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â–  Abbreviation / Long Form : M6G / morphine-6-glucuronide

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Abbreviation:   M6G  (>> Co-occurring Abbreviation)
Long Form:   morphine-6-glucuronide
 Abbreviation Variation
 Long Form Variation
 Pair(Abbreviation/Long Form) Variation
No. Year Title Co-occurring Abbreviation
2021 Bridging the gap between in silico and in vivo by modeling opioid disposition in a kidney proximal tubule microphysiological system. CKD, CLR, HUVEC, PBPK, PTEC, VPT-MPS
2021 No significant influence of OCT1 genotypes on the pharmacokinetics of morphine in adult surgical patients. M3G
2021 Pharmacokinetic modeling of morphine and its glucuronides: Comparison of nebulization versus intravenous route in healthy volunteers. i.v, M3G, NEB, PK
2021 Pharmacokinetics of Morphine and Morphine-6-Glucuronide During Postoperative Pain Therapy in Cardiac Surgery Patients. CL
2021 Physiologically based pharmacokinetic/pharmacodynamic model for the prediction of morphine brain disposition and analgesia in adults and children. BBB, CSF, ECF, P-gp
2020 CaMKII is activated in opioid induced conditioned place preference, but alphaCaMKII Thr286 autophosphorylation is not necessary for its establishment. CaMKII, CPP
2020 Determination of Morphine, Fentanyl and Their Metabolites in Small Sample Volumes Using Liquid Chromatography Tandem Mass Spectrometry. LC-MS-MS, M3G
2020 Metabolism, pharmacokinetics and selected pharmacodynamic effects of codeine following a single oral administration to horses. C6G, M3G
2020 Use of a Noninvasive Brain-Penetrating Peptide-Drug Conjugate Strategy to Improve the Delivery of Opioid Pain Relief Medications to the Brain. An2, BBB
10  2019 A Randomized, Crossover Study on the Effect of Food on the Pharmacokinetic Characteristics of Morphine ARER (MorphaBond™ ER), an Abuse-Deterrent Formulation of Extended-Release Morphine. AUC, tmax
11  2019 Advances in the Physicochemical Profiling of Opioid Compounds of Therapeutic Interest. M6S, QSAR
12  2019 Comparison of the Detection Windows of Heroin Metabolites in Human Urine Using Online SPE and LC-MS/MS: Importance of Morphine-3-Glucuronide. 6-MAM, LODs, M3G, MOR, SPE
13  2019 Effects of Obstructive Sleep Apnea and Obesity on Morphine Pharmacokinetics in Children. CRP, IL, M3G, OSAS, Vd
14  2019 Morphine Use in Renal Failure: A Case Report of Single-Dose Morphine Toxicity in a Patient Requiring Peritoneal Dialysis. ---
15  2019 Pharmacokinetics and selected pharmacodynamics of morphine and its active metabolites in horses after intravenous administration of four doses. M3G, NCA
16  2018 Can measurements of heroin metabolites in post-mortem matrices other than peripheral blood indicate if death was rapid or delayed? 6-AM, M3G
17  2018 Postmortem tissue distribution of morphine and its metabolites in a series of heroin-related deaths. 6-MAM, M3G
18  2018 Prolonged central apnoea after intravenous morphine administration in a 12-year-old male with a UGT1A1 loss-of-function polymorphism. M3G, UGT
19  2018 Relative Oral Bioavailability of an Abuse-deterrent, Extended-release Formulation of Morphine Versus Extended-release Morphine: A 2-period, Single-dose, Randomized Crossover Study in Healthy Subjects. ER
20  2017 An observational study examining the effects of a surgically induced inflammatory response on the distribution of morphine and its metabolites into cerebrospinal fluid. AUC, BBB, CSF, IL, M3G, P-gp
21  2017 Brain-derived neurotrophic factor involved epigenetic repression of UGT2B7 in colorectal carcinoma: A mechanism to alter morphine glucuronidation in tumor. BDNF, CRC, PRC, UGT
