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■ Abbreviation / Long Form : CdA / 2-chlorodeoxyadenosine

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Total Number of Papers: 90
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Abbreviation:   CdA  (>> Co-occurring Abbreviation)
Long Form:   2-chlorodeoxyadenosine
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No. Year Title Co-occurring Abbreviation
2015 Hairy Cell Leukemia Presenting with Duodenal Involvement Duodenum: A Case Report. CT, EGD, HCL, TRAP
2010 Nucleoside analogs induce proteasomal down-regulation of p21 in chronic lymphocytic leukemia cell lines. CLL, NAs, PCNA
2009 Impaired up-regulation of polo-like kinase 2 in B-cell chronic lymphocytic leukaemia lymphocytes resistant to fludarabine and 2-chlorodeoxyadenosine: a potential marker of defective damage response. ATM, B-CLL, PNA
2007 Chromosomal translocations independently predict treatment failure, treatment-free survival and overall survival in B-cell chronic lymphocytic leukemia patients treated with cladribine. B-CLL, FISH
2006 Inhibition of the ERK pathway promotes apoptosis induced by 2-chloro-2'-deoxyadenosine in the B-cell leukemia cell line EHEB. B-CLL, MAPK/ERK
2006 Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits. ara-C, dCK, dFdG, dFdU, RR
2006 Pharmacological inhibition of the MAPK/ERK pathway increases sensitivity to 2-chloro-2'-deoxyadenosine (CdA) in the B-cell leukemia cell line EHEB. B-CLL, ERK, MAPK
2005 [Treatment results of Langerhans cell histiocytosis with LSH II protocol]. CR
2004 Activation of deoxycytidine kinase by protein kinase inhibitors and okadaic acid in leukemic cells. dCK, OA, PP2A
10  2004 Determination of the deoxycytidine kinase activity in cell homogenates with a non-radiochemical assay using reversed-phase high performance liquid chromatography; Identification of a novel metabolite of 2-chlorodeoxyadenosine. CdAMP, dCK
11  2004 Effects of 2-chloro-2'-deoxyadenosine on the cell cycle in the human leukemia EHEB cell line. ---
12  2004 High incidence of complications after 2-chloro-2'-deoxyadenosine combined with cyclophosphamide in patients with advanced lymphoproliferative malignancies. CLL, CP, CR, NHL, PR
13  2004 Selective increase of dATP pools upon activation of deoxycytidine kinase in lymphocytes: implications in apoptosis. dCK
14  2003 Expression of deoxycytidine kinase in leukaemic cells compared with solid tumour cell lines, liver metastases and normal liver. AML, CT RT-PCR, dCK
15  2003 Mosquito has a single multisubstrate deoxyribonucleoside kinase characterized by unique substrate specificity. BVDU
16  2002 2-Chloro-2'-deoxyadenosine inhibits DNA repair synthesis and potentiates UVC cytotoxicity in chronic lymphocytic leukemia B lymphocytes. B-CLL, HU
17  2002 Flow cytometry of peripheral blood and bone marrow cells from patients with hairy cell leukemia: phenotype of hairy cells, lymphocyte subsets and detection of minimal residual disease after treatment. BM, FC, HCL, HCs, IFN, MRD, PB
18  2002 Hairy cell leukemia. CRs, DCF, HCL
19  2002 Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release. CdATP, dCK, dGK
20  2001 Guillain-Barre syndrome following 2-chlorodeoxyadenosine treatment for Hairy Cell Leukemia. abs, GB
21  2000 Distribution of 2-chloro-2'-deoxyadenosine, 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, fludarabine and cytarabine in mice: a whole-body autoradiography study. CAFdA, F-ara-A
22  2000 Metabolism and cytotoxic effects of 2-chloroadenine, the major catabolite of 2-chloro-2'-deoxyadenosine. B-CLL, CAde
23  2000 Phase I/II study of 2-chloro-2'-deoxyadenosine with cyclophosphamide in patients with pretreated B cell chronic lymphocytic leukemia and indolent non-Hodgkin's lymphoma. CP, i.v, MTD
24  1999 Expression and release of chemokines associated with apoptotic cell death in human promonocytic U937 cells and peripheral blood mononuclear cells. NO, PBMC
25  1999 Potentiation of antitumor effects of cyclophosphamide derivatives in B-chronic lymphocytic leukemia cells by 2-chloro-2'-deoxyadenosine. 4-HC, B-CLL, CP, MAF
