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■ Abbreviation / Long Form : MAPKs / mitogen-activated protein kinases

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Abbreviation:   MAPKs  (>> Co-occurring Abbreviation)
Long Form:   mitogen-activated protein kinases
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No. Year Title Co-occurring Abbreviation
2021 (3α)-3-(tiglinoyloxy)-ent-kaur-16-en-19-oic acid, isolated from Wedelia trilobata L., exerts an anti-inflammatory effect via the modulation of NF-κB, MAPK and mTOR pathway and autophagy in LPS-stimulated macrophages. COX-2, IL-6, iNOS, LPS, NF-kappaB, NO, PGE2, ROS, TNF-alpha
2021 2,4-Dimethoxy-6-Methylbenzene-1,3-diol, a Benzenoid From Antrodia cinnamomea, Mitigates Psoriasiform Inflammation by Suppressing MAPK/NF-κB Phosphorylation and GDAP1L1/Drp1 Translocation. DMD, IMQ
2021 3,5-Dimethoxy-4-hydroxy myricanol attenuated oxidative stress-induced toxicity on cardiomyoblast cells. DHM, ELISA, HO-1, NF-kappaB
2021 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53. NAC, ROS
2021 A Crosstalk Between Dual-Specific Phosphatases and Dual-Specific Protein Kinases Can Be A Potential Therapeutic Target for Anti-cancer Therapy. CDK, CLK, DUSPs, DYRKs, MKPs, mTOR, mTORC1, PI3K, PTKs, PTPs
2021 A new synthetic antitumor naphthoquinone induces ROS-mediated apoptosis with activation of the JNK and p38 signaling pathways. JNK
2021 A Novel Cyclic Pentadepsipeptide, N-Methylsansalvamide, Suppresses Angiogenic Responses and Exhibits Antitumor Efficacy against Bladder Cancer. MMP-9, MSSV, VEGF
2021 A novel JNK induces innate immune response by activating the expression of antimicrobial peptides in Chinese mitten crab Eriocheir sinensis. AMPs, JNK, ORF, S_TKc
2021 A Phase 1/2 Study of Flavocoxid, an Oral NF-κB Inhibitor, in Duchenne Muscular Dystrophy. 10MWT, 5-LOX, COX, DMD, GPx, IL, NF-kappaB, TNF
10  2021 A walk-through MAPK structure and functionality with the 30-year-old yeast MAPK Slt2. CWI
11  2021 Acetate stimulates lipogenesis via AMPKα signaling in rabbit adipose-derived stem cells. ADSCs, AMPK, ERK, JNK
12  2021 Acetylated Resveratrol and Oxyresveratrol Suppress UVB-Induced MMP-1 Expression in Human Dermal Fibroblasts. HDF, MMP, OXYRES, RES
13  2021 Adaptation of the emerging pathogenic yeast Candida auris to high caspofungin concentrations correlates with cell wall changes. CPF, HS, PG, TE
14  2021 An Antioxidant Sesquiterpene Inhibits Osteoclastogenesis Via Blocking IPMK/TRAF6 and Counteracts OVX-Induced Osteoporosis in Mice. ASBMR, CUL, IPMK, NF-kappaB, ROS
15  2021 Anti-Inflammatory and Anti-Oxidant Effects of Korean Ginseng Berry Extract in LPS-Activated RAW264.7 Macrophages. CAT, COX-2, GSH-Px, IL, iNOS, JNK, KGB, LPS, NO, ROS, SOD
16  2021 Anti-Inflammatory Effect of Pineapple Rhizome Bromelain through Downregulation of the NF-κB- and MAPKs-Signaling Pathways in Lipopolysaccharide (LPS)-Stimulated RAW264.7 Cells. CB, COX, IL, iNOS, LPS, NF-kappaB, NO, PB, TNF
17  2021 Anti-Metastatic and Anti-Inflammatory Effects of Matrix Metalloproteinase Inhibition by Ginsenosides. ECM, ERK, JNK, MMPs
18  2021 Anti-Neuroinflammatory Effects and Mechanism of Action of Fructus ligustri lucidi Extract in BV2 Microglia. FLL, FLLE, HO, IL-6, LPS, NF-kappaB, NO, TNF-alpha
