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■ Abbreviation / Long Form : NKCC1 / Na+-K+-2Cl- cotransporter 1

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Total Number of Papers: 212
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Abbreviation:   NKCC1  (>> Co-occurring Abbreviation)
Long Form:   Na+-K+-2Cl- cotransporter 1
 Abbreviation Variation
 Long Form Variation
 Pair(Abbreviation/Long Form) Variation
No. Year Title Co-occurring Abbreviation
2022 ---
2022 CAII, CD15, EN1, GCDFP-15, MUC-1
2022 A subpopulation of agouti-related peptide neurons exciting corticotropin-releasing hormone axon terminals in median eminence led to hypothalamic-pituitary-adrenal axis activation in response to food restriction. AgRP, CRH, GABA, HPA, ME
2022 Bumetanide attenuates sevoflurane-induced neuroapoptosis in the developing dentate gyrus and impaired behavior in the contextual fear discrimination learning test. GABA
2022 Chloride Ions, Vascular Function and Hypertension. ---
2022 Differential distribution and genetic determination of eccrine sweat glands and hair follicles in the volar skin of C57BL/6 mice and SD rats. En1, ESGs, HE, HFs, IFPs, LHX2, SD
2022 Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling. hNKCC1
2022 Molecular mechanisms underlying guanylin-induced transcellular Cl- secretion into the intestinal lumen of seawater-acclimated eels. AE, CLC, GN, NKA
2022 NKCC1 to KCC2 mRNA Ratio in Schizophrenia and Its Psychopathology: a Case-Control Study. BPRS, GABA, KCC2, mRNA, PANSS, RT-PCR, SCZ
10  2022 Osmoregulatory strategies of estuarine fish Scatophagus argus in response to environmental salinity changes. DEPs, NKA
11  2022 Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters. CSF, IVH, PEA, PHH, SAH
12  2022 Role of SPAK-NKCC1 signaling cascade in the choroid plexus blood-CSF barrier damage after stroke. ChP, CPECs, CSF, SPAK, TJs
13  2022 Striatal Chloride Dysregulation and Impaired GABAergic Signaling Due to Cation-Chloride Cotransporter Dysfunction in Huntington's Disease. BG, CCCs, CNS, GABA, GABAARs, HD, KCC2
14  2022 The Acute Effects of Furosemide on Na-K-Cl Cotransporter-1, Fetuin-A and Pigment Epithelium-Derived Factor in the Guinea Pig Cochlea. EP
15  2021 Aldosterone up-regulates basolateral Na+ -K+ -2Cl- cotransporter-1 to support enhanced large-conductance K+ channel-mediated K+ secretion in rat distal colon. ---
16  2021 All-Atom Simulations Uncover the Molecular Terms of the NKCC1 Transport Mechanism. CCC
17  2021 Analgesic Effect of Bumetanide on Neuropathic Pain in Patients With Spinal Cord Injury. KCC2, NRS, PMLs, SCI
18  2021 Axonal GABAA stabilizes excitability in unmyelinated sensory axons secondary to NKCC1 activity. DRG, GABAAR
19  2021 Bumetanide prevents diazepam-modified anxiety-like behavior in lipopolysaccharide-treated mice. GABA, LPS
20  2021 CLP290 promotes the sedative effects of midazolam in neonatal rats in a KCC2-dependent manner: A laboratory study in rats. GABAA, KCC2
21  2021 Comparative Effects of L. plantarum CGMCC 1258 and L. reuteri LR1 on Growth Performance, Antioxidant Function, and Intestinal Immunity in Weaned Pigs. ADG, BW, CFTR, CON, GSH-Px, IFN-gamma, IL-1beta, MDA, SOD, TGF-beta, TNF-alpha
22  2021 Extreme winter cold-induced osmoregulatory, metabolic, and physiological responses in European seabass (Dicentrarchus labrax) acclimatized at different salinities. BUN, CFTR, GOT, GPT, HSP70, IGF1, LDH, TNF-alpha
23  2021 Increased intracellular Cl- concentration in pulmonary arterial myocytes is associated with chronic hypoxic pulmonary hypertension. CHPH, KCC, PAs, PASMCs, PH