26  1999 Responses in refractory hairy cell leukemia to a recombinant immunotoxin. CR, HCL
27  1999 Second malignancies as a consequence of nucleoside analog therapy for chronic lymphoid leukemias. CI, CLL, DCF, HCL
28  1998 Activation of deoxycytidine kinase during inhibition of DNA synthesis in human lymphocytes. ---
29  1998 Autoimmune haemolysis in patients with B-CLL treated with chlorodeoxyadenosine (CDA). B-CLL, taGVHD
30  1998 Chronic lymphocytic leukemia treatment. CB, FDB
31  1998 Comparison of infrared spectra of CLL cells with their ex vivo sensitivity (MTT assay) to chlorambucil and cladribine. CLB, CLL, LDA
32  1998 Complete regression of a suprasellar secondary mass in a patient with low-grade non-Hodgkin's lymphoma (NHL) treated with 2-chlorodeoxyadenosine (CdA) NHL
33  1998 Enhanced cytotoxicity of nucleoside analogs by overexpression of mitochondrial deoxyguanosine kinase in cancer cell lines. ara-G, dFdG, dGK
34  1998 Phosphorylation of anticancer nucleoside analogs by human mitochondrial deoxyguanosine kinase. ara-G, dCyd, dFdC, dFdG, dGuo
35  1997 Deoxycytidine in human plasma: potential for protecting leukemic cells during chemotherapy. ---
36  1997 P53, MDM-2, BAX and BCL-2 and drug resistance in chronic lymphocytic leukemia. CLB, CLL, F-ara-A
37  1997 Similarity of apoptosis induction by 2-chlorodeoxyadenosine and cisplatin in human mononuclear blood cells. PARP, PBMCs, PHA
38  1997 Type of inducing signal regulates transactivation by p53. PARP, PBMC, PHA
39  1996 2-chloro-2'-deoxyadenosine: clinical applications in hematology. ---
40  1996 Chlorodeoxyadenosine and arabinosylcytosine in patients with acute myelogenous leukemia: pharmacokinetic, pharmacodynamic, and molecular interactions. AML, ara-C, ara-CMP, CdAMP
41  1996 Determination of 2-chloro-2'-deoxyadenosine nucleotides in leukemic cells by ion-pair high-performance liquid chromatography. CdATP
42  1996 In vitro activity on myeloid progenitors of a combination of 2-chloro-2'-deoxyadenosine and interferon alpha: the effects of IL-1 and GM-CSF. GM-CSF, IFN-alpha, IL-1
43  1996 In vitro cytotoxicity of 2-chlorodeoxyadenosine and chlorambucil in chronic lymphocytic leukemia. CLB, CLL, Flu
44  1996 Infectious complications after 2-chlorodeoxyadenosine therapy. ---
45  1996 On the phosphorylation of 2-chlorodeoxyadenosine (CdA) and its correlation with clinical response in leukemia treatment. ---
46  1996 Retroviral transfer of deoxycytidine kinase into tumor cell lines enhances nucleoside toxicity. ara-C, dCK
47  1995 2-Chlorodeoxyadenosine (CdA) for patients with previously untreated chronic lymphocytic leukemia (CLL). CLL
48  1995 Bioavailability and bacterial degradation of rectally administered 2-chloro-2'-deoxyadenosine. CAde
49  1995 Cellular pharmacokinetics of 2-chloro-2'-deoxyadenosine nucleotides: comparison of intermittent and continuous intravenous infusion and subcutaneous and oral administration in leukemia patients CdAN
50  1995 Comparison of antitumor activities of 2-chlorodeoxyadenosine and 9-beta-arabinosyl-2-fluoroadenine in chronic lymphocytic leukemia and marrow cells in vitro. CLB, CLL, Flu
51  1995 Differences in kinetic properties of pure recombinant human and mouse deoxycytidine kinase. ara-G, dAdo, dCK, dCyd, ddCyd
52  1995 Evaluation of the cytotoxic activity of gemcitabine in primary cultures of tumor cells from patients with hematologic or solid tumors. ara-C, FMCA
53  1995 Expression of deoxycytidine kinase and phosphorylation of 2-chlorodeoxyadenosine in human normal and tumour cells and tissues. dCK
54  1995 Kinetics and metabolism of 2-chloro-2'-deoxyadenosine and 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine in the isolated perfused rat liver. CAde, CAFdA
55  1995 Modulation of purine analogs- and chlorambucil-induced cytotoxicity by alpha-interferon and interleukin-2 in chronic lymphocytic leukemia. alpha-IFN, CLB, r-IL
56  1995 Subcutaneous injections of 2-chlorodeoxyadenosine for symptomatic hairy cell leukemia. CR, HCL, PR
57  1995 Survival and maturation of heterotopic fetal brain stem xenografts after treatment with 2-chlorodeoxyadenosine and cyclosporine A. CsA
