L-NMMA (1 time)
LPS (1 time)
1995 5,6-Dihydroxyindole-2-carboxylic acid, a diffusible melanin precursor, is a potent stimulator of lipopolysaccharide-induced production of nitric oxide by J774 macrophages.
38  anti-inflammatory activities of SPEE, expression of NO synthase
(1 time)
Allergy and Immunology
(1 time)
COX-2 (1 time)
HPLC (1 time)
LPS (1 time)
2012 Spirodela polyrhiza (L.) Sch. ethanolic extract inhibits LPS-induced inflammation in RAW264.7 cells.
39  anti-inflammatory effect of MSCs by enhancing nitric oxide synthase
(1 time)
Cell Biology
(1 time)
EGFP (1 time)
HNF-4alpha (1 time)
MSCs (1 time)
2019 Mesenchymal stem cells overexpressing hepatocyte nuclear factor-4 alpha alleviate liver injury by modulating anti-inflammatory functions in mice.
40  arginase-1(Arg-1)-induced nitric oxide synthase
(1 time)
Allergy and Immunology
(1 time)
Arg-1 (1 time)
Foxp3 vaccine (1 time)
MDSC (1 time)
2018 Prophylactic DNA vaccine targeting Foxp3+ regulatory T cells depletes myeloid-derived suppressor cells and improves anti-melanoma immune responses in a murine model.
41  calmodulin-independent NOS
(1 time)
Nephrology
(1 time)
AT1 (1 time)
cNOS (1 time)
IMCD (1 time)
2000 H+-ATPase activity on unilateral ureteral obstruction: interaction of endogenous nitric oxide and angiotensin II.
42  calmodulin-independent NOS activity
(1 time)
Nephrology
(1 time)
cNOS (1 time)
GFR (1 time)
NOS (1 time)
2003 Role of endogenous nitric oxide in unilateral ureteropelvic junction obstruction in children.
43  endothelial nitric oxide synthase
(1 time)
Molecular Biology
(1 time)
AGEs (1 time)
NAPDH (1 time)
Noxo1 (1 time)
2017 Pigment epithelium‑derived factor protects human glomerular mesangial cells from diabetes via NOXO1‑iNOS suppression.
44  glucose-induced CD68, TREM-1, p-STAT-1, and M1 marker
(1 time)
Cell Biology
(1 time)
DN (1 time)
VD (1 time)
2019 Active vitamin D regulates macrophage M1/M2 phenotypes via the STAT-1-TREM-1 pathway in diabetic nephropathy.
45  hepatic nitric oxide synthase
(1 time)
Pharmacology
(1 time)
CAT (1 time)
COX-2 (1 time)
D-GalN (1 time)
2016 The protective effect of total phenolics from Oenanthe Javanica on acute liver failure induced by D-galactosamine.
46  hepatocyte-inducible NO synthase
(1 time)
Laboratory Techniques and Procedures
(1 time)
BDL (1 time)
NO (1 time)
SNO (1 time)
2010 Inhibition of nitric oxide synthesis during induced cholestasis ameliorates hepatocellular injury by facilitating S-nitrosothiol homeostasis.
47  human-inducible NOS
(1 time)
Dentistry
(1 time)
NO (1 time)
1998 Production of human-inducible nitric oxide synthase in radicular cysts.
48  identify NO synthase
(1 time)
Natural Science Disciplines
(1 time)
CTSK (1 time)
LVEDD (1 time)
LVEDs (1 time)
2016 Qishen Yiqi Drop Pill improves cardiac function after myocardial ischemia.
49  IDO but also nitric oxide synthase
(1 time)
Allergy and Immunology
(1 time)
IDO (1 time)
IFN-gamma (1 time)
LPS (1 time)
2010 Primary murine microglia are resistant to nitric oxide inhibition of indoleamine 2,3-dioxygenase.
50  IFNgamma mRNA and undetectable levels of nitric oxide synthase
(1 time)
Allergy and Immunology
(1 time)
IFN-gamma (1 time)
PA (1 time)
2003 Antifungal activity of macrophages engineered to produce IFNgamma: inducibility by picolinic acid.
51  IkB degradation, and NO synthase
(1 time)
Biology
(1 time)
BAPTA-AM (1 time)
NMDA (1 time)
2002 Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes.