22  2017 Influence of Morbid Obesity on the Pharmacokinetics of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide. i.v, M3G
23  2017 Sex-dependent influences of morphine and its metabolites on pain sensitivity in the rat. M3G, TLR4
24  2017 Simultaneous determination of morphine-6-d-glucuronide, morphine-3-d-glucuronide and morphine in human plasma and urine by ultra-performance liquid chromatography-tandem mass spectrometry: Application to M6G injection pharmacokinetic study. M3G, MOR
25  2017 The regioselective glucuronidation of morphine by dimerized human UGT2B7, 1A1, 1A9 and their allelic variants. M3G, UGT
26  2016 A Prospective Population Pharmacokinetic Study on Morphine Metabolism in Cancer Patients. AUC, eGFR, M3G
27  2016 Activation of mu-opioid receptor and Toll-like receptor 4 by plasma from morphine-treated mice. M3G
28  2016 Post-mortem levels and tissue distribution of codeine, codeine-6-glucuronide, norcodeine, morphine and morphine glucuronides in a series of codeine-related deaths. C6G, M3G
29  2016 Reverse of Acute and Chronic Morphine Tolerance by Lithocholic Acid via Down-Regulating UGT2B7. CaMKIIalpha, LCA, M3G, MOR, mPFCs, SPE, UGT2B7
30  2016 siRNA capsulated brain-targeted nanoparticles specifically knock down OATP2B1 in mice: a mechanism for acute morphine tolerance suppression. CaMKIIalpha, CsA, mPFC
31  2016 The effect of morbid obesity on morphine glucuronidation. M3G, PK, RYGB
32  2016 The toxicology of heroin-related death: estimating survival times. 6MAM, CI, CNS, M3G, OR
33  2015 A Compartmental Analysis for Morphine and Its Metabolites in Young Children After a Single Oral Dose. FOCE, M3G
34  2015 A validated method for simultaneous determination of codeine, codeine-6-glucuronide, norcodeine, morphine, morphine-3-glucuronide and morphine-6-glucuronide in post-mortem blood, vitreous fluid, muscle, fat and brain tissue by LC-MS. C6G, M3G
35  2015 Capillary electrophoresis-mass spectrometry determination of morphine and its isobaric glucuronide metabolites. BGE, CE-MS, ESI-QTOF, LC-MS, LOD, M3G
36  2015 Estimation of the Time Interval between the Administration of Heroin and the Sampling of Blood in Chronic Inhalers. 6-AM, M3G, MOR
37  2015 Pharmacokinetics of Morphine, Morphine-3-Glucuronide and Morphine-6-Glucuronide in Terminally Ill Adult Patients. eGFR, M3G, NONMEM
38  2015 Serum and urine concentrations of morphine and morphine metabolites in patients with advanced cancer receiving continuous intravenous morphine: an observational study. M3G
39  2014 3-Methoxynaltrexone is not a selective antagonist for the acute psychomotor stimulating effects of heroin and 6-monoacetylmorphine in mice. 3-MeONtx, 6-MAM, NTX
40  2014 Clinical pharmacokinetics of morphine and its metabolites during morphine dose titration for chronic cancer pain. M3G
41  2014 Detection of morphine-3-sulfate and morphine-6-sulfate in human urine and plasma, and formation in liver cytosol. M3G, M3S, M6S
42  2014 In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile. ---
43  2014 Mechanistic basis of altered morphine disposition in nonalcoholic steatohepatitis. M3G, NASH
44  2014 Morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7: kinetic, inhibition, and molecular modeling studies. HLM, M-3-glucoside, M3G, UDP-Glc, UDP-GlcUA
45  2014 Morphine glucuronidation increases its analgesic effect in guinea pigs. M3G
46  2014 Morphine-6-glucuronide is responsible for the analgesic effect after morphine administration: a quantitative review of morphine, morphine-6-glucuronide, and morphine-3-glucuronide. AUC, CSF
47  2014 Opioids as an alternative to amide-type local anaesthetics for intra-articular application. ---
