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■ Abbreviation / Long Form : 12-LOX / 12-lipoxygenase

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Total Number of Papers: 122
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Abbreviation:   12-LOX  (>> Co-occurring Abbreviation)
Long Form:   12-lipoxygenase
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No. Year Title Co-occurring Abbreviation
2022 A cell-free difunctional demineralized bone matrix scaffold enhances the recruitment and osteogenesis of mesenchymal stem cells by promoting inflammation resolution. 12S-HETE, Apt19S, DBM, LDs, MaR1, MSCs, SPMs
2022 INTERCEPT Pathogen Reduction in Platelet Concentrates, in Contrast to Gamma Irradiation, Induces the Formation of trans-Arachidonic Acids and Affects Eicosanoid Release during Storage. 11-HETE, 12-HEPE, HPODE, UVA
2022 Key Role of 12-Lipoxygenase and Its Metabolite 12-Hydroxyeicosatetraenoic Acid (12-HETE) in Diabetic Retinopathy. 12-HETE, DR, ROS
2022 ML355 Modulates Platelet Activation and Prevents ABT-737 Induced Apoptosis in Platelets. Syk
2022 Senescence-associated tumor growth is promoted by 12-Lipoxygenase. SASP
2021 12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes. T1D
2021 Docking and mutagenesis studies lead to improved inhibitor development of ML355 for human platelet 12-lipoxygenase. ---
2021 Matrix stiffness regulates bone repair by modulating 12-lipoxygenase-mediated early inflammation. DBM, MSCs, PUFAs, SPMs
2021 Platelet ACKR3/CXCR7 favors antiplatelet lipids over an atherothrombotic lipidome and regulates thromboinflammation. 12-HETrE, CAD, COX-1, DGLA
10  2021 Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase. 12-HETE, EMT, EVs, mEVs, PLs
11  2021 Profiling oxylipins released from human platelets activated through the GPVI collagen receptor. COX-1, GPVI
12  2021 [Antagonistic effect of 12-lipoxygenase inhibitor ML355 on lipopolysaccharide induced inflammatory response in mice]. 12-HETE, ALOX15, CCK-8, DMSO, ELISA, ERK, IFN-gamma, JNK, LPS, MAPK, PMs, qRT-PCR, TNF-alpha
13  2020 12-Lipoxygenase as a key pharmacological target in the pathogenesis of diabetic nephropathy. CREB, HETE, p38MAP, TGF-beta
14  2020 12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA2gamma knockout. 2-AA-LPC, 2-AA-LPE, PNPLA8
15  2020 A 12-lipoxygenase-Gpr31 signaling axis is required for pancreatic organogenesis in the zebrafish. ---
16  2020 Baicalein Alleviates Erectile Dysfunction Associated With Streptozotocin-Induced Type I Diabetes by Ameliorating Endothelial Nitric Oxide Synthase Dysfunction, Inhibiting Oxidative Stress and Fibrosis. BE, CC, DMED
17  2020 DHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway. DHA, omega-3 PUFA
18  2020 Lipid Receptor GPR31 (G-Protein-Coupled Receptor 31) Regulates Platelet Reactivity and Thrombosis Without Affecting Hemostasis. AC, GPR31, GPR310, PAR
19  2020 Omega-6 DPA and its 12-lipoxygenase-oxidized lipids regulate platelet reactivity in a nongenomic PPARalpha-dependent manner. PPARalpha, PUFAs
20  2020 Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages. ESCC
21  2020 Synthetic high-density lipoproteins loaded with an antiplatelet drug for efficient inhibition of thrombosis in mice. sHDL
22  2020 The SP1-12LOX axis promotes chemoresistance and metastasis of ovarian cancer. AA, CCK-8, ChIP, EMT, IHC, MRPs, qPCR, SKOV3
23  2020 [Research progress of 12-HETE in the inflammation and oxidative stress]. AA, PLA2
24  2019 12-Lipoxygenase is a Critical Mediator of Type II Pneumocyte Senescence, Macrophage Polarization and Pulmonary Fibrosis after Irradiation. 12S-HETE, NOX4, RIPF
25  2019 12-Lipoxygenase promotes epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway in gastric cancer cells. CCK-8, EMT, GC, qRT-PCR
26  2019 A maresin 1/RORalpha/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis. DHA, MaR1, NASH, RORalpha
27  2019 Arachidonic acid-rich ARASCO oil has anti-inflammatory and antidiabetic actions against streptozotocin + high fat diet induced diabetes mellitus in Wistar rats. AA, COX-2, HFD, LPCLN2, NF-kappaB
28  2019 Bradykinin sensitizes the cough reflex via a B2 receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase. BK, COX, i.c.v
29  2019 Pneumolysin Induces 12-Lipoxygenase-Dependent Neutrophil Migration during Streptococcus pneumoniae Infection. CDC, PLY