52  IL-6; Type 2 nitric oxide synthase
(1 time)
Virology
(1 time)
--- 1995 Activation of astrocytes in the spinal cord of mice chronically infected with a neurotropic coronavirus.
53  imidazo(4,5-b)pyridines as selective nitric oxide synthase
(1 time)
Biochemistry
(1 time)
--- 2011 Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights.
54  immune compartments
(1 time)
Neurology
(1 time)
nNOS (1 time)
NO (1 time)
2010 Nitric oxide signaling in brain function, dysfunction, and dementia.
55  immunochemistry showed the presence of inducible
(1 time)
Endocrinology
(1 time)
ecNOS (1 time)
NOS (1 time)
2002 Early effects of diabetes on inducible nitric oxide synthase in the kidney.
56  immunocontent of nitric oxide synthase inducible
(1 time)
Brain
(1 time)
OGD (1 time)
2003 Diphenyl diselenide protects rat hippocampal slices submitted to oxygen-glucose deprivation and diminishes inducible nitric oxide synthase immunocontent.
57  immunohistochemical
(1 time)
Allergy and Immunology
(1 time)
EGCG (1 time)
Fl (1 time)
MDA (1 time)
2016 Epigallocatechin gallate potentially abrogates fluoride induced lung oxidative stress, inflammation via Nrf2/Keap1 signaling pathway in rats: An in-vivo and in-silico study.
58  immunohistochemical-inducible nitric oxide synthase
(1 time)
GSH-Px (1 time)
IL-1beta (1 time)
IR (1 time)
2015 Effects of hypothermia on skeletal ischemia reperfusion injury in rats.
59  immunohistochemically whether the expression of both the inducible
(1 time)
Dentistry
(1 time)
NO (1 time)
NOS (1 time)
2000 Expression of nitric oxide synthase in pleomorphic adenomas of the parotid.
60  immunohistochemistry for NO synthase induced
(1 time)
Biology
(1 time)
CD (1 time)
COX-2 (1 time)
EPI (1 time)
2018 Epiisopiloturine, an imidazole alkaloid, reverses inflammation and lipid peroxidation parameters in the Crohn disease model induced by trinitrobenzenosulfonic acid in Wistar rats.
61  immunohistochemistry was performed using antibodies against inducible
(1 time)
Ophthalmology
(1 time)
AMD (1 time)
EC (1 time)
NO (1 time)
2010 Low nitric oxide synthases (NOSs) in eyes with age-related macular degeneration (AMD).
62  immunologic NO synthase
(1 time)
Allergy and Immunology
(1 time)
NO (1 time)
PKC (1 time)
PMA (1 time)
1994 Phorbol ester synergistically increases interferon-gamma-induced nitric oxide synthesis in murine microglial cells.
63  immunoresponsive gene 1, nitric oxide synthase-2
(1 time)
Cell Biology
(1 time)
IDO1-2 (1 time)
2019 Indoleamine 2,3-Dioxygenase Activity in Chlamydia muridarum and Chlamydia pneumoniae Infected Mouse Lung Tissues.
64  immunostained for inducible
(1 time)
Allergy and Immunology
(1 time)
NO (1 time)
1997 Immunolocalization of the inducible nitric oxide synthase isoform in human fetal membranes.
65  including apoptosis, nitric oxide synthase
(1 time)
Biochemistry
(1 time)
CNS (1 time)
IH (1 time)
NO (1 time)
2015 SENP1 inhibits the IH-induced apoptosis and nitric oxide production in BV2 microglial cells.
66  increase of nitrite reductase
(1 time)
Medicine
(1 time)
CHF (1 time)
PICS (1 time)
2010 [Assessment of natriuretic peptide indices and oxidative stress in patients with chronic heart failure].