19  2021 Anti-thrombotic effects mediated by dihydromyricetin involve both platelet inhibition and endothelial protection. DHM
20  2021 Anticarin β Inhibits Human Glioma Progression by Suppressing Cancer Stemness via STAT3. STAT3
21  2021 Antiseptic effect of antimicrobial peptide psacotheasin 2 derived from the yellow-spotted longicorn beetle (Psacothea hilaris). COX-2, iNOS, LPS, NF-kB
22  2021 Antitumor and antimigration effects of Salvia clandestina L. extract on osteosarcoma cells. ---
23  2021 AoBck1 and AoMkk1 Are Necessary to Maintain Cell Wall Integrity, Vegetative Growth, Conidiation, Stress Resistance, and Pathogenicity in the Nematode-Trapping Fungus Arthrobotrys oligospora. CWI, NT, RT-PCR
24  2021 Ascorbic Acid Suppresses House Dust Mite-Induced Expression of Interleukin-8 in Human Respiratory Epithelial Cells. HDM, IL-8, ROS
25  2021 Assessment on the adverse effects on different kinds of fish induced by methamphetamine during the natural attenuation process based on adverse outcome pathway. AOP, DFw, METH
26  2021 BC and 1,4NQ-BC up-regulate the cytokines and enhance IL-33 expression in LPS pretreatment of human bronchial epithelial cells☆. BC, LPS, PI3K
27  2021 C-Jun N-terminal kinase post-translational regulation of pain-related Acid-Sensing Ion Channels 1b and 3. ASICs, ASICs, JNK
28  2021 CHIP-overexpressing Wharton's jelly-derived mesenchymal stem cells attenuate hyperglycemia-induced oxidative stress-mediated kidney injuries in diabetic rats. HG, WJMSCs
29  2021 Chromatin phosphoproteomics unravels a function for AT-hook motif nuclear localized protein AHL13 in PAMP-triggered immunity. AHL, PAMP
30  2021 Combinative treatment of Curdione and docetaxel triggers reactive oxygen species (ROS)-mediated intrinsic apoptosis of triple-negative breast cancer cells. DTX, PI3K, ROS, TNBC
31  2021 Combined Beneficial Effect of Genistein and Atorvastatin on Adipogenesis in 3T3-L1 Adipocytes. GR, PPARgamma
32  2021 Combined Toxicity of Metal Nanoparticles: Comparison of Individual and Mixture Particles Effect. DEP, NPs, QSAR, ROS
33  2021 Constitutive activation of mitogen-activated protein kinase kinase (MEK1) in ileal enterocytes leads to dysplasia and a predisposition to cancer. CA-MEK1
34  2021 Contributions of Sodium-Hydrogen Exchanger 1 and Mitogen-Activated Protein Kinases to Enhanced Retinal Venular Constriction to Endothelin-1 in Diabetes. ERK, ET-1, JNK, PKC
35  2021 CQMUH-011 Inhibits LPS-Induced Microglia Activation and Ameliorates Brain Ischemic Injury in Mice. ERK, I/R, IkappaBalpha, IL, LPS, MyD88, PCNA, TLR4, tMCAO, TNF
36  2021 Curcumin functions as an anti-inflammatory and antioxidant agent on arsenic-induced hepatic and kidney injury by inhibiting MAPKs/NF-κB and activating Nrf2 pathways. NF-kappaB
37  2021 Cyclooxygenase inhibition attenuates brain angiogenesis and independently decreases mouse survival under hypoxia. BBB, COX, CXCR4, VEGFR2
38  2021 Cytotoxic Fractions from Hechtia glomerata Extracts and p-Coumaric Acid as MAPK Inhibitors. pCA, ROS
39  2021 D-dopachrome tautomerase activates COX2/PGE2 pathway of astrocytes to mediate inflammation following spinal cord injury. BBB, CNS, DDT, MIF
