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■ Abbreviation / Long Form : CNF1 / cytotoxic necrotizing factor 1

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Total Number of Papers: 183
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Abbreviation:   CNF1  (>> Co-occurring Abbreviation)
Long Form:   cytotoxic necrotizing factor 1
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2022 Immunomodulatory properties of CNF1 toxin from E. coli: implications for colorectal carcinogenesis. CRC
2021 "Effect of Subinhibitory Concentrations of Some Antibiotics and Low Doses of Gamma Radiation on the Cytotoxicity and Expression of Colibactin by an Uropathogenic Escherichia coli isolate". ---
2021 Conformational Insights into the Control of CNF1 Toxin Activity by Peptidyl-Prolyl Isomerization: A Molecular Dynamics Perspective. CNF1CD, SWII
2021 CTX-CNF1 Recombinant Protein Selectively Targets Glioma Cells In Vivo. BBB, CTX
2021 Effects of the Escherichia coli Bacterial Toxin Cytotoxic Necrotizing Factor 1 on Different Human and Animal Cells: A Systematic Review. ---
2021 Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice. ---
2020 Cnf1 Variants Endowed with the Ability to Cross the Blood-Brain Barrier: A New Potential Therapeutic Strategy for Glioblastoma. BBB, GBM
2020 Cytotoxic necrotizing factor 1 promotes bladder cancer angiogenesis through activating RhoC. HIF1alpha, HSF1, HSP90alpha, RhoC, UPEC, VEGF
2020 Revisiting Old Ionophore Lasalocid as a Novel Inhibitor of Multiple Toxins. ---
10  2020 The Bacterial Toxin CNF1 Protects Human Neuroblastoma SH-SY5Y Cells against 6-Hydroxydopamine-Induced Cell Damage: The Hypothesis of CNF1-Promoted Autophagy as an Antioxidant Strategy. PD, ROS
11  2019 Eye Drop Instillation of the Rac1 Modulator CNF1 Attenuates Retinal Gliosis and Ameliorates Visual Performance in a Rat Model of Hypertensive Retinopathy. GFAP
12  2019 Prevalence and pathologic effects of colibactin and cytotoxic necrotizing factor-1 (Cnf 1) in Escherichia coli: experimental and bioinformatics analyses. UPEC
13  2019 The bacterial protein CNF1 as a new strategy against Plasmodium falciparum cytoadherence. CM
14  2019 The Escherichia coli protein toxin cytotoxic necrotizing factor 1 induces epithelial mesenchymal transition. EMT
15  2018 Analysing the Structural Effect of Point Mutations of Cytotoxic Necrotizing Factor 1 (CNF1) on Lu/BCAM Adhesion Glycoprotein Association. B-CAM, Lu
16  2018 Bacterial Toxins and Targeted Brain Therapy: New Insights from Cytotoxic Necrotizing Factor 1 (CNF1). ---
17  2018 Context-Dependent Requirements for FimH and Other Canonical Virulence Factors in Gut Colonization by Extraintestinal Pathogenic Escherichia coli. ExPEC
18  2018 Cytotoxic Necrotizing Factor 1 Downregulates CD36 Transcription in Macrophages to Induce Inflammation During Acute Urinary Tract Infections. UPEC, UTIs
19  2018 Reversible senescence of human colon cancer cells after blockage of mitosis/cytokinesis caused by the CNF1 cyclomodulin from Escherichia coli. ---
20  2018 Screening of a Drug Library Identifies Inhibitors of Cell Intoxication by CNF1. ---
21  2018 Simulated microgravity inhibits cell focal adhesions leading to reduced melanoma cell proliferation and metastasis via FAK/RhoA-regulated mTORC1 and AMPK pathways. FAK, SMG
22  2018 Simulated Microgravity Reduces Focal Adhesions and Alters Cytoskeleton and Nuclear Positioning Leading to Enhanced Apoptosis via Suppressing FAK/RhoA-Mediated mTORC1/NF-kappaB and ERK1/2 Pathways. FAs, NEPs, SMG
