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■ Abbreviation / Long Form : I3C / indole-3-carbinol

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Total Number of Papers: 602
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Abbreviation:   I3C  (>> Co-occurring Abbreviation)
Long Form:   indole-3-carbinol
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2023 Anti-cancer potential of synergistic phytochemical combinations is influenced by the genetic profile of prostate cancer cell lines. EGCG, PCa
2023 Aryl Hydrocarbon Receptor Activation Ameliorates Acute Respiratory Distress Syndrome through Regulation of Th17 and Th22 Cells in the Lungs. AhR, ARDS
2023 Cruciferous vegetable-derived indole-3-carbinol prevents coronavirus cell egression mechanisms in tracheal and intestinal 3D in vitro models. NEDD4, WWP1
2023 Indole-3-carbinol ameliorated the thioacetamide-induced hepatic encephalopathy in rats. CYP2E1, IL, TAA
2023 Indole-3-carbinol mitigates oxidative stress and inhibits inflammation in rat cerebral ischemia/reperfusion model. CIRI
2023 Indole-3-Carbinol: Occurrence, Health-Beneficial Properties, and Cellular/Molecular Mechanisms. DIM
2023 Maximizing the value of indole-3-carbinol, from its distribution in dietary sources, health effects, metabolism, extraction, and analysis in food and biofluids. GLS
2023 Microwave bag cooking affects the quality, glucosinolates content and hydrolysate production of broccoli florets. GLSs, SFN
2023 Targeting WWP1 ameliorates cardiac ischemic injury by suppressing KLF15-ubiquitination mediated myocardial inflammation. KLF15, MI, NRCMs, rAAV9
10  2023 The Plant Derived 3-3'-Diindolylmethane (DIM) Behaves as CB2 Receptor Agonist in Prostate Cancer Cellular Models. DIM
11  2022 Analysis of anticancer compound, indole-3-carbinol, in broccoli using a new ultrasound-assisted dispersive-filter extraction method based on poly(deep eutectic solvent)-graphene oxide nanocomposite. d-SPE, F-SPE, HPLC, PDES-GO, UADFE
12  2022 Carbon-nitrogen bond formation to construct novel polyketide-indole hybrids from the indole-3-carbinol exposed culture of Daldinia eschscholzii. C-N, ECD, PDB
13  2022 Characterization of LTr1 derived from cruciferous vegetables as a novel anti-glioma agent via inhibiting TrkA/PI3K/AKT pathway. ROS
14  2022 Diindolylmethane ameliorates platelet aggregation and thrombosis: In silico, in vitro, and in vivo studies. ADP, cAMP, COX-1, DIM, GPVI, P2Y12, PGE2, ROS, TTO, TXB2
15  2022 Diindolylmethane Derivatives: New Selective Blockers for T-Type Calcium Channels. DIM, DIM-one
16  2022 Encapsulation of indole-3-carbinol in Pickering emulsions stabilized by OSA-modified high amylose corn starch: Preparation, characterization and storage stability properties. DS, EE, EI, OSA
17  2022 Indole-3-carbinol (I3C) as Leukemia Therapeutic Agents: Review. WBC
18  2022 Indole-3-Carbinol (I3C) Protects the Heart From Ischemia/Reperfusion Injury by Inhibiting Oxidative Stress, Inflammation, and Cellular Apoptosis in Mice. CK, DHE, IL-1beta, IL-6, LDH, MDA, MIRI, NO, ROS, T-AOC, TNF-alpha
19  2022 Indole-3-carbinol ameliorated the neurodevelopmental deficits in neonatal anoxic injury in rats. ETC, HIF-1alpha, MMP, mPTP, PND
20  2022 Indole-3-carbinol in vitro antiviral activity against SARS-Cov-2 virus and in vivo toxicity. hLORGs, i.g, i.p
21  2022 Indole-3-Carbinol Inhibits the Growth of Endometriotic Lesions by Suppression of Microvascular Network Formation. p-ERK, PI3K, VEGFR2
22  2022 Indole-3-Carbinol Selectively Prevents Chronic Stress-Induced Depression-but not Anxiety-Like Behaviors via Suppressing Pro-Inflammatory Cytokine Production and Oxido-Nitrosative Stress in the Brain. BDNF, CSDS, IL-1beta, MDA, TNF-alpha
23  2022 Indole-3-Carbinol Stabilizes p53 to Induce miR-34a, Which Targets LDHA to Block Aerobic Glycolysis in Liver Cancer Cells. LDHA