67  indicating the presence of active nitric oxide synthase
(1 time)
Biochemistry
(1 time)
MPO (1 time)
2007 Pathways for intracellular generation of oxidants and tyrosine nitration by a macrophage cell line.
68  indicator of oxidative stress
(1 time)
Natural Science Disciplines
(1 time)
cART (1 time)
HAND (1 time)
PPARgamma (1 time)
2019 Peroxisome Proliferator-Activated Receptor-gamma agonists exhibit anti-inflammatory and antiviral effects in an EcoHIV mouse model.
69  induce the host to produce nitric oxide synthetase
(1 time)
Microbiology
(1 time)
S. Typhimurium (1 time)
2012 Salmonella "sops" up a preferred electron receptor in the inflamed intestine.
70  induceble and soluble isoform
(1 time)
Complementary Therapies
(1 time)
AG (1 time)
CM (1 time)
LDH (1 time)
1998 [Effects of selective induceble nitric oxide synthase inhibitor on immunological hepatic injury in rat].
71  induced mRNA for NO synthase
(1 time)
Biology
(1 time)
AIDS (1 time)
AM (1 time)
BAL (1 time)
1995 Rapid induction of mRNA for nitric oxide synthase II in rat alveolar macrophages by intratracheal administration of Mycobacterium tuberculosis and Mycobacterium avium.
72  induced the expression of NO synthase
(1 time)
Allergy and Immunology
(1 time)
EAE (1 time)
MBP (1 time)
2003 Sodium phenylacetate inhibits adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice at multiple steps.
73  inducer of glial nitric oxide synthase
(1 time)
Neurology
(1 time)
ADC (1 time)
1995 Agmatine (decarboxylated arginine) is synthesized and stored in astrocytes.
74  Inducible arginine oxidation and subsequent NO production by correspondent synthase
(1 time)
Biochemistry
(1 time)
--- 2011 Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights.
75  inducible biological signals, such as nitric oxide synthase
(1 time)
Laboratory Techniques and Procedures
(1 time)
BP (1 time)
CH (1 time)
DBP (1 time)
2007 Hemodynamic and molecular response to intermittent hypoxia (IH) versus continuous hypoxia (CH) in normal humans.
76  inducible by cytokines and endotoxines
(1 time)
Allergy and Immunology
(1 time)
cNOS (1 time)
NO (1 time)
2003 [Is use of nitric oxide (NO) synthase inhibitors justified for therapy of septic shock?].
77  inducible form of nitrous oxide
(1 time)
Endocrinology
(1 time)
PG (1 time)
2002 Between prepartum luteolysis and onset of expulsion.
78  inducible form of NOS protein
(1 time)
Allergy and Immunology
(1 time)
AG (1 time)
IFN-gamma (1 time)
IL-10 (1 time)
2000 Essential role of nitric oxide and interferon-gamma for tumor immunotherapy with interleukin-10.
79  inducible form of the enzyme NO synthase
(1 time)
Allergy and Immunology
(1 time)
NO (1 time)
1994 TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide.
80  inducible form of the NO synthase enzyme
(1 time)
Gastroenterology
(1 time)
NO (1 time)
2003 Nitric oxide in inflammatory bowel disease.
81  Inducible macrophage NO synthase
(1 time)
Biochemistry
(1 time)
L-NOHA (1 time)
1995 Reconstitution of the second step in NO synthesis using the isolated oxygenase and reductase domains of macrophage NO synthase.
82  inducible macrophage-type NOS
(1 time)
Allergy and Immunology
(1 time)
ALA (1 time)
eNOS (1 time)
NADPH-d (1 time)
2005 The effects of alpha-lipoic acid on nitric oxide synthetase dispersion in penile function in streptozotocin-induced diabetic rats.
83  inducible mouse macrophage NOS
(1 time)
Biochemistry
(1 time)
cNOS (1 time)
NA (1 time)
1993 Selective inhibition of constitutive nitric oxide synthase by L-NG-nitroarginine.
84  inducible nitric oxide expression
(1 time)
Dentistry
(1 time)
--- 2007 Inducible nitric oxide expression correlates with the level of inflammation in periapical cysts.
