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■ Abbreviation / Long Form : HLE / human leukocyte elastase

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Total Number of Papers: 229
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Abbreviation:   HLE  (>> Co-occurring Abbreviation)
Long Form:   human leukocyte elastase
 Abbreviation Variation
 Long Form Variation
 Pair(Abbreviation/Long Form) Variation
No. Year Title Co-occurring Abbreviation
2021 Lossen Rearrangement of p-Toluenesulfonates of N-Oxyimides in Basic Condition, Theoretical Study, and Molecular Docking. ---
2021 Proteinase 3 contributes to endothelial dysfunction in an experimental model of sepsis. CORM-3, HUVECs, PMNs, PR3
2021 Therapeutic benefits of recombinant alpha1-antitrypsin IgG1 Fc-fusion protein in experimental emphysema. AAT, AATD, CS, DC, EP, pAAT, PPE
2018 Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2' site binding inhibitor. ---
2015 Phenalenones: insight into the biosynthesis of polyketides from the marine alga-derived fungus Coniothyrium cereale. ---
2015 Stabilization of porcine pancreatic elastase crystals by glutaraldehyde cross-linking. PPE
2013 Efficient inhibition of human leukocytic elastase by means of alpha1-antitrypsin/peptide complexes. COPD, PMN
2012 alpha1Proteinase inhibitor regulates CD4+ lymphocyte levels and is rate limiting in HIV-1 disease. ---
2012 In vitro evaluation of the antielastase activity of polycyclic beta-lactams. HLPR3, PPE
10  2012 Marilines A-C: novel phthalimidines from the sponge-derived fungus Stachylidium sp. CD
11  2012 Methyl 3-[(1,1-dioxo-1lamda(6),2-benzothiazol-3-yl)amino]-5-nitrothiophene-2-carboxyl-ate. ---
12  2012 Trivaric acid, a potent depside human leukocyte elastase inhibitor. ---
13  2012 [Coumarins of Anemone raddeana Regel and their biological activity]. RARalpha
14  2011 Characterizing the dynamics and ligand-specific interactions in the human leukocyte elastase through molecular dynamics simulations. COPD, MD
15  2011 The action of neutrophil serine proteases on elastin and its precursor. CG, PR3
16  2010 Antimicrobial phenalenone derivatives from the marine-derived fungus Coniothyrium cereale. ---
17  2010 Inhibition of human leukocyte elastase, plasmin and matrix metalloproteinases by oleic acid and oleoyl-galardin derivative(s). MMP-2
18  2010 Spartinoxide, a new enantiomer of A82775C with inhibitory activity toward HLE from the marine-derived Fungus Phaeosphaeria spartinae. ---
19  2010 Synthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-beta-lactam inhibitor of human leukocyte elastase. ---
20  2009 4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase. ---
21  2009 Cytotoxic and HLE-inhibitory tetramic acid derivatives from marine-derived fungi. ---
22  2009 New polyketides from the marine-derived fungus Phaeosphaeria spartinae. ---
23  2008 Cutaneous vasculitis in breast cancer treated with chemotherapy. ANCA, EGFR, MPO
24  2008 Human leukocyte elastase counteracts matrix metalloproteinase-7 induced apoptosis resistance of tumor cells. ---
25  2008 Study of the refirming effect of a plant complex. PPE
26  2008 The effects of areca catechu L extract on anti-aging. PPE
27  2007 Crystallization and preliminary diffraction studies of porcine pancreatic elastase in complex with a novel inhibitor. PPE
28  2007 NF-kappaB signaling, elastase localization, and phagocytosis differ in HIV-1 permissive and nonpermissive U937 clones. ---
29  2007 Polymorphism R62W results in resistance of CD23 to enzymatic cleavage in cultured cells. SNP
30  2007 The sulfate groups of chondroitin sulfate- and heparan sulfate-containing proteoglycans in neutrophil plasma membranes are novel binding sites for human leukocyte elastase and cathepsin G. CG, PMSF
31  2006 Elastin changes during chronological and photo-ageing: the important role of lysozyme. SSR
32  2006 Proteolytic cleavage of annexin 1 by human leukocyte elastase. ---
33  2006 Structure of the complex of porcine pancreatic elastase with a trimacrocyclic peptide inhibitor FR901451. PPE
34  2005 2',5'-Oligoadenylate size is critical to protect RNase L against proteolytic cleavage in chronic fatigue syndrome. CFS, LMW, PBMC
35  2005 2,4,5-Triphenylisothiazol-3 (2H)-one 1,1-dioxides as inhibitors of human leukocyte elastase. ---
36  2005 Antiprotease function of airway secretions in purulent tracheobronchitis. DNase