58  1994 2-Chloro-2'-deoxyadenosine--clinical, biochemical and pharmacokinetic considerations. ---
59  1994 2-Chlorodeoxyadenosine therapy in advanced chronic lymphocytic leukaemia. CLL
60  1994 2-Chlorodeoxyadenosine therapy in Waldenstrom's macroglobulinaemia. WM
61  1994 Analysis of 2-chloro-2'-deoxyadenosine in human blood plasma and urine by high-performance liquid chromatography using solid-phase extraction. CAde, CV, HPLC, IS, UV
62  1994 Flow cytometry of blood and bone marrow cells from patients with hairy cell leukemia: phenotype of hairy cells and lymphocyte subsets after treatment with 2-chlorodeoxyadenosine. HCL, NK
63  1994 Impaired interferon alpha response in hairy cell leukemia is corrected by therapy with 2-chloro-2'-deoxyadenosine: implications for susceptibility to opportunistic infections. HCL, MNC
64  1994 In vitro activity of 2-chlorodeoxyadenosine (CdA) in primary cultures of human haematological and solid tumours. FMCA
65  1994 Phosphorylation of 2-chlorodeoxyadenosine (CdA) in extracts of peripheral blood mononuclear cells of leukaemic patients. HCL
66  1994 Properties and levels of deoxynucleoside kinases in normal and tumor cells; implications for chemotherapy. dCK, dGK
67  1994 Protein binding of 2-chloro 2'-deoxyadenosine (cladribine) in healthy subjects and in patients with leukaemia. ---
68  1994 Retreatment of chronic lymphocytic leukemia with 2-chlorodeoxyadenosine (CdA) at relapse following CdA-induced remission: no acquired resistance. CLL
69  1993 Effect of deoxycytidine on 2-chloro-deoxyadenosine-mediated growth inhibition of normal human erythroid and myeloid progenitor cells. 3-ABA, BFU-E, dCyt, NAD
70  1993 High complete remission rate from 2-chloro-2'-deoxyadenosine in previously treated patients with B-cell chronic lymphocytic leukemia: response predicted by rapid decrease of blood lymphocyte count. CLL, CRs, Ig, PRs
71  1993 On the bioavailability of 2-chloro-2'-deoxyadenosine (CdA). The influence of food and omeprazole. Tmax
72  1993 Substrate specificity of mitochondrial 2'-deoxyguanosine kinase. Efficient phosphorylation of 2-chlorodeoxyadenosine. dCyd, dGK, dGuo
73  1993 Successful treatment of patients with hairy cell leukemia (HCL) using a single cycle of 2-chloro-2'-deoxyadenosine (CdA). ADA, dCF, HCL
74  1992 On the bioavailability of oral and subcutaneous 2-chloro-2'-deoxyadenosine in humans: alternative routes of administration. AUCs, PBS, s.c
75  1992 Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine. SCID
76  1992 Rapid recovery from cytopenia in hairy cell leukemia after treatment with 2-chloro-2'-deoxyadenosine (CdA): relation to opportunistic infections. CR
77  1992 Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues. AraT, AZT, dCK
78  1991 2-Chlorodeoxyadenosine inhibits the repair of DNA double-strand breaks and does not inhibit the repair of DNA single-strand breaks in X-irradiated Chinese hamster V79 cells. Dq, dsb and ssb
79  1991 Current Status of U.S. Clinical Trials in Chronic Lymphocytic Leukemia. CLB, CLL, DCF, FLUDARA, pts
80  1991 Determination of 2-chloro-2'-deoxyadenosine in human plasma. ---
81  1991 Inhibitory effect of 2-chlorodeoxyadenosine on granulocytic, erythroid, and T-lymphocytic colony growth. ---
82  1991 On the pharmacokinetics of 2-chloro-2'-deoxyadenosine in humans. ---
83  1990 Recent advances in the treatment of B-cell chronic lymphocytic leukemia. DCF
84  1989 Current approaches to the chemotherapy of B-cell chronic lymphocytic leukemia: a review. CLB, CLL, DCF
85  1989 Profound toxicity of deoxyadenosine and 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. ADA
86  1988 Prevention of 1-beta-D arabinofuranosylcytosine toxicity by 4-nitrobenzyl-6-thioinosine or dipyridamole in human leukemia cell lines. Ara-A, ara-C, BUdR, DP, NBTI
87  1988 Programmed cell death and adenine deoxynucleotide metabolism in human lymphocytes. CLL
88  1985 Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. ADA
89  1984 Antileukemic and immunosuppressive activity of 2-chloro-2'-deoxyadenosine. ---
90  1983 Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes. ---