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■ Abbreviation / Long Form : IRAK / IL-1 receptor-associated kinase

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Total Number of Papers: 73
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Abbreviation:   IRAK  (>> Co-occurring Abbreviation)
Long Form:   IL-1 receptor-associated kinase
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No. Year Title Co-occurring Abbreviation
2021 IRAK-M knockout promotes allergic airway inflammation, but not airway hyperresponsiveness, in house dust mite-induced experimental asthma model. AHR, BAL, HDM, KO, WT
2020 The Leucine-Rich Repeat Region of CARMIL1 Regulates IL-1-Mediated ERK Activation, MMP Expression, and Collagen Degradation. IL, IL-1R1, LRR, WT
2020 Toll-Like Receptor 7 Stimulation Promotes the Development of Atherosclerosis in Apolipoprotein E-Deficient Mice. EMPs, ROS, TLRs
2019 Monophosphoryl lipid A induces protection against LPS in medullary thick ascending limb through induction of Tollip and negative regulation of IRAK-1. MPLA, MTAL, PI3K, TLR4, TRIF
2018 IRAK4 activity controls immune responses to intracellular bacteria Listeria monocytogenes and Mycobacterium smegmatis. IRAK4KI, WT
2018 Regulation of IL-1 signaling through control of focal adhesion assembly. ACP, KD, MMP-3, MyD88
2018 Understanding early TLR signaling through the Myddosome. ---
2017 Expression of X-linked Toll-like receptor 4 signaling genes in female vs. male neonates. BTK, IKKgamma, TLR, UCB
2017 Glutamate alleviates muscle protein loss by modulating TLR4, NODs, Akt/FOXO and mTOR signaling pathways in LPS-challenged piglets. BW, Glu, LD, mTOR, NF-kappaB, NODs, RIPK, TLR4
10  2017 Immunomodulatory Molecule IRAK-M Balances Macrophage Polarization and Determines Macrophage Responses during Renal Fibrosis. CKD, UUO
11  2017 Lactobacillus paracasei modulates LPS-induced inflammatory cytokine release by monocyte-macrophages via the up-regulation of negative regulators of NF-kappaB signaling in a TLR2-dependent manner. L. paracasei, SOCS, TLR
12  2017 Toll-like receptor 2 dominance over Toll-like receptor 4 in stressful conditions for its detrimental role in the heart. I/R, MyD, TLR, TRAIP
13  2015 Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance. NF-kappaB, TAK, TBK, TLR, TRIF
14  2015 Profiling of microRNAs involved in retinal degeneration caused by selective Muller cell ablation. CALM, JAK2, miRNAs
15  2014 Curcumin blocks interleukin-1 signaling in chondrosarcoma cells. IL, NF
16  2014 IL-1 Receptor-Associated Kinase Signaling and Its Role in Inflammation, Cancer Progression, and Therapy Resistance. ---
17  2014 Protective effects of lupeol against D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure in mice. GalN, IL, LPS, TLR, TNF, TRIF
18  2013 A secreted Plasmodium falciparum kinase reveals a signature motif for classification of tyrosine kinase-like kinases. RLK, TKL
19  2013 Effects of Enterococcus faecalis lipoteichoic acid on receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in periodontal ligament fibroblasts. ELISA, LTA, MAPK, MTT, OPG, RANKL
20  2011 Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression. IKK, TAK, TRAF
21  2011 Ginsenoside Rg5 ameliorates lung inflammation in mice by inhibiting the binding of LPS to toll-like receptor-4 on macrophages. LPS, TLR
22  2011 Identification of interleukin-1 receptor-associated kinase 1 as a critical component that induces post-transcriptional activation of IkappaB-zeta. IL, TRAF
23  2011 Kalopanaxsaponin A ameliorates experimental colitis in mice by inhibiting IRAK-1 activation in the NF-kappaB and MAPK pathways. IL, LPS, NF-kappaB, TNBS, TNF
24  2011 Morphine inhibits murine dendritic cell IL-23 production by modulating Toll-like receptor 2 and Nod2 signaling. BMDCs, DCs, IRF3, LTA, MDP, PLY, TLR
25  2011 PTEN limits alveolar macrophage function against Pseudomonas aeruginosa after bone marrow transplantation. AM, BMT, PTEN CKO
26  2011 TGF-beta1 re-programs TLR4 signaling in L. donovani infection: enhancement of SHP-1 and ubiquitin-editing enzyme A20. IL, LPS, rh, TGF, TLR, TNF, VL
27  2010 Interleukin-32alpha production is regulated by MyD88-dependent and independent pathways in IL-1beta-stimulated human alveolar epithelial cells. COPD, IL, MAP, PI3K, PK, SFK, siRNA
28  2009 Induction of IL-10+ CD4+ CD25+ regulatory T cells with decreased NF-kappaB expression during immunotherapy. Der p, IRF3, TLR
29  2008 Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation. IL-1
30  2008 TNF/IL-1/NIK/NF-kappa B transduction pathway: a comparative study in normal and pathological human prostate (benign hyperplasia and carcinoma). BPH, IL, NF, NIK, NP, PC, PIN, TNF, TRAF
31  2008 TRAF6 is a critical signal transducer in IL-33 signaling pathway. MCP, NF-kappaB, TRAF6
32  2007 Bcl10 mediates LPS-induced activation of NF-kappaB and IL-8 in human intestinal epithelial cells. IEC, LPS, MALT, siRNA, TLR