24  2022 Indole-3-Carbinol, a Phytochemical Aryl Hydrocarbon Receptor-Ligand, Induces the mRNA Overexpression of UBE2L3 and Cell Proliferation Arrest. AhR, CC, HPV, XREs
25  2022 Layered Double Hydroxide@Metal-Organic Framework Hybrids for Extraction of Indole-3-Carbinol From Cruciferous Vegetables. MOF
26  2022 Minor bioactive indoles from kimchi mirror the regioselectivity in indole-3-carbinol oligomerization. ---
27  2022 Nanoencapsulation of Bimi extracts increases its bioaccessibility after in vitro digestion and evaluation of its activity in hepatocyte metabolism. DIM, ITCs, SFN, TEM
28  2022 Neuroprotective effects of indole-3-carbinol on the rotenone rat model of Parkinson's disease: Impact of the SIRT1-AMPK signaling pathway. alpha-Syn, DA, PD, ROT, TH
29  2022 Pharmacokinetic and Pharmacodynamic Properties of Indole-3-carbinol in Experimental Focal Ischemic Injury. CSF, DIM, MCAO
30  2022 Post-ingestion conversion of dietary indoles into anticancer agents. DIM, RFD
31  2022 Prostate histological investigation in rats exposed to bisphenol a and phytochemicals during the perinatal period and subjected to hormonal stimulus in adulthood. BPA, GEN
32  2022 Salicylic Acid Regulates Indole-3-Carbinol Biosynthesis Under Blue Light in Broccoli Sprouts (Brassica oleracea L.). DEGs, KEGG, SA
33  2022 Spodoptera frugiperda Sf9 cells as a model system to investigate the role of detoxification gene expression in response to xenobiotics. CncC, IC50, Maf, P450s
34  2022 Studies on the mode of action of synthetic diindolylmethane derivatives against triple negative breast cancer cells. DIM
35  2022 The synthesis of indole-3-carbinols (I3C) and their application to access unsymmetrical bis(3-indolyl)methanes (BIMs) bearing a quaternary sp3-carbon. BIMs
36  2021 3,3'-Diindolylmethane Suppresses the Growth of Hepatocellular Carcinoma by Regulating Its Invasion, Migration, and ER Stress-Mediated Mitochondrial Apoptosis. DHE, DIM, EMT, HCC, ROS, UPR
37  2021 Activating AhR alleviates cognitive deficits of Alzheimer's disease model mice by upregulating endogenous Abeta catabolic enzyme Neprilysin. AhR, ChIP, CNS, L-KN, NEP
38  2021 An HECT domain ubiquitin ligase CgWWP1 regulates granulocytes proliferation in oyster Crassostrea gigas. SW, Ub
39  2021 Anticancer Effects of Combination of Indole-3-Carbinol and Hydroxychloroquine on Ehrlich Ascites Carcinoma via Targeting Autophagy and Apoptosis. EAC, HCQ
40  2021 Cardioprotective potential of indol-3-carbinol against high salt induced myocardial stress and hypertrophy in Sprague dawley rats besides molecular docking on muscarinic receptor-2. ---
41  2021 Chitosan and chitosan/PEG nanoparticles loaded with indole-3-carbinol: Characterization, computational study and potential effect on human bladder cancer cells. DFT, DLS, DSC, FEG-SEM, FTIR, MTT, TGA, XRD, ZP
42  2021 Combinations of Phytochemicals More Efficiently than Single Components Activate Nrf2 and Induce the Expression of Antioxidant Enzymes in Pancreatic Cancer Cells. PEITC, RES, XAN
43  2021 Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-kappaB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo. PEITC, RES
44  2021 Dietary Indole-3-Carbinol Activates AhR in the Gut, Alters Th17-Microbe Interactions, and Exacerbates Insulitis in NOD Mice. AhR, NOD, T1D
45  2021 Indol-3-Carbinol and Quercetin Ameliorate Chronic DSS-Induced Colitis in C57BL/6 Mice by AhR-Mediated Anti-Inflammatory Mechanisms. 6-TG, AhR, DSS, IBD
46  2021 Indole glucosinolates exhibit anti-inflammatory effects on Ehrlich ascites carcinoma cells through modulation of inflammatory markers and miRNAs. 5-FU, DIM, EAC, NF-kappaB
47  2021 Indole-3-carbinol ameliorates necroptosis and inflammation of intestinal epithelial cells in mice with ulcerative colitis by activating aryl hydrocarbon receptor. AhR, DAI, HI, IAPs, RIPK1, UC