23  2018 The Bacterial Protein CNF1 as a Potential Therapeutic Strategy against Mitochondrial Diseases: A Pilot Study. MERRF
24  2018 The Bacterial Toxin CNF1 Induces Activation and Maturation of Human Monocyte-Derived Dendritic Cells. moDCs
25  2017 Cytotoxic necrotizing factor 1 promotes prostate cancer progression through activating the Cdc42-PAK1 axis. PCa, UPEC
26  2017 Cytotoxic Necrotizing Factor-1 (CNF1) does not promote E. coli infection in a murine model of ascending pyelonephritis. UPEC, UTI
27  2017 High Affinity Binding of Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1) to Lu/BCAM Adhesion Glycoprotein. B-CAM, Lu
28  2017 High yield purification and first structural characterization of the full-length bacterial toxin CNF1. CD, DLS, IMAC
29  2017 Progression of motor deficits in glioma-bearing mice: impact of CNF1 therapy at symptomatic stages. GBM
30  2016 Electrophysiology of glioma: a Rho GTPase-activating protein reduces tumor growth and spares neuron structure and function. ---
31  2016 Immunoadjuvant Properties of the Rho Activating Factor CNF1 in Prophylactic and Curative Vaccination against Leishmania infantum. mCNF1, Th, WT
32  2016 Secretion of Alpha-Hemolysin by Escherichia coli Disrupts Tight Junctions in Ulcerative Colitis Patients. E. coli, IBD, TER, UC
33  2016 The bacterial toxin CNF1 as a tool to induce retinal degeneration reminiscent of retinitis pigmentosa. RP
34  2016 The effects of cytotoxic necrotizing factor 1 expression in the uptake of Escherichia coli K1 by macrophages and the onset of meningitis in newborn mice. Deltacnf1
35  2016 Therapeutic effects of the Rho GTPase modulator CNF1 in a model of Parkinson's disease. DA, PD
36  2015 Antibodies against hemolysin and cytotoxic necrotizing factor type 1 (CNF1) reduce bladder inflammation in a mouse model of urinary tract infection with toxigenic uropathogenic Escherichia coli. Hly, UPEC
37  2015 Cell-to-cell propagation of the bacterial toxin CNF1 via extracellular vesicles: potential impact on the therapeutic use of the toxin. EVs
38  2015 CNF1 Enhances Brain Energy Content and Counteracts Spontaneous Epileptiform Phenomena in Aged DBA/2J Mice. ---
39  2014 Cervico-vaginopathogenic Escherichia coli in Iran: Serogroup distributions, virulence factors and antimicrobial resistance properties. CVEC, E. coli, HlyA, OmpT
40  2014 Enhancement of mitochondrial ATP production by the Escherichia coli cytotoxic necrotizing factor 1. ---
41  2014 Lu/BCAM adhesion glycoprotein is a receptor for Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1). B-CAM, Lu
42  2014 The bacterial protein toxin, cytotoxic necrotizing factor 1 (CNF1) provides long-term survival in a murine glioma model. TMZ
43  2014 The E. coli CNF1 as a pioneering therapy for the central nervous system diseases. CNS
44  2013 Cytotoxic necrotizing factor 1 contributes to Escherichia coli meningitis. ---
45  2013 Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1. CNFy, MEFs
46  2012 CNF1 improves astrocytic ability to support neuronal growth and differentiation in vitro. ---
47  2012 Cytotoxic necrotizing factor 1 and hemolysin from uropathogenic Escherichia coli elicit different host responses in the murine bladder. UPEC
48  2012 Modification of plant Rac/Rop GTPase signalling using bacterial toxin transgenes. ---
49  2011 Activation of Rho GTPases triggers structural remodeling and functional plasticity in the adult rat visual cortex. MD, OD
50  2011 Escherichia coli producing CNF1 toxin hijacks Tollip to trigger Rac1-dependent cell invasion. UPEC