48  2014 Pharmacokinetic interactions between ethanol and heroin: a study on post-mortem cases. 6-MAM, M3G
49  2014 Population pharmacokinetics of morphine and morphine-6-glucuronide following rectal administration--a dose escalation study. RSE
50  2014 Quantification of morphine and its major metabolites M3G and M6G in antemortem and postmortem samples. M3G
51  2013 Effect of 12-oxochenodeoxycholate on the pharmacokinetics and pharmacodynamics of morphine 6-glucuronide in Wistar rats. AUAE, AUC
52  2013 Endogenous morphine-6-glucuronide (M6G) is present in the plasma of patients: validation of a specific anti-M6G antibody for clinical and basic research. ELISA, M3G, MS
53  2013 Invitro morphine metabolism by rat microglia. M3G, PG, UGTs
54  2013 Pivaloylcodeine, a new codeine derivative, for the inhibition of morphine glucuronidation. An in vitro study in the rat. M3G
55  2013 Simultaneous analysis of codeine and its active metabolites in human plasma using liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study after oral administration of codeine. IS, LLOQ, M3G, MRM, RE, RSD, SPE
56  2013 The impact of CYP2D6 polymorphisms on the pharmacokinetics of codeine and its metabolites in Mongolian Chinese subjects. M3G
57  2012 High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS. ECMO, M3G, QC, RSD, SPE
58  2012 Inhibition of morphine glucuronidation in the liver microsomes of rats and humans by monoterpenoid alcohols. M3G, RLM, UDP
59  2012 Investigation of morphine and morphine glucuronide levels and cytochrome P450 isoenzyme 2D6 genotype in codeine-related deaths. CYP2D6, M3G
60  2012 Preclinical pharmacology and opioid combinations. ---
61  2012 Repeated exposure to codeine alters morphine glucuronidation by affecting UGT gene expression in the rat. M3G, UGTs
62  2012 Serum concentrations of opioids when comparing two switching strategies to methadone for cancer pain. 3DS, PI, SAG
63  2012 The role of mu opioid receptors in psychomotor stimulation and conditioned place preference induced by morphine-6-glucuronide. CPP
64  2012 [Prolonged disturbance of consciousness and respiratory depression induced by controlled-release morphine, requiring long-term naloxone administration in a hemodialysis patient with cancer--a case report]. ---
65  2011 A sensitive assay for the quantification of morphine and its active metabolites in human plasma and dried blood spots using high-performance liquid chromatography-tandem mass spectrometry. DBS, M3G
66  2011 Effect of bile salts on the transport of morphine-6-glucuronide in rat brain endothelial cells. BBB, DC, MKC, RBE4, TC
67  2011 Identification and characterization of seven new exon 11-associated splice variants of the rat mu opioid receptor gene, OPRM1. ---
68  2011 Induction of morphine-6-glucuronide synthesis by heroin self-administration in the rat. i.v, M3G, MOR, SA
69  2011 Morphine and its metabolites after patient-controlled analgesia: considerations for respiratory depression. M3G, PCA
70  2011 Morphine metabolism, transport and brain disposition. BBB, M3G, UGT
71  2011 Pharmacokinetic-pharmacodynamic modelling of opioids in healthy human volunteers. a minireview. PK/PD
72  2011 Synthesis and biological evaluation of analogues of M6G. ---
73  2011 The influence of active transport systems on morphine -6-glucuronide transport in MDCKII and MDCK-PGP cells. P-gp
74  2010 A randomised controlled trial on the efficacy and side-effect profile (nausea/vomiting/sedation) of morphine-6-glucuronide versus morphine for post-operative pain relief after major abdominal surgery. PCA, PONV
75  2010 Arterial and venous pharmacokinetics of morphine-6-glucuronide and impact of sample site on pharmacodynamic parameter estimates. ---