48  2021 Indole-3-carbinol induces apoptosis-like death in Escherichia coli on different contribution of respective reactive oxygen species. ROS
49  2021 Indole-3-carbinol inhibits the proliferation of colorectal carcinoma LoVo cells through activation of the apoptotic signaling pathway. ---
50  2021 Indoles Derived From Glucobrassicin: Cancer Chemoprevention by Indole-3-Carbinol and 3,3'-Diindolylmethane. AhR, DIM
51  2021 Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis. AhR, NEC, TLR4
52  2021 Metabolites in the association between early-life famine exposure and type 2 diabetes in adulthood over a 5-year follow-up period. PC
53  2021 Pharmacophore-inspired discovery of FLT3 inhibitor from kimchi. AML, DIM, FLT3, IG
54  2021 Sclerotinia sclerotiorum Response to Long Exposure to Glucosinolate Hydrolysis Products by Transcriptomic Approach. AITC
55  2021 Synbiotic supplementation attenuates the promoting effect of indole-3-carbinol on colon tumorigenesis. DMH, SYN
56  2021 The Differential Selectivity of Aryl Hydrocarbon Receptor (AHR) Agonists towards AHR-Dependent Suppression of Mammosphere Formation and Gene Transcription in Human Breast Cancer Cells. 3-MC, AhR, BaP, beta-NF, DMBA, FICZ, IAA, KYN, XRE
57  2021 The E3 Ubiquitin Ligase NEDD4-1 Mediates Temozolomide-Resistant Glioblastoma through PTEN Attenuation and Redox Imbalance in Nrf2-HO-1 Axis. GBM, NEDD4-1, PTEN, ROS, TMZ
58  2021 The Influence of Red Cabbage Extract Nanoencapsulated with Brassica Plasma Membrane Vesicles on the Gut Microbiome of Obese Volunteers. GSLs, MeJA, SFN
59  2021 Tryptophan metabolites modulate inflammatory bowel disease and colorectal cancer by affecting immune system. AhR, IDO1, KMO
60  2020 Combination of xanthohumol and phenethyl isothiocyanate inhibits NF-kappaB and activates Nrf2 in pancreatic cancer cells. PC, PEITC, RES, XAN
61  2020 Dietary AhR Ligands Regulate AhRR Expression in Intestinal Immune Cells and Intestinal Microbiota Composition. AhR, AhRR, DSS, WT
62  2020 Dietary Indole-3-Carbinol Alleviated Spleen Enlargement, Enhanced IgG Response in C3H/HeN Mice Infected with Citrobacter rodentium. CR
63  2020 Effect of indole-3-carbinol on transcriptional profiling of wound-healing genes in macrophages of systemic lupus erythematosus patients: an RNA sequencing assay. MDMs, SLE
64  2020 Gellan gum-based hydrogel containing nanocapsules for vaginal indole-3-carbinol delivery in trichomoniasis treatment. NC-I3C
65  2020 Immune and microRNA responses to Helicobacter muridarum infection and indole-3-carbinol during colitis. DSS, EHH, H. muridarum, miRNAs
66  2020 Indole-3-Carbinol Inhibits Citrobacter rodentium Infection through Multiple Pathways Including Reduction of Bacterial Adhesion and Enhancement of Cytotoxic T Cell Activity. CR
67  2020 Indole-3-carbinol prevents colitis and associated microbial dysbiosis in an IL-22-dependent manner. ---
68  2020 Indole-3-carbinol regulates microglia homeostasis and protects the retina from degeneration. AhR, LPS, NO, qRT-PCR, SD-OCT
69  2020 Induction of apoptosis in indole-3-carbinol-treated lung cancer H1299 cells via ROS level elevation. FACS, NAC, ROS, TdT
70  2020 Modulation of Estrogen alpha and Progesterone Receptors in Triple Negative Breast Cancer Cell Lines: The Effects of Vorinostat and Indole-3-Carbinol In Vitro. ER, HER2, PR
71  2020 Modulatory Effect of Indoles on the Expression of miRNAs Regulating G1/S Cell Cycle Phase in Breast Cancer Cells. CDKs, DIM
72  2020 Overexpression of the ribosomal S30 subunit leads to indole-3-carbinol tolerance in Arabidopsis thaliana. FOX
73  2020 Prenatal indole-3-carbinol administration activates aryl hydrocarbon receptor-responsive genes and attenuates lung injury in a bronchopulmonary dysplasia model. AhR, RACs, RT-qPCR
74  2020 Protective effect of Indole-3-carbinol, an NF-kappaB inhibitor in experimental paradigm of Parkinson's disease: In silico and in vivo studies. LD, LPS, NF-kappaB, PD
