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■ Abbreviation / Long Form : FADD / Fas-associated death domain

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Abbreviation:   FADD  (>> Co-occurring Abbreviation)
Long Form:   Fas-associated death domain
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2022 PEA-15 engages in allosteric interactions using a common scaffold in a phosphorylation-dependent manner. DD, DED, DISC, ERK, PEA-15
2021 Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation. AEC, HDM, RIPK3
2021 Autophagy-Related Three-Gene Prognostic Signature for Predicting Survival in Esophageal Squamous Cell Carcinoma. ARGs, ESCC, ITGA6, TCGA
2021 Bile Acid Toxicity and Protein Kinases. Bax, Bcl-2, BH3, cAMP, DISC, IL-1beta, MAPK, MLKL, NADPH, PI3K, RIP1, ROS
2021 CTRP3 promotes TNF-α-induced apoptosis and barrier dysfunction in salivary epithelial cells. Bcl-2, CTRP3, SMG, TNF
2021 Differentially expressed immune response genes in COVID-19 patients based on disease severity. APOBEC3G, COVID-19, miR, MM, SARS-CoV-2, SC
2021 Effects of Galphai2 and Galphaz protein knockdown on alpha2A-adrenergic and cannabinoid CB1 receptor regulation of MEK-ERK and FADD pathways in mouse cerebral cortex. alpha2A-AR, CB1, WIN
2021 Excessive manganese alters serum biochemical indices, induces histopathological alterations, and activates apoptosis in liver and cerebrum of Jianzhou Da'er goat (Capra hircus). ALP, AST, Bax, Bcl-2, Caspase-3, 8, 9, GSH-Px, IFN-gamma, MDA, TNF-alpha, TNFR1
2021 FADD regulates antibacterial immune responses via the immune deficiency signaling pathway in the Chinese mitten crab. AMPs, IMD
10  2021 Intrinsic and Extrinsic Cell Apoptotic Pathways in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Systematic Review. FasL, TRAIL
11  2021 Landfill soil leachates from Nigeria and India induced DNA damage and alterations in genes associated with apoptosis in Jurkat cell. AIFM2, API5, PI, RT-PCR
12  2021 Long-chain PUFA ameliorate ETEC-induced intestinal inflammation and cell injury by modulating pyroptosis and necroptosis signaling pathways in IPEC-1 cells. ARA, ASC, EPA, ETEC, HMGB1, IL, IPEC-1, MLKL, NLRP3, p-RIP1, PGAM5, PUFA, RIP, TEER, TLR4, TNF-alpha
13  2021 Loss of FADD and Caspases Affects the Response of T-Cell Leukemia Jurkat Cells to Anti-Cancer Drugs. PCD
14  2021 Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex. DED, DISC, DRs, IL, TRAIL
15  2021 Platelets express adaptor proteins of the extrinsic apoptosis pathway and can activate caspase-8. DEDAF, ITP, TNF
16  2021 PM2.5 Aggravated OVA-Induced Epithelial Tight Junction Disruption Through Fas Associated via Death Domain-Dependent Apoptosis in Asthmatic Mice. EMT, GSEA, OVA, PM2.5, TUNEL, ZO
17  2021 Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol. RIPK1, TRAIL-R1, TRAIL-R2
18  2021 Roles of TNF receptor-associated and Fas-associated death domain proteins in the apoptosis of Eimeria tenella host cells. TRADD
19  2021 The cardioprotective effect of microRNA-103 inhibitor against isoprenaline-induced myocardial infarction in mice through targeting FADD/RIPK pathway. CK-MB, LNA, MI, miR-103, RIPK
20  2021 The lncRNA H19-Derived MicroRNA-675 Promotes Liver Necroptosis by Targeting FADD. HCC, miR-675, RIP3
21  2021 The stressosome, a caspase-8-activating signalling complex assembled in response to cell stress in an ATG5-mediated manner. cFLIPL, DD, DEDs, ER
22  2021 Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) loss in canine mammary carcinoma. TRAIL, TUNEL
23  2020 A cytosolic heat shock protein 90 and co-chaperone p23 complex activates RIPK3/MLKL during necroptosis of endothelial cells in acute respiratory distress syndrome. ARDS, Hsp90, MLKL, TNFR1, TRADD
24  2020 Ancestral role of TNF-R pathway in cell differentiation in the basal metazoan Hydra. TNFRs, TRAF
25  2020 Antitumor effects of curcumin on the proliferation, migration and apoptosis of human colorectal carcinoma HCT‑116 cells. MMP, NF