40  2021 Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways. NF-kappaB
41  2021 Discovery of novel MIF inhibitors that attenuate microglial inflammatory activation by structures-based virtual screening and in vitro bioassays. MIF, NF-kappaB
42  2021 Downregulation of Snail by DUSP1 Impairs Cell Migration and Invasion through the Inactivation of JNK and ERK and Is Useful as a Predictive Factor in the Prognosis of Prostate Cancer. DUSP1, ERK, JNK, PC
43  2021 Dual Activity of Ginsenoside Rb1 in Hypertrophic Cardiomyocytes and Activated Macrophages: Implications for the Therapeutic Intervention of Cardiac Hypertrophy. Ang II, IL, LPS, miR-155, TNF
44  2021 Effect of Cone of Pinus densiflora on DNCB-Induced Allergic Contact Dermatitis-Like Skin Lesion in Balb/c Mice. ACD, CP
45  2021 Effects of trans-resveratrol on type 1 diabetes-induced up-regulation of apoptosis and mitogen-activated protein kinase signaling in retinal pigment epithelium of Dark Agouti rats. Bcl-2, CASP3, ERK1, JNK1, RPE
46  2021 EGCG Induces Pro-inflammatory Response in Macrophages to Prevent Bacterial Infection through the 67LR/p38/JNK Signaling Pathway. EGCG, IL-1beta, MCP-1, TNF-alpha
47  2021 Enhancement of skin barrier and hydration-related molecules by protopanaxatriol in human keratinocytes. FLG, HAS, PPT, TGM
48  2021 Extract of Seaweed Codium fragile Inhibits Integrin αIIbβ3-Induced Outside-in Signaling and Arterial Thrombosis. ---
49  2021 Fine-Tuning of Platelet Responses by Serine/Threonine Protein Kinases and Phosphatases-Just the Beginning. ---
50  2021 Formononetin attenuates H2O2-induced cell death through decreasing ROS level by PI3K/Akt-Nrf2-activated antioxidant gene expression and suppressing MAPK-regulated apoptosis in neuronal SH-SY5Y cells. Nrf2, PI3K, ROS
51  2021 Ganoderma lucidum: A potential source to surmount viral infections through β-glucans immunomodulatory and triterpenoids antiviral properties. G. lucidum, NF-kappaB, PAMPs
52  2021 Hemeprotein amplifies the innate immune receptors of Ctenopharyngodon idellus kidney cells through NF-κB- and MAPK-dependent reactive oxygen species generation. CAT, HO-1, IL, LPS, NF, PRR, ROS, SOD, TLR2, TNF
53  2021 Hsp90 modulates human sperm capacitation via the Erk1/2 and p38 MAPK signaling pathways. 17-AAG, CASA, Cdc37, Co-IP, Hsp90
54  2021 Hypoxic Jumbo Squid Activate Neuronal Apoptosis but Not MAPK or Antioxidant Enzymes during Oxidative Stress. ---
55  2021 Identification of 4'-Demethyltangeretin as a Major Urinary Metabolite of Tangeretin in Mice and Its Anti-inflammatory Activities. 4DT, LPS, NF-kappaB, TAN
56  2021 Imipramine alleviates memory impairment and hippocampal apoptosis in STZ-induced sporadic Alzheimer's rat model: Possible contribution of MAPKs and insulin signaling. AD, IRS1, Ser307, MWM, STZ
57  2021 Immunomodulatory Effects of Curcumin in Rheumatoid Arthritis: Evidence from Molecular Mechanisms to Clinical Outcomes. AP-1, NF-kappaB, RA, Th
58  2021 Impact of environmental toxicants on p38- and ERK-MAPK signaling pathways in the central nervous system. CNS, ERK
59  2021 Inhibition of p38 Mitogen-Activated Protein Kinase Impairs Mayaro Virus Replication in Human Dermal Fibroblasts and HeLa Cells. HDFs, MAYV
60  2021 Interaction of RIPK1 and A20 modulates MAPK signaling in murine acetaminophen toxicity. ASK1, Co-IP, JNK, RCD, RIPK1