30  2018 12-HETE facilitates cell survival by activating the integrin-linked kinase/NF-κB pathway in ovarian cancer. 12-HETE, ILK, LDH, NF-kappaB
31  2018 12-Lipoxygenase promotes invasion and metastasis of human gastric cancer cells via epithelial-mesenchymal transition. EMT
32  2018 Oxygenation of polyunsaturated fatty acids and oxidative stress within blood platelets. ARA, DHA, EPA, PUFA
33  2018 Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications. ---
34  2017 Crataegus orientalis Leaves and Berries: Phenolic Profiles, Antioxidant and Anti-inflammatory Activity. COX-1
35  2017 Cytosolic Phospholipase A2alpha Promotes Pulmonary Inflammation and Systemic Disease during Streptococcus pneumoniae Infection. AA, HXA3, PLA2, PMNs
36  2017 First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis. ---
37  2017 Glucose impairs aspirin inhibition in platelets through a NAD(P)H oxidase signaling pathway. NOX, p38 MAPK, PLA2, ROS
38  2017 Molecular mechanisms of nonalcoholic fatty liver disease: Potential role for 12-lipoxygenase. NAFLD
39  2017 Targeting 12-Lipoxygenase as a Potential Novel Antiplatelet Therapy. ---
40  2016 12(S)-HETrE, a 12-Lipoxygenase Oxylipin of Dihomo-gamma-Linolenic Acid, Inhibits Thrombosis via Galphas Signaling in Platelets. DGLA
41  2016 A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway. 12-HETE
42  2016 Convergence of eicosanoid and integrin biology: Role of Src in 12-LOX activation. ---
43  2016 On the cellular metabolism of the click chemistry probe 19-alkyne arachidonic acid. AA, AA-alk, LTB4, PL
44  2014 ALOX12 in human toxoplasmosis. 12-HPETE
45  2014 Analysis, physiological and clinical significance of 12-HETE: a neglected platelet-derived 12-lipoxygenase product. 12-HETE, COX, ELISA, HPLC, RIA
46  2014 Evaluation of 12-lipoxygenase (12-LOX) and plasminogen activator inhibitor 1 (PAI-1) as prognostic markers in prostate cancer. APTT, BPH, CRP, Hct, INR, PAI-1, PLT, PSA, TGB, WBC
47  2014 In vitro extinction learning in Hermissenda: involvement of conditioned inhibition molecules. AA, caPP1, CI, H.c, LSs, PP1, PP2B
48  2014 Liquid chromatography-tandem mass spectrometry for simultaneous measurement of thromboxane B2 and 12(S)-hydroxyeicosatetraenoic acid in serum. AA, TX
49  2014 Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages. 13,14-diHDHA, 13R,14S-diHDHA, AA, DHA, MaR1, MaR2, sEH
50  2014 Platelet 12-LOX is essential for FcgammaRIIa-mediated platelet activation. ---
51  2014 The oxido-reductase enzyme glutathione peroxidase 4 (GPX4) governs Salmonella Typhimurium-induced neutrophil transepithelial migration. GPX4, HXA3, S. Typhimurium
52  2014 [Selective 12-lipoxygenase inhibition potentiates the effect of radiation on human prostate cancer cells in vitro and in vivo]. ---
53  2013 12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity. ---
54  2013 Expression of cyclooxygenase-2, 12-lipoxygenase, and inducible nitric oxide synthase in head and neck squamous cell carcinoma. COX-2, HNSCC, iNOS
55  2013 Inhibition of 12-lipoxygenase reduces platelet activation and prevents their mitogenic function. ASMC, CDC, ROS
56  2013 Polymorphisms in arachidonic acid metabolism-related genes and the risk and prognosis of colorectal cancer. COX-2, CRC, PCR-RFLP, PLA2
57  2013 Radiosensitivity of human prostate cancer cells can be modulated by inhibition of 12-lipoxygenase. PCa
58  2013 Systemic disease during Streptococcus pneumoniae acute lung infection requires 12-lipoxygenase-dependent inflammation. HXA3, PMNs
59  2013 Transient heparin-induced platelet activation linked to generation of platelet 12-lipoxygenase. Findings from a randomised controlled trial. 12-HETE, AA, ADP, CEA, COX-1, LMWH
60  2012 Inhibition of 12-lipoxygenase reduces proliferation and induces apoptosis of hepatocellular carcinoma cells in vitro and in vivo. HCC, RT-PCR
61  2012 Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation. AA, ALA, DGLA, EDA, EPA, LA
62  2012 Non-synonymous polymorphism (Gln261Arg) of 12-lipoxygenase in colorectal and thyroid cancers. AG
63  2012 Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. i.t
64  2011 Analysis of omega-3 and omega-6 fatty acid-derived lipid metabolite formation in human and mouse blood samples. 12-HEPE, 12-HETE, 14-HDHA, DHA, EPA
65  2011 Arachidonate 12-lipoxygenase may serve as a potential marker and therapeutic target for prostate cancer stem cells. ABCG2, PCa, PCa SCs, SP
