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■ Abbreviation / Long Form : CA / clavulanic acid

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Abbreviation:   CA  (>> Co-occurring Abbreviation)
Long Form:   clavulanic acid
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No. Year Title Co-occurring Abbreviation
2021 Clavulanic Acid Production by Streptomyces clavuligerus: Insights from Systems Biology, Strain Engineering, and Downstream Processing. S. clavuligerus
2021 Enhanced production of clavulanic acid by improving glycerol utilization using reporter-guided mutagenesis of an industrial Streptomyces clavuligerus strain. ---
2021 Statistical Optimizing of Medium for Clavulanic Acid Production by Streptomyces clavuligerus Using Response Surface Methodology. ---
2021 TCA Cycle and Its Relationship with Clavulanic Acid Production: A Further Interpretation by Using a Reduced Genome-Scale Metabolic Model of Streptomyces clavuligerus. S. clavuligerus
2020 A Genome-Scale Insight into the Effect of Shear Stress During the Fed-Batch Production of Clavulanic Acid by Streptomyces Clavuligerus. TCA
2020 Clavulanic Acid in the Scope of Helicobacter pylori Treatment: A Literature Review and Beyond. H. pylori, PBPs
2020 The bioavailability and pharmacokinetics of an amoxicillin-clavulanic acid granular combination after intravenous and oral administration in swine. AMX
2019 Application of Acid and Cold Stresses to Enhance the Production of Clavulanic Acid by Streptomyces clavuligerus. ---
2019 Characterization of the Metabolic Response of Streptomyces clavuligerus to Shear Stress in Stirred Tanks and Single-Use 2D Rocking Motion Bioreactors for Clavulanic Acid Production. STR
10  2019 Comparative Transcriptome Analysis of Streptomyces Clavuligerus in Response to Favorable and Restrictive Nutritional Conditions. ---
11  2019 Data of clavulanic acid and clavulanate-imidazole stability atlow temperatures. CAI, HPLC, S. clavuligerus
12  2019 Data set of in silico simulation for the production of clavulanic acid and cephamycin C by Streptomyces clavuligerus using a genome scale metabolic model. CephC, S. clavuligerus
13  2019 Degradation Kinetics of Clavulanic Acid in Fermentation Broths at Low Temperatures. ---
14  2019 Homologous expression of lysA encoding diaminopimelic acid (DAP) decarboxylase reveals increased antibiotic production in Streptomyces clavuligerus. CephC, DAP, glpFp
15  2019 Improved production of clavulanic acid by reverse engineering and overexpression of the regulatory genes in an industrial Streptomyces clavuligerus strain. ---
16  2019 The CagRS Two-Component System Regulates Clavulanic Acid Metabolism via Multiple Pathways in Streptomyces clavuligerus F613-1. G3P, TCS
17  2019 The effects of clavulanic acid and amoxicillin on cue-primed reinstatement of cocaine seeking. AMX, NAc, PFC
18  2019 The two-component system CepRS regulates the cephamycin C biosynthesis in Streptomyces clavuligerus F613-1. TCS
19  2018 Bibliometric Analysis of Global Research on Clavulanic Acid. S. clavuligerus
20  2018 Ceftriaxone and clavulanic acid induce antiallodynia and anti-inflammatory effects in rats using the carrageenan model. Carr, CFX
21  2018 Class A beta-lactamases and inhibitors: In silico analysis of the binding mode and the relationship with resistance. SB, TZ
22  2018 Effects of Clavulanic Acid on the Acquisition and Reinstatement Following Morphine-induced Conditioned Place Preference in Mice. CPP, GLT-1, NMDA
23  2018 Effects of Clavulanic Acid Treatment on Reinstatement to Methamphetamine, Glial Glutamate Transporters, and mGluR 2/3 Expression in P Rats Exposed to Ethanol. CPP, dmPFC, GLAST, GLT-1, METH, NAc
24  2018 Neuroprotective effect of clavulanic acid on trimethyltin (TMT)-induced cytotoxicity in PC12 cells. DCFH-DA, ROS, TMT