24  2021 Inhibition of the NKCC1/NF-kappaB Signaling Pathway Decreases Inflammation and Improves Brain Edema and Nerve Cell Apoptosis in an SBI Rat Model. BBB, IL-1beta, IL-6, NF-kappaB, SBI, SD, TNF-alpha
25  2021 Inhibition of the p‑SPAK/p‑NKCC1 signaling pathway protects the blood‑brain barrier and reduces neuronal apoptosis in a rat model of surgical brain injury. BBB, SBI
26  2021 Multiple Na,K-ATPase Subunits Colocalize in the Brush Border of Mouse Choroid Plexus Epithelial Cells. AQP1, STED
27  2021 Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases. COs, dCOs, GABARs, HC
28  2021 Oligodendrocytic Na+-K+-Cl- co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain. ---
29  2021 Ovariectomy and high salt increase blood pressure and alter sodium transport proteins in peripheral blood mononuclear cells of adult Wistar rats. BP, D1DR, HDZ, NKA, PBMCs, SGK1
30  2021 Rapid volume pulsation of the extracellular space coincides with epileptiform activity in mice and depends on the NBCe1 transporter. AQP4, DIDS, ECS, PTQ, RVP
31  2021 The combination of hair follicle-specific marker LHX2 and co-expressed marker can distinguish between sweat gland placodes and hair placodes in rat. ESG, HF, LEF1, LHX2, NKA, WB
32  2021 WNK3 Promotes Neuronal Survival after Traumatic Brain Injury in Rats. BBB, TBI
33  2020 A mutation in the Na-K-2Cl cotransporter-1 leads to changes in cellular metabolism. EGFP, MDCK, WT
34  2020 Acorus tatarinowii Schott extract reduces cerebral edema caused by ischemia-reperfusion injury in rats: involvement in regulation of astrocytic NKCC1/AQP4 and JNK/iNOS-mediated signaling. AQP4, ICAM-1, iNOS, MCAO, MMP-9, p-JNK, SCP, VEGFA, ZO-1
35  2020 Additive Effect of Resveratrol on Astrocyte Swelling Post-exposure to Ammonia, Ischemia and Trauma In Vitro. AHE, OGD, TBI
36  2020 Aquaporin 1 and the Na+/K+/2Cl- cotransporter 1 are present in the leptomeningeal vasculature of the adult rodent central nervous system. AQP1, CSF, SAS
37  2020 Asthmatic Airway Vagal Hypertonia Involves Chloride Dyshomeostasis of Preganglionic Neurons in Rats. BALF, BDNF, GABA, KCC2
38  2020 Blockade of Cell Volume Regulatory Protein NKCC1 Increases TMZ-Induced Glioma Apoptosis and Reduces Astrogliosis. ---
39  2020 Chloride - The Underrated Ion in Nociceptors. CFTR, DRG, GABA, KCC2, VRACs
40  2020 Differential expression of Na+/K+/Cl- cotransporter 1 in neurons and glial cells within the superficial spinal dorsal horn of rodents. ---
41  2020 Expression of Cl- channels/transporters in nasal polyps. AE2, CFTR
42  2020 Expression of GSK3β, PICK1, NEFL, C4, NKCC1 and Synaptophysin in peripheral blood mononuclear cells of the first-episode schizophrenia patients. FES, GSK-3beta, HC, NEFL, PBMCs, PICK1, qPCR, SYP, SZ
43  2020 Fluid shear stress enhances differentiation of jejunal human enteroids in Intestine-Chip. DRA, HUVECs, REG1A, SI
44  2020 Immunohistochemical characterization and change in location of branchial ionocytes after transfer from freshwater to seawater in the euryhaline obscure puffer, Takifugu obscurus. FW, NKA, SW
45  2020 NFAT5 and HIF-1alpha Coordinate to Regulate NKCC1 Expression in Hippocampal Neurons After Hypoxia-Ischemia. HI, HIE, HIF-1alpha, HRE, NFAT5, OGD, TonE
46  2020 Overexpression of chloride importer NKCC1 contributes to the sensory-affective and sociability phenotype of rats following neonatal maternal separation. NMS, OTergic
47  2020 Preliminary study of analgesic effect of bumetanide on neuropathic pain in patients with spinal cord injury. KCC2, NRS, PMLs
48  2020 Role of NKCC1 Activity in Glioma K+ Homeostasis and Cell Growth: New Insights With the Bumetanide-Derivative STS66. BMT, BrdU, TMZ
49  2020 Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function. CCCs, GABA, GABAa Rs, KCC2