37  2005 Design, synthesis, and enzymatic evaluation of N1-acyloxyalkyl- and N1-oxazolidin-2,4-dion-5-yl-substituted beta-lactams as novel inhibitors of human leukocyte elastase. COPD
38  2005 Pseudosaccharin amine derivatives: synthesis and elastase inhibitory activity. ---
39  2005 Synthesis and anti-elastase properties of 6-amino-2-phenyl-4H-3,1-benzoxazin-4-one aminoacyl and dipeptidyl derivatives. ---
40  2005 Synthesis and in vitro evaluation of pseudosaccharinamine derivatives as potential elastase inhibitors. PPE
41  2005 The N-terminal tetrapeptide of neutrophil proteinase 3 causes S-phase arrest in granulopoietic progenitors. BrdU, CMP, GMP, PR3
42  2004 Beta-lactams as versatile synthetic intermediates for the preparation of heterocycles of biological interest. ---
43  2004 Detection rate and antigenic specificities of antineutrophil cytoplasmic antibodies in chinese patients with clinically suspected vasculitis. ANA, ANCA, BPI, ELISAs, IIF, MPO, PR3
44  2004 Disruption of the murine alpha1-antitrypsin/PI2 gene. alpha1-AT, CYT
45  2004 Human leukocyte elastase and cathepsin G are specific inhibitors of C5a-dependent neutrophil enzyme release and chemotaxis. fMLP, IL-8, LTB4, PMNs
46  2004 Human leukocyte elastase induces keratinocyte proliferation by epidermal growth factor receptor activation. ---
47  2004 Mechanism-based inactivation of human leukocyte elastase via an enzyme-induced sulfonamide fragmentation process. ---
48  2004 Potent inhibition of human leukocyte elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamide derivatives. ---
49  2004 Structure-activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors. ACPC, BPC, HCV, NS3, PPE
50  2004 The prevalence and target antigens of antithyroid drugs induced antineutrophil cytoplasmic antibodies (ANCA) in Chinese patients with hyperthyroidism. ANCA, BPI, IIF, MMI, MPO, PR3, PTU
51  2003 A novel orally active inhibitor of HLE. ---
52  2003 Alpha-aminoxy acids as building blocks for the oxime and hydroxylamine pseudopeptide links. Application to the synthesis of human elastase inhibitors. ---
53  2003 Biochemical and pharmacological characterization of 2-(9-(2-piperidinoethoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a novel, orally active elastase inhibitor. ---
54  2003 Epitope mapping of anti-PR3 antibodies using chimeric human/mouse PR3 recombinant proteins. hPR3, MPO, mPR3, PR3
55  2003 HIV-1 preferentially binds receptors copatched with cell-surface elastase. GP
56  2003 Limited proteolysis of surfactant protein D causes a loss of its calcium-dependent lectin functions. CRD, SP-D
57  2003 Neutrophil serine proteinases activate human nonepithelial cells to produce inflammatory cytokines through protease-activated receptor 2. CatG, HGF, PARs, PR3
58  2003 [Antineutrophil cytoplasmic antibody associated vasculitis induced by antithyroid agents]. ANA, ANCA, AZU, BPI, CG, IIF, LF, MMI, MPO, PR3, PTU
59  2002 Disruption of CD40/CD40 ligand interaction with cleavage of CD40 on human gingival fibroblasts by human leukocyte elastase resulting in down-regulation of chemokine production. CD40L, HGF, IL
60  2002 Elastolysis by proteinase 3 and its inhibition by alpha(1)-proteinase inhibitor: a mechanism for the incomplete inhibition of ongoing elastolysis. CatG, PR3
61  2002 Leukocyte elastase inhibition therapy in cystic fibrosis: role of glycosylation on the distribution of alpha-1-proteinase inhibitor in blood versus lung. ---
62  2002 Triterpenes and phytosterols as human leucocyte elastase inhibitors. ---
63  2002 Urinary bikunin determination provides insight into proteinase/proteinase inhibitor imbalance in patients with inflammatory diseases. APP, Bk, CRP, IalphaI, P alpha I
64  2002 [Clinicopathological characteristics of propylthiouracil-induced antineutrophil cytoplasmic antibodies-positive vasculitis and their target antigens: a report of 4 cases and literature review]. ANCA, AZU, BPI, CG, LF, MPO, PR3, PTU
65  2001 1,2,5-Thiadiazolidin-3-one 1,1 dioxide: a powerful scaffold for probing the S' subsites of (chymo)trypsin-like serine proteases. CatG, PR3
66  2001 6-Acylamino-2-1[(ethylsulfonyl)oxy]-1H-isoindole-1,3-diones mechanism-based inhibitors of human leukocyte elastase and cathepsin G: effect of chirality in the 6-acylamino substituent on inhibitory potency and selectivity. ---
67  2001 Analysis of anti-neutrophil cytoplasmic antibodies (ANCA): frequency and specificity in a sample of 191 homozygous (PiZZ) alpha1-antitrypsin-deficient subjects. alphaGr, ANCA, BPI, LF, MPO, PR3