25  2018 Streptomyces clavuligerus shows a strong association between TCA cycle intermediate accumulation and clavulanic acid biosynthesis. FBA, S. clavuligerus, TCA
26  2018 Transcriptional Studies on a Streptomyces clavuligerus oppA2 Deletion Mutant: N-Acetylglycyl-Clavaminic Acid Is an Intermediate of Clavulanic Acid Biosynthesis. AGCA, LC-MS
27  2017 Proteome-wide alterations in an industrial clavulanic acid producing strain of Streptomyces clavuligerus. Car, PNPase, TCS
28  2017 The performance of a resazurin chromogenic agar plate with a combined disc method for rapid screening of extended-spectrum-beta-lactamases, AmpC beta-lactamases and co-beta-lactamases in Enterobacteriaceae. CPD, CX, ESBL, RCA
29  2016 An improved HPLC-DAD method for clavulanic acid quantification in fermentation broths of Streptomyces clavuligerus. HPLC, Sc
30  2016 Effect of aeration and agitation on extractive fermentation of clavulanic acid by using aqueous two-phase system. ATPS, OTR, OUR
31  2016 Inversion of the stereochemical configuration (3S, 5S)-clavaminic acid into (3R, 5R)-clavulanic acid: A computationally-assisted approach based on experimental evidence. NAG-clavam, Sc
32  2015 Clavulanic acid enhances glutamate transporter subtype I (GLT-1) expression and decreases reinforcing efficacy of cocaine in mice. CTX, GLT-1, PR, SA
33  2015 Dissociation of cephamycin C and clavulanic acid biosynthesis by 1,3-diaminopropane in Streptomyces clavuligerus. CephC
34  2015 The Pathway-Specific Regulator ClaR of Streptomyces clavuligerus Has a Global Effect on the Expression of Genes for Secondary Metabolism and Differentiation. ---
35  2014 Clavulanic acid production by the MMS 150 mutant obtained from wild type Streptomyces clavuligerus ATCC 27064. ---
36  2014 Clavulanic acid production estimation based on color and structural features of Streptomyces clavuligerus bacteria using self-organizing map and genetic algorithm. GA-BPN, RE, SC, SOM
37  2014 Clavulanic acid reduces rewarding, hyperthermic and locomotor-sensitizing effects of morphine in rats: a new indication for an old drug? CPP, CTX
38  2014 Simultaneous liquid chromatography-mass spectrometry quantification of cefixime and clavulanic acid in human plasma. CX, LC-APCI-MS
39  2013 Clavulanic acid production by Streptomyces clavuligerus: biogenesis, regulation and strain improvement. ---
40  2013 Coordination of glycerol utilization and clavulanic acid biosynthesis to improve clavulanic acid production in Streptomyces clavuligerus. G3P, gyl
41  2013 Expression of the endogenous and heterologous clavulanic acid cluster in Streptomyces flavogriseus: why a silent cluster is sleeping. RT-PCR, SCos-CA
42  2013 Simultaneous pharmacokinetic assessment of cefadroxil and clavulanic acid in human plasma by LC-MS and its application to bioequivalence studies. AUC0-12h, CF, IS, LC-APCI-MS, SIM, SPE
43  2013 Simultaneous quantification of cefpodoxime proxetil and clavulanic acid in human plasma by LC-MS using solid phase extraction with application to pharmacokinetic studies. CDPX, CP, HPLC-APCI-MS, SIM, SPE
44  2013 Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway. ORF12, PBP
45  2012 Development of a colorimetric assay for rapid quantitative measurement of clavulanic acid in microbial samples. ---
46  2012 Induction of holomycin production and complex metabolic changes by the argR mutation in Streptomyces clavuligerus NP1. CoA
47  2012 Shear conditions in clavulanic acid production by Streptomyces clavuligerus in stirred tank and airlift bioreactors. ---
48  2012 Simultaneous diffuse reflectance infrared determination of clavulanic acid and amoxicillin using multivariate calibration techniques. AMO, DRIFTS, iPLS, PLS, RMSEP, siPLS