85  inducible nitric oxide synthetase of macrophages
(1 time)
Medicine
(1 time)
IL-12 (1 time)
TGF-beta (1 time)
1999 [TH1 response in the experimental infection with Trypanosoma cruzi].
86  inducible nitrogenase
(1 time)
Critical Care
(1 time)
3-DZNeP (1 time)
CLP (1 time)
HE (1 time)
2019 [Effects of histone methyltransferase inhibitor on the polarization of peritoneal macrophages in septic mice].
87  inducible nitrous oxide
(1 time)
Pharmacology
(1 time)
Arg1 (1 time)
PKI (1 time)
2016 Exenatide (a GLP-1 agonist) expresses anti-inflammatory properties in cultured human monocytes/macrophages in a protein kinase A and B/Akt manner.
88  inducible NOS inhibitor
(1 time)
Cell Biology
(1 time)
AUC (1 time)
BDL (1 time)
Ca (1 time)
2003 Altered calcium regulation in freshly isolated aortic smooth muscle cells from bile duct-ligated rats: role of nitric oxide.
89  inducible NOS protein
(1 time)
Physiology
(1 time)
ICa (1 time)
1998 Modulation of guinea-pig cardiac L-type calcium current by nitric oxide synthase inhibitors.
90  inducible NuOmicron synthase
(1 time)
Genetics, Medical
(1 time)
COX-2 (1 time)
IKK (1 time)
IL (1 time)
2012 Soybean glyceollins mitigate inducible nitric oxide synthase and cyclooxygenase-2 expression levels via suppression of the NF-kappaB signaling pathway in RAW 264.7 cells.
91  inducible synthase of NO
(1 time)
Allergy and Immunology
(1 time)
NO (1 time)
PBMCs (1 time)
PMN (1 time)
2005 iNOS expression and NO production by neutrophils in cancer patients.
92  induction of a NOS enzyme
(1 time)
Anti-Bacterial Agents
(1 time)
eNOS (1 time)
NO (1 time)
1998 Nitric oxide in sepsis and endotoxaemia.
93  induction of inducible nitric synthase
(1 time)
Anatomy
(1 time)
SGCs (1 time)
TUNEL (1 time)
1997 Effect of aging on the expression of iNOS and cell death in the mouse cochlear spiral ganglion.
94  Induction of the high output nitric oxide synthase isoform
(1 time)
Cardiology
(1 time)
NO (1 time)
2001 Nitric oxide: not just a negative inotrope.
95  INF-gamma, and nitric oxide synthase
(1 time)
Pharmacognosy
(1 time)
IgG (1 time)
IgM (1 time)
IL-6 (1 time)
2015 Pleurotus nebrodensis polysaccharide (PN-S) enhances the immunity of immunosuppressed mice.
96  infected macrophages
(1 time)
Cell Biology
(1 time)
CAFs (1 time)
GSEA (1 time)
HD (1 time)
2014 JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: connecting fibrosis, inflammation, and stemness for cancer prevention.
97  infection, NO synthase
(1 time)
Virology
(1 time)
CNS (1 time)
NO (1 time)
SIV (1 time)
1999 Increased expression of nitric oxide synthase and dendritic injury in simian immunodeficiency virus encephalitis.
98  inflammatory cell recruitment or NO synthase activity
(1 time)
Biochemistry
(1 time)
MPO (1 time)
PMNs (1 time)
SPF (1 time)
2007 NADPH oxidase but not myeloperoxidase protects lymphopenic mice from spontaneous infections.
99  inflammatory mediators
(1 time)
Nutritional Sciences
(1 time)
LPS (1 time)
MH (1 time)
ROS (1 time)
2018 Protective effects of Manuka honey on LPS-treated RAW 264.7 macrophages. Part 2: Control of oxidative stress induced damage, increase of antioxidant enzyme activities and attenuation of inflammation.