68  2001 Inhibition of serine proteases by functionalized sulfonamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold. CatG, PR3
69  2001 Matrix proteinase inhibition by AE-941, a multifunctional antiangiogenic compound. MMPs, PPE
70  2001 Potential of pyrazolooxadiazinone derivatives as serine protease inhibitors. ---
71  2001 Slow human immunodeficiency virus (HIV) infectivity correlated with low HIV coreceptor levels. HIV
72  2001 Synthesis and in-vitro evaluation of novel low molecular weight thiocarbamates as inhibitors of human leukocyte elastase. ---
73  2000 1H-pyrazolo[2,3-d][1,2,4]triazine-3,7-diones as a new class of human leukocyte elastase inhibitors. ---
74  2000 2-(diethylamino)thieno1,3oxazin-4-ones as stable inhibitors of human leukocyte elastase. ---
75  2000 Cleavage of CD14 on human gingival fibroblasts cocultured with activated neutrophils is mediated by human leukocyte elastase resulting in down-regulation of lipopolysaccharide-induced IL-8 production. HGF, PMNs
76  2000 Cleavage of the fifth component of complement and generation of a functionally active C5b6-like complex by human leukocyte elastase. ---
77  2000 DNA from bronchial secretions modulates elastase inhibition by alpha(1)-proteinase inhibitor and oxidized secretory leukoprotease inhibitor. SLPI
78  2000 Evaluation of analgesic and anti-inflammatory activity of novel beta-lactam monocyclic compounds. ---
79  2000 Potent inhibition of serine proteases by heterocyclic sulfide derivatives of 1,2,5-thiadiazolidin-3-one 1,1 dioxide. CatG, PR3
80  2000 Structure of porcine pancreatic elastase complexed with FR901277, a novel macrocyclic inhibitor of elastases, at 1.6 A resolution. PPE
81  2000 Synthesis, inhibitory activity towards human leukocyte elastase and molecular modelling studies of 1-carbamoyl-4-methyleneaminoxyazetidinones. LG
82  2000 Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates. CatG, PR3
83  1999 Alpha1-antitrypsin phenotypes and anti-neutrophil cytoplasmic auto-antibodies in inflammatory bowel disease. alpha1-AT, ANCA, BPI, CD, IIF, LF, MPO, PI, PR3, UC
84  1999 Interaction between leukocyte elastase and elastin: quantitative and catalytic analyses. ---
85  1999 Proteolysis of monocyte CD14 by human leukocyte elastase inhibits lipopolysaccharide-mediated cell activation. LPS, PMA, PMN, TNF-alpha
86  1999 Separation of the four stereoisomers of a potent inhibitor (L-694,458) of human leukocyte elastase and its determination in human plasma using achiral/chiral chromatography with column switching. DEA, HPLC, IPA, MTBE
87  1999 Simultaneous determination of Pseudomonas aeruginosa elastase, human leukocyte elastase and cathepsin G activities by micellar electrokinetic chromatography. CatG, MEKC, PsE
88  1999 Succinimide and saccharin-based enzyme-activated inhibitors of serine proteases. ---
89  1999 Use of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds in the design of potent inhibitors of serine proteinases. ---
90  1998 Design and synthesis of hydrazinopeptides and their evaluation as human leukocyte elastase inhibitors. ---
91  1998 Disulphide bonds assignment in the inter-alpha-inhibitor heavy chains--structural and functional implications. CD, IalphaI, ITI
92  1998 Effect of hydrophobization of basic pancreatic proteinase inhibitor on the inhibition of bovine trypsin and human leukocyte elastase. BPTI
93  1998 Interaction of human leukocyte elastase with plasma fibronectin and its inhibition by soybean Bowman-Birk protease inhibitor. BBI, FN
94  1998 Leucocyte membrane expression of proteinase 3 correlates with disease activity in patients with Wegener's granulomatosis. ANCA, BVAS, MPO, PR3, WG
95  1998 Morphometric analysis of human gingival elastic fibres degradation by human leukocyte elastase protective effect of avocado and soybean unsaponifiables (ASU). ASU
96  1998 Potent and specific inhibition of human leukocyte elastase, cathepsin G and proteinase 3 by sulfone derivatives employing the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold. CatG, PR3
97  1998 Proteolytic cleavage of ICAM-1 by human neutrophil elastase. ---
98  1997 Anionic- and lipophilic-mediated surface binding inhibitors of human leukocyte elastase. ---
99  1997 Anti-neutrophil cytoplasmic antibody (ANCA) in malaria is directed against cathepsin G. a-ANCA, ANCA, CG, IIF, LF, MPO, PR3
100  1997 Conjugation of the Bowman-Birk soybean proteinase inhibitor with hydroxyethylstarch. ---