33  2007 Effects of PM2.5 collected from Cache Valley Utah on genes associated with the inflammatory response in human lung cells. MICA, RT-PCR
34  2007 Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells. DC, IRF, MyD88, TLR
35  2006 GM-CSF regulates a PU.1-dependent transcriptional program determining the pulmonary response to LPS. AMs, GM-CSF, LPS, TLR
36  2006 Neutrophil-derived elastase induces TGF-beta1 secretion in human airway smooth muscle via NF-kappaB pathway. ASM, NE, TLR4
37  2005 Differential gene expression in coronary arteries from patients presenting with ischemic heart disease: further evidence for the inflammatory basis of atherosclerosis. CAD, cDNA, DCM, IHD, IL-1beta, STAT6
38  2005 Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction. IFN, IRF, pDCs, TLR, TLRs, TNF
39  2005 Mycobacterium tuberculosis lipoarabinomannan-mediated IRAK-M induction negatively regulates Toll-like receptor-dependent interleukin-12 p40 production in macrophages. IL-12, LPS, Man-LAMs
40  2005 Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance. PH, TNF
41  2004 Epigallocatechin-3-gallate, a green tea-derived polyphenol, inhibits IL-1 beta-dependent proinflammatory signal transduction in cultured respiratory epithelial cells. EGCG, IKK, IL-1beta, IL-8, NF-kappaB, TNF-alpha
42  2004 Expression of neutral sphingomyelinase-2 (NSMase-2) in primary rat hepatocytes modulates IL-beta-induced JNK activation. IL, JNK, nSMase, nSMase2
43  2004 Interleukin-1beta maintains an apoptosis-resistant phenotype in the blast cells of acute myeloid leukaemia via multiple pathways. AML
44  2004 Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection. EMSA, GP, I/R, IKKbeta, PI3K, TLR, TTC
45  2004 The IL-1 receptor accessory protein is essential for PI 3-kinase recruitment and activation. IL-1, IL-1RAcP, JNK, PI 3-kinase
46  2003 Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6. KO, LMP1, MEFs, TRAF
47  2003 Inhibition of interleukin-12 p40 transcription and NF-kappaB activation by nitric oxide in murine macrophages and dendritic cells. IL-12, LPS, NO, SNAP
48  2003 IRAK-dependent phosphorylation of Stat1 on serine 727 in response to interleukin-1 and effects on gene expression. IFN-gamma, IL-1, MAP, PI3K, TNF
49  2003 Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR . dsRNA, IL-1, MAP, PKR, TAK1, TLR3
50  2003 Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies. aPLs, APS, EC, IL-1beta, LPS, NF-kappaB, TLR, TNF-alpha
51  2003 [Interleukin 1 signal transduction]. IL-1, MyD88, TRAF6
52  2002 A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways. LPS, TLR
53  2002 In vivo response of neutrophils and epithelial cells to lipopolysaccharide injected into the monkey ileum. LPS, TLR
54  2002 IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. MAP
55  2002 Porphyromonas gingivalis lipopolysaccharide signaling in gingival fibroblasts-CD14 and Toll-like receptors. AP-1, ERK1, IL, LPS, MCP-1, MyD88, NF-kappaB, P. gingivalis, TLR4, TLRs, TNF-alpha
56  2002 Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression. AP-1, AS, IL, NF-kappaB, ODN, PI 3-kinase, RA, VCAM
57  2001 Distinct mechanism of Helicobacter pylori-mediated NF-kappa B activation between gastric cancer cells and monocytic cells. IL, PAI, TLR4, TNF-alpha
58  2001 IL-1 receptor-associated kinase modulates host responsiveness to endotoxin. ---
59  2001 IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK). JNK
60  2001 Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway. IL-1
61  2001 IRAK and TAK1 are required for IL-18-mediated signaling. IL-18, TAK1
62  2001 Micrococci and peptidoglycan activate TLR2-->MyD88-->IRAK-->TRAF-->NIK-->IKK-->NF-kappaB signal transduction pathway that induces transcription of interleukin-8. IKK, IL-8, NIK, PGN, TLR2, TRAF6
63  2001 Negative regulation of toll-like receptor-mediated signaling by Tollip. IL, TLR
64  2000 T6BP, a TRAF6-interacting protein involved in IL-1 signaling. ---
65  2000 Toll-like receptor 4-mediated signal pathway induced by Porphyromonas gingivalis lipopolysaccharide in human gingival fibroblasts. AP-1, HGFs, IL, LPS, MyD88, NF-kappaB, TLR4
66  1999 Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice. IFN, IL, JNK, NF, NK
67  1999 Effects of IL-1 receptor-associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity. IL-1
68  1999 Murine microglial cells produce and respond to interleukin-18. IL, LPS, TNF
69  1999 Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase. IL-1
70  1999 The interleukin 1 receptor: ligand interactions and signal transduction. IL-1, PI3K
71  1998 Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells. IL-18, IL-18R, NF-kappaB, TRAF6
72  1998 Overview of interleukin-18: more than an interferon-gamma inducing factor. IFN-gamma, IGIF, IL-18, NF-kappaB
73  1998 Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. IL-1, JNK