100  inflammatory response through the reduction of nitric oxide synthase
(1 time)
Pharmacology
(1 time)
4-HNE (1 time)
AKI (1 time)
COX-2 (1 time)
2018 Improvement of Cisplatin-induced renal dysfunction by Schisandra chinensis stems via anti-inflammation and anti-apoptosis effects.
101  inflammatory response, upregulation of nitric oxide synthase
(1 time)
Pharmacology
(1 time)
COX-2 (1 time)
LPS (1 time)
2006 Anti-inflammatory effect of Ruta graveolens L. in murine macrophage cells.
102  inhibit the expression and activity of both cytosolic
(1 time)
Neurology
(1 time)
AMK (1 time)
aMT (1 time)
PD (1 time)
2009 Melatonin and its brain metabolite N(1)-acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice.
103  inhibited oxidative activities with reducing nitric oxide synthase
(1 time)
Allergy and Immunology
(1 time)
ALF (1 time)
CAT (1 time)
d-GalN (1 time)
2019 Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
104  inhibiting the synthesis of cytokine-activated NO synthase
(1 time)
Food
(1 time)
ER (1 time)
NF-kappaB (1 time)
NO (1 time)
2017 Spirulina Extract Enhanced a Protective Effect in Type 1 Diabetes by Anti-Apoptosis and Anti-ROS Production.
105  inhibitors
(1 time)
Substance-Related Disorders
(1 time)
ATP (1 time)
EtOH (1 time)
NO (1 time)
2014 Functional role for mouse cerebellar NO/cGMP/KATP pathway in ethanol-induced ataxia.
106  inhibitors of nNOS, macrophage nitric oxide synthase
(1 time)
Chemistry
(1 time)
eNOS (1 time)
nNOS (1 time)
1997 Selective inhibition of neuronal nitric oxide synthase by N omega-nitroarginine-and phenylalanine-containing dipeptides and dipeptide esters.
107  inhibitors with affinity for the inducible
(1 time)
Cell Biology
(1 time)
AP (1 time)
cNOS (1 time)
DAHP (1 time)
1997 Involvement of nitric oxide in the interferon-gamma-induced inhibition of growth hormone and prolactin secretion in anterior pituitary cell cultures.
108  inhibitory NOS
(1 time)
Cell Biology
(1 time)
CATH.a (1 time)
eNOS (1 time)
L-NIO (1 time)
2011 Angiotensin-(1-7) increases neuronal potassium current via a nitric oxide-dependent mechanism.
109  inhibits Kupffer cell nitric oxide synthase
(1 time)
Allergy and Immunology
(1 time)
KC (1 time)
1996 Gadolinium chloride inhibits Kupffer cell nitric oxide synthase (iNOS) induction.
110  injection of benzo(a)pyrene into iNOS-deficient
(1 time)
Neoplasms
(1 time)
PCTc (1 time)
2009 Impact of inducible nitric oxide synthase gene on tumor progression.
111  iNO synthase
(1 time)
Hematology
(1 time)
B-CLL (1 time)
NO (1 time)
2002 Analysis of resveratrol-induced apoptosis in human B-cell chronic leukaemia.
112  inotilone affected the protein expression of MMPs, nitric oxide synthase
(1 time)
Natural Science Disciplines
(1 time)
COX (1 time)
FAK (1 time)
IL (1 time)
2019 Inotilone from Inonotus linteus suppresses lung cancer metastasis in vitro and in vivo through ROS-mediated PI3K/AKT/MAPK signaling pathways.
113  Interestingly, we observed dose-dependent nitric oxide
(1 time)
Biochemistry
(1 time)
SERCA (1 time)
Tb (1 time)
2015 Trilobolide-porphyrin conjugates: on synthesis and biological effects evaluation.
114  interleukin-1-beta-inducible NO synthase
(1 time)
Biochemistry
(1 time)
ERK (1 time)
MAPK (1 time)
VCAM-1 (1 time)
2004 Angiotensin II differentially regulates interleukin-1-beta-inducible NO synthase (iNOS) and vascular cell adhesion molecule-1 (VCAM-1) expression: role of p38 MAPK.