51  2011 Modulation of RhoGTPases improves the behavioral phenotype and reverses astrocytic deficits in a mouse model of Rett syndrome. MRS, RTT
52  2011 mRNA context dependent regulation of cytotoxic necrotizing factor 1 translation by GidA, a tRNA modification enzyme in Escherichia coli. HBMEC
53  2011 Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway. ---
54  2011 Relationship between O serotype and virulent genes in Escherichia coli causing urinary tract infections. Hly, sfa
55  2011 The involvement of SelB in the expression of cytotoxic necrotizing factor 1 in Escherichia coli. ---
56  2011 Virulence characteristics and antimicrobial susceptibility of uropathogenic Escherichia coli strains. aer, afa, hly, pap, UPEC
57  2011 Virulence factors and genetic variability of uropathogenic Escherichia coli isolated from dogs and cats in Italy. ERIC, PCR, REP, sfa, UPEC
58  2011 YgfZ contributes to secretion of cytotoxic necrotizing factor 1 into outer-membrane vesicles in Escherichia coli. HBMEC, OMVs
59  2010 Actin re-organization induced by Chlamydia trachomatis serovar D--evidence for a critical role of the effector protein CT166 targeting Rac. CGTs, CT166-mut, TcdB
60  2010 Actin reorganization contributes to loss of cell adhesion in pemphigus vulgaris. Dsg, FRAP, PV-IgG
61  2010 Differential role of Rho GTPases in intestinal epithelial barrier regulation in vitro. C3 TF, LT, TER
62  2010 Escherichia coli cytotoxic necrotizing factor 1 (CNF1): toxin biology, in vivo applications and therapeutic potential. ---
63  2010 Prevention of Escherichia coli K1 penetration of the blood-brain barrier by counteracting the host cell receptor and signaling molecule involved in E. coli invasion of human brain microvascular endothelial cells. HBMEC
64  2009 Characterization of cytotoxic necrotizing factor 1-producing Escherichia coli strains from faeces of healthy macaques. ---
65  2009 Cleavage of Escherichia coli cytotoxic necrotizing factor 1 is required for full biologic activity. ---
66  2009 Ferredoxin is involved in secretion of cytotoxic necrotizing factor 1 across the cytoplasmic membrane in Escherichia coli K1. fdx, HBMEC
67  2009 Tenascin C and tenascin R similarly prevent the formation of myelin membranes in a RhoA-dependent manner, but antagonistically regulate the expression of myelin basic protein via a separate pathway. ECM, MBP, TN-C, TN-R
68  2009 The Rac GTPase-activating bacterial protein toxin CNF1 induces analgesia up-regulating mu-opioid receptors. MORs
69  2008 Cytotoxic necrotizing factor 1 (CNF1) induces an inflammatory response in the urinary tract in vitro but not in vivo. ---
70  2008 Cytotoxic necrotizing factor type 1-neutralizing monoclonal antibody NG8 recognizes three amino acids in a C-terminal region of the toxin and reduces toxin binding to HEp-2 cells. mAb
71  2008 Hemolysin of uropathogenic Escherichia coli evokes extensive shedding of the uroepithelium and hemorrhage in bladder tissue within the first 24 hours after intraurethral inoculation of mice. Hly, UPEC, UTIs
72  2008 The Rho-activating CNF1 toxin from pathogenic E. coli: a risk factor for human cancer development? ---
73  2007 Cytotoxic necrotizing factor 1 prevents apoptosis via the Akt/IkappaB kinase pathway: role of nuclear factor-kappaB and Bcl-2. ---
74  2007 Enhancement of learning and memory after activation of cerebral Rho GTPases. ---
75  2007 Intranasal immunization with tetanus toxoid and CNF1 as a new mucosal adjuvant protects BALB/c mice against lethal challenge. ---
76  2007 Specificity of immunomodulator secretion in urinary samples in response to infection by alpha-hemolysin and CNF1 bearing uropathogenic Escherichia coli. alpha-Hly, IL-8, MCP-1, MIP-3alpha, UTIs
