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■ Abbreviation / Long Form : 5 alpha-DHT / 5 alpha-dihydrotestosterone

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Total Number of Papers: 226
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Abbreviation:   5 alpha-DHT  (>> Co-occurring Abbreviation)
Long Form:   5 alpha-dihydrotestosterone
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2022 A composite of hepatocyte growth factor and 5α-dihydrotestosterone-gelatin microspheres with adipose-derived stem cells enhances wound healing. ADSCs, HGF
2021 Combined MD and QM/MM Investigations of Hydride Reduction of 5alpha-Dihydrotestosterone Catalyzed by Human 3alpha-Hydroxysteroid Dehydrogenase Type 3: Importance of Noncovalent Interactions. 3alpha-HSD, MD, NADPH, NCI, QM/MM
2021 Genome analyses and androgen quantification for an infant with 5α-reductase type 2 deficiency. ---
2021 Plasma androgens and the presence and course of depression in a large cohort of men. DHEAS, MDD
2021 The role of 5-reduction in physiology and metabolic disease: evidence from cellular, pre-clinical and human studies. 5betaR
2020 Androgens stimulate erythropoiesis through the DNA-binding activity of the androgen receptor in non-hematopoietic cells. AR, EPO
2020 Consequences of steroid-5alpha-reductase deficiency and inhibition in vertebrates. 3alpha-diol, 5ARIs, ALLO, DUT, FIN, SRD5alpha2
2020 Different regulation of lipogenesis in sebocytes and subcutaneous preadipocytes in hamsters in vitro. IGF-1, TG
2020 Effect of testosterone and estrogen supplementation on the resistance to systemic Candida albicans infection in mice. C. albicans
10  2020 Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm. AGA, BPH, IR, NAFLD
11  2020 Maternal effects and urbanization: Variation of yolk androgens and immunoglobulin in city and forest blackbirds. ---
12  2019 Design and development of letrozole nanoemulsion: A comparative evaluation of brain targeted nanoemulsion with free letrozole against status epilepticus and neurodegeneration in mice. 3alpha-diol, KA, LET, LET-NE, LET-NE, PDI, SE
13  2019 Design, synthesis and characterization of a PEGylated stanozolol for potential therapeutic applications. AAS, AChE, AR, STZ
14  2019 Formation of 5alpha-dihydrotestosterone from 5alpha-androstane-3alpha,17beta-diol in prostate cancer LAPC-4 cells - Identifying inhibitors of non-classical pathways producing the most potent androgen. 3alpha-diol, AR, PC
15  2019 Intracrinology-revisited and prostate cancer. DHEA
16  2018 A review of the role of estrogen in dermal aging and facial attractiveness in women. CEE, ER
17  2018 Aromatase inhibition by letrozole attenuates kainic acid-induced seizures but not neurotoxicity in mice. 3alpha-diol, 3alpha-HSOR, DHT, KA
18  2018 Hyperhomocysteinemia and hyperandrogenemia share PCSK9-LDLR pathway to disrupt lipid homeostasis in PCOS. CVD, HA, Hcy, HHcy, HTL, PCOS, StAR
19  2018 Identification of SEPTIN12 as a novel target of the androgen and estrogen receptors in human testicular cells. AR, EDCs, ERalpha, SEPT12, SNPs
20  2017 DHRS7 (SDR34C1) - A new player in the regulation of androgen receptor function by inactivation of 5alpha-dihydrotestosterone? 3alphaAdiol, AR
21  2017 Dihydrotestosterone, a robust promoter of osteoblastic proliferation and differentiation: understanding of time-mannered and dose-dependent control of bone forming cells. ALP, ARS, CN, EDX, SEM, VG
22  2017 Dysregulation of the Anti-Mullerian Hormone System by Steroids in Women With Polycystic Ovary Syndrome. AMH, FF, GCs, mRNA, PCOS
23  2017 Long-lasting masculinizing effects of postnatal androgens on myelin governed by the brain androgen receptor. AR