115  interleukin-1beta-induced nitric oxide synthase
(1 time)
Vascular Diseases
(1 time)
MAPKs (1 time)
2000 N-Acetyl-L-cysteine potentiates interleukin-1beta induction of nitric oxide synthase : role of p44/42 mitogen-activated protein kinases.
116  into the normally insertless inducible
(1 time)
Biochemistry
(1 time)
CaM (1 time)
2001 Control of electron transfer in nitric-oxide synthases. Swapping of autoinhibitory elements among nitric-oxide synthase isoforms.
117  investigated the effects of NO synthase
(1 time)
Neurology
(1 time)
NO (1 time)
ROS (1 time)
2000 Nitric oxide synthase induction in astroglial cell cultures: effect on heat shock protein 70 synthesis and oxidant/antioxidant balance.
118  investigated the modulating factor(s) affecting NO synthase
(1 time)
Immunity
(1 time)
IFN (1 time)
Mtb (1 time)
NO (1 time)
2009 Nitric Oxide Synthesis is Modulated by 1,25-Dihydroxyvitamin D3 and Interferon-gamma in Human Macrophages after Mycobacterial Infection.
119  investigated whether enhanced nitric oxide synthase
(1 time)
Pediatrics
(1 time)
CAL (1 time)
KD (1 time)
NO (1 time)
2004 Enhanced iNOS expression in leukocytes and circulating endothelial cells is associated with the progression of coronary artery lesions in acute Kawasaki disease.
120  investigators have proposed that the expression of this inducible enzyme
(1 time)
Medicine
(1 time)
NO (1 time)
1996 Expression of nitric oxide synthase in ulcerative colitis.
121  involvement of the glial NOS isoform
(1 time)
Neurology
(1 time)
nNOS (1 time)
NO (1 time)
2010 Astrocytic iNOS-dependent enhancement of synaptic release in mouse neocortex.
122  ischemia on inducible
(1 time)
Brain
(1 time)
cNOS (1 time)
MCA (1 time)
1995 Marked induction of calcium-independent nitric oxide synthase activity after focal cerebral ischemia.
123  isoform NOS
(1 time)
Toxicology
(1 time)
ACh (1 time)
eNOS (1 time)
SNP (1 time)
2007 Direct effects of lead (Pb2+) on the relaxation of in vitro cultured rat aorta to acetylcholine.
124  isoform of nitric oxide
(1 time)
Neurology
(1 time)
HIV-1 (1 time)
IFN-gamma (1 time)
LPS (1 time)
1999 Human immunodeficiency virus type 1 Tat protein stimulates inducible nitric oxide synthase expression and nitric oxide production in microglial cultures.
125  isoform of the enzyme NO synthase
(1 time)
Medicine
(1 time)
NO (1 time)
1999 [Nitric oxide--an important mediator in sepsis?].
126  isoform, ranging from oxidative stress amplification
(1 time)
Biochemistry
(1 time)
nNOS (1 time)
NO (1 time)
NOSs (1 time)
2010 NO synthase isoforms specifically modify peroxynitrite reactivity.
127  isoform-selective NOS
(1 time)
Pharmacology
(1 time)
NO (1 time)
NOS (1 time)
STZ (1 time)
2002 Effects of nitric oxide synthase inhibitors and melatonin on the hyperglycemic response to streptozotocin in rats.
128  isoforms of which have been identified: inducible
(1 time)
General Surgery
(1 time)
NADPH (1 time)
NO (1 time)
RN (1 time)
2002 The role of nitric oxide in reflux nephropathy.
129  isolated from neuronal sources; NOS-2
(1 time)
Nutritional Sciences
(1 time)
IL (1 time)
NO (1 time)
NOS (1 time)
1998 The role of nitric oxide in hepatic metabolism.
130  isomers of NOS--inducible
(1 time)
Reproduction
(1 time)
NO (1 time)
PTnotL (1 time)
TL (1 time)
2005 mRNA expression and localization of bNOS, eNOS and iNOS in human cervix at preterm and term labour.
