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■ Abbreviation / Long Form : IRAK / IL-1R-associated kinase

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Total Number of Papers: 52
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Abbreviation:   IRAK  (>> Co-occurring Abbreviation)
Long Form:   IL-1R-associated kinase
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No. Year Title Co-occurring Abbreviation
2021 Bone marrow mesenchymal stem cell-derived exosomes induce the Th17/Treg imbalance in immune thrombocytopenia through miR-146a-5p/IRAK1 axis. BMSCs, ITP
2020 Functional Variation of IL-1R-Associated Kinases in the Conserved MyD88-TRAF6 Pathway during Evolution. ---
2019 IRAK-M Associates with Susceptibility to Adult-Onset Asthma and Promotes Chronic Airway Inflammation. DC, KO
2018 Leishmania donovani Exploits Tollip, a Multitasking Protein, To Impair TLR/IL-1R Signaling for Its Survival in the Host. ---
2016 Epigenetic and Transcriptional Regulation of IRAK-M Expression in Macrophages. C/EBP
2016 Lack of IL-1 Receptor-Associated Kinase-4 Leads to Defective Th1 Cell Responses and Renders Mice Susceptible to Mycobacterial Infection. ---
2016 Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity. ---
2016 Transduction of Functionally Contrasting Signals by Two Mycobacterial PPE Proteins Downstream of TLR2 Receptors. MKP-1, PKC, PPE
2015 Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways. CoPP, HO, I/R, MyD88, TLR, TRIF, ZnPP
10  2015 In Vitro Reconstitution of the Toll/Interleukin-1 Receptor (TIR) Domain Complex Between TLR5/6 and Myd88. AP-1, MyD88, NF-kB, TIR, TLRs
11  2015 IRAK1 Drives Intestinal Inflammation by Promoting the Generation of Effector Th Cells with Optimal Gut-Homing Capacity. ---
12  2015 MyD88: a central player in innate immune signaling. IL-1, IL-1R, NF-kappaB, TLR
13  2015 Regulation of inflammasome activation. AIM2, ASC, NLR, pro-IL-1beta, RIP
14  2013 Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome. ---
15  2013 Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice. BMDMs, pDCs, TRAF6, TRIF
16  2011 IL-1R-associated kinase-1 mediates protein kinase Cdelta-induced IL-1beta production in monocytes. PKC
17  2011 The dual functions of IL-1 receptor-associated kinase 2 in TLR9-mediated IFN and proinflammatory cytokine production. pDCs
18  2010 A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantation. AM, BMT
19  2010 IL-1alpha modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil. ---
20  2010 SMAD4 is required for development of maximal endotoxin tolerance. sh
21  2009 Adiponectin promotes endotoxin tolerance in macrophages by inducing IRAK-M expression. gAd
22  2009 Impaired priming and activation of the neutrophil NADPH oxidase in patients with IRAK4 or NEMO deficiency. NOX, PMN
23  2007 6-Methylprednisolone down-regulates IRAK-M in human and murine osteoclasts and boosts bone-resorbing activity: a putative mechanism for corticoid-induced osteoporosis. 6-MP
24  2007 Cutting Edge: IL-1 receptor-associated kinase 4 structures reveal novel features and multiple conformations. ---
25  2007 Early and preferential induction of IL-1 receptor-associated kinase-M in THP-1 cells by LPS derived from Porphyromonas gingivalis. E. coli, P. gingivalis, si
26  2007 Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model. ---
27  2007 TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathway. PMN
28  2007 Variant IL-1 receptor-associated kinase-1 mediates increased NF-kappa B activity. ---
29  2006 IRAK-4 mutation (Q293X): rapid detection and characterization of defective post-transcriptional TLR/IL-1R responses in human myeloid and non-myeloid cells. ---
30  2006 TLR2- and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes. ---
31  2005 Cutting edge: molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling. ---
32  2005 Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4. ---
33  2004 Functions of toll-like receptors: lessons from KO mice. LRR, PAMPs, TLRs
34  2004 The heat-shock-induced suppression of the IkappaB/NF-kappaB cascade is due to inactivation of upstream regulators of IkappaBalpha through insolubilization. HS, IKK, NIK
35  2003 Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections. ---
36  2003 IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Th1 cell responses. TLRs
37  2003 Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. DD, IL-1R, MyD88s, NF, TIR, TLRs
38  2003 MyD88S, a splice variant of MyD88, differentially modulates NF-kappaB- and AP-1-dependent gene expression. AP, IL-1R, JNK, NF-kappaB, TLR
39  2003 Role of adapters in Toll-like receptor signalling. IL-1R, TLRs
40  2003 Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways. LPS, MALP-2, Pyk2, TLR
41  2002 Divergence of apoptosis-inducing and preventing signals in bacteria-faced macrophages through myeloid differentiation factor 88 and IL-1 receptor-associated kinase members. FADD, MyD88, TRAF6, YopP
42  2002 Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo. GM-CSF, LPS, MAP, TNF-alpha
43  2002 IRAK-4 as the central TIR signaling mediator in innate immunity. IL-1R, TLRs, TNF
44  2002 Lipopolysaccharide- and lipoteichoic acid-induced tolerance and cross-tolerance: distinct alterations in IL-1 receptor-associated kinase. LTA, TLR
45  2002 Listeriolysin O secreted by Listeria monocytogenes induces NF-kappaB signalling by activating the IkappaB kinase complex. IKKbeta, LLO
46  2002 Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex. IL-1, IL-1R, IRAK4, TLR, TRAF6, TRAF6
47  2002 Regulation of IL-1 receptor-associated kinases by lipopolysaccharide. TLR
48  2002 Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88. DD, ID, IL-1R, TIR, TLR
49  1999 Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. ---
50  1999 Signaling events induced by lipopolysaccharide-activated toll-like receptor 2. DN, TLR2
51  1999 Tyrosine kinase is essential for the constitutive expression of type I interleukin-1 receptor in human fibroblast cells. IL-1RI
52  1997 IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. IL-1R, NF-kappaB