50  2020 Surfactant Attenuates Air Embolism-Induced Lung Injury by Suppressing NKCC1 Expression and NF-kappaB Activation. AE, ALI
51  2020 The Excitatory Effects of GABA within the Suprachiasmatic Nucleus: Regulation of Na-K-2Cl Cotransporters (NKCCs) by Environmental Lighting Conditions. GABA, LD, NKCC1-ir, NKCCs, SCN
52  2020 The Therapeutic Potential of Neuronal K-Cl Co-Transporter KCC2 in Huntington's Disease and Its Comorbidities. CCCs, GABA, HD, KCC2
53  2019 A dileucine motif in the COOH-terminal domain of NKCC1 targets the cotransporter to the plasma membrane. SLC12A2
54  2019 Comparative transcriptome analysis reveals osmotic-regulated genes in the gill of Chinese mitten crab (Eriocheir sinensis). CS, DRD1, GST, NKA, TCA
55  2019 Differential antigen expression between human eccrine sweat glands and hair follicles/pilosebaceous units. alpha-SMA, CEA, EMA
56  2019 Effects of salt-loading on supraoptic vasopressin neurones assessed by ClopHensorN chloride imaging. AVP, EU, KCC2, SL, SL, SON, TrkB
57  2019 Enhanced Activity by NKCC1 and Slc26a6 Mediates Acidic pH and Cl- Movement after Cardioplegia-Induced Arrest of db/db Diabetic Heart. ---
58  2019 Functional characterization and osmoregulatory role of the Na+-K+-2Cl- cotransporter in the gill of sea lamprey (Petromyzon marinus), a basal vertebrate. SW
59  2019 Ion uptake pathways in European sea bass Dicentrarchus labrax. asic4, cac, FW, SW
60  2019 KCC2 expression levels are reduced in post mortem brain tissue of Rett syndrome patients. E/I, KCC2, MeCP2, RTT
61  2019 Novel Treatment Targets Based on Insights in the Etiology of Depression: Role of IL-6 Trans-Signaling and Stress-Induced Elevation of Glutamate and ATP. IL-6, KCC2
62  2019 Repeated anodal trans-spinal direct current stimulation results in long-term reduction of spasticity in mice with spinal cord injury. a-tsDCS, a-tsDCS, KCC2, tsDCS
63  2019 The Pharmacological Assessment of GABAA Receptor Activation in Experimental Febrile Seizures in Mice. FSs
64  2018 Activation of TRPV1 channels leads to stimulation of NKCC1 cotransport in the lens. TRPV
65  2018 Expression and localization of Forkhead transcription factor A1 in the three-dimensional reconstructed eccrine sweat glands. alpha-SMA, GCDFP-15
66  2018 Functional Significance of the Excitatory Effects of GABA in the Suprachiasmatic Nucleus. GABA, GABAAR, KCCs, SCN
67  2018 Genetic and pharmacological inactivation of apical Na+-K+-2Cl- cotransporter 1 in choroid plexus epithelial cells reveals the physiological function of the cotransporter. CPECs, CSF, CWV, EM, LCIM
68  2018 Inhibition of NKCC1 Modulates Alveolar Fluid Clearance and Inflammation in Ischemia-Reperfusion Lung Injury via TRAF6-Mediated Pathways. AFC, ALI, ENaC, HR, IR, NF-kappaB, p38 MAPK, TRAF6
69  2018 Mistargeting of a truncated Na-K-2Cl cotransporter in epithelial cells. MDCK
70  2018 Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers. CA2, CA4, cAMP, CFTR, DRA
71  2018 NKCC1 Inhibition Attenuates Chronic Cerebral Hypoperfusion-Induced White Matter Lesions by Enhancing Progenitor Cells of Oligodendrocyte Proliferation. BCAS, CNS, OLs, WMLs
72  2018 Pharmaco-resistant Neonatal Seizures: Critical Mechanistic Insights from a Chemoconvulsant Model. ASD, BTN, HIE, KCC2, PB, PTZ, SE
73  2018 Postnatal Changes in K+/Cl- Cotransporter-2 Expression in the Forebrain of Mice Bearing a Mutant Nicotinic Subunit Linked to Sleep-Related Epilepsy. KCC2, nAChR, PFC, WT
74  2018 Pretreatment with AQP4 and NKCC1 Inhibitors Concurrently Attenuated Spinal Cord Edema and Tissue Damage after Spinal Cord Injury in Rats. AQP4, LDH, SCI
