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■ Abbreviation / Long Form : Heph / hephaestin

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Total Number of Papers: 52
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Abbreviation:   Heph  (>> Co-occurring Abbreviation)
Long Form:   hephaestin
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No. Year Title Co-occurring Abbreviation
2022 Conditional knockout of hephaestin in the neural retina disrupts retinal iron homeostasis. Cp
2022 Minimal effect of conditional ferroportin KO in the neural retina implicates ferrous iron in retinal iron overload and degeneration. Cp, FPN, KO
2022 The biology of mammalian multi-copper ferroxidases. Cp, MCFs, Zp
2022 Zinc induces hephaestin expression via a PI3K-CDX2 dependent mechanism to regulate iron transport in intestinal Caco-2 cells. CDX2
2021 Effect of atrazine on accumulation of iron via the iron transport proteins in the midbrain of SD rats. ATR, DMT1, FPN1, TfR, TH
2021 Impact of maternal iron deficiency anaemia on the expression of the newly discovered multi-copper ferroxidase, Zyklopen, in term placentas. Cp, IDA, MCF
2021 Relationship between Down-Regulation of Copper-Related Genes and Decreased Ferroportin Protein Level in the Duodenum of Iron-Deficient Piglets. FPN, RBCs
2021 The Ferroxidase Hephaestin in Lung Cancer: Pathological Significance and Prognostic Value. GEPIA
2020 miR-194-5p inhibits SLC40A1 expression to induce cisplatin resistance in ovarian cancer. CCK-8
10  2019 Active compounds of herbs ameliorate impaired cognition in APP/PS1 mouse model of Alzheimer's disease. AD, Cp, FPN1, Tf, TfR1
11  2019 Biallelic HEPHL1 variants impair ferroxidase activity and cause an abnormal hair phenotype. Cp, HEPHL1
12  2019 Fluorescence resonance energy transfer links membrane ferroportin, hephaestin but not ferroportin, amyloid precursor protein complex with iron efflux. APP, CFP, Cp, FPN, YFP
13  2019 Multi-copper ferroxidase deficiency leads to iron accumulation and oxidative damage in astrocytes and oligodendrocytes. Cp, KO, WT
14  2019 Quantum Blue Reduces the Severity of Woody Breast Myopathy via Modulation of Oxygen Homeostasis-Related Genes in Broiler Chickens. DRS, Hb, HBM, NC, PHD2, QB, WB
15  2019 Upregulation of bone morphogenetic protein 2 ( Bmp2) in dorsal root ganglion in a rat model of bone cancer pain. BMP, BMP-2, IRS-1, SDPR, TTR
16  2018 Ablation of hephaestin and ceruloplasmin results in iron accumulation in adipocytes and type 2 diabetes. Cp, KO, MCFs
17  2018 Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux. Cp, MCFs
18  2018 Deletion of hephaestin and ceruloplasmin induces a serious systemic iron deficiency and disrupts iron homeostasis. Cp, FPN1, GPx, KO, MCFs, SOD, TfR1, WT
19  2018 Expression of Duodenal Iron Transporter Proteins in Diabetic Patients with and without Iron Deficiency Anemia. DMT1, IDA
20  2018 Intestinal hephaestin potentiates iron absorption in weanling, adult, and pregnant mice under physiological conditions. ---
21  2018 Organ‑specific expression of the divalent ion channel proteins NCKX3, TRPV2, CTR1, ATP7A, IREG1 and HEPH in various canine organs. CTR1, IREG1, TRPV2
22  2018 Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin. Cp, MCFs
23  2017 Hepatic iron storage is related to body adiposity and hepatic inflammation. CR
24  2016 Effects of Octylphenol and Bisphenol A on the Metal Cation Transporter Channels of Mouse Placentas. BPA, EDCs, IREG1, OP
25  2016 Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney. Cp, KO, MCFs
26  2015 Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone. Cp, FPN
27  2015 Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain. CNS, Cp, CP KO, DMT1, FPN1, Heph KO, MCFs, WT
28  2013 Silencing the Menkes copper-transporting ATPase (Atp7a) gene in rat intestinal epithelial (IEC-6) cells increases iron flux via transcriptional induction of ferroportin 1 (Fpn1). FPN1, shRNA
29  2012 Discovery of a cytosolic/soluble ferroxidase in rodent enterocytes. FOX, sla
30  2012 Ferroportin-1 is a 'nuclear'-negative acute-phase protein in rat liver: a comparison with other iron-transport proteins. APR, DMT1, FPN1, HJV, Tf, TfR1
31  2012 Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium. Cp, RPE
32  2012 Immunoreactive hephaestin and ferroxidase activity are present in the cytosolic fraction of rat enterocytes. Cp, FOX
33  2011 Ferroportin 1 and hephaestin expression in BeWo cell line with different iron treatment. FPN1
34  2011 Interactions between ferroportin and hephaestin in rat enterocytes are reduced after iron ingestion. FPN
35  2010 Identification of zyklopen, a new member of the vertebrate multicopper ferroxidase family, and characterization in rodents and human cells. Cp, MCF
36  2009 Age-dependent expression of hephaestin in the brain of ceruloplasmin-deficient mice. Cp
37  2008 Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. AMD, Cp
38  2008 Iron feeding induces ferroportin 1 and hephaestin migration and interaction in rat duodenal epithelium. BBM, BLM, FPN1
39  2008 The iron regulatory hormone hepcidin reduces ferroportin 1 content and iron release in H9C2 cardiomyocytes. Cp, FPN1
40  2007 Colocalization of ferroportin-1 with hephaestin on the basolateral membrane of human intestinal absorptive cells. FPN1, TfR
41  2007 Development and iron-dependent expression of hephaestin in different brain regions of rats. BBB, FP1
42  2007 Elevated iron absorption in the neonatal rat reflects high expression of iron transport genes in the distal alimentary tract. ---
43  2007 Expression of ferroportin1, hephaestin and ceruloplasmin in rat heart. Cp, FPN1
44  2006 Decreased hephaestin activity in the intestine of copper-deficient mice causes systemic iron deficiency. ---
45  2006 Modulation of iron transport proteins in human colorectal carcinogenesis. DCYTB, DMT1, FPN, PCR, TfR1
46  2005 CDX2-regulated expression of iron transport protein hephaestin in intestinal and colonic epithelium. CRC
47  2005 Unexpected role of ceruloplasmin in intestinal iron absorption. Cp
48  2004 Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration. Cp
49  2002 Copper repletion enhances apical iron uptake and transepithelial iron transport by Caco-2 cells. DMT1, FPN1
50  2002 Quantitative evaluation of expression of iron-metabolism genes in ceruloplasmin-deficient mice. Cp, DMT1, FPN1
51  2000 Genes that modify the hemochromatosis phenotype in mice. B2M, HH
52  2000 Large-insert clone/STS contigs in Xq11-q12, spanning deletions in patients with androgen insensitivity and mental retardation. AR, CAI, EPLG2, MSN, OPHN1