26  2020 Arg-GlcNAcylation on TRADD by NleB and SseK1 Is Crucial for Bacterial Pathogenesis. A/E, DD, EPEC, RIPK1, S. Typhimurium, TNFR1
27  2020 Bicyclic alpha-Iminophosphonates as High Affinity Imidazoline I2 Receptor Ligands for Alzheimer's Disease. I2-IR
28  2020 Cell-Penetrable Peptide-Conjugated FADD Induces Apoptosis and Regulates Inflammatory Signaling in Cancer Cells. DISC, Tat
29  2020 Ceramide Pathway Regulators Predict Clinical Prognostic Risk and Affect the Tumor Immune Microenvironment in Lung Adenocarcinoma. LASSO, LUAD, RELA
30  2020 Copper Induces Oxidative Stress and Apoptosis in the Mouse Liver. AHR, AIF, Apaf-1, ASA, Bak, Bax, Bcl-2, Bcl-xL, Bim, CAT, Cyt C, EndoG, GSH-Px, MMP, PC, ROS, SOD, TNFR1, TRADD
31  2020 Coronin 1B regulates the TNFalpha-induced apoptosis of HUVECs by mediating the interaction between TRADD and FADD. HUVECs, TNF-alpha, TRADD
32  2020 Cucurbita ficifolia Fruit Extract Induces Tp53/Caspase-Mediated Apoptosis in MCF-7 Breast Cancer Cells. BAK, Bax, C. ficifolia, FAS
33  2020 Fas-associated death domain (FADD) in sea cucumber (Apostichopus japonicus): Molecular cloning, characterization and pro-apoptotic function analysis. ---
34  2020 Gene Expression Alterations Associated with Oleuropein-Induced Antiproliferative Effects and S-Phase Cell Cycle Arrest in Triple-Negative Breast Cancer Cells. BCL10, BFAR, BIRC5, BNIP2, BNIP3, BRAF, CARD, CASP1, CASP14, CASP4, CASP6, CYCS, GADD45A, IAP, OL, PYD, RIPK2, TNBC, TNFRSF10A, TNFRSF21
35  2020 Knock down of Fas-Associated Protein with Death Domain (FADD) Sensitizes Osteosarcoma to TNFalpha-induced Cell Death. NF-kappaB, OS
36  2020 MicroRNA-129-5p affects immune privilege and apoptosis of nucleus pulposus cells via regulating FADD in intervertebral disc degeneration. IDD, miR-129-5p, NP
37  2020 Necroptotic-susceptible dendritic cells exhibit enhanced antitumor activities in mice. DCs, WT
38  2020 Neuroprotective Effect of Rhodiola crenulata in D-Galactose-Induced Aging Model. ---
39  2020 OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis. HCC, RIPK1
40  2020 Overexpression of FADD and Bcl-XS proteins as novel prognostic biomarkers for surgically resected non-small cell lung cancer. NSCLC
41  2020 Prognostic and Clinicopathological Significance of FADD Upregulation in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis. CI, HNSCC, HR, OR
42  2020 The role of Mycobacterium tuberculosis complex species on apoptosis and necroptosis state of macrophages derived from active pulmonary tuberculosis patients. CI, MTBC, OR, RIP3, TB
43  2019 Atrazine induces necroptosis by miR-181-5p targeting inflammation and glycometabolism in carp lymphocytes. ATR, CYLD, miRNAs, MLKL, RIP1, RIP3
44  2019 c-FLIP, a Novel Biomarker for Cancer Prognosis, Immunosuppression, Alzheimer's Disease, Chronic Obstructive Pulmonary Disease (COPD), and a Rationale Therapeutic Target. AD, c-FLIPL, COPD, DISC
45  2019 Connexin 43 dephosphorylation contributes to arrhythmias and cardiomyocyte apoptosis in ischemia/reperfusion hearts. Cx43, Fas, I/R, S282A
46  2019 DR4-Associated Death Receptor Signal Promotes Cartilage Damage in Patients With Kashin-Beck Disease. c-FLIP, DR, KBD, NC, OA
47  2019 FADD-deficient mouse embryonic fibroblasts undergo RIPK1-dependent apoptosis and autophagy after NB-UVB irradiation. MEFs, NB-UVB, ROS, UVB, WT
48  2019 Fluorofenidone inhibits apoptosis of renal tubular epithelial cells in rats with renal interstitial fibrosis. Apaf-1, CHOP, Col I, UUO
49  2019 Foxo3a-dependent miR-633 regulates chemotherapeutic sensitivity in gastric cancer by targeting Fas-associated death domain. DOX, FOXO3a, miRNAs
50  2019 Ganoderma lucidum spore oil induces apoptosis of breast cancer cells in vitro and in vivo by activating caspase-3 and caspase-9. Bax, Bcl-2, G. lucidum, GLSO, TRAF2, XIAP