131  its activity toward nitric oxide synthase
(1 time)
Biochemistry
(1 time)
--- 1998 Oleuropein, the bitter principle of olives, enhances nitric oxide production by mouse macrophages.
132  its enzymatic activity by nitric oxide and nitric oxide synthase
(1 time)
Biochemistry
(1 time)
C/EBP (1 time)
COX-2 (1 time)
CREB (1 time)
2006 Signalling networks regulating cyclooxygenase-2.
133  its metabolites (nitrate/nitrite) and the enzyme responsible for its production
(1 time)
Allergy and Immunology
(1 time)
cGMP (1 time)
NO (1 time)
2015 Role of nitric oxide in immune responses against viruses: beyond microbicidal activity.
134  lipopolysaccharide-inducible nitric oxide synthase
(1 time)
Pharmacology
(1 time)
--- 1996 Functional effects of econazole on inducible nitric oxide synthase: production of a calmodulin-dependent enzyme.
135  LPS-induced NO products, NO synthase
(1 time)
Chemistry
(1 time)
COX-2 (1 time)
NF-kappaB (1 time)
NO (1 time)
2016 A tryptamine-paeonol hybridization compound inhibits LPS-mediated inflammation in BV2 cells.
136  LPS-induced protein and mRNA expression levels of nitric oxide synthase
(1 time)
Inflammation
(1 time)
COX-2 (1 time)
IL-1beta (1 time)
JNK (1 time)
2015 Pharmacological mechanism underlying anti-inflammatory properties of two structurally divergent coumarins through the inhibition of pro-inflammatory enzymes and cytokines.
137  LPS-induced synthesis of both mRNA and protein of NO synthase
(1 time)
Biochemistry
(1 time)
BMD (1 time)
LPS (1 time)
NF (1 time)
2005 Anti-inflammatory benzene diamine compound inhibited toll-like receptor 4-mediated inducible nitric oxide synthase expression and nuclear factor-kappa B activation.
138  LPS-induced up-regulations of NO synthase
(1 time)
Biochemistry
(1 time)
BuChE (1 time)
CA (1 time)
COX-2 (1 time)
2019 A caffeic acid-ferulic acid hybrid compound attenuates lipopolysaccharide-mediated inflammation in BV2 and RAW264.7 cells.
139  macrophage-inducible form of NO synthase
(1 time)
Physiology
(1 time)
NO (1 time)
1996 Expression of the inducible nitric oxide synthase gene in diaphragm and skeletal muscle.
140  macrophage-inducible form of NOS
(1 time)
Biochemistry
(1 time)
NOS (1 time)
1996 Induction of inducible nitric-oxide synthase by the heterotrimeric G protein Galpha13.
141  macrophage-inducible NOS
(1 time)
Physiology
(1 time)
IFN (1 time)
IL-1 (1 time)
LPS (1 time)
1994 Cytokine-induced expression of nitric oxide synthase in C2C12 skeletal muscle myocytes.
142  NOS II
(1 time)
Biochemistry
(1 time)
ISBN (1 time)
NO (1 time)
NT (1 time)
2000 Nitrite inhalation in rats elevates tissue NOS III expression and alters tyrosine nitration and phosphorylation.
143  NOS isomers, inducible
(1 time)
Nervous System Diseases
(1 time)
GDNF (1 time)
NOS (1 time)
2016 Are Temporal Differences in GDNF and NOS Isoform Induction Contributors to Neurodegeneration? A Fluorescence Microscopy-Based Study.
144  NOS-inducible
(1 time)
Allergy and Immunology
(1 time)
cAMP (1 time)
COX (1 time)
IL-1beta (1 time)
2003 Interactions between the nitric oxide and prostaglandin E2 biosynthetic pathways in human amnion-like WISH cells.
145  pro-inflammatory mediators' expression such as nitric oxide synthase
(1 time)
Allergy and Immunology
(1 time)
Abeta1-42 (1 time)
COX-2 (1 time)
EsA (1 time)
2017 Esculentoside A exerts anti-inflammatory activity in microglial cells.