24  2017 Negative Impact of Testosterone Deficiency and 5alpha-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men. AGA, BMD, BPH, CV, ED, FM, IR, LBM, MetS, NAFLD, TD
25  2016 Androgens modulate gene expression and specific DNA methylation pattern of steroid 5alpha-reductases in the frog Silurana tropicalis. 5beta-DHT, Srd5beta
26  2016 Identification of a new plant extract for androgenic alopecia treatment using a non-radioactive human hair dermal papilla cell-based assay. 5alpha-R, AGA, Am, AR, HHDPCs, TLC
27  2016 Sex steroid profiles in zebra finches: Effects of reproductive state and domestication. DHEA
28  2014 Avicequinone C isolated from Avicennia marina exhibits 5alpha-reductase-type 1 inhibitory activity using an androgenic alopecia relevant cell-based assay system. 5alpha-R, AGA, Am, HHDPCs, TLC
29  2014 Effects of 5alpha-dihydrotestosterone on expression of genes related to steroidogenesis and spermatogenesis during the sex determination and differentiation periods of the pejerrey, Odontesthes bonariensis. 11-KT
30  2014 Functional mechanism of C-terminal tail in the enzymatic role of porcine testicular carbonyl reductase: a combined experiment and molecular dynamics simulation study of the C-terminal tail in the enzymatic role of PTCR. nsSNV, SDR
31  2014 Medical hypothesis: loss of the endocrine function of the prostate is important to the pathophysiology of postprostatectomy erectile dysfunction. ED
32  2014 Potential targets in the discovery of new hair growth promoters for androgenic alopecia. AGA
33  2014 The dark side of 5alpha-reductase inhibitors' therapy: sexual dysfunction, high Gleason grade prostate cancer and depression. 5alpha-R, 5alpha-RIs, BPH, LUTS
34  2014 Transcriptomic profiling in Silurana tropicalis testes exposed to finasteride. ---
35  2013 Estradiol and testosterone regulate arginine-vasopressin expression in SH-SY5Y human female neuroblastoma cells through estrogen receptors-alpha and -beta. AVP, ERs
36  2013 Expression of aldo-keto reductase family 1 member C3 (AKR1C3) in neuroendocrine tumors & adenocarcinomas of pancreas, gastrointestinal tract, and lung. 3alpha-diol, AKR1C3, DDx, NE
37  2013 Spectrophotometric method for the assay of steroid 5alpha-reductase activity of rat liver and prostate microsomes. 5alpha-diol, 5alpha-SR, thio-NAD
38  2012 Aldo-keto reductase family 1 member C3 (AKR1C3) is expressed in adenocarcinoma and squamous cell carcinoma but not small cell carcinoma. 3alpha-diol, AKR1C3, DDx, HSD, NSCLC
39  2012 Biochemical investigation and gene analysis of equol: a plant and soy-derived isoflavonoid with antiaging and antioxidant properties with potential human skin applications. ECM, ELN, FACS, hMFC
40  2011 Androgen and androgen metabolite levels in serum and urine of East African chimpanzees (Pan troglodytes schweinfurthii): comparison of EIA and LC-MS analyses. EIA
41  2011 Equol an isoflavonoid: potential for improved prostate health, in vitro and in vivo evidence. DMSO, LH, PSA
42  2011 Increased JNK1 activity contributes to the upregulation of ApoD in the apocrine secretory gland cells from axillary osmidrosis. ---
43  2011 Mono-(2-ethylhexyl) phthalate directly alters the expression of Leydig cell genes and CYP17 lyase activity in cultured rat fetal testis. 17 alpha-OHP, INSL3, MEHP
44  2011 Trace analysis of 28 steroids in surface water, wastewater and sludge samples by rapid resolution liquid chromatography-electrospray ionization tandem mass spectrometry. ADD, ADR, DES, EADR, ET, MP, MT
45  2010 Effect of caponization and exogenous androgen implantation on muscle characteristics of male chickens. 19-NorT, Chol, sham, TES
46  2010 Effects of caponization and different forms of exogenous androgen implantation on immunity in male chicks. 19-NorT, DTH, PHA-P, SHAM, TES