51  2019 Identification of potential binding pocket on viral oncoprotein HPV16 E6: a promising anti-cancer target for small molecule drug discovery. HPV
52  2019 Lactobacillus plantarum C88 protects against aflatoxin B1-induced liver injury in mice via inhibition of NF-kappaB-mediated inflammatory responses and excessive apoptosis. ALP, ALT, AST, Fas, IFN-gamma, IkappaB, IL-1beta, NF-kappaB, TLR2, TNF-alpha, TRADD
53  2019 miR-27a regulates vascular remodeling by targeting endothelial cells' apoptosis and interaction with vascular smooth muscle cells in aortic dissection. AD, ECs, GDF8, MMP20
54  2019 Molecular cloning and characterization of FADD from the manila clam Ruditapes philippinarum. ---
55  2019 PEA-15 C-Terminal Tail Allosterically Modulates Death-Effector Domain Conformation and Facilitates Protein-Protein Interactions. CS, DED, DISC, DRS, ERK, NMR, PEA-15
56  2019 Protective effect of remifentanil on myocardial ischemia-reperfusion injury through Fas apoptosis signaling pathway. CK, CK-MB, ELISA, FasL, IL-6, IR, IR, LDH, MDA, RFT, RFT, RT-PCR, SD, sham, SOD, TNF-alpha, TUNEL
57  2019 S194-P-FADD as a marker of aggressiveness and poor prognosis in human T-cell lymphoblastic lymphoma. ---
58  2019 SPOP inhibits mice pancreatic stellate cell activation by promoting FADD degradation in cerulein-induced chronic pancreatitis. CP, IL-6, NF-kappaB, PSCs, SPOP
59  2019 The classical NLRP3 inflammasome controls FADD unconventional secretion through microvesicle shedding. IL-1beta
60  2019 The first cloned sea cucumber FADD from Holothuria leucospilota: Molecular characterization, inducible expression and involvement of apoptosis. LPS, ORF, UTR
61  2019 Topiramate Reverses Physiological and Behavioral Alterations by Postoperative Cognitive Dysfunction in Rat Model Through Inhibiting TNF Signaling Pathway. Bax, Bcl-2, Fas, HE, MWM, PARP-1, POCD, TNF, TPM
62  2019 ZBP1 mediates interferon-induced necroptosis. IFNs, ISG, ND, RIPK1, SIRS
63  2019 [Effect of enalapril on apoptosis of renal tubular epithelial cells in renal interstitial fibrosis in rats]. Apaf-1, CHOP, UUO
64  2019 [Herbal cake-partitioned moxibustion improves intestinal epithelial barrier dysfunction by suppressing TNF-alpha-mediated apoptosis pathway of intestinal epithelium in rats with Crohn's disease]. CD, Moxi, RIP1, TNF, TNFR1
65  2018 A Novel AKT Activator, SC79, Prevents Acute Hepatic Failure Induced by Fas-Mediated Apoptosis of Hepatocytes. DISC, FLICE
66  2018 A Suicide Switch Directly Eliminates Intracellular scFv Oligomers in the Cytoplasm of Mammalian Cells. scFv
67  2018 An RNA Aptamer Targeting the Receptor Tyrosine Kinase PDGFRalpha Induces Anti-tumor Effects through STAT3 and p53 in Glioblastoma. GBM, PDGFRalpha, TNF
68  2018 Antagonist of cIAP1/2 and XIAP enhances anti-tumor immunity when combined with radiation and PD-1 blockade in a syngeneic model of head and neck cancer. CTL, HNSCCs, TNF
69  2018 Cadmium-induced apoptosis in neuronal cells is mediated by Fas/FasL-mediated mitochondrial apoptotic signaling pathway. Bax, Bcl-2, Cd, FasL, MMP
70  2018 Combined effects of 17beta-estradiol and exercise training on cardiac apoptosis in ovariectomized rats. Bad, Bax, Bcl-2, Bcl-xL, ERalpha, ERbeta, IGF-1, IGF-1R, OVX-E2, p-PI3K, pBad, SHAM, tBid, TNF-alpha
71  2018 Detection of RIPK1 in the FADD-Containing Death Inducing Signaling Complex (DISC) During Necroptosis. DISC, TNFRSF
72  2018 Edaravone attenuates neuronal apoptosis in hypoxic-ischemic brain damage rat model via suppression of TRAIL signaling pathway. Bax, Bcl-2, DR5, HIBD, Sham, TRAIL
73  2018 Escin induces apoptosis in human bladder cancer cells: An in vitro and in vivo study. DMSO, NF-kappaB, PBMC, ROS
74  2018 FADD (Fas-Associated Protein With Death Domain), Caspase-3, and Caspase-8 and Incidence of Ischemic Stroke. MDCS
75  2018 FADD at the Crossroads between Cancer and Inflammation. DR