61  2021 Interplay Between CMGC Kinases Targeting SR Proteins and Viral Replication: Splicing and Beyond. CDKs, CLKs, GSKs, SR
62  2021 Intrinsic apoptosis and cytokine induction regulated in human tonsillar epithelial cells infected with enterovirus A71. EV-A71
63  2021 Ishige okamurae Suppresses Trimethyltin-Induced Neurodegeneration and Glutamate-Mediated Excitotoxicity by Regulating MAPKs/Nrf2/HO-1 Antioxidant Pathways. HO-1, IOE, Nrf2, TMT
64  2021 Jasmonate Compounds and Their Derivatives in the Regulation of the Neoplastic Processes. ---
65  2021 JNK in Tumor Microenvironment: Present Findings and Challenges in Clinical Translation. JNKs, TME
66  2021 Lipopolysaccharide-Induced Nitric Oxide and Prostaglandin E2 Production Is Inhibited by Tellimagrandin II in Mouse and Human Macrophages. COX-2, LPS, NF-kappaB, NO, PGE2, TGII
67  2021 Literature-Based Drug Repurposing in Traditional Chinese Medicine: Reduced Inflammatory M1 Macrophage Polarization by Jisil Haebaek Gyeji-Tang Alleviates Cardiovascular Disease In Vitro and Ex Vivo. CVD, JHGT
68  2021 Mechanical stretching of the pulmonary vein mediates pulmonary hypertension due to left heart disease by regulating SAC/MAPK pathway and the expression of IL-6 and TNF-α. IL-6, SAC, TNF-alpha
69  2021 Mechanistic insights and perspectives involved in neuroprotective action of quercetin. JNK, NDDs, Nrf2, PGC-1alpha, PON2, TNF-alpha
70  2021 MEK1/2-ERK Pathway Alterations as a Therapeutic Target in Sporadic Alzheimer's Disease: A Study in Senescence-Accelerated OXYS Rats. AD, SPs
71  2021 Metformin inhibits MAPK signaling and rescues pancreatic aquaporin 7 expression to induce insulin secretion in type 2 diabetes mellitus. AQP7, T2DM
72  2021 Methylation of dual-specificity phosphatase 4 controls cell differentiation. DUSPs, MDS, MK
73  2021 Mitogen and Stress-Activated Kinases 1 and 2 Mediate Endothelial Dysfunction. KO, NO
74  2021 Mitogen-activated protein kinase 11 (MAPK11) maintains growth and photosynthesis of potato plant under drought condition. MAPK11
75  2021 MKP-1 is required to limit myeloid-cell mediated oral squamous cell carcinoma progression and regional extension. MKPs, OSCC, TAMs
76  2021 MMP-7 affects peritoneal ultrafiltration associated with elevated aquaporin-1 expression via MAPK/ERK pathway in peritoneal mesothelial cells. AQP1, MMPs, PD
77  2021 MNK as a potential pharmacological target for suppressing LPS-induced acute lung injury in mice. ALI, ARDS, BALF, BMDMs, eIF4E, IL-6, KC, TNF-alpha
78  2021 Modulation of proinflammatory mediators by viruses-bacteria synergism in human osteoblasts-an in vitro study. COX-2, ELISA, ERK, IL, JNK, Pg-LPS, PGE2
79  2021 Mogroside V Alleviates Lipopolysaccharide-Induced Neuroinflammation via Inhibition of TLR4-MyD88 and Activation of AKT/AMPK-Nrf2 Signaling Pathway. AD, CNS, COX-2, GCLC, HD, HMGB1, HO-1, IL-1beta, iNOS, Mog, MyD88, NF-kappaB, Nrf2, TLR4, TNF-alpha
80  2021 Myostatin Deficiency Protects C2C12 Cells from Oxidative Stress by Inhibiting Intrinsic Activation of Apoptosis. HR, IR, JNK, Mstn
81  2021 Nano-Curcumin Protects Against Sodium Nitrite-Induced Lung Hypoxia Through Modulation of Mitogen-Activated Protein Kinases/c-Jun NH2-Terminal Kinase Signaling Pathway. CRN, JNK, MMP, N-CRN, SN, TIMPs, TNF-alpha