47  2010 LC-MS analysis of androgen metabolites in serum and urine from east African chimpanzees (Pan troglodytes schweinfurthii). ---
48  2010 New frontiers in androgen biosynthesis and metabolism. CRPC
49  2009 Effect of caponization and different exogenous androgen on hepatic lipid and beta-oxidase of male chickens. 19-NorT, Chol, ECH, KT, MDH, SHAM, TES
50  2009 Peptide antagonist of the androgen receptor. AR, LBD, NTD
51  2009 Steroid hormone transforming aldo-keto reductases and cancer. AKR, PG
52  2008 5alpha-androstane-3alpha,17beta-diol selectively activates the canonical PI3K/AKT pathway: a bioinformatics-based evidence for androgen-activated cytoplasmic signaling. 3alpha-diol, 3alpha-HSDs, AR
53  2008 5alpha-androstane-3alpha,17beta-diol supports human prostate cancer cell survival and proliferation through androgen receptor-independent signaling pathways: implication of androgen-independent prostate cancer progression. 3alpha-diol, 3alpha-HSDs, AR
54  2008 Stimulation of N-terminal truncated isoform of androgen receptor stabilizes human ether-a-go-go-related gene-encoded potassium channel protein via activation of extracellular signal regulated kinase 1/2. AR, hERG
55  2007 Pre-receptor regulation of the androgen receptor. 3alpha-diol, AKR, AR, HSDs
56  2007 Testosterone metabolism to 5alpha-dihydrotestosterone and synthesis of sebaceous lipids is regulated by the peroxisome proliferator-activated receptor ligand linoleic acid in human sebocytes. PPAR
57  2006 A neuroactive steroid 5alpha-androstane-3alpha,17beta-diol regulates androgen receptor level in astrocytes. 3alpha-diol, AR, ERK, GFAP, MAPK, ONH, PI3K
58  2006 Androgen decreases osteoprotegerin expression in prostate cancer cells. OPG
59  2006 Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in men. AKR1C, BMI, OM, s.c
60  2006 Effect of 5alpha-dihydrotestosterone and testosterone on apoptosis in human dermal papilla cells. DPC
61  2006 Effects of caponization and different exogenous androgen on the bone characteristics of male chickens. 19-NorT, SHAM, TES
62  2006 Roles of type 10 17beta-hydroxysteroid dehydrogenase in intracrinology and metabolism of isoleucine and fatty acids. HSD, SCHSD
63  2005 Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen. AKR
64  2005 Expression of 3alpha- and 3beta-hydroxy steroid dehydrogenase mRNA in COCs and granulosa cells determines Zearalenone biotransformation. alpha-ZOL, beta-ZOL, COCs, HSD, PGN, PGTN, ZEA
65  2005 Macrophage may responses to androgen via its receptor. RA
66  2004 5alpha-Androstane-3alpha,17beta-diol activates pathway that resembles the epidermal growth factor responsive pathways in stimulating human prostate cancer LNCaP cell proliferation. 3alpha-diol, EGF
67  2004 Dissection of the physiological interconversion of 5alpha-DHT and 3alpha-diol by rat 3alpha-HSD via transient kinetics shows that the chemical step is rate-determining: effect of mutating cofactor and substrate-binding pocket residues on catalysis. 3alpha-diol, 3alpha-HSDs
68  2004 Partitioning of 5alpha-dihydrotestosterone and 5alpha-androstane-3alpha, 17beta-diol activated pathways for stimulating human prostate cancer LNCaP cell proliferation. 3alpha-diol, 3alpha-HSDs, AR, ARGs
69  2004 Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid. AKR, HSDs
70  2003 Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells. 17beta-HSD, 3alpha-diol, AKRs, NADPH
71  2003 Proposed mechanism for sperm chromatin condensation/decondensation in the male rat. 3alpha-diol, 3alpha-HSD, ABP
72  2003 Responsiveness of Dupuytren's disease fibroblasts to 5 alpha-dihydrotestosterone. ---
73  2003 Role of human type 3 3alpha-hydroxysteroid dehydrogenase (AKR1C2) in androgen metabolism of prostate cancer cells. 3alpha-diol, 3alpha-HSD, AKRs