75  2020 Quercetin and indole-3-carbinol inhibit extracellular matrix expression in human primary uterine leiomyoma cells. ---
76  2020 Rapid measurement of indole levels in Brassica vegetables using one millilitre binary organic extraction solvent and capillary electrophoresis-UV analysis. CE, DIM, DMF, I3A, IAA, LOD, UV
77  2020 Supplementation of endogenous Ahr ligands reverses insulin resistance and associated inflammation in an insulin-dependent diabetic mouse model. AhR, ICAM, IL-1beta, iNOS, MYD88, Reg3beta, TNF-alpha, Trp
78  2020 [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol, an indole-3-carbinol derivative, inhibits glutamate release in rat cerebrocortical nerve terminals by suppressing the P/Q-type Ca2+ channels and Ca2+/calmodulin/protein kinase A pathway. 4-AP, AC, CIM, PKA
79  2019 3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2. DIM
80  2019 Anti-Cancer Effects of 3, 3'-Diindolylmethane on Human Hepatocellular Carcinoma Cells Is Enhanced by Calcium Ionophore: The Role of Cytosolic Ca2+ and p38 MAPK. CCK-8, DIM, p-p38
81  2019 Cytotoxic and antibacterial polyketide-indole hybrids synthesized from indole-3-carbinol by Daldinia eschscholzii. AONS, CD, ECD, PIHs
82  2019 Depletion of dietary aryl hydrocarbon receptor ligands alters microbiota composition and function. AhR, Ig
83  2019 Glucosinolate-Degradation Products as Co-Adjuvant Therapy on Prostate Cancer in Vitro. 4PI, AIPC, AITC, DOCE, GS-degradation products, IB, PEITC, SFN
84  2019 Gradual hypertension induction in middle-aged Cyp1a1-Ren2 transgenic rats produces significant impairments in spatial learning. ---
85  2019 Hydroxyl Radical Scavenging of Indole-3-Carbinol: A Mechanistic and Kinetic Study. ---
86  2019 Indole Treatment Alleviates Intestinal Tissue Damage Induced by Chicken Coccidiosis Through Activation of the Aryl Hydrocarbon Receptor. AhR, DIM, Th17
87  2019 Indole-3-Carbinol Induces Apoptosis in Human Osteosarcoma MG-63 and U2OS Cells. FACS
88  2019 Indole-3-carbinol inhibits lipid deposition and promotes autophagy in hyperlipidemia zebrafish larvae. HCD
89  2019 Inhibition of Tumor Growth by Dietary Indole-3-Carbinol in a Prostate Cancer Xenograft Model May Be Associated with Disrupted Gut Microbial Interactions. ---
90  2019 Role of NF-kB RelB in Aryl Hydrocarbon Receptor-Mediated Ligand Specific Effects. AhR, AhRR, BMM, FICZ, IDO1, IL, LPS, TCDD, wt
91  2019 Strain-specific altered nicotine metabolism in 3,3'-diindolylmethane (DIM) exposed mice. DIM, FMO, ppm
92  2019 The absence of sympathoexcitation during the development of hypertension in Cyp1a1 Ren-2 transgenic rats. Ang II, BP, iTGR, RAS, SNS
93  2019 [Prostate cancer prevention. the current trends]. EGCG, PIN
94  2018 20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats. 20-HETE, Ang II, CYP450, SBP
95  2018 3,3'-Diindolylmethane Enhances Glucose Uptake Through Activation of Insulin Signaling in 3T3-L1 Adipocytes. DIM
96  2018 3,3'-Diindolylmethane Suppressed Cyprodinil-Induced Epithelial-Mesenchymal Transition and Metastatic-Related Behaviors of Human Endometrial Ishikawa Cells via an Estrogen Receptor-Dependent Pathway. CYP, DIM, EMT, ER
97  2018 A new promising way of maintenance therapy in advanced ovarian cancer: a comparative clinical study. EGCG, OS, PFS
98  2018 Adiponectin attenuates kidney injury and fibrosis in deoxycorticosterone acetate-salt and angiotensin II-induced CKD mice. Ang II, ApN, CKD, CYP1A1, DOCA, WT
99  2018 Anticarcinogenic effect of indole-3-carbinol (I3C) on human hepatocellular carcinoma SNU449 cells. HCC
100  2018 Aryl Hydrocarbon Receptor Ligands Indoxyl 3-sulfate and Indole-3-carbinol Inhibit FMS-like Tyrosine Kinase 3 Ligand-induced Bone Marrow-derived plasmacytoid Dendritic Cell Differentiation. AhR, BM, DCs, Flt3L, I3S, pDCs, STAT3