66  2011 Distinct role of nitric oxide and peroxynitrite in mediating oligodendrocyte toxicity in culture and in experimental autoimmune encephalomyelitis. DETA NONOate, DPT NONOate, EAE, iNOS, LPS, OLs, ROS
67  2011 Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: implications in retinal neovascularization. 12-HETE, NV, OIR, PDR, PEDF, VEGF
68  2011 Link between metformin and the peroxisome proliferator-activated receptor gamma pathway in the uterine tissue of hyperandrogenized prepubertal mice. PPARgamma
69  2011 Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation. AA, PKC
70  2011 Role of 12-lipoxygenase in regulation of ovarian cancer cell proliferation and survival. EOC
71  2011 Twelve oxo-eicosatetraenoic acid induces fetal membrane release after delivery in cows. 12-oxoETE, ARA, COX, MMP, PG, RFM
72  2010 Direction of neutrophil movements by Campylobacter-infected intestinal epithelium. ---
73  2010 Inflammatory hyperalgesia induces essential bioactive lipid production in the spinal cord. COX
74  2010 Liquid chromatography/tandem mass spectrometry study of anti-inflammatory activity of plantain (Plantago L.) species. COX-1
75  2010 Thrombin-activated human platelets acutely generate oxidized docosahexaenoic-acid-containing phospholipids via 12-lipoxygenase. HDOHE, LC
76  2009 Glutathione disulfide induces neural cell death via a 12-lipoxygenase pathway. ---
77  2009 Survival effects of cyclooxygenase-2 and 12-lipooxygenase in Egyptian women with operable breast cancer. BC, COX-2, DFS, OS
78  2009 Vitamin K prevents oxidative cell death by inhibiting activation of 12-lipoxygenase in developing oligodendrocytes. ROS
79  2008 A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors. 15-LOX, 5-HPETE, 5-LOX, 5-oxo-ETE, COX
80  2008 Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes. 5-LOX, COX-2, DDIT3, ROS
81  2008 Co-oxidation-mediated xenobiotic activation and cytotoxicity by 12-lipoxygenase in intact platelets. AA, PHS
82  2008 Immunohistochemical localization of anabolic and catabolic enzymes for anandamide and other putative endovanilloids in the hippocampus and cerebellar cortex of the mouse brain. AEA, COMT, COX-2, FAAH, NADAs, NAEs, NAPE-PLD, TRPV1
83  2007 12-lipoxygenase induces apoptosis of human gastric cancer AGS cells via the ERK1/2 signal pathway. BIM, PKC
84  2007 12-Lipoxygenase-derived eicosanoids protect against myocardial ischemia/reperfusion injury via activation of neuronal TRPV1. AA, TRPV1
85  2007 Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids. BBIQ, DPPH
86  2007 Insulin-like growth factor-II regulates the 12-lipoxygenase gene expression and promotes cell proliferation in human keratinocytes via the extracellular regulatory kinase and phosphatidylinositol 3-kinase pathways. ERK, IGF-II, PI3K
87  2007 Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms. CI, COX-2, ESCC, OR
88  2007 Platelet activation triggered by Chlamydia pneumoniae is antagonized by 12-lipoxygenase inhibitors but not cyclooxygenase inhibitors. CDC, COX, PAF, SNAP
89  2007 Possible involvement of 12-lipoxygenase activation in glucose-deprivation/reload-treated neurons. GD/R, PARP, ROS
90  2006 Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol. HCA
91  2006 Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis. ---
92  2006 Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenase. 12-HETE, HUVECs, MAPKs, PPARalpha
93  2005 Molecular mechanisms of fenretinide-induced apoptosis of neuroblastoma cells. ROS
94  2005 Zaltoprofen inhibits bradykinin-induced responses by blocking the activation of second messenger signaling cascades in rat dorsal root ganglion cells. COXs, DRG, NSAID
95  2004 12-Lipoxygenase metabolism in mouse distal convoluted tubule cells. ELISA, MDCT, RT-PCR
96  2004 Alterations of activities of cytosolic phospholipase A2 and arachidonic acid-metabolizing enzymes in di-(2-ethylhexyl)phthalate-induced testicular atrophy. AA, COX-2, cPLA2, CYP4A1, DEHP, PPARalpha
97  2004 Comparison of gene expression in squamous cell carcinoma and adenocarcinoma of the uterine cervix. ACA, NSQ, PCR, RhGC, SCC, try2
98  2004 Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation. MAPK, ROS
99  2003 Biosynthesis of hepoxilins: evidence for the presence of a hepoxilin synthase activity in rat insulinoma cells. AA, cGPx, PHGPx
100  2003 Growth factor-induced proliferation in corneal epithelial cells is mediated by 12(S)-HETE. AA, BC, CDC, EGF, HGF, KGF