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■ Abbreviation / Long Form : HK / high molecular weight kininogen

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Total Number of Papers: 246
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Abbreviation:   HK  (>> Co-occurring Abbreviation)
Long Form:   high molecular weight kininogen
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No. Year Title Co-occurring Abbreviation
2021 Analysis of cold activation of the contact system in hereditary angioedema with normal C1 inhibitor. C1-INH, FXII, HAE
2021 Blood Clotting and the Pathogenesis of Types I and II Hereditary Angioedema. FXII, HAE, PK
2021 Contact System Activation in Plasma from Dengue Patients Might Harness Endothelial Virus Replication through the Signaling of Bradykinin Receptors. DENV, HBMECs, KKS, PKa, ZIKV
2021 Effect of Anabolic-Androgenic Steroid Abuse on the Contact Activation System. AAS, C1-INH, CAS, EKP, FXII
2021 Identification of Human Kinin-Forming Enzyme Inhibitors from Medicinal Herbs. ACEI, BK, FXIIa, KKS
2021 Sex-specific differences in plasma levels of FXII, HK, and FXIIa-C1-esterase inhibitor complexes in community acquired pneumonia. C1INH, CAP, FXII
2020 Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery. FNII, FXII, gC1qR, HKD5, PK
2020 Hereditary angioedema: Investigational therapies and future research. MASP-1
2020 High molecular weight kininogen contributes to early mortality and kidney dysfunction in a mouse model of sickle cell disease. SCD
10  2020 The evolution of factor XI and the kallikrein-kinin system. FIX, FXI, FXIIa, KKS
11  2020 The synthetic LPS binding peptide 19-2.5 interferes with clotting and prevents degradation of high molecular weight kininogen in plasma. LPS
12  2019 An antibody against HK blocks Alzheimer's disease peptide beta-amyloid-induced bradykinin release in human plasma. AD
13  2019 Differential processing of high-molecular-weight kininogen during normal pregnancy. ---
14  2019 Plasma Concentrations of High Molecular Weight Kininogen and Prekallikrein and Venous Thromboembolism Incidence in the General Population. VTE
15  2019 Plasma kallikrein contributes to ambient particulate matter-induced lung injury. BALF, FXII, KAL, KKS, pKal, PM, TAT
16  2019 Prospective study of plasma high molecular weight kininogen and prekallikrein and incidence of coronary heart disease, ischemic stroke and heart failure. ARIC, PK
17  2019 Protease activity in single-chain prekallikrein. FXII, PK, PKa
18  2019 The C1q Receptors: Focus on gC1qR/p33 (C1qBP, p32, HABP-1)1. FII, PRR
19  2018 A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain. FXII, HAE, HC, PK
20  2018 An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema. C1-INH, FXII, HAE, RNAi, siRNA
21  2018 Cell Receptor and Cofactor Interactions of the Contact Activation System and Factor XI. CAS, FXI, FXII, PK
22  2018 The blood fluke Schistosoma mansoni cleaves the coagulation protein high molecular weight kininogen (HK) but does not generate the vasodilator bradykinin. ---
23  2018 The Plasma Kallikrein-Kininogen Pathway Is Critical in the Pathogenesis of Colitis in Mice. DSS, FXII, IBD, KKS, pKal, TNBS
24  2017 A kallikrein-targeting RNA aptamer inhibits the intrinsic pathway of coagulation and reduces bradykinin release. APTT, BK, FXIIa, SELEX
25  2017 An essential role of high-molecular-weight kininogen in endotoxemia. HC, LC, LPS
26  2017 Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice. AD, FXII
27  2017 G Protein-Coupled Kinin Receptors and Immunity Against Pathogens. BK, FXII, KKS, PK
28  2017 Limited role of kininogen in the host response during gram-negative pneumonia-derived sepsis. Ctrl ASO, KNG
29  2017 Nucleic acids as cofactors for factor XI and prekallikrein activation: Different roles for high-molecular-weight kininogen. FXI, FXIIa, PK
30  2017 Streptococcus gallolyticus subsp. gallolyticus endocarditis isolate interferes with coagulation and activates the contact system. ---
31  2017 The glucocorticoid inhibits neutrophils formed extracellular traps (NETs) and suppresses the inflammation caused by fallopian tube staphylococcal infection. citH3, NET, NETs
32  2017 The Procoagulant Activity of Apoptotic Cells Is Mediated by Interaction with Factor XII. FXII, PS
33  2016 A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain. FXI