82  2021 Nobiletin Inhibits Inflammatory Reaction in Interleukin-1β-Stimulated Human Periodontal Ligament Cells. hPDLCs, IL, NF
83  2021 Nuclear translocation of the tagged endogenous MAPK MPK-1 denotes a subset of activation events in C. elegans development. ERKs, VPCs
84  2021 Orexin-A Attenuates Inflammatory Responses in Lipopolysaccharide-Induced Neural Stem Cells by Regulating NF-KB and Phosphorylation of MAPK/P38/Erk Pathways. CCK-8, HE, LPS, NF-kB, NSCs
85  2021 Oxidative Stress Signaling in Blast TBI-Induced Tau Phosphorylation. BOP, ERK, GSK-3beta, JNK
86  2021 Pathogen- and plant-derived peptides trigger plant immunity. PAMPs, PRRs, PTI, ROS
87  2021 Pentalinonsterol, a Phytosterol from Pentalinon andrieuxii, is Immunomodulatory through Phospholipase A2 in Macrophages toward its Antileishmanial Action. BMDMs, PLA2
88  2021 Performance of the Polydopamine-Graphene Oxide Composite Substrate in the Osteogenic Differentiation of Mouse Embryonic Stem Cells. ALP, BMPR, ERK, ESCs, GO, JNK, PDA, PT, SEM, XPS
89  2021 Phosphorylation of intestine-specific homeobox by ERK1 modulates oncogenic activity and sorafenib resistance. ERK, HCC, ISX
90  2021 PKCδ/MAPKs and NF-κB Pathways are Involved in the Regulation of Ingenane-Type Diterpenoids from Euphorbia neriifolia on Macrophage Function. Euph E, Euri A, NF-kappaB, PKCdelta
91  2021 Plantanone C attenuates LPS-stimulated inflammation by inhibiting NF-κB/iNOS/COX-2/MAPKs/Akt pathways in RAW 264.7 macrophages. CCK-8, COX-2, ELISA, ERK, IkappaB, IL-1beta, iNOS, JNK, LPS, NF-kappaB, NO, PC, PGE2, TNF-alpha
92  2021 Polysaccharides from Ulva prolifera O.F. Müller inhibit cell proliferation via activating MAPK signaling in A549 and H1650 cells. MMPs, NSCLC, ROS, U. prolifera
93  2021 Potato StMPK7 is a downstream component of StMKK1 and promotes resistance to the oomycete pathogen Phytophthora infestans. CA-StMKK1, SA, StMKK1
94  2021 Potentiated Response of ERK/MAPK Signaling is Associated with Prolonged Withdrawal from Cocaine Behavioral Sensitization. BS, ERK, NAc
95  2021 PPARγ Attenuates Interleukin-1β-Induced Cell Apoptosis by Inhibiting NOX2/ROS/p38MAPK Activation in Osteoarthritis Chondrocytes. COX-2, NAC, NOX, OA, PGE2, PPARgamma, ROS
96  2021 Prostaglandin E2 induces dual-specificity phosphatase-1, thereby attenuating inflammatory genes expression in human osteoarthritic synovial fibroblasts. DUSP, MMPs, NGF, OA, PG
97  2021 Prostaglandin E2 receptor PTGER4-expressing macrophages promote intestinal epithelial barrier regeneration upon inflammation. DSS, IBD, PGE2
98  2021 Protective Effect of Membrane-Free Stem Cells against Lipopolysaccharide and Interferon-Gamma-Stimulated Inflammatory Responses in RAW 264.7 Macrophages. ADSCs, COX-2, ERK, IFN-gamma, iNOS, LPS, MFSC-Ex, NF-kappaB, NO, PGE2
99  2021 Protective Effect of Osmundacetone against Neurological Cell Death Caused by Oxidative Glutamate Toxicity. ERK, HO-1, HSP70, JNK, OAC, ROS
100  2021 Rapamycin reduces orofacial nociceptive responses and microglial p38 mitogen-activated protein kinase phosphorylation in trigeminal nucleus caudalis in mouse orofacial formalin model. Fos-ir, mTOR, p-p38, TNC