49  2011 Extractive fermentation of clavulanic acid by Streptomyces DAUFPE 3060 using aqueous two-phase system. ---
50  2010 Enhancement of clavulanic acid production by expressing regulatory genes in gap gene deletion mutant of Streptomyces clavuligerus NRRL3585. GAPDH
51  2010 Role of sigma-factor (orf21) in clavulanic acid production in Streptomyces clavuligerus NRRL3585. ---
52  2010 Superoxide dismutase (SOD) genes in Streptomyces peucetius: effects of SODs on secondary metabolites production. ACT, DXR, SOD
53  2009 An approach to strain improvement and enhanced production of clavulanic acid in Streptomyces clavuligerus. MIC
54  2009 Application of a double-reporter-guided mutant selection method to improve clavulanic acid production in Streptomyces clavuligerus. RGMS
55  2009 Broth microdilution method to detect extended-spectrum beta-lactamases and AmpC beta-lactamases in enterobacteriaceae isolates by use of clavulanic acid and boronic acid as inhibitors. ATM, BA, BMD, CAZ, CTX, ESBLs, PABL
56  2009 Crystal structures of an oligopeptide-binding protein from the biosynthetic pathway of the beta-lactamase inhibitor clavulanic acid. 3S,5S, orf7
57  2009 Development of a new HPLC method for the simultaneous determination of ticarcillin and clavulanic acid in pharmaceutical formulations. TIC
58  2009 Performance of the Phoenix bacterial identification system compared with disc diffusion methods for identifying extended-spectrum beta-lactamase, AmpC and KPC producers. ESBLs
59  2009 Screening of variables influencing the clavulanic acid production by Streptomyces DAUFPE 3060 strain. ---
60  2008 Clavulanic acid: a review. ---
61  2008 Evaluation of the effects of the parameters involved in the purification of clavulanic acid from fermentation broth by aqueous two-phase systems. ---
62  2008 High concentrations of clavulanic acid but not of its degradation products decrease glycerol consumption and oxygen uptake rates in cultures of Streptomyces clavuligerus. ---
63  2007 Clavulanic acid decomposition is catalyzed by the compound itself and by its decomposition products. ---
64  2007 Detection of extended-spectrum beta-lactamases by using boronic acid as an AmpC beta-lactamase inhibitor in clinical isolates of Klebsiella spp. and Escherichia coli. BA, CAZ, CTX, ESBL, pAmpCs
65  2007 Enhancement of clavulanic acid by replicative and integrative expression of ccaR and cas2 in Streptomyces clavuligerus NRRL3585. ---
66  2006 Characterization of pbpA and pbp2 encoding penicillin-binding proteins located on the downstream of clavulanic acid gene cluster in Streptomyces clavuligerus. PBPs
67  2006 Influence of feeding conditions on clavulanic acid production in fed-batch cultivation with medium containing glycerol. SPI
68  2005 Using redox potential to detect microbial activities during clavulanic acid biosynthesis in Streptomyces clavuligerus. ---
69  2004 Influence of dissolved oxygen and shear conditions on clavulanic acid production by Streptomyces clavuligerus. ---
70  2004 Utility of NCCLS guidelines for identifying extended-spectrum beta-lactamases in non-Escherichia coli and Non-Klebsiella spp. of Enterobacteriaceae. BMD, ESBLs, ICARE
71  2003 Evaluation of the NCCLS extended-spectrum beta-lactamase confirmation methods for Escherichia coli with isolates collected during Project ICARE. BMD, ESBL, ICARE, IEF, NCCLS
72  2003 Survey of plasmid-associated genetic markers in enterobacteriaceae with reduced susceptibilities to cephalosporins. ESBL
73  2002 Clavulanic acid degradation in Streptomyces clavuligerus fed-batch cultivations. ---
74  2002 Kinetic studies of clavulanic acid recovery by ion exchange chromatography. ---
75  2002 [Sinusal penetration of amoxicillin-clavulanic acid. Formulation 1 g./125 mg., twice daily versus formulation 500 mg./125 mg., three times daily]. AMX