34  2016 Complement, Kinins, and Hereditary Angioedema: Mechanisms of Plasma Instability when C1 Inhibitor is Absent. ---
35  2016 Kininogen Cleavage Assay: Diagnostic Assistance for Kinin-Mediated Angioedema Conditions. AE, C1-INH
36  2016 Polyphosphate and RNA Differentially Modulate the Contact Pathway of Blood Clotting. polyP
37  2016 Serum stimulation of CCR7 chemotaxis due to coagulation factor XIIa-dependent production of high-molecular-weight kininogen domain 5. CCL19, CCR7, TSP-4
38  2016 The complement and contact activation systems: partnership in pathogenesis beyond angioedema. FXII
39  2015 Activation of the factor XII-driven contact system in Alzheimer's disease patient and mouse model plasma. AD, FXII
40  2015 Contact pathway of coagulation and inflammation. FXII, PK
41  2015 Histidine-rich glycoprotein binds DNA and RNA and attenuates their capacity to activate the intrinsic coagulation pathway. ---
42  2014 High-molecular-weight kininogen cleavage correlates with disease states in the bradykinin-mediated angioedema due to hereditary C1-inhibitor deficiency. C1-INH, HAE-C1-INH
43  2014 Pathogenic mechanisms of bradykinin mediated diseases: dysregulation of an innate inflammatory pathway. C1-INH, factor XIIf, HAE, Hsp90, PK
44  2014 Pleiotropic effects of a vibrio extracellular protease on the activation of contact system. PPK
45  2014 Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits. ASOs
46  2014 The bradykinin-forming cascade: a historical perspective. Hsp90
47  2013 Endothelial cell permeability during hantavirus infection involves factor XII-dependent increased activation of the kallikrein-kinin system. BK, EC, ECIS, FXII, HFRS, HPS, KAL, KKS, PK, VE, VEGF, VSMC
48  2013 Factor XII-independent activation of the bradykinin-forming cascade: Implications for the pathogenesis of hereditary angioedema types I and II. C1-INH
49  2013 Structure of plasma and tissue kallikreins. KKS, KLKs, LK, PK
50  2013 Substrate specificity studies of the cysteine peptidases falcipain-2 and falcipain-3 from Plasmodium falciparum and demonstration of their kininogenase activity. FP-2, FP-3, FRET
51  2013 Targeting gC1qR domains for therapy against infection and inflammation. BK, ECs, uPAR
52  2013 The kallikrein-kinin system in experimental Chagas disease: a paradigm to investigate the impact of inflammatory edema on GPCR-mediated pathways of host cell invasion by Trypanosoma cruzi. CCM, ETRs, LBK, TCTs, TLR2
53  2012 Angio-oedema induced by oestrogen contraceptives is mediated by bradykinin and is frequently associated with urticaria. C1-INH
54  2012 Chimeric glutathione S-transferases containing inserts of kininogen peptides: potential novel protein therapeutics. ---
55  2012 Domain 5 of high molecular weight kininogen inhibits collagen-mediated cancer cell adhesion and invasion in association with alpha-actinin-4. GST
56  2012 Ferritin blocks inhibitory effects of two-chain high molecular weight kininogen (HKa) on adhesion and survival signaling in endothelial cells. HKa
57  2012 Immobilized transition metal ions stimulate contact activation and drive factor XII-mediated coagulation. DOGS-NTA, FXI, FXII
58  2011 Activation of the contact system at the surface of Fusobacterium necrophorum represents a possible virulence mechanism in Lemierre's syndrome. FXI
59  2011 Cleavage of kininogen and subsequent bradykinin release by the complement component: mannose-binding lectin-associated serine protease (MASP)-1. BK, HAE, MASP
60  2011 Heparin affects the interaction of kininogen on endothelial cells. ECM, PK
61  2011 High molecular weight kininogen activates B2 receptor signaling pathway in human vascular endothelial cells. BK, HPAEC, NO, PK
62  2011 Interaction of high-molecular-weight kininogen with endothelial cell binding proteins suPAR, gC1qR and cytokeratin 1 determined by surface plasmon resonance (BiaCore). CK1, suPAR, uPAR
63  2011 Molecular determinants of the interaction between human high molecular weight kininogen and Candida albicans cell wall: Identification of kininogen-binding proteins on fungal cell wall and mapping the cell wall-binding regions on kininogen molecule. CWP
64  2010 Activation of the plasma kallikrein-kinin system on human lung epithelial cells. BK, Hsp90, KKS, PK, PPK
65  2010 Biochemical characterization of a novel high-affinity and specific plasma kallikrein inhibitor. BK, NO