74  2003 Structure-function relationships in 3alpha-hydroxysteroid dehydrogenases: a comparison of the rat and human isoforms. 3alpha-HSDs, AKR
75  2003 Temporal effect of tamoxifen on cytochrome P450 side chain cleavage gene expression and steroid concentration in adult male rats. TAM
76  2002 The vasodepressor effect of androgens in pithed rats: potential role of calcium channels. 5 beta-DHT, DBP, NIF
77  2001 Nongenomic effect of testosterone on chloride secretion in cultured rat efferent duct epithelia. ---
78  2001 Steroid 5alpha-reductases and 3alpha-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism. 3alpha-HSD, 5alpha-R
79  2000 Androgen formation and metabolism in the pulmonary epithelial cell line A549: expression of 17beta-hydroxysteroid dehydrogenase type 5 and 3alpha-hydroxysteroid dehydrogenase type 3. HSD
80  1999 7alpha-Iodo and 7alpha-fluoro steroids as androgen receptor-mediated imaging agents. ---
81  1999 A yeast screen system for aromatase inhibitors and ligands for androgen receptor: yeast cells transformed with aromatase and androgen receptor. AG
82  1999 Androgen actions on central serotonin neurotransmission: relevance for mood, mental state and memory. DR, SERT
83  1999 Androgen-metabolizing enzymes show region-specific changes across the breeding season in the brain of a wild songbird. ---
84  1999 Effects of androgens on the insulin-like growth factor system in an androgen-responsive human osteoblastic cell line. IGFBPs, IGFs, mRNA
85  1999 Molecular and cellular analyses of melatonin receptor-mediated cAMP signaling in rat corpus epididymis. PTX
86  1999 Nuclear matrix targeting of the protein kinase CK2 signal as a common downstream response to androgen or growth factor stimulation of prostate cancer cells. NM
87  1999 Pretranslational up-regulation of the hepatic microsomal delta4-3-oxosteroid 5alpha-oxidoreductase in male rat liver by all-trans-retinoic acid. ATRA
88  1999 Serotonin transporter (SERT) mRNA and binding site densities in male rat brain affected by sex steroids. DR, EB, SERT, TP
89  1999 Testicular endocrine function, seasonality and semen quality of the stallion. bpl, DHEA, spl
90  1998 A risk-benefit assessment of treatment with finasteride in benign prostatic hyperplasia. BPH
91  1998 Effects of gonadal and adrenal androgens in a novel androgen-responsive human osteoblastic cell line. ALP, AR, TGF-beta1, TIEG
92  1998 Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution. 3alpha-HSD, AR, HSD
93  1998 Hormonal regulation of microsomal flavin-containing monooxygenase activity by sex steroids and growth hormone in co-cultured adult male rat hepatocytes. FMO, hGH, LDH
94  1998 Interleukin-6 and epidermal growth factor promote anchorage-independent growth of immortalized human prostatic epithelial cells treated with N-methyl-N-nitrosourea. EGF, IL, MNU
95  1998 Sex steroid control of mood, mental state and memory. SERT
96  1998 Testosterone as well as estrogen increases serotonin2A receptor mRNA and binding site densities in the male rat brain. 5-HT2AR
97  1997 Androgens influence estrogen-induced responses in human breast carcinoma cells through cytochrome P450 aromatase. ---
98  1997 Androgens modulate nitric oxide synthase messenger ribonucleic acid expression in neurons of the major pelvic ganglion in the rat. mRNA, NOS-I
99  1997 Development and characterization of a conditionally immortalized human osteoblastic cell line stably transfected with the human androgen receptor gene. AR, ARE-CAT, hAR, hFOB, RT-PCR
100  1997 Effect of gonadal steroid hormones on plasma growth hormone concentrations in sexually immature rainbow trout, Oncorhynchus mykiss. 17alphaMT, GH