76  2010 Hydrophilic interaction liquid chromatography and accurate mass measurement for quantification and confirmation of morphine, codeine and their glucuronide conjugates in human urine. C6G, ESI, HILIC-TOFMS, ISCID, M3G, SPE
77  2010 Impact of anti-cancer drugs and other determinants on serum protein binding of morphine 6-glucuronide. AAG, HAS
78  2010 Molecular cloning of the baboon UDP-glucuronosyltransferase 2B gene family and their activity in conjugating morphine. M3G, UGT2Bs
79  2010 Naloxone reversal of morphine- and morphine-6-glucuronide-induced respiratory depression in healthy volunteers: a mechanism-based pharmacokinetic-pharmacodynamic modeling study. ---
80  2010 Pharmacokinetics of intra-articular morphine in horses with lipopolysaccharide-induced synovitis. IA, LPS, SF
81  2010 Pharmacokinetics of morphine after intramuscular injection in common goldfish Carassius auratus and Atlantic salmon Salmo salar. IM, M3G
82  2010 Relationships between plasma concentrations of morphine, morphine-3-glucuronide, morphine-6-glucuronide, and intravenous morphine titration outcomes in the postoperative period. IMT, M3G, PACU
83  2010 [Simultaneous determination of opioid compounds in human urine by UPLC-MS/MS]. 6-MAM, COD, M3G, M3G-d3, MOR, MOR-d3
84  2009 A validated hybrid quadrupole linear ion-trap LC-MS method for the analysis of morphine and morphine glucuronides applied to opiate deaths. 6-AM, M3G, MRM
85  2009 Characterization of human and bovine phosphatidylethanolamine-binding protein (PEBP/RKIP) interactions with morphine and morphine-glucuronides determined by noncovalent mass spectrometry. ESI-MS, PE
86  2009 Influence of the CYP2D6 polymorphism and hemodialysis on codeine disposition in patients with end-stage renal disease. C6G, EMs, HD, LC-MS, M3G, PMs
87  2009 Interactions between morphine and the morphine-glucuronides measured by conditioned place preference and locomotor activity. CPP, M3G
88  2009 Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions. ---
89  2009 Morphine-6beta-glucuronide rapidly increases pain sensitivity independently of opioid receptor activity in mice and humans. ---
90  2009 Pharmacokinetic and pharmacodynamic study of morphine and morphine 6-glucuronide after oral and intravenous administration of morphine in children with cancer. ---
91  2008 Behavioural sensitization in mice induced by morphine-glucuronide metabolites. M3G
92  2008 Cation-selective exhaustive injection and sweeping micellar electrokinetic chromatography for analysis of morphine and its four metabolites in human urine. CSEI-Sweep-MEKC, M3G, NM
93  2008 Contribution of UDP-glucuronosyltransferase 1A1 and 1A8 to morphine-6-glucuronidation and its kinetic properties. UGT
94  2008 Different time schedules affect conditioned place preference after morphine and morphine-6-glucuronide administration. CPP
95  2008 Differential effect of morphine and morphine-6-glucuronide on the control of breathing in the anesthetized cat. 3mNTX
96  2008 Efficacy and safety of morphine-6-glucuronide (M6G) for postoperative pain relief: a randomized, double-blind study. ---
97  2008 Endogenous morphine in SH-SY5Y cells and the mouse cerebellum. ---
98  2008 Evidence for separate involvement of different mu-opioid receptor subtypes in itch and analgesia induced by supraspinal action of opioids. muOR
99  2008 Flexible dosing of tincture of opium in the management of opioid withdrawal: pharmacokinetics and pharmacodynamics. BP, M3G, TOP
100  2008 In vivo chronic exposure to heroin or naltrexone selectively inhibits liver microsome formation of estradiol-3-glucuronide in the rat. E17G, E3G, M3G, UGT