66  2010 Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis. EGFR, FXII, MAPK44, uPAR
67  2010 Inhibition of metastasis of syngeneic murine melanoma in vivo and vasculogenesis in vitro by monoclonal antibody C11C1 targeted to domain 5 of high molecular weight kininogen. ---
68  2010 Kinins, airway obstruction, and anaphylaxis. ---
69  2010 The plasma bradykinin-forming pathways and its interrelationships with complement. C1-INH, Hsp90, uPAR
70  2009 Aberrant processing of plasma vitronectin and high-molecular-weight kininogen precedes the onset of preeclampsia. DIGE, VN
71  2009 Factor XII-independent cleavage of high-molecular-weight kininogen by prekallikrein and inhibition by C1 inhibitor. C1-INH, PK
72  2009 High molecular weight kininogen binds to laminin--characterization and kinetic analysis. ---
73  2009 Human plasma kallikrein-kinin system: physiological and biochemical parameters. ACE, BK, FXII, HAE, KKS, PK
74  2009 Kininogen in autoimmune uveitis: decrease in peripheral blood stream versus increase in target tissue. ERU
75  2009 Neutrophil-derived proteinase 3 induces kallikrein-independent release of a novel vasoactive kinin. PR3
76  2009 Treatment of invasive streptococcal infection with a peptide derived from human high-molecular weight kininogen. ---
77  2008 Cleavage of high-molecular-weight kininogen by elastase and tryptase is inhibited by ferritin. BK
78  2008 Involvement of heparan sulfate proteoglycans in cellular uptake of high molecular weight kininogen. HSPG, RAECs
79  2008 Kininogen adsorption to the cell surface of Candida spp. ---
80  2007 Antithrombotic activity of kininogen is mediated by inhibitory effects of domain 3 during arterial injury in vivo. GST, HKd
81  2007 Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis. LK, mKng1
82  2007 Identification and characterization of a new kallikrein-kinin system inhibitor from the salivary glands of the malaria vector mosquito Anopheles stephensi. FXII, HUVECs, PK
83  2007 Identification of lipopolysaccharide binding site on high molecular weight kininogen. BK, KKS, PRCP
84  2007 Molecular modeling of the prekallikrein structure provides insights into high-molecular-weight kininogen binding and zymogen activation. PK
85  2007 Myeloperoxidase interacts with endothelial cell-surface cytokeratin 1 and modulates bradykinin production by the plasma Kallikrein-Kinin system. CK1, MPO
86  2007 The contribution of gC1qR/p33 in infection and inflammation. ---
87  2006 Endothelial-cell apoptosis induced by cleaved high-molecular-weight kininogen (HKa) is matrix dependent and requires the generation of reactive oxygen species. BK, HKa
88  2006 gC1qR/p33 serves as a molecular bridge between the complement and contact activation systems and is an important catalyst in inflammation. EC, FXII
89  2006 High-molecular-weight kininogen fragments stimulate the secretion of cytokines and chemokines through uPAR, Mac-1, and gC1qR in monocytes. BK, ERK, GST, IL, mAbs, TNF
90  2006 Regulation of angiogenesis by the kallikrein-kinin system. BK
91  2006 The contact system--a novel branch of innate immunity generating antibacterial peptides. ---
92  2005 Contribution of the N-terminal and C-terminal domains of haemaphysalin to inhibition of activation of plasma kallikrein-kinin system. ---
93  2005 Formation of bradykinin: a major contributor to the innate inflammatory response. Hsp90
94  2005 Identification and characterization of the plasma kallikrein-kinin system inhibitor, haemaphysalin, from hard tick, Haemaphysalis longicornis. ---
95  2005 Increased activity of plasma and tissue kallikreins, plasma kininase II and salivary kallikrein in pemphigus foliaceus (fogo selvagem). LK, PF
96  2005 Inhibition of angiogenesis by cleaved high molecular weight kininogen (HKa) and HKa domain 5. BK, HKa, HPRG
97  2005 Interplay between parasite cysteine proteases and the host kinin system modulates microvascular leakage and macrophage infection by promastigotes of the Leishmania donovani complex. ACE, CAP, N-Pip-hF-VSPh, VL
98  2005 Local bradykinin formation is controlled by glycosaminoglycans. GAGs
99  2005 Modulation of inflammation by kininogen deficiency in a rat model of inflammatory arthritis. PG-PS
100  2005 Overexpression of prolylcarboxypeptidase enhances plasma prekallikrein activation on Chinese hamster ovary cells. CHO, EGFP, HUVEC, PK