77  2007 The role of VASP in regulation of cAMP- and Rac 1-mediated endothelial barrier stabilization. F/R, MyEnd, VASP, WT
78  2007 Two domains of cytotoxic necrotizing factor type 1 bind the cellular receptor, laminin receptor precursor protein. LRP, mAbs
79  2006 A multinucleating Escherichia coli cytotoxin perturbs cell cycle in cultured epithelial cells. ---
80  2006 A single amino acid substitution in the enzymatic domain of cytotoxic necrotizing factor type 1 of Escherichia coli alters the tissue culture phenotype to that of the dermonecrotic toxin of Bordetella spp. DNT
81  2006 Active cytotoxic necrotizing factor 1 associated with outer membrane vesicles from uropathogenic Escherichia coli. UPEC
82  2006 Cytotoxic necrotizing factor type 1 delivered by outer membrane vesicles of uropathogenic Escherichia coli attenuates polymorphonuclear leukocyte antimicrobial activity and chemotaxis. OMVs, PMNs, UPEC
83  2006 Escherichia coli cytotoxic necrotizing factor 1 blocks cell cycle G2/M transition in uroepithelial cells. ---
84  2005 Cytotoxic necrotizing factor type 1 production by uropathogenic Escherichia coli modulates polymorphonuclear leukocyte function. PMNs, UPEC
85  2005 Differential involvement of the actin cytoskeleton in differentiation and mitogenesis of thyroid cells: inactivation of Rho proteins contributes to cyclic adenosine monophosphate-dependent gene expression but prevents mitogenesis. DCB, pRb
86  2005 The Rho GTPase activators CNF1 and DNT bacterial toxins have mucosal adjuvant properties. DNT, OVA
87  2004 67-kDa laminin receptor promotes internalization of cytotoxic necrotizing factor 1-expressing Escherichia coli K1 into human brain microvascular endothelial cells. CNF1-67LR, HBMEC
88  2004 Detection of virulence factors in alpha-haemolytic Escherichia coli strains isolated from various clinical materials. aer, afaI, hly
89  2004 E. coli CNF1 toxin: a two-in-one system for host-cell invasion. UPEC
90  2004 Enteroaggregative and cell-detaching Escherichia coli strains among Polish children with and without diarrhea. CDEC
91  2004 Escherichia coli cytotoxic necrotizing factor 1 inhibits intestinal epithelial wound healing in vitro after mechanical injury. FAK, MAPK
92  2004 Identification and characterization of the Pasteurella multocida toxin translocation domain. PMT
93  2004 Isotype-specific degradation of Rac activated by the cytotoxic necrotizing factor 1. ---
94  2004 Patterns of variations in Escherichia coli strains that produce cytolethal distending toxin. CDT
95  2004 [Prevalence and characterization of uropathogenic Escherichia coli producing cytotoxic necrotizing factor type 1 (CNF1) in the center of Tunisia]. ---
96  2003 37-kDa laminin receptor precursor modulates cytotoxic necrotizing factor 1-mediated RhoA activation and bacterial uptake. LRP
97  2003 Actin can reorganize into podosomes in aortic endothelial cells, a process controlled by Cdc42 and RhoA. ---
98  2003 Constitutive activation of Rho proteins by CNF-1 influences tight junction structure and epithelial barrier function. AJs, F-actin, JAM-1, p-MLC, TJ, ZO-1
99  2003 Cytotoxic necrotizing factor 1 enhances reactive oxygen species-dependent transcription and secretion of proinflammatory cytokines in human uroepithelial cells. IL-6, ROS
100  2003 Cytotoxic necrotizing factor 1 of Escherichia coli stimulates Rho/Rho-kinase-dependent myosin light-chain phosphorylation without inactivating myosin light-chain phosphatase in endothelial cells. MLC