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■ Abbreviation / Long Form : CFSs / common fragile sites

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Total Number of Papers: 100
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Abbreviation:   CFSs  (>> Co-occurring Abbreviation)
Long Form:   common fragile sites
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No. Year Title Co-occurring Abbreviation
2022 Characterization of Chromosomal Instability in Glioblastoma. APH, CIN, CNS, GBM
2022 Lost by Transcription: Fork Failures, Elevated Expression, and Clinical Consequences Related to Deletions in Metastatic Colorectal Cancer. DELs, DUPs, mCRC
2022 New Era of Mapping and Understanding Common Fragile Sites: An Updated Review on Origin of Chromosome Fragility. ---
2021 Common Threads: Aphidicolin-Inducible and Folate-Sensitive Fragile Sites in the Human Genome. APH, BIR, FXS, MiDAS, RFSs
2021 FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability. UBL5
2021 Locus-specific transcription silencing at the FHIT gene suppresses replication stress-induced copy number variant formation and associated replication delay. APH, CNV
2021 Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization. CTL, FATS
2021 Transcription-Replication Collisions and Chromosome Fragility. MiDAS, RS
2021 Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites. pol
10  2020 3D genome organization contributes to genome instability at fragile sites. RT
11  2020 Break-induced replication promotes fragile telomere formation. ALT, alt-NHEJ, BIR, DSB
12  2020 Common Fragile Sites Are Characterized by Faulty Condensin Loading after Replication Stress. FISH, MiDAS
13  2020 Common fragile sites: protection and repair. ---
14  2020 Genome-wide high-resolution mapping of mitotic DNA synthesis sites and common fragile sites by direct sequencing. MDSs
15  2020 High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing. MiDAS
16  2020 Impaired Replication Timing Promotes Tissue-Specific Expression of Common Fragile Sites. BrdU, CNTNAP2, DMD, FISH, IMR-90, LSAMP, MRC-5, NEGR1
17  2020 Transcription-replication conflicts as a source of common fragile site instability caused by BMI1-RNF2 deficiency. RNAPII, TRCs
18  2020 [The relationship between HPV integration and prognosis of cervical cancer]. HPV
19  2019 AT-dinucleotide rich sequences drive fragile site formation. AT-DRSs
20  2019 Dicer prevents genome instability in response to replication stress. FA
21  2019 Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability. CFS, ChIP, RS
22  2019 Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D. ---
23  2019 The epicenter of chromosomal fragility of Fra14A2, the mouse ortholog of human FRA3B common fragile site, is largely attached to the nuclear matrix in lymphocytes but not in other cell types that do not express such a fragility. ---
24  2019 Transcription-dependent regulation of replication dynamics modulates genome stability. ---
25  2019 Transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide. ---
26  2018 A journey with common fragile sites: From S phase to telophase. ---
27  2018 BLM prevents instability of structure-forming DNA sequences at common fragile sites. ---
28  2018 Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse. ERFSs, RPA
29  2018 Folate deficiency drives mitotic missegregation of the human FRAXA locus. RFSs
30  2018 Genome-wide analysis of the spatiotemporal regulation of firing and dormant replication origins in human cells. MCM, TSSs
31  2018 Genomic instability in fragile sites-still adding the pieces. ---
32  2018 Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism. ALT, MiDAS
33  2018 Inducing and Detecting Mitotic DNA Synthesis at Difficult-to-Replicate Loci. BIR, IF, RS
34  2018 The concerted roles of FANCM and Rad52 in the protection of common fragile sites. DSB, FA, HR
35  2018 The FRA14B common fragile site maps to a region prone to somatic and germline rearrangements within the large GPHN gene. CGH, GPHN, RLFS
36  2018 The role of fork stalling and DNA structures in causing chromosome fragility. ---
37  2017 DNA polymerases eta and kappa exchange with the polymerase delta holoenzyme to complete common fragile site synthesis. Pols
38  2017 DNA replication stress drives fragile site instability. ---
39  2017 Fragile sites in cancer: more than meets the eye. ---
40  2017 RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis. ---
41  2016 FANCD2 Facilitates Replication through Common Fragile Sites. ---
42  2016 Role of DNA Repair Factor Xeroderma Pigmentosum Protein Group C in Response to Replication Stress As Revealed by DNA Fragile Site Affinity Chromatography and Quantitative Proteomics. GG-NER, RS, XPC
43  2016 The complex nature of fragile site plasticity and its importance in cancer. ---
44  2016 Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage Response. DDR
45  2016 WWOX guards genome stability by activating ATM. ATM
46  2015 Genomic instability in the PARK2 locus is associated with Parkinson's disease. aCGH, EOPD, FoSTeS, MLPA, MMBIR, NHEJ, PD
47  2015 Replication stress activates DNA repair synthesis in mitosis. ---
48  2014 A selected group of large common fragile site genes have decreased expression in oropharyngeal squamous cell carcinomas. OPSCC
49  2014 Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress? ---
50  2014 CtIP maintains stability at common fragile sites and inverted repeats by end resection-independent endonuclease activity. CtBP, DSBs, HR