76  2018 Gender difference in the effect of progesterone on neonatal hypoxic/ischemic brain injury in mouse. FJB, MRI, NHI, PROG, TNFR1, TRAF6, TRIF
77  2018 H19 suppresses the growth of hepatoblastoma cells by promoting their apoptosis via the signaling pathways of miR-675/FADD and miR-138/PTK2. FAK, HBV, HIFIA, IHC, PTK2, TUNEL
78  2018 Hepatitis B Spliced Protein (HBSP) Suppresses Fas-Mediated Hepatocyte Apoptosis via Activation of PI3K/Akt Signaling. DISC, FLICE, FLIPL, HBSP, HBV, PHH, PI3K
79  2018 Improved age-related deficits in cognitive performance and affective-like behavior following acute, but not repeated, 8-OH-DPAT treatments in rats: regulation of hippocampal FADD. ---
80  2018 Interleukin-35 Inhibits TNF-alpha-Induced Osteoclastogenesis and Promotes Apoptosis via Shifting the Activation From TNF Receptor-Associated Death Domain (TRADD)-TRAF2 to TRADD-Fas-Associated Death Domain by JAK1/STAT1. IL-35, TRADD, TRAP
81  2018 Irigenin sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells. c-FLIP, DR5, Iri, NAC, ROS, TRAIL
82  2018 K6 linked polyubiquitylation of FADD by CHIP prevents death inducing signaling complex formation suppressing cell death. CHIP, DISC
83  2018 Molecular cloning and characterization of FADD from the orange-spotted grouper (Epinephelus coioides). bp, FHM, GS, IFN, ISRE, SGIV
84  2018 Palmitic Acid-Induced Podocyte Apoptosis via the Reactive Oxygen Species-Dependent Mitochondrial Pathway. Bcl-2, CKD, PA, ROS
85  2018 Rhinovirus 3C protease suppresses apoptosis and triggers caspase-independent cell death. 3Cpro, ds, RIPK1, RIPK3, ROS, TLR3
86  2018 RIP3-deficience attenuates potassium oxonate-induced hyperuricemia and kidney injury. ABCG2, HU, IkappaBalpha, MDA, NF-kappaB, NLRP3, OAT1, OCT1, OCTN1, RIP3, SOD, TLR4
87  2018 Rs217727 polymorphism in H19 promotes cell apoptosis by regulating the expressions of H19 and the activation of its downstream signaling pathway. HCC, miR, PCR, UTR
88  2018 SPOP promotes FADD degradation and inhibits NF-kappaB activity in non-small cell lung cancer. NSCLC, SPOP
89  2018 Stimulation of Fas/FasL-mediated apoptosis by luteolin through enhancement of histone H3 acetylation and c-Jun activation in HL-60 leukemia cells. ChIP, ERK, FasL, JNK
90  2018 The extracellular SEMA domain attenuates intracellular apoptotic signaling of semaphorin 6A in lung cancer cells. SEMA6A
91  2018 The Protective Effects of Clams on Hypercholesterolemia in Late-Stage Triple-Transgenic Alzheimer's Diseased Mice Hearts. AD, GC
92  2018 Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) induces FAS dependent apoptosis in human vascular smooth muscle cells. ADAM17, Bcl-2, c-FLIP, CrmA, DISC, FAS, TIMP-3, VSMCs
93  2018 Ulmus macrocarpa Hance improves benign prostatic hyperplasia by regulating prostatic cell apoptosis. Bax, Bcl-2, BOO, BPH, DHT, FasL, LUTS, PCNA, TP, UMH
94  2018 [Expression of c-FLIP in peripheral blood mononuclear cells of patients with rheumatoid arthritis and its relation with extrinsic apoptotic pathway]. PBMCs
95  2017 A protective role for FADD dominant negative (FADD-DN) mutant in trinitrochlorobenzene (TNCB)-induced murine contact hypersensitivity reactions. CHS, FADD-DN, TNCB
96  2017 Bufadienolides from amphibians: A promising source of anticancer prototypes for radical innovation, apoptosis triggering and Na+/K+-ATPase inhibition. ---
97  2017 Complement C5a induces mesenchymal stem cell apoptosis during the progression of chronic diabetic complications. Bax, Bcl-2, C5aR, MSCs
98  2017 D4F alleviates macrophage-derived foam cell apoptosis by inhibiting the NF-kappaB-dependent Fas/FasL pathway. FasL, NF-kappaB, ox-LDL
99  2017 DDIAS suppresses TRAIL-mediated apoptosis by inhibiting DISC formation and destabilizing caspase-8 in cancer cells. DDIAS, DISC, HCC, NSCLC, TRAIL
100  2017 Decreased cortical FADD protein is associated with clinical dementia and cognitive decline in an elderly community sample. DLPFC