76  2001 Characterization of clinical isolates of Klebsiella pneumoniae from 19 laboratories using the National Committee for Clinical Laboratory Standards extended-spectrum beta-lactamase detection methods. CAZ, CTX, ESBLs, ICARE, IEF, NCCLS
77  2000 Molecular basis for enhanced biosynthesis of clavulanic acid by a redox-cycling agent, phenazine methosulfate, in Streptomyces clavuligerus. CMC, PMS
78  2000 [Bacterial growth delay in E. coli: demonstration and evaluation of the beta-lactamase post-inhibitor effect on 6 strains with different resistance phenotypes]. AMX, PLIE
79  2000 [Study on the beta-lactamases of the Escherichia coli HX88108 resistant to ceforperazon]. CPZ, SBT
80  1999 [In vitro demonstration of a true post-beta-lactamases inhibitor effect (PLIE) of clavulanic acid on Klebsiella pneumoniae and Haemophilus influenzae]. AMX, BRDs, PAE, PLIE
81  1998 A novel extended-spectrum TEM-type beta-lactamase (TEM-52) associated with decreased susceptibility to moxalactam in Klebsiella pneumoniae. AMX-CA, ATM, CAZ, CTX, MOX
82  1996 Simultaneous production and decomposition of clavulanic acid during Streptomyces clavuligerus cultivations. ---
83  1995 Activity of beta-lactamase inhibitor combinations on Escherichia coli isolates exhibiting various patterns of resistance to beta-lactam agents. MIC
84  1995 Multicentre comparative study of the efficacy and safety of azithromycin compared with amoxicillin/clavulanic acid in the treatment of paediatric patients with otitis media. ---
85  1995 The argG gene of Streptomyces clavuligerus has low homology to unstable argG from other actinomycetes: effect of amplification on clavulanic acid biosynthesis. ASS, nt, Scl, Sco, Sl
86  1992 Cefuroxime and cefuroxime axetil versus amoxicillin plus clavulanic acid in the treatment of lower respiratory tract infections. ---
87  1991 Ampicillin-sulbactam and ticarcillin-clavulanic acid: a comparison of their in vitro activity and review of their clinical efficacy. SB
88  1991 Comparative study of azithromycin and amoxicillin/clavulanic acid in the treatment of lower respiratory tract infections. ---
89  1989 Biliary elimination of ticarcillin plus clavulanic acid (Claventin): experimental and clinical study. TIC
90  1989 [Efficiency of tazobactam as inhibitor of beta-lactamases, combined with piperacillin, against resistant strains to this penicillin]. TZ
91  1988 Induction of chromosomal beta-lactamases by different concentrations of clavulanic acid in combination with ticarcillin. ---
92  1988 [Evaluation of the biliary excretion of a ticarcillin-clavulanic acid combination in man]. TIC
93  1987 In vitro activity of ampicillin alone and in combination with different concentrations of 6 beta-bromopenicillanic acid, clavulanic acid and mecillinam. BPA
94  1987 In vitro susceptibility of Mycobacterium tuberculosis, Mycobacterium africanum, Mycobacterium bovis, Mycobacterium avium, Mycobacterium fortuitum, and Mycobacterium chelonae to ticarcillin in combination with clavulanic acid. M. chelonei
95  1987 [Clavulanic acid. Its effect on Staphylococcus aureus other than its inhibitory effect on beta-lactamases]. PC
96  1987 [Direct determination of clavulanic acid in biological fluids using HPLC]. TBAB
97  1986 Activity of penicillin or ticarcillin in combination with clavulanic acid in the treatment of experimental intra-abdominal abscess. ---
98  1986 Effect of clavulanic acid on the activity of ticarcillin against Pseudomonas aeruginosa. ---
99  1985 Amoxycillin and clavulanic acid combination in the treatment of experimentally induced bacterial cystitis in cats. A-CA
100  1984 In vitro activity of ticarcillin plus clavulanic acid against 632 clinical isolates. ---