51  2014 Interplay between genetic and epigenetic factors governs common fragile site instability in cancer. ---
52  2014 Large transcription units unify copy number variants and common fragile sites arising under replication stress. CNVs
53  2014 Molecular characterization of common fragile sites as a strategy to discover cancer susceptibility genes. ---
54  2014 Prognostic significance of decreased expression of six large common fragile site genes in oropharyngeal squamous cell carcinomas. OPSCCs
55  2014 TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling. DC
56  2014 Updating the mechanisms of common fragile site instability: how to reconcile the different views? ---
57  2014 Very large common fragile site genes and their potential role in cancer development. ---
58  2013 A blooming resolvase at chromosomal fragile sites. ---
59  2013 Common fragile site profiling in epithelial and erythroid cells reveals that most recurrent cancer deletions lie in fragile sites hosting large genes. ---
60  2013 DNA synthesis by Pol eta promotes fragile site stability by preventing under-replicated DNA in mitosis. Pol eta
61  2013 ERCC1 and MUS81-EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis. CIN, FANC
62  2013 Infection with retroviral vectors leads to perturbed DNA replication increasing vector integrations into fragile sites. MLV
63  2013 Instability at the FRA8I common fragile site disrupts the genomic integrity of the KIAA0146, CEBPD and PRKDC genes in colorectal cancer. ---
64  2013 MUS81 promotes common fragile site expression. ---
65  2013 Structure-specific endonucleases: guardians of fragile site stability. UFBs
66  2012 A genome-wide analysis of common fragile sites: what features determine chromosomal instability in the human genome? aCFSs
67  2012 Common fragile sites: genomic hotspots of DNA damage and carcinogenesis. CACG
68  2012 Genomic rearrangements at the FRA2H common fragile site frequently involve non-homologous recombination events across LTR and L1(LINE) repeats. ---
69  2012 Mechanism of replicative DNA polymerase delta pausing and a potential role for DNA polymerase kappa in common fragile site replication. Pols, QP
70  2012 The complex basis underlying common fragile site instability in cancer. ---
71  2012 Topoisomerase II- and condensin-dependent breakage of MEC1ATR-sensitive fragile sites occurs independently of spindle tension, anaphase, or cytokinesis. RSZs
72  2011 Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes. ---
73  2011 Common fragile site tumor suppressor genes and corresponding mouse models of cancer. ---
74  2011 Common fragile sites: mechanisms of instability revisited. ---
75  2010 ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment. 2AP, APH
76  2010 Mechanisms of genomic instabilities underlying two common fragile-site-associated loci, PARK2 and DMD, in germ cell and cancer cell lines. ---
77  2009 Common fragile sites are characterized by histone hypoacetylation. ---
78  2009 Impaired replication dynamics at the FRA3B common fragile site. APH
79  2009 WWOX: its genomics, partners, and functions. SDR, WWOX
80  2008 Differential loss of expression of common fragile site genes between oral tongue and oropharyngeal squamous cell carcinomas. HPV, SCCs
81  2008 DMD and IL1RAPL1: two large adjacent genes localized within a common fragile site (FRAXC) have reduced expression in cultured brain tumors. ---
82  2008 Replication timing of two human common fragile sites: FRA1H and FRA2G. ---
83  2008 Stably transfected common fragile site sequences exhibit instability at ectopic sites. ---
84  2007 Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study. GC, RS
85  2007 Replication stress induces tumor-like microdeletions in FHIT/FRA3B. aCGH
86  2007 Transcriptional profiling of genes at the human common fragile site FRA1H in tumor-derived cell lines. PCR
87  2006 Chromosomal fragile sites FRA3B and FRA16D show correlated expression and association with failure of apoptosis in lymphocytes from patients with thyroid cancer. LOH
88  2006 Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes. ---
89  2006 Correlated break at PARK2/FRA6E and loss of AF-6/Afadin protein expression are associated with poor outcome in breast cancer. TMA, TSG
90  2006 Identification of the human/mouse syntenic common fragile site FRA7K/Fra12C1--relation of FRA7K and other human common fragile sites on chromosome 7 to evolutionary breakpoints. ---
91  2006 RORA, a large common fragile site gene, is involved in cellular stress response. RORA
92  2005 Common fragile sites, extremely large genes, neural development and cancer. ---
93  2003 Characterization of the common fragile site FRA9E and its potential role in ovarian cancer. DD, LOE, LOH, PAPPA
94  2003 Common fragile sites are preferential targets for HPV16 integrations in cervical tumors. HPV
95  2003 How common are common fragile sites in humans: interindividual variation in the distribution of aphidicolin-induced fragile sites. APC
96  2003 Preferential integration of human papillomavirus type 18 near the c-myc locus in cervical carcinoma. HPV
97  2002 A role for common fragile site induction in amplification of human oncogenes. BFB
98  2002 The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1. FHIT
99  2002 Transcriptional profiling reveals that several common fragile-site genes are downregulated in ovarian cancer. ---
100  2000 Human papillomavirus type 16 integrations in cervical tumors frequently occur in common fragile sites. HPV