75  2018 Regulation of erythrocyte Na+/K+/2Cl- cotransport by an oxygen-switched kinase cascade. deoxyHb, NO, OSR1, oxyHb, PPP, RBC
76  2018 Shifts in the relationship between mRNA and protein abundance of gill ion-transporters during smolt development and seawater acclimation in Atlantic salmon (Salmo salar). NKAalpha1a, Salmo salar
77  2018 Vitexin reduces epilepsy after hypoxic ischemia in the neonatal brain via inhibition of NKCC1. EEG, FCM, OGD, RBMECs, SD
78  2017 A novel organotypic 3D sweat gland model with physiological functionality. AQP5
79  2017 A salt-sensing kinase in T lymphocytes, SGK1, drives hypertension and hypertensive end-organ damage. Ang II, DOCA-salt, SGK1-dependent
80  2017 Actions of quercetin, a flavonoid, on ion transporters: its physiological roles. ---
81  2017 Actions of Quercetin, a Polyphenol, on Blood Pressure. ENaC
82  2017 Astaxanthin protects astrocytes against trauma-induced apoptosis through inhibition of NKCC1 expression via the NF-kappaB signaling pathway. ATX, IL, TNF
83  2017 Bumetanide reduce the seizure susceptibility induced by pentylenetetrazol via inhibition of aberrant hippocampal neurogenesis in neonatal rats after hypoxia-ischemia. DG, EEG, HI, HIBD, PTZ
84  2017 Bumetanide treatment during early development rescues maternal separation-induced susceptibility to stress. GABAA, KCC2
85  2017 Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission. APP, KCC2, USF1
86  2017 Cytokine-Regulation of Na+-K+-Cl- Cotransporter 1 and Cystic Fibrosis Transmembrane Conductance Regulator-Potential Role in Pulmonary Inflammation and Edema Formation. ARDS, CFTR
87  2017 Epithelial disruptions, but not immune cell invasion, induced secretory dysfunction following innate immune activation in a novel model of acute salivary gland injury. AQP5, BM, M3R, MPO, SG, SMGs, TJ, TMEM16A
88  2017 Evaluating the involvement of cerebral microvascular endothelial Na+/K+-ATPase and Na+-K+-2Cl- co-transporter in electrolyte fluxes in an invitro blood-brain barrier model of dehydration. BBB
89  2017 Inhibition of Na+-K+-2Cl- cotransporter attenuates blood-brain-barrier disruption in a mouse model of traumatic brain injury. BBB, CCI, TBI
90  2017 Inhibition of Nkcc1 promotes axonal growth and motor recovery in ischemic rats. BDA, CST
91  2017 Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy. MHC
92  2017 NKCC1 Regulates Migration Ability of Glioblastoma Cells by Modulation of Actin Dynamics and Interacting with Cofilin. GBM, NKCC1-KD
93  2017 Reduced protein expressions of cytomembrane GABAARbeta3 at different postnatal developmental stages of rats exposed prenatally to valproic acid. ASD, GABAARbeta3, KCC2, m-GABAARbeta3
94  2017 The chloride co-transporters, NKCC1 and KCC2, in experimental autoimmune encephalomyelitis (EAE). EAE, KCC2, MS, qRT-PCR
95  2017 The Subiculum: A Potential Site of Ictogenesis in a Neonatal Seizure Model. HP, NMDARs
96  2017 Two Phase Modulation of [Formula: see text] Entry and Cl-/[Formula: see text] Exchanger in Submandibular Glands Cells by Dexmedetomidine. DEX, HSG, LPS, PDE4D, SMG
97  2016 A Stenohaline Medaka, Oryzias woworae, Increases Expression of Gill Na(+), K(+)-ATPase and Na(+), K(+), 2Cl(-) Cotransporter 1 to Tolerate Osmotic Stress. EXP, NKA, NKA-IR, SW
98  2016 Bumetanide, an Inhibitor of NKCC1 (Na-K-2Cl Cotransporter Isoform 1), Enhances Propofol-Induced Loss of Righting Reflex but Not Its Immobilizing Actions in Neonatal Rats. GABA, LORR, pCREB
99  2016 Effectiveness of ketogenic diet in pentylenetetrazol-induced and kindling rats as well as its potential mechanisms. KCC2, KD, PTZ
100  2016 Expressions of ion co-transporter genes in salicylate-induced tinnitus and